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1. 发明申请

WO9852913A3 LEUKOTRIENE B4 ANTAGONISTS, IN PARTICULAR 3-OXA-TETRAHYDRONAPHTHALENE-LTB4 ANTAGONISTS 审中-公开
标题翻译：亮氨酸B4拮抗剂，特别是3-氧化四氢噻吩 - LTB4拮抗剂
公开(公告)号：WO9852913A3
公开(公告)日：1999-02-25
申请号：PCT/EP9803137
申请日：1998-05-22
申请人： SCHERING AG , BUCHMANN BERND , FROEHLICH WOLFGANG , GIESEN CLAUDIA , HENNEKES HARTWIG , REHWINKEL HARTMUT , SKUBALLA WERNER , SCHNEIDER FRANK
发明人： BUCHMANN BERND , FROEHLICH WOLFGANG , GIESEN CLAUDIA , HENNEKES HARTWIG , REHWINKEL HARTMUT , SKUBALLA WERNER , SCHNEIDER FRANK
IPC分类号： C07C59/72 , C07C69/712 , C07C69/92 , C07C405/00
CPC分类号： C07C69/712 , C07C59/72 , C07C69/92
摘要： The invention relates to leukotriene B4 antagonists of general formula (I) in which the contact of the chain O-(CH2)p-R1 can be situated at one of the free positions on the aromatic compound. R1 stands for CH2OH, COOR4, CONR5R6; R2 stands for H or an organic acid radical with 1-15 C atoms; R3 stands for H, C1-C14-alkyl, C3-C10-cycloalkyl, a C6-C10-aryl radical or a 5-6-link aromatic heterocyclic ring; R4 is H, C1-C10-alkyl, C3-C10-cycloalkyl, a C6-C10-aryl radical, CH2-CO-(C6-C10)aryl or a 5-6-link aromatic heterocyclic ring; A is a trans-, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group; B is a C1-C10-alkylene group or the group (a) or (b); D is a direct bonding, oxygen, sulphur, -C C-, -CH=CR7, or a direct bonding together with B; Y is a C1-C8-alkyl, C3-C10-cycloalkyl; R5 and R6 are identical or different and are H; R7 is H, C1-C5-alkyl, chlorine, bromine; R8 is the same as R3; p is 1-6; m is 1-3, n is 2-5. When R4 is hydrogen. The invention also relates to their salts with physiologically compatible bases and their cyclodextrin clathrates. The leukotriene antagonists are effective dermatological products.

2. 发明申请

WO2008145305A4 METHOD FOR MACHINING MATERIAL USING LASER RADIATION AND APPARATUS FOR CARRYING OUT THE METHOD 审中-公开
标题翻译：用于材料加工的方法采用激光辐射和设备用于实施该方法
公开(公告)号：WO2008145305A4
公开(公告)日：2009-01-29
申请号：PCT/EP2008004127
申请日：2008-05-23
申请人： FRAUNHOFER GES FORSCHUNG , PETRING DIRK , SCHNEIDER FRANK , SCHULZ WOLFGANG , NIESSEN MARKUS
发明人： PETRING DIRK , SCHNEIDER FRANK , SCHULZ WOLFGANG , NIESSEN MARKUS
IPC分类号： B23K26/06
CPC分类号： B23K26/0617 , B23K26/0604 , B23K26/382 , B23K26/384 , B23K26/389
摘要： The invention relates to a method for machining material using laser radiation, in which the unfocused laser radiation is focused through a focusing optics to a smaller beam cross section, the optical axis of the focused laser radiation, referred to as beam axis, is directed at the material surface, the beam waist, which results from the focusing operation, of the focused laser radiation is held in the region of the interface, which forms, of laser radiation and material, the laser radiation is partially absorbed on the interface such that due to induced material ablation or induced material displacement the interface and thus also the laser radiation penetrate into the material, wherein the spacing of the beam waist from the upper or lower side of the interface in the axial direction corresponds at most to triple the value of the penetration depth of the interface into the material, which is characterized in that the focusing operation is effected such that components of the laser radiation are made divergent not just in the propagation direction downstream of the beam waist but also in the beam waist and/or also in the propagation direction upstream of the beam waist and are thus directed away from the beam axis, and in that these components and angles of divergence are larger than those of the effects of imaging errors, which are inadvertently produced using standard optics and are tolerated. The invention furthermore relates to an apparatus for carrying out the method.
摘要翻译：本发明涉及一种方法，用于与激光辐射，其中，所述未聚焦的激光辐射由聚焦光学器件聚焦到一个较小的光束横截面加工材料时，聚焦的激光辐射的光轴，被称为光束轴被引导到材料表面，其从所述聚焦的聚焦光束束腰导致激光辐射保持在激光束和材料的相互作用的形成区域的区域中，激光辐射被吸收在交互表面的一部分，使得交互表面贯通诱导材料去除或材料的诱导位移并因此也在材料中的激光辐射，的束腰其中，所述距离在轴向方向上的相互作用表面的顶部或底部表面至多对应于所述相互作用表面的该材料中的穿透深度，其特征在于的三倍的值即执行聚焦，使得激光辐射的部分不仅在束腰的传播方向，而且在光束腰和/或也在束腰前的传播方向发散，从而引导从光束轴远离的，并且这些部件和发散角大比的像差的影响与标准的光学器件被无意产生和被接受。此外，本发明涉及一种装置，用于执行该方法。

3. 发明申请

WO2008043685A3 DEVICE AND METHOD FOR DETERMINING GAP SIZE AND COHESION OF TWO ADJACENT COMPONENTS 审中-公开
标题翻译：用于确定调整分量的列和平衡的装置和方法
公开(公告)号：WO2008043685A3
公开(公告)日：2008-10-09
申请号：PCT/EP2007060425
申请日：2007-10-02
申请人： SIEMENS AG , METZLER MICHAEL , SCHNEIDER FRANK , FORSTER FRANK
发明人： METZLER MICHAEL , SCHNEIDER FRANK , FORSTER FRANK
IPC分类号： G06T7/00
CPC分类号： G01B11/14 , G06T7/521
摘要： The invention relates to a method for determining a gap size. A three-dimensional image is generated of the region with the gap. The measured values of the contours defining the gap are smoothed and then the gap size (Sp) determined from the smoothed contours using a stored instruction set. The invention further related to a corresponding device.
摘要翻译：本发明涉及一种确定间隙尺寸的方法。从具有待检查间隙的区域为此目的生成三维图像。确定间隙的轮廓的测量值被平滑，然后在存储的指令之后根据平滑后的轮廓确定间隙尺寸（Sp）。另外，本发明涉及相关联的装置。

4. 发明申请

WO02059350A2 USE OF SIALYL TRANSFERASES FOR DIAGNOSING AND TREATING TUMOROUS DISEASES 审中-公开
标题翻译：使用V0N唾液酸转移肿瘤疾病的诊断与治疗
公开(公告)号：WO02059350A2
公开(公告)日：2002-08-01
申请号：PCT/DE0200263
申请日：2002-01-25
申请人： MAX DELBRUECK CENTRUM , SCHNEIDER FRANK , KEMMNER WOLFGANG
发明人： SCHNEIDER FRANK , KEMMNER WOLFGANG
IPC分类号： A61K38/00 , A61K48/00 , C12N9/10 , C12N15/113 , C12Q1/00
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N9/1081 , C12N2310/111
摘要： The invention relates to the use of sialyltransferases, in particular of sialyltransferase ST6GalNAc-II for diagnosing and treating tumorous diseases. The mRNA expression of the sialyltransferase enzyme ST6GalNAc-II increases in cases where lymph node metastases occur. Research into 40 well-documented cases of colorectal carcinomas show that the expression of ST6GalNAc-II constitutes a prognostic factor for the survival of such patients. In addition, by blocking the expression of sialyltransferase ST6GalNAc-II, the synthesis of the tumour-linked antigen TF can be blocked, potentially improving the prognosis. The invention also relates to the inhibition of the expression of the enzyme by pharmaceutical agents.
摘要翻译：本发明涉及使用唾液酸转移酶，特别是唾液酸转移酶II ST6GalNAc用于肿瘤疾病的诊断和治疗。唾液酸转移酶II ST6GalNAc酶的mRNA表达，其中淋巴结转移发生的情况下被增加。研究表明，40大肠癌是ST6GalNAc-II表达是此类患者的生存预后因素的证据充分的案件。此外，可以通过阻断唾液酸转移酶II ST6GalNAc，肿瘤相关抗原TF的合成的表达被阻断，可能预测可以得到改善。通过药剂酶的表达抑制是同样是本发明的主题。

5. 发明申请

WO2011026487A3 ADJUSTING METHOD AND MODULAR ADJUSTING DEVICE FOR ALIGNING THE AXIS OF A SHOOTING SIMULATOR PARALLEL TO THE LINE OF SIGHT OF A FIREARM 审中-公开
标题翻译：校准程序和模块化调整为视线ONE SHOT枪模拟轴SHOT模拟器的平行取向
公开(公告)号：WO2011026487A3
公开(公告)日：2011-04-28
申请号：PCT/DE2010050067
申请日：2010-09-03
申请人： ESW GMBH , HUENNIGER HEINRICH , SCHALLER UWE , SCHNEIDER FRANK , DOEGE GUNTHER
发明人： HUENNIGER HEINRICH , SCHALLER UWE , SCHNEIDER FRANK , DOEGE GUNTHER
IPC分类号： F41G1/54 , F41A33/02 , F41G1/44 , F41G3/26
CPC分类号： F41G1/54 , F41A33/02 , F41G1/44 , F41G3/2655 , F41G3/326
摘要： The invention relates to an adjusting method and an adjusting device for adjusting an axis (2.3) of a shooting simulator (2) to the line of sight (1.2) of the sighting apparatus (1.1) of a firearm (1). The adjusting device is composed of two modules, i.e. a display module (3) having an axis (3.3) and a camera module (4) having an axis (4.3). The axis (3.3) of the display module can be adjusted so as to be aligned with the line of sight (1.2) by moving crosshairs on the display (3.1). In order to align the axis (2.3) of the simulator with the previously adjusted axis (3.3) of the display module, and thus with the line of sight (1.2), a laser beam emitted by the shooting simulator is represented on the camera chip and is moved into a position that is adequate to the crosshairs by actuating a tilting mechanism which is part of the shooting simulator (2).
摘要翻译：本发明涉及一种调整方法和一种用于调节纬纱模拟器（2）的模拟轴（2.3）到视线枪支（1）的瞄准装置（1.1）的线（1.2）的调整装置。调整装置由两个模块组成，即具有显示模块轴（3.3）的显示模块（3）和具有照相机模块轴（4.3）的照相机模块（4）。显示模块轴（3.3）可通过将显示屏（3.1）上的一条线移动到瞄准线（1.2）进行调整。通过由照相机芯片上的射击模拟激光束发射的再现和通过用于拍摄模拟器操作属于（2）Verkippeinrichtung被带入一个适当的用于分划板位置，模拟器轴（2.3）的先前调节的显示模块轴（3.3），从而视线（1.2）对齐。

6. 发明申请

WO2010094735A3 QUENCHING MACHINE AND METHOD FOR FIXTURE QUENCHING BY INDUCTION 审中-公开
标题翻译：大小的机器和方法感应式夹具硬化
公开(公告)号：WO2010094735A3
公开(公告)日：2011-01-20
申请号：PCT/EP2010052032
申请日：2010-02-18
申请人： EMA INDUTEC GMBH , GOY WILFRIED , DOERING TORSTEN , SCHNEIDER FRANK
发明人： GOY WILFRIED , DOERING TORSTEN , SCHNEIDER FRANK
IPC分类号： C21D1/10 , C21D1/42 , C21D1/673 , C21D9/00 , C21D9/32 , C21D9/34 , C21D9/40
CPC分类号： C21D1/673 , C21D1/10 , C21D1/42 , C21D9/0006 , C21D9/0018 , C21D9/0068 , C21D9/32 , C21D9/34 , C21D9/40 , Y02P10/253
摘要： The invention relates to a quenching machine (1) for fixture quenching a workpiece (2). Said quenching machine (1) comprises an inductor (3) for heating the workpiece (2) introduced into the quenching machine (1). The invention also relates to a method in which a workpiece (2) introduced into the quenching machine (1) is heated by induction.
摘要翻译：本发明涉及一种淬火机（1），用于固定硬化工件（2）。硬度机器（1）包括用于在机器中加热该硬度的电感器（3）（1）引入的工件（2）。在该方法中，在淬火机（1）被加热，是引入工件（2）通过感应来实现。

7. 发明申请

WO2011026487A4 ADJUSTING METHOD AND MODULAR ADJUSTING DEVICE FOR ALIGNING THE AXIS OF A SHOOTING SIMULATOR PARALLEL TO THE LINE OF SIGHT OF A FIREARM 审中-公开
标题翻译：校准程序和模块化调整为视线ONE SHOT枪模拟轴SHOT模拟器的平行取向
公开(公告)号：WO2011026487A4
公开(公告)日：2011-06-23
申请号：PCT/DE2010050067
申请日：2010-09-03
申请人： ESW GMBH , HUENNIGER HEINRICH , SCHALLER UWE , SCHNEIDER FRANK , DOEGE GUNTHER
发明人： HUENNIGER HEINRICH , SCHALLER UWE , SCHNEIDER FRANK , DOEGE GUNTHER
IPC分类号： F41G1/54 , F41A33/02 , F41G1/44 , F41G3/26
CPC分类号： F41G1/54 , F41A33/02 , F41G1/44 , F41G3/2655 , F41G3/326
摘要： The invention relates to an adjusting method and an adjusting device for adjusting an axis (2.3) of a shooting simulator (2) to the line of sight (1.2) of the sighting apparatus (1.1) of a firearm (1). The adjusting device is composed of two modules, i.e. a display module (3) having an axis (3.3) and a camera module (4) having an axis (4.3). The axis (3.3) of the display module can be adjusted so as to be aligned with the line of sight (1.2) by moving crosshairs on the display (3.1). In order to align the axis (2.3) of the simulator with the previously adjusted axis (3.3) of the display module, and thus with the line of sight (1.2), a laser beam emitted by the shooting simulator is represented on the camera chip and is moved into a position that is adequate to the crosshairs by actuating a tilting mechanism which is part of the shooting simulator (2).
摘要翻译：本发明涉及一种调整方法和一种用于调节纬纱模拟器（2）的模拟轴（2.3）到视线枪支（1）的瞄准装置（1.1）的线（1.2）的调整装置。该调节装置由两个模块，即具有显示模块轴（3.3）和相机模块（4）的相机模块轴（4.3）的显示模块（3）。显示模块轴（3.3）由在屏幕上（3.1）到视线（1.2）在对准线具有可调节上的分划板的位移形成。通过由照相机芯片上的射击模拟激光束发射的再现和通过用于拍摄模拟器操作属于（2）Verkippeinrichtung被带入一个适当的用于分划板位置，模拟器轴（2.3）的先前调节的显示模块轴（3.3），从而视线（1.2）对齐。

8. 发明申请

WO2007093450A3 DEUTERATED CATECHOLAMINE DERIVATIVES AND MEDICAMENTS COMPRISING SAID COMPOUNDS 审中-公开
标题翻译：包含所述化合物的氘代儿茶酚衍生物和药物
公开(公告)号：WO2007093450A3
公开(公告)日：2007-09-27
申请号：PCT/EP2007001555
申请日：2007-02-16
申请人： BIRDS PHARMA GMBH BEROLINA INN , ALKEN RUDOLF-GIESBERT , SCHNEIDER FRANK
发明人： ALKEN RUDOLF-GIESBERT , SCHNEIDER FRANK
IPC分类号： C07C229/26 , C07B59/00
CPC分类号： C07C229/36 , C07B59/001 , C07B2200/07
摘要： The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine derivatives as well as physiologically acceptable salts thereof, and also pharmaceutical compositions, which contain these compounds, also in combination with enzyme inhibitors, for the treatment of dopamine deficiency diseases or diseases which are based on disrupted tyrosine transport or disrupted tyrosine decarboxylase, as well as other disorders.
摘要翻译：本发明涉及氘化儿茶酚胺衍生物以及含有这些化合物的药物。此外，本发明涉及氘化儿茶酚胺衍生物及其生理学上可接受的盐的用途，以及含有这些化合物以及酶抑制剂的药物组合物，用于治疗多巴胺缺乏疾病或基于破坏酪氨酸转运或破坏酪氨酸脱羧酶，以及其他疾病。

9. 发明申请

WO9814548A2 METHOD FOR PRODUCING A DETERGENT, SPECIALLY A POWDER DETERGENT FOR DISH WASHING MACHINES 审中-公开
标题翻译：用于生产清洁剂，特别是机线束合一粉末
公开(公告)号：WO9814548A2
公开(公告)日：1998-04-09
申请号：PCT/DE9702254
申请日：1997-10-01
申请人： SCHMITZ HERBERT , BONERT KARL HEINZ , SCHNEIDER FRANK
发明人： SCHMITZ HERBERT , BONERT KARL-HEINZ , SCHNEIDER FRANK
IPC分类号： C11D3/10 , C11D3/20 , C11D11/00 , C11D17/00
CPC分类号： C11D3/0052 , C11D3/10 , C11D3/2086 , C11D11/00 , C11D17/0091
摘要： Soda and citric acid are mixed intensively by extracting the heat in a batch method in order to produce sodium hydrogen carbonate, sodium nitrate and a residual soda, which is further treated afterwards with a polymer. Thus, a detergent compound is reasonably produced, which can be further processed at will.
摘要翻译：苏打和柠檬酸下在间歇方法除去热量集中地混合以产生碳酸氢钠，柠檬酸钠和残余钠的一部分，然后将其优选地进一步用聚合物进行处理。这产生了良好的生产洗涤剂化合物，该化合物可以被进一步处理。

10. 发明申请

WO9741995A3 WORKPIECE LASER MACHINING PROCESS 审中-公开
标题翻译：工件激光加工工艺
公开(公告)号：WO9741995A3
公开(公告)日：1997-12-11
申请号：PCT/DE9700808
申请日：1997-04-23
申请人： FRAUNHOFER GES FORSCHUNG , ZEFFERER HARTMUT , SCHNEIDER FRANK , PREISSIG KAI UWE , SCHULZ WOLFGANG , PETRING DIRK
发明人： ZEFFERER HARTMUT , SCHNEIDER FRANK , PREISSIG KAI-UWE , SCHULZ WOLFGANG , PETRING DIRK
IPC分类号： B23K26/03 , C21D1/09 , C21D11/00 , B23K26/08
CPC分类号： B23K26/034 , C21D1/09 , C21D11/00
摘要： In a process for machining workpieces (10) with laser radiation (11), the irradiated machining area (12) is monitored by a measurement technique by means of which response signals (26) are determined and a process parameter (16) is modulated with an excitation frequency (φ). In order to prevent a process state to exceed a predetermined limit, the process state is monitored to check if it approaches said predetermined limit. In order to carry out this process even on non-coated workpieces, and in particular without requiring equivalent thermal networks of the workpieces to be machined, the alternating fractions (UM1(t)sin(φt+Υ)) of measurement signals (14) of at least one excitation frequency (φ) are used to determine the response signals (26), the machining-specific relation between the response signals and the process parameter (16) at the excitation frequency (φ) is predetermined, and the response signals (26) are used to monitor and/or regulate the process state, depending on said relation.

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