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1. 发明申请

WO2011046771A1 SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF 审中-公开
标题翻译：增加p53活性的替代药物及其用途
公开(公告)号：WO2011046771A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/051403
申请日：2010-10-05
申请人： SCHERING CORPORATION , BOGEN, Stephane, L. , MA, Yao , WANG, Yaolin , LAHUE, Brian Robert , NAIR, Latha, G. , SHIZUKA, Manami , VOSS, Matthew Ernst , KIROVA-SNOVER, Margarita , PAN, Weidong , TIAN, Yuan , KULKARNI, Bheemashankar, A. , GIBEAU, Craig, R. , LIU, Yuan , SCAPIN, Giovanna , RINDGEN, Diane , DOLL, Ronald, J. , GUZI, Timothy, J. , HICKLIN, Danny, J. , NOMEIR, Amin , SEIDEL-DUGAN, Cynthia , SHIPPS, Gerald, W., Jr. , MACCOSS, Malcolm
发明人： BOGEN, Stephane, L. , MA, Yao , WANG, Yaolin , LAHUE, Brian Robert , NAIR, Latha, G. , SHIZUKA, Manami , VOSS, Matthew Ernst , KIROVA-SNOVER, Margarita , PAN, Weidong , TIAN, Yuan , KULKARNI, Bheemashankar, A. , GIBEAU, Craig, R. , LIU, Yuan , SCAPIN, Giovanna , RINDGEN, Diane , DOLL, Ronald, J. , GUZI, Timothy, J. , HICKLIN, Danny, J. , NOMEIR, Amin , SEIDEL-DUGAN, Cynthia , SHIPPS, Gerald, W., Jr. , MACCOSS, Malcolm
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供本文所述的式（1）化合物或其药学上可接受的盐，溶剂合物或酯。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

2. 发明申请

WO2013096150A1 SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS 审中-公开
标题翻译：取代的管道作为HDM2抑制剂
公开(公告)号：WO2013096150A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/069996
申请日：2012-12-17
申请人： MERCK SHARP & DOHME CORP. , MA, Yao , SHIZUKA, Manami , GUZI, Timothy, J. , LIU, Yuan , TIAN, Yuan , LAHUE, Brian, R. , GIBEAU, Craig, R. , SHIPPS, Gerald, W., Jr. , WANG, Yaolin , BOGEN, Stephane, L. , NAIR, Latha, G. , PAN, Weidong , VOSS, Matthew, E. , KIROVA-SNOVER, Margarita , CLAYTON, W. Brent , MCCOY, Mark, A.
发明人： MA, Yao , SHIZUKA, Manami , GUZI, Timothy, J. , LIU, Yuan , TIAN, Yuan , LAHUE, Brian, R. , GIBEAU, Craig, R. , SHIPPS, Gerald, W., Jr. , WANG, Yaolin , BOGEN, Stephane, L. , NAIR, Latha, G. , PAN, Weidong , VOSS, Matthew, E. , KIROVA-SNOVER, Margarita , CLAYTON, W. Brent , MCCOY, Mark, A.
IPC分类号： A61K31/497
CPC分类号： C07D495/04 , C07D409/14
摘要： The present invention provides a compound of Formula I(The formula should be inserted here) as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译：本发明提供如本文所述的式I化合物（该式应该在此插入）或其药学上可接受的盐或溶剂化物。代表性化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

3. 发明申请

WO2012178155A2 LED CANDLE BULB AND LED CANDLE LIGHT 审中-公开
标题翻译： LED蜡烛灯和LED蜡烛灯
公开(公告)号：WO2012178155A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043981
申请日：2012-06-25
申请人： ORGANO BULB INC. , LIU, Yuan , LI, Qing (Charles)
发明人： LIU, Yuan , LI, Qing (Charles)
IPC分类号： F21V17/00 , F21V29/00
CPC分类号： F21V23/009 , F21K9/232 , F21S6/001 , F21V3/02 , F21V29/70
摘要： The present invention is directed generally to electric lighting, and more particularly to a light emitting diode (LED) candle bulb and LED candle light. More particularly, the present invention relates to a candle light assembly comprising: a bulb enclosing a volume and having an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a heat sink base with an opening at a longitudinal end, wherein the opening has an interior circumference which is threaded; a connector for securing the bulb to the heat sink base, which has an upper exterior threaded portion for communicating with the threaded bulb and a lower exterior threaded portion for communicating with the threaded base; and an optics assembly comprising an LED, a lens, and a drive circuit for operating the LED. The LED candle lights according to embodiments of the invention can provide bright lighting similar to that of traditional incandescent candle light without overheating.
摘要翻译：本发明一般涉及电照明，更具体地涉及发光二极管（LED）蜡烛灯泡和LED蜡烛灯。更具体地说，本发明涉及一种蜡烛灯组件，其包括：封闭容积的灯泡，在纵向端部具有开口，其中所述开口具有螺纹的内圆周; 具有在纵向端部处的开口的散热器基座，其中所述开口具有螺纹的内周; 用于将灯泡固定到散热器基座的连接器，该基座具有用于与螺纹灯泡连通的上部外部螺纹部分和用于与螺纹基座连通的下部外部螺纹部分; 以及包括用于操作LED的LED，透镜和驱动电路的光学组件。根据本发明的实施例的LED蜡烛灯可以提供类似于传统白炽灯的明亮的照明，而不会过热。

4. 发明申请

WO2002062953A3 HUMAN HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CATION CHANNEL HCN1 审中-公开
公开(公告)号：WO2002062953A3
公开(公告)日：2002-08-15
申请号：PCT/US2002/003074
申请日：2002-01-18
申请人： MERCK & CO., INC. , FOLANDER, Kimberly, L. , LIU, Yuan , SWANSON, Richard, J.
发明人： FOLANDER, Kimberly, L. , LIU, Yuan , SWANSON, Richard, J.
IPC分类号： C12N15/00
摘要： The present invention is directed to novel human DNA sequences encoding human HCN1 proteins, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and activators of cation channels containing the human HCN1 proteins.

5. 发明申请

WO2021102202A2 HYDROGENATED POLYMERS AND RUBBER COMPOSITIONS INCORPORATING THE SAME 审中-公开
公开(公告)号：WO2021102202A2
公开(公告)日：2021-05-27
申请号：PCT/US2020/061385
申请日：2020-11-19
申请人： BRIDGESTONE CORPORATION , KANATOMI, Yoshihiko , MAGISTRELLI, Jeffrey M. , HUE, Ryan J. , LIU, Yuan
发明人： KANATOMI, Yoshihiko , MAGISTRELLI, Jeffrey M. , HUE, Ryan J. , LIU, Yuan
IPC分类号： C08F36/04 , C08F236/10 , C08F136/06 , C08F8/42 , C08F8/04 , C08K3/36 , C08K3/06 , C08L9/00 , C08L9/06 , B60C1/00
摘要： Embodiments of the present disclosure are directed to functional polymers produced by copolymerization of at least one conjugated diolefin monomer and optionally one or more vinyl monomer, the functional polymer comprising at least one functional group having silica reactive moieties, wherein the functional copolymer has a degree of hydrogenation of from 40% to 98 mol% and a vinyl content of about 50% or less.

6. 发明申请

WO2020172565A1 METHODS AND MATERIALS FOR INCREASING OR MAINTAINING NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE-2 (NMNAT2) POLYPEPTIDE LEVELS 审中-公开
公开(公告)号：WO2020172565A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/019285
申请日：2020-02-21
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , CHEN, Beibei , FINKEL, Toren , LIU, Yuan
发明人： CHEN, Beibei , FINKEL, Toren , LIU, Yuan
IPC分类号： C07D261/20 , A61P25/02
摘要： This document provides methods and materials for increasing or maintaining NMNAT2 polypeptide levels within cells. For example, compounds (e.g., organic compounds) having the ability to increase or maintain NMNAT2 polypeptide levels within cells, formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for making formulations containing compounds having the ability to increase or maintain NMNAT2 polypeptide levels within cells, methods for increasing or maintain NMNAT2 polypeptide levels within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in NMNAT2 polypeptide levels are provided (or for preventing said condition).

7. 发明申请

WO2014100314A1 THIAZOLE-SUBSTITUTED AMINOPYRIDINES AS SPLEEN TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：噻唑取代的氨基酰亚胺作为分离型酪氨酸激酶抑制剂
公开(公告)号：WO2014100314A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/076341
申请日：2013-12-19
申请人： MERCK SHARP & DOHME CORP. , ALTMAN, Michael, D. , ANDRESEN, Brian, M. , ARRINGTON, Kenneth, L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , HAIDLE, Andrew, M. , LIU, Yuan , NORTHRUP, Alan , O'BOYLE, Brendan , OTTE, Ryan, D. , REUTERSHAN, Michael, H. , VITHARANA, Dilrukshi , WOO, Hyun Chong
发明人： ALTMAN, Michael, D. , ANDRESEN, Brian, M. , ARRINGTON, Kenneth, L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , HAIDLE, Andrew, M. , LIU, Yuan , NORTHRUP, Alan , O'BOYLE, Brendan , OTTE, Ryan, D. , REUTERSHAN, Michael, H. , VITHARANA, Dilrukshi , WOO, Hyun Chong
IPC分类号： A61K31/44 , A61P35/00
CPC分类号： C07D417/14 , A61K31/444 , A61K45/06
摘要： The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , C y , and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译：本发明提供了式（I）（I）的某些噻唑取代的氨基吡啶化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，R6，Cy和下标t如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。

8. 发明申请

WO2012151137A1 AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 审中-公开
标题翻译：含氨基吡啶类的吡咯啉类激酶（SYK）抑制剂
公开(公告)号：WO2012151137A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/035725
申请日：2012-04-30
申请人： MERCK SHARP & DOHME CORP. , ROMEO, Eric Thomas , MACHACEK, Michelle, R. , TROTTER, Benjamin Wesley , MILLER, Thomas Allen , ANDRESEN, Brian Michael , ANTHONY, Neville John , TAOKA, Brandon, M. , LIU, Yuan
发明人： ROMEO, Eric Thomas , MACHACEK, Michelle, R. , TROTTER, Benjamin Wesley , MILLER, Thomas Allen , ANDRESEN, Brian Michael , ANTHONY, Neville John , TAOKA, Brandon, M. , LIU, Yuan
IPC分类号： A01N43/40 , A61K31/44 , C07D401/02
CPC分类号： A61K31/444 , A61K31/496 , A61K31/675 , A61K31/69 , A61K45/06 , C07D277/04 , C07D417/14 , C07F5/025 , C07F9/65583
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译：本发明提供某些含有氨基 - 吡啶的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。

9. 发明申请

WO2009048927A1 VERNONIA OIL POLYOLS 审中-公开
标题翻译： VERNONIA油多元醇
公开(公告)号：WO2009048927A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079167
申请日：2008-10-08
申请人： UNIVERSITY OF SOUTHERN MISSISSIPPI , RAWLINS, James, W. , MENDON, Sharathkumar, K. , LIU, Yuan
发明人： RAWLINS, James, W. , MENDON, Sharathkumar, K. , LIU, Yuan
IPC分类号： C11C1/04 , C11C3/06 , C08G18/00
CPC分类号： C11C3/06 , C08G18/36 , C08G18/6696 , C08G2101/0008 , C08G2101/0025 , C08G2101/005 , C08G2101/0083 , C11C1/04
摘要： The present invention discloses polyols synthesized from vemonia oil. The process for synthesizing a vemonia oil-based polyol involves reducing vernonia oil to vernolic acid; heating the vernolic acid at elevated temperatures to form oligomers; and forming the polyol by transesterification of the oligomers with glycerol. The polyols synthesized according to the present invention have lower viscosity values at similar hydroxyl values compared to polyols synthesized from other vegetable oils. The lower viscosity values are of importance in the synthesis of foams as it promotes foam growth.
摘要翻译：本发明公开了从vemonia油合成的多元醇。合成基于油的多元醇多元醇的方法包括将葵花油降低至戊醛酸; 在升高的温度下加热钒酸以形成低聚物; 并通过低聚物与甘油的酯交换形成多元醇。根据本发明合成的多元醇与其它植物油合成的多元醇相比，具有较低的粘度值。在促进泡沫生长时，较低的粘度值在泡沫的合成中是重要的。

10. 发明申请

WO2007076927A1 ANTI-IL-6 ANTIBODIES PREVENTING THE BINDING OF IL-6 COMPLEXED WITH IL-6RALPHA TO GP130 审中-公开
标题翻译：抗IL-6抗体，预防与IL-6RALPHA复合的IL-6与GP130的结合
公开(公告)号：WO2007076927A1
公开(公告)日：2007-07-12
申请号：PCT/EP2006/012236
申请日：2006-12-19
申请人： MERCK PATENT GMBH , WAY, Jeffrey, C. , GILLIES, Stephen, D. , LO, Kin-Ming , LIU, Yuan
发明人： WAY, Jeffrey, C. , GILLIES, Stephen, D. , LO, Kin-Ming , LIU, Yuan
IPC分类号： C07K16/24 , A61K39/395 , A61P35/00 , C12N15/13 , C07K19/00 , C07K14/54
CPC分类号： C07K14/5412 , A61K2039/505 , C07K14/7155 , C07K16/248 , C07K16/2866 , C07K16/3023 , C07K16/3053 , C07K16/3061 , C07K2317/24 , C07K2317/32 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention provides anti IL-6 antibodies including an antibody variable region that prevents IL-6 from binding to gp130. The present invention also provides compositions and methods for treating IL-6 related diseases based on the IL-6 antagonists of the invention.
摘要翻译：本发明提供抗IL-6抗体，其包括防止IL-6与gp130结合的抗体可变区。本发明还提供了基于本发明的IL-6拮抗剂治疗IL-6相关疾病的组合物和方法。

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