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1. 发明申请

WO1995030692A1 ANTI-FUNGAL CYCLIC DEPSIPEPTIDES 审中-公开
标题翻译：抗真菌循环阻滞剂
公开(公告)号：WO1995030692A1
公开(公告)日：1995-11-16
申请号：PCT/US1995005020
申请日：1995-05-01
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , COOPER, Alan, B. , SAKSENA, Anil , RANE, Dinanath, F. , JAO, Edwin , GIRIJAVALLABHAN, Viyyoor, M. , GANGULY, Ashit , DESAI, Jagdish, A. , WANG, James
IPC分类号： C07K11/02
CPC分类号： C07K11/02 , A61K38/00
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, X1, X2, X3, X4, X5, X6, X7, and X8, as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.
摘要翻译：描述了本文所述的式（I）化合物或其药学上可接受的盐，其中R1，R2，X1，X2，X3，X4，X5，X6，X7和X8。这些化合物可用作治疗真菌感染的药剂。

2. 发明申请

WO1991019693A1 ESTERS AND CYCLIC DIESTERS OF 4-HYDROXY-1,3-BENZENEDIMETHANOL AND COMPOSITIONS AND METHODS EMPLOYING SUCH COMPOUNDS 审中-公开
标题翻译： 4-羟基-1,3-苯二甲酰胺及其组合物的酯和循环系统及其使用方法
公开(公告)号：WO1991019693A1
公开(公告)日：1991-12-26
申请号：PCT/US1991003966
申请日：1991-06-11
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , BLYTHIN, David, J. , SHUE, Ho-Jane , GANGULY, Ashit
IPC分类号： C07C219/30
CPC分类号： C07D491/04 , C07C217/46 , C07C217/70 , C07C219/30 , C07D321/00 , C07D495/04
摘要： Novel compounds selected from the group consisting of: (A) compounds of formula I(1), wherein: one of R and R represents the group (a) and the other represents hydrogen or R CO-; R represents C1 to C6-alkyl or the group -(CH2)n-Z-(CH2)m-Ar; Z represents O, S or -CH2-; n represents an integer of 1 to 8; m represents zero or an integer of 1 to 8; R is C1 to C10 alkyl, C3 to C8 cycloalkyl, aryl, heteroaryl, -N(R R ), or R O-; R , R , R , and R are each independently selected from hydrogen, C1 to C6 alkyl and Ar ; R and R are each independently C1-C8 alkyl; Ar and Ar are each independently selected from the group consisting of phenyl or substituted phenyl, (B) compounds of formula I(2), wherein: R represents C1 to C6-alkyl or the group -(CH2)n-Z-(CH2)m-Ar ; Ar is selected from the group consisting of phenyl, substituted phenyl, or phenyl optionally substituted by two adjacent groups which together form an additional benzenoid ring; ring Q represents one of the rings Q1, Q2, Q3 or Q4, and pharmaceutically acceptable acid addition salts thereof are described. These compounds possess favorable properties for the treatment of asthma and all types of chronic, obstructionary bronchopulmonary diseases.
摘要翻译：选自以下的新型化合物：（A）式I（1）化合物，其中：R 1和R 2之一表示（a）基团，另一个表示氢或R 7 CO - ; R 5表示C 1 -C 6烷基或基团 - （CH 2）n-Z-（CH 2）m -Ar; Z表示O，S或-CH 2 - ; n表示1〜8的整数， m表示0或1〜8的整数， R 7是C 1至C 10烷基，C 3至C 8环烷基，芳基，杂芳基，-N（R 9 R 10）或R 11 O-; R 3，R 4，R 9和R 10各自独立地选自氢，C 1至C 6烷基和Ar 1; R 6和R 11各自独立地为C 1 -C 8烷基; Ar和Ar 1各自独立地选自苯基或取代的苯基，（B）式I（2）的化合物，其中：R 5a表示C1至C6-烷基或基团 - （CH2） NZ-（CH 2）M-的Ar <2>; Ar 2选自苯基，取代的苯基或任选被两个相邻基团取代的苯基，它们一起形成另外的苯环; 环Q表示环Q1，Q2，Q3或Q4中的一个，并且其药学上可接受的酸加成盐被描述。这些化合物具有治疗哮喘和所有类型的慢性阻塞性支气管肺疾病的有利性质。

3. 发明申请

WO1997023495A1 WATER SOLUBLE ANTIBIOTICS 审中-公开
标题翻译：水溶性抗生素
公开(公告)号：WO1997023495A1
公开(公告)日：1997-07-03
申请号：PCT/US1996019599
申请日：1996-12-18
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , GIRIJAVALLABHAN, Viyyoor, M. , SAKSENA, Anil, K. , BENNETT, Frank , JAO, Edwin , PATEL, Naginbhai, M. , GANGULY, Ashit
IPC分类号： C07H17/04
CPC分类号： C07H17/04
摘要： The compound of formula (I) wherein R , R , R , R , R , R , R , and R are as defined herein, are described. These compounds are antibacterial agents.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8的式（I）化合物为在此描述。这些化合物是抗菌剂。

4. 发明申请

WO1996034857A1 SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS 审中-公开
标题翻译：作为神经营养因子拮抗剂的替代物，水合物和油脂
公开(公告)号：WO1996034857A1
公开(公告)日：1996-11-07
申请号：PCT/US1996005659
申请日：1996-05-01
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , REICHARD, Gregory, A. , ASLANIAN, Robert, G. , ALAIMO, Cheryl, L. , KIRKUP, Michael, P. , LUPO, Andrew , MANGIARACINA, Pietro , MCCORMICK, Kevin, D. , PIWINSKI, John, J. , SHANKAR, Bandarpalle , SHIH, Neng-Yang , SPITLER, James, M. , TING, Pauline, C. , GANGULY, Ashit , CARRUTHERS, Nicholas, I.
IPC分类号： C07D211/52
CPC分类号： C07D295/185 , C07D211/52 , C07D211/58 , C07D211/76 , C07D295/13 , C07D333/22 , C07D401/04 , C07D401/06 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3; b, d and e are independently 0, 1 or 2; R is H, C1-6 alkyl, -OH or C2-C6 hydroxyalkyl; A is an optionally substituted oxime, hydrazone or olefin; X is a bond, -C(O)-, -O-, -NR -, -S(O)e-, -N(R )C(O)-, -C(O)N(R )-, -OC(O)NR -, -OC(=S)NR -, -N(R )C(=S)O-, -C(=NOR )-, -S(O)2N(R )-, -N(R )S(O)2-, -N(R )C(O)O- or -OC(O)-; T is H, phthalimidyl, aryl, heterocycloalkyl, heteroaryl, cycloalkyl or bridged cycloalkyl; Q is -SR , -N(R )(R ), -OR , phenyl, naphthyl or heteroaryl; R , R , R , R , R and R are H, C1-6 alkyl, C2-C6 hydroxyalkyl, C1-C6 alkoxy-C1-C6 alkyl, phenyl or benzyl; or R and R , together with the nitrogen to which they are attached, form a ring; R is R or -OR ; Z is morpholinyl, optionally N-substituted piperazinyl, optionally substituted (a), or substituted (b); g is 0-3 and h is 1-4, provided the sum of h and g is 1-7; wherein aryl, heterocycloalkyl, heteroaryl, cycloalkyl and bridged cycloalkyl groups are optionally substituted; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.
摘要翻译：由结构式（I）表示的化合物或其药学上可接受的盐，其中：a为0,1,2或3; b，d和e独立地为0,1或2; R为H，C 1-6烷基，-OH或C 2 -C 6羟烷基; A是任选取代的肟，腙或烯烃; X是键，-C（O） - ， - O - ， - NR 6 - ， - S（O）e - ， - N（R 6）C（O） N（R 6） - ， - OC（O）NR 6 - ， - OC（= S）NR 6 - ， - N（R 6）C（= S）（= NOR 1） - ， - S（O）2 N（R 6） - ， - N（R 6）S（O）2 - ， - N（R 6） O-或-OC（O） - ; T是H，苯二酰亚氨基，芳基，杂环烷基，杂芳基，环烷基或桥连环烷基; Q是-SR 6，-N（R 6）（R 7），-OR 6，苯基，萘基或杂芳基; R 6a，R 7a，R 8a，R 9a，R 6和R 7是H，C 1-6烷基，C 2 -C 6羟烷基，C 1 -C 6烷氧基-C 1 -C 6 烷基，苯基或苄基; 或R 6和R 7与它们所连接的氮一起形成环; R 9a是R 6或-OR 6; Z是吗啉基，任选取代的N-取代的哌嗪基，任选取代的（a）或取代的（b）; g为0-3，h为1-4，h和g之和为1-7; 其中芳基，杂环烷基，杂芳基，环烷基和桥连环烷基任选被取代; 公开了用所述化合物治疗哮喘，咳嗽，支气管痉挛，炎性疾病和胃肠道疾病的方法，以及包含所述化合物的药物组合物。

5. 发明申请

WO1989000571A2 BICYCLIC COMPOUNDS, THEIR USE AS PHARMACEUTICALS, THEIR PREPARATION, AND INTERMEDIATES USEFUL IN THEIR PREPARATION 审中-公开
标题翻译：双环化合物，它们作为药物的用途，它们的制备和用于其制备的中间体
公开(公告)号：WO1989000571A2
公开(公告)日：1989-01-26
申请号：PCT/US1988002375
申请日：1988-07-20
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , BLYTHIN, David, J. , SHUE, Ho-Jane , GALA, Dinesh , STEINMAN, Martin , GANGULY, Ashit
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D215/36 , C07D453/02
摘要： Bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in the treatment of hyperproliferative skin desease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed. Many of the compounds are novel; inventive methods for their preparation and for the preparation of intermediates, are also disclosed.
摘要翻译：本发明描述了可用作抗过敏剂，抗炎剂和/或细胞保护剂并可用于治疗过度增殖性皮肤病症的双环化合物。还公开了使用这些化合物的药物组合物和治疗方法。这些化合物中有许多是新的; 还描述了其制备和制备中间体化合物的新方法。

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