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1. 发明申请

WO1998005366A1 TERMINAL STERILISATION PROCESS FOR FILLED SYRINGES UNDER AN AUXILIARY PRESSURE 审中-公开
标题翻译：法支护压力充式注射器的最终灭菌
公开(公告)号：WO1998005366A1
公开(公告)日：1998-02-12
申请号：PCT/DE1997001671
申请日：1997-08-01
申请人： SCHERING AKTIENGESELLSCHAFT , KOLBERG, Reiner
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61L02/04
CPC分类号： A61L2/20 , A61L2/04 , A61L2/07 , A61L2/12 , A61M5/24 , A61M2005/3123
摘要： A process is disclosed for manufacturing a previously filled, sterile syringe. The syringe has a syringe body (2) with a proximal (5) and a distal end, a syringe outlet at its distal end, a closure, a stopper (8), a fluid and a gaseous medium. The fluid medium is a contrasting agent. The process has the following steps: a syringe body (2) sealed by a closure at its distal outlet is filled through its proximal end (5). A compression device (1) introduces the stopper (8) into the proximal end (5) of the syringe body (2) and extracts air from the syringe body (2) through needles (6). The piston is lowered into the syringe body (2) and the compression device (1) is removed therefrom. Finally, the syringe is treated by autoclave in a sterilisation chamber.
摘要翻译：本发明包括一种制造预填充，无菌注射器的方法。注射器包括注射器本体（2）具有近端（5）和远端，在其远端的注射器出口件，封闭，插塞（8）和一个流体和气态介质。流体介质是造影剂。该方法包括以下步骤：a注射器本体（2），其已经被密封在与闭合远端注射器出口，穿过近侧端（5）被填充。一种压缩装置（1）承载在近端插头（8）所述注射器本体（5）（2）。在这种情况下，由压缩装置（1）通过针（6）的空气从注射器主体（2）的装置抽吸。将烧瓶被留在注射器本体（2），压缩装置（1）被取出。然后将注射器在一个消毒腔室高压灭菌。

2. 发明申请

WO1999001160A1 SACCHARIDE CONJUGATES, PHARMACEUTICALS CONTAINING THE SAME, PROCESS FOR PREPARING THE SAME AND THEIR USE 审中-公开
标题翻译：糖缀合物，含制药，制造方法相同，它们的用途
公开(公告)号：WO1999001160A1
公开(公告)日：1999-01-14
申请号：PCT/EP1998003142
申请日：1998-05-27
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , MARESKI, Peter , PLATZEK, Johannes , RADÜCHEL, Bernd , BERNDORFF, Dietmar , WEINMANN, Hanns-Joachim
IPC分类号： A61K49/00
CPC分类号： A61K49/124 , A61K49/085 , A61K49/146
摘要： Conjugates consist of an amino-group-containing polymer, signal-generating group(s) which contain metal ion(s), and mono- or oligosaccharides, and optionally of cations of inorganic and/or organic bases, amino acids or amino acid amides. These conjugates are valuable compounds for diagnosis and therapy.
摘要翻译：由含氨基的聚合物的缀合物，含有信令组（一个或多个）和单糖或寡糖，以及无机和/或有机碱，氨基酸或氨基酸酰胺任选阳离子金属离子（S）是用于诊断和治疗价值的化合物。

3. 发明申请

WO1998024803A1 STEROID ESTERS, METHOD FOR THE MANUFACTURE THEREOF AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：甾族酯，PROCESS FOR THEIR和制药用
公开(公告)号：WO1998024803A1
公开(公告)日：1998-06-11
申请号：PCT/EP1997006829
申请日：1997-12-08
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , KLAR, Ulrich , CLEVE, Arwed , SCHWEDE, Wolfgang , NEEF, Günter , OTTOW, Eckhard , CHWALISZ, Kristof , SCHNEIDER, Martin
IPC分类号： C07J53/00
CPC分类号： C07J53/002 , Y10S514/843
摘要： Disclosed are novel steroid esters of formula (I), wherein m means 1 or 2, n is 0 or 1, X is F or CN and the line drawn between carbon atoms 15 and 16 symbolizes the possible presence of a dual bond, excluding compound (Z)-6'-(4-cyanphenyl)-9,11 alpha -dihydro-17 beta -hydroxy-17 alpha -[3-(1-oxo-2-methylpropoxy)-1-propenyl]-4'H-naphto[3',2',1';10,9,11] ester-4-en-3-on. Derivatization occurs with a carboxylic acid. The novel compounds are characterized by a significantly enhanced solubility in comparison with the basic hydroxy compounds, and by enhanced biological effectiveness and selectivity. Said novel compounds are suitable for the production of medicaments.
摘要翻译：它描述了式（I）其中m是1或2的新的类固醇酯，n为0或1，X为F或CN和碳原子数为15和16之间的虚线，双键的符号，但不包括化合物（Z）的任选存在 - 6 ' - （4-氰基苯基）-9,11二氢-α17的β - 羟基17α - [3-（1-氧代-2-甲基丙氧基）-1-丙烯基] -4'H - 萘并[3' ，2”，1' ：10,9,11]雌-4-烯-3-酮。衍生化用的羧酸中进行。新化合物由显着改进的溶解度以及通过增加的生物活性和选择性是从基础羟基化合物区别开来。这些新化合物是适用于生产药品。

4. 发明申请

WO1998024801A1 OXYIMINOPREGNANCARBOLACTONE 审中-公开
公开(公告)号：WO1998024801A1
公开(公告)日：1998-06-11
申请号：PCT/EP1997006657
申请日：1997-12-01
申请人： SCHERING AKTIENGESELLSCHAFT , LAURENT, Henry , LIPP, Ralph , ESPERLING, Peter , TACK, Johannes-Wilhelm
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07J41/00
CPC分类号： C07J41/0016
摘要： Disclosed are 3-oxyiminopregnan-21-carbolactone, (E,Z) mixtures and isomerically pure (E) and (Z) compounds, the production and use thereof as medicaments.
摘要翻译： 3- Oxyiminopregnan -21-内酯，（E，Z）-mixtures，和异构体纯的（E） - 和（Z）的化合物，它们的制备和在药物组合物使用进行了描述。

5. 发明申请

WO1998020856A2 MICROPARTICLES CONTAINING ACTIVE SUBSTANCES, AGENTS CONTAINING THE SAME, THEIR USE IN ULTRASOUND-CONTROLLED RELEASING OF ACTIVE SUBSTANCES AS WELL AS THE METHOD FOR THEIR PRODUCTION 审中-公开
标题翻译：有源音响微粒含剂，它们的使用在生产活性物质和方法，超声控释
公开(公告)号：WO1998020856A2
公开(公告)日：1998-05-22
申请号：PCT/EP1997006257
申请日：1997-11-04
申请人： SCHERING AKTIENGESELLSCHAFT , WEITSCHIES, Werner , BERGMANN, Martina , UHLENDORF, Volkmar , HELDMANN, Dieter
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K09/00
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/5026 , A61K9/5089
摘要： The invention relates to microparticles containing active substances, wherein the active substance has been dissolved, suspended or emulsified in a low boiling fluid phase, the agents containing these particles, their use in ultrasound controlled in vivo releasing of active substances, as well as the method for producing said particles and agents.
摘要翻译：本发明涉及含有药物的微型颗粒，将活性化合物溶解，悬浮或以低siedenen液体相中乳化，含有这些药剂的颗粒，其用于超声体内药物释放，并用于生产颗粒和装置引导过程使用。

6. 发明申请

WO1998007740A1 7'alpha'-('xi'-AMINOALKYL)ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7'alpha'-('xi'-AMINOALKYL)ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS 审中-公开
标题翻译： 7ALPHA-（XI-氨基烷基） - 雌三烯，制造方法药物制剂THAT THIS 7ALPHA-（XI-氨基烷基） - 雌三烯容纳和它们在药物的生产
公开(公告)号：WO1998007740A1
公开(公告)日：1998-02-26
申请号：PCT/EP1997004517
申请日：1997-08-20
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , BOHLMANN, Rolf , BITTLER, Dieter , HEINDI, Josef , HEINRICH, Nikolaus , HOFMEISTER, Helmut , KÜNZER, Hermann , SAUER, Gerhard , HEGELE-HARTUNG, Christa , LICHTNER, Rosemarie , NISHINO, Yukishige , PARCZYK, Karsten , SCHNEIDER, Martin
IPC分类号： C07J53/00
CPC分类号： C07J53/008 , C07J41/0072 , C07J43/006 , C07J53/002
摘要： The present invention describes new substituted 7α-(κ-aminoalkyl)-estratrienes of general formula (I), in which the side chain SK is a radical of partial formula (II), where m equals 4, 5 or 6; n equals 0, 1 or 2; x equals 0, 1 or 2; A is a hydrogen atom or a C1-5-alkyl group; B and D represent each a hydrogen atom, or A and B represent together an alkylene group -(CH2)p- where p = 2, 3, 4 or 5 and D is a hydrogen atom, or A and D form together an alkylene group -(CH2)q- where q = 2, 3 or 4 and B is a hydrogen atom; and E is a non-substituted ethyl radical or an ethyl radical fluorinated one to five times; or the terminal substituent -(CH2)3-E in the side chain is substituted by an optionally substituted aryl or heteroaryl radical bonded to the sulphur atom directly or by a mono-, di- or trimethylene group; R3 is a hydrogen atom, a hydrocarbon radical with up to 8 carbon atoms or a radical of partial formula R3'-C(O)-, where R3' is a hydrogen atom or a hydrocarbon radical with up to 8 carbon atoms or a phenyl radical; R11 is a hydrogen atom, a halogen atom or a nitrooxy group -O-NO¿2?, R?14, R15α, R15β, R16α and R16β¿ represent each a hydrogen atom or R?14 and R15α¿ are an additional bond or a methylene bridge, or R15β is a methyl group and R15α is a hydrogen atom, R?15α and R15β¿ represent each a methyl group, or R?15β and R16β¿ form together a methylene bridge, or R?16α or R16β¿ are a halogen atom or R?16α and R16β¿ form together a methylidene group, and the remaining substitutents R?14, R15α, R15β, R16α and R16β¿ represent each a hydrogen atom, R17' at the α- or β-position is a hydrogen atom, a C¿1-5? alkyl, C2-5 alkenyl or C2-5 alkinyl group or a trifluoromethyl group; and R?17'¿ is a hydrogen atom or a radical of partial formula R17'''-C(O)-, where R17''' is a hydrogen atom or a hydrocarbon radical with up to 8 carbon atoms, or when R17' is at the α-position, R17' forms together with R14 an ethano bridge, provided that when A and B do not stand together for -(CH¿2?)p- or A and D stand together for -(CH2)q-, at least one of the substituents R?11, R14, R15α, R15β, R16α and R16b¿ be not a hydrogen atom. Also disclosed are the physiologically tolerable addition salts of these compounds with organic and inorganic acids. These new compounds have a very strong anti-estrogenic activity. Some of them are pure anti-estrogenes, others are anti-estrogenes with a partial estrogenic effect. Because of their spectrum of activity, these new compounds are most suitable for preparing medicaments for tumor therapy and hormone substitution therapy.

7. 发明申请

WO1998007661A1 PROCESS FOR DECOMPOSING TRIIODOBENZENE DERIVATIVES 审中-公开
标题翻译：方法去除TRIIODBENZOLDERIVATEN的
公开(公告)号：WO1998007661A1
公开(公告)日：1998-02-26
申请号：PCT/DE1997001820
申请日：1997-08-18
申请人： SCHERING AKTIENGESELLSCHAFT , KRAUSE, Werner , KLAGES, Uwe , RODE, Ulrike , MÜLLER, Rudolf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C02F01/72
CPC分类号： A62D3/38 , A62D2101/22 , A62D2101/28 , C02F1/58 , C02F1/70 , C02F1/72 , C02F1/722 , C02F3/34 , C02F3/342
摘要： The invention concerns the decomposition of triiodobenzene derivatives in aqueous media at low temperature by one of the following processes: mixing with manganese (III) compounds; mixing with white rot fungi; and mixing with the manganese-dependent peroxidase of a white rot fungus.
摘要翻译： Triiodbenzolderivaten的降解在低温下的水性介质通过以下中的一个：与位移锰（III）化合物; 位移与白腐真菌; 位移与漫画依赖性过氧化物一个Weissfäulepilzes。

8. 发明申请

WO1998001163A2 PSEUDOPOLYROTAXANES 审中-公开
标题翻译： pseudopolyrotaxanes
公开(公告)号：WO1998001163A2
公开(公告)日：1998-01-15
申请号：PCT/EP1997003344
申请日：1997-06-25
申请人： SCHERING AKTIENGESELLSCHAFT , PLATZEK, Johannes , SCHMITT-WILLICH, Heribert
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K49/00
CPC分类号： A61K49/12 , A61K49/04 , A61K49/0442 , A61K49/085 , C08B37/0015 , C08L71/02 , Y10S514/836 , C08L2666/26
摘要： The invention concerns novel pseudopolyrotaxanes which contain metal complexes or iodine-containing benzene derivatives and are valuable compounds for diagnostic purposes. The pseudopolyrotaxane complexes have the general formula (I), in which n designates the numbers 6, 7 or 8, m designates the numbers 2 to 50; X is a direct bond or the group -O-CO-CH(CH3)-; R1 and Y have the meanings given in the description; and R3-Y-R4 are polyalkylene glycols.
摘要翻译：本发明涉及新的金属配合物或含有pseudopolyrotaxanes含碘苯衍生物。它们是诊断有价值的化合物。准聚轮烷配合物具有通式（I），其中n为6，7或8中，m是数字2〜50，X为直接键或基团-O-CO-CH（CH 3） - ，R 1和Y 具有在说明书中给出的含义，并且构成R3-Y-R 4的聚亚烷基二醇。

9. 发明申请

WO1998000430A1 IMIDAZOL DERIVATIVES USEFUL AS NITROGEN MONOXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：咪唑衍生物硝酸合酶抑制剂
公开(公告)号：WO1998000430A1
公开(公告)日：1998-01-08
申请号：PCT/DE1997001351
申请日：1997-06-25
申请人： SCHERING AKTIENGESELLSCHAFT , HÖLSCHER, Peter , REHWINKEL, Hartmut , BURTON, Gerardine , MÖWES, Manfred , HILLMANN, Margrit
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Compounds having the formulas (I) and (Ia) are disclosed, as well as their preparation and use in medicaments.
摘要翻译：本发明涉及式（I）和（Ia），以及它们在药物制备和使用的化合物。

10. 发明申请

WO1997032890A1 (Z)-11'beta'-[4-(DIMETHYLAMINO)PHENYL]-17'beta'-HYDROXY-17'alpha'-(3-HYDROXY-1-PROPENYL)ESTR-4-ENE-3-ONE AS CRYSTALLINE AN-SOLVATE 审中-公开
标题翻译：（Z）-11β - [4-（二甲基氨基）苯基] -17的β - 羟基 - 17α - （3-羟基-1-丙烯基）雌-4-烯-3-酮，为结晶非溶剂化物
公开(公告)号：WO1997032890A1
公开(公告)日：1997-09-12
申请号：PCT/EP1997001150
申请日：1997-03-08
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , CLEVE, Arwed , WINTER, Gabriele , SCHMITZ, Thomas , NICKISCH, Klaus
IPC分类号： C07J41/00
CPC分类号： C07J41/0083
摘要： The invention concerns a crystalline (Z)-11 beta -[4-(dimethylamino)phenyl]-17 beta -hydroxy-17 alpha -(3-hydroxy-1-propenyl)estr-4-ene-3-one (compound I) in the form of the an-solvate. The crystalline an-solvate of compound I is prepared by heating a crystallizate of compound I in water in order to remove the solvent of crystallization, the crystallizate being obtained from a solution in an organic solvent.
摘要翻译：本发明描述了结晶的（Z）-11β - [4-（二甲基氨基）苯基] -17的β - 羟基 - 17α - （3-羟基-1-丙烯基）雌-4-烯-3-酮（化合物I ）在Ansolvats的形式。化合物I的这种结晶Ansolvats的制备通过在水I的化合物的有机溶剂中加热由溶液得到的膜的晶体，以除去结晶溶剂来完成的。

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