专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011079102A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS 审中-公开
标题翻译：作为β-谷胱甘肽酶抑制剂的间苯二酚苄基苯胺
公开(公告)号：WO2011079102A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061461
申请日：2010-12-21
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , NIEDUZAK, Thaddeus R. , POLI, Gregory B. , SHUM, Patrick Wai-Kwok , STOKLOSA, Gregory T. , ZHAO, Zhicheng
发明人： CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , NIEDUZAK, Thaddeus R. , POLI, Gregory B. , SHUM, Patrick Wai-Kwok , STOKLOSA, Gregory T. , ZHAO, Zhicheng
IPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D498/14 , A61K31/454 , A61P29/00
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D498/14
摘要： The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).
摘要翻译：本发明公开并要求一系列式（I）的取代的吲哚基 - 哌啶基苄基胺，其中R 1，R 2和R 3如本文所述。更具体地，本发明的化合物是β-胰蛋白酶的抑制剂，因此可用作药剂。此外，本发明还公开了制备取代的吲哚基 - 哌啶基苄胺的方法。在其中一个实施方案中，提供其中R 3是（II）的式（I）化合物。

2. 发明申请

WO2011078984A1 [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF 审中-公开
标题翻译： [4- [5-氨基-2-氟 - 苯基] - 哌啶-1-基] - （1H-吡咯烷 - 吡啶）-MetANANES及其合成
公开(公告)号：WO2011078984A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/060006
申请日：2010-12-13
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , NIEDUZAK, Thaddeus R. , POLI, Gregory B. , SHUM, Patrick Wai-Kwok , STOKLOSA, Gregory T. , ZHAO, Zhicheng
发明人： CHOI-SLEDESKI, Yong Mi , NIEDUZAK, Thaddeus R. , POLI, Gregory B. , SHUM, Patrick Wai-Kwok , STOKLOSA, Gregory T. , ZHAO, Zhicheng
IPC分类号： C07D471/04 , A61K31/4523 , A61P11/06
CPC分类号： C07D471/04
摘要： The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase including but not limited to for example asthma and other inflammatory diseases including age-related macular degeneration.
摘要翻译：本发明涉及用于治疗和改善炎性疾病的化合物和组合物。具体来说，本发明涉及具有类胰蛋白酶抑制活性的化合物及其中间体，包含这些化合物的药物组合物，以及治疗患有病症或疾病的受试者的方法，所述疾病或病症可以通过施用类胰蛋白酶抑制剂而被改善，包括：但不限于例如哮喘和其它炎性疾病，包括年龄相关性黄斑变性。

3. 发明申请

WO2011087652A1 TROPINONE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS 审中-公开
标题翻译： TROPINONE BENZYLAMINES作为β-TRYPTASE抑制剂
公开(公告)号：WO2011087652A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060004
申请日：2010-12-13
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , SHUM, Patrick Wai-Kwok
发明人： CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , SHUM, Patrick Wai-Kwok
IPC分类号： C07D451/02 , A61K31/46 , A61P29/00
CPC分类号： C07D451/02
摘要： The present invention discloses and claims a series of substituted tropinone benzylamines of formula (I). More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted tropinone benzylamines.
摘要翻译：本发明公开并要求一系列式（I）的替代的托品酮苄胺。更具体地，本发明的化合物是β-胰蛋白酶的抑制剂，因此可用作药剂。此外，本发明还公开了取代的托品酮苄胺的制备方法。

4. 发明申请

WO2011079103A1 SPIROPIPERIDINE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS 审中-公开
标题翻译：螺吡啶苯甲酰胺作为β-酪氨酸酶抑制剂
公开(公告)号：WO2011079103A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061464
申请日：2010-12-21
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , POLI, Gregory B.
发明人： CHOI-SLEDESKI, Yong Mi , LIANG, Guyan , POLI, Gregory B.
IPC分类号： C07D491/107 , A61K31/438 , A61P19/02 , A61P11/06 , A61P17/00
CPC分类号： C07D491/107
摘要： The present invention discloses and claims a series of substituted spiropiperidine benzylamines of formula (I) wherein R is as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents for treating joint inflammation, including arthritis, rheumatoid arthritisand other arthritic condition such as rheumatoid spondylitis, gouty arthπtis, traumatic arthritis, rubella arthritis, psoriatic arthritis, osteoarthritis or other chronic inflammatory joint disease, or diseases of joint cartilage destruction, ocular conjunctivitis, vernal conjunctivitis, inflammatory bowel disease, asthma, allergic rhinitis, interstitial lung diseases, fibrosis, sceleroderma, pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, neurofibromas, hypertrophic scars, various dermatological conditions, for example, atopic dermatitis and psoriasis, myocardial infarction, stroke, angina or other consequences of atherosclerotic plaque rupture, as well as periodontal disease, diabetic retinopathy, macular degeneration, acute macular degeneration, wet macular degeneration, tumour growth, anaphylaxis, multiple sclerosis, peptic ulcers, or a syncytial viral infection.
摘要翻译：本发明公开并要求一系列取代的式（I）的哌啶哌啶苄胺，其中R如本文所述。更具体地说，本发明的化合物是β-胰蛋白酶抑制剂，因此可用作治疗关节炎的药剂，包括关节炎，类风湿性关节炎和其它关节炎病症如类风湿性脊椎炎，痛风性关节炎，创伤性关节炎，风疹性关节炎，牛皮癣关节炎，骨关节炎或其他慢性炎性关节疾病，关节软骨破坏性疾病，眼结膜炎，春季结膜炎，炎性肠病，哮喘，过敏性鼻炎，间质性肺病，纤维化，强迫症，肺纤维化，肝硬化，心肌纤维化，神经纤维瘤，肥厚性瘢痕，各种皮肤病学条件，例如特应性皮炎和牛皮癣，心肌梗死，中风，心绞痛或动脉粥样硬化斑块破裂的其他后果，以及牙周病，糖尿病性视网膜病变，黄斑变性，急性黄斑变性，湿性黄斑变性，肿瘤生长，过敏反应，多发性硬化，消化性溃疡或合胞病毒感染。

5. 发明申请

WO2011079095A1 PRODRUGS OF [4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF 审中-公开
标题翻译： [4 [4-（5-氨基-2-氟 - 苯基） - 哌啶-1-基] - （1H-吡咯烷 - 吡啶）-METANANES的合成及其合成
公开(公告)号：WO2011079095A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061434
申请日：2010-12-21
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , POLI, Gregory B.
发明人： CHOI-SLEDESKI, Yong Mi , POLI, Gregory B.
IPC分类号： C07D401/06 , A61K31/454 , A61P29/00
CPC分类号： C07D401/06
摘要： The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase including but not limited to for example asthma and other inflammatory diseases including acute macular degeneration.
摘要翻译：本发明涉及用于治疗和改善炎性疾病的化合物和组合物。具体来说，本发明涉及具有类胰蛋白酶抑制活性的化合物及其中间体，包含这些化合物的药物组合物，以及治疗患有病症或疾病的受试者的方法，所述疾病或病症可以通过施用类胰蛋白酶抑制剂而被改善，包括：但不限于例如哮喘和其它炎性疾病，包括急性黄斑变性。

6. 发明申请

WO2011106334A1 TREATMENT OF DERMATOLOGICAL ALLERGIC CONDITIONS 审中-公开
标题翻译：治疗过敏性过敏症状
公开(公告)号：WO2011106334A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/025785
申请日：2011-02-23
申请人： SANOFI , CHOI-SLEDESKI, Yong Mi , FITCH, Neil , MINNICH, Anne
发明人： CHOI-SLEDESKI, Yong Mi , FITCH, Neil , MINNICH, Anne
IPC分类号： A61K31/404 , A61P17/00
CPC分类号： A61K31/404
摘要： A treatment for a dermatological allergic condition is disclosed, using a compound: as [4-(5-Aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone.
摘要翻译：公开了使用化合物作为[4-（5-氨基甲基-2-氟苯基）哌啶-1-基] [7-氟-1-（2-甲氧基乙基）-4-三氟甲氧基 - 1H-吲哚-3-基]甲酮。

7. 发明申请

WO2011078983A1 TREATMENT FOR INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：炎症性皮肤病的治疗
公开(公告)号：WO2011078983A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/060002
申请日：2010-12-13
申请人： SANOFI , MINNICH, Anne , BEKASI, Eszter , CHOI-SLEDESKI, Yong Mi
发明人： MINNICH, Anne , BEKASI, Eszter , CHOI-SLEDESKI, Yong Mi
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/12 , A61K9/16 , A61K9/20 , A61K9/50 , A61K31/404 , A61P1/00
CPC分类号： A61K31/404 , A61K9/2054
摘要： A treatment for inflammatory bowel disease is disclosed, using a compound: as [4-(5-aminomethyl-2-fluorophenyl)piperidine-1-yl][7-fluoro-1-(2-methoxyethyl)-4-trifluoromethoxy-1H-indol-3-yl]methanone.
摘要翻译：公开了使用化合物作为[4-（5-氨基甲基-2-氟苯基）哌啶-1-基] [7-氟-1-（2-甲氧基乙基）-4-三氟甲氧基-1H- 吲哚-3-基]甲酮。

8. 发明申请

WO2006086734A1 SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS 审中-公开
标题翻译：取代的丙酸磷酸酯
公开(公告)号：WO2006086734A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/004938
申请日：2006-02-10
申请人： AVENTIS PHARMACEUTICALS INC. , COLLIS, Alan, John , POLI, Gregory, Bernard , CHOI-SLEDESKI, Yong Mi
发明人： COLLIS, Alan, John , POLI, Gregory, Bernard , CHOI-SLEDESKI, Yong Mi
IPC分类号： C07F9/655 , C07F9/48 , A61K31/66 , A61P25/22
CPC分类号： C07F9/65517 , C07F9/3211
摘要： The present invention relates to certain esters of substituted 3-aminopropane phosphinic acid derivatives of formula I as disclosed herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
摘要翻译：本发明涉及本文公开的式I的取代的3-氨基丙烷次膦酸衍生物的某些酯。本发明的化合物可用于治疗各种疾病，包括但不限于抑郁，焦虑，某些精神症状，认知障碍和精神分裂症。

9. 发明申请

WO2005118618A1 SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES 审中-公开
标题翻译：取代的丙酸磷酸衍生物
公开(公告)号：WO2005118618A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/019657
申请日：2005-06-03
申请人： AVENTIS PHARMACEUTICALS INC. , CHOI-SLEDESKI, Yong Mi , LEVELL, Julian , POLI, Gregory, Bernard , CZEKAJ, Mark , COLLIS, Alan, John , VAZ, Roy
发明人： CHOI-SLEDESKI, Yong Mi , LEVELL, Julian , POLI, Gregory, Bernard , CZEKAJ, Mark , COLLIS, Alan, John , VAZ, Roy
IPC分类号： C07K5/06
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/301 , C07F9/303 , C07F9/5727 , C07F9/5728 , C07F9/65037 , C07F9/65067 , C07K5/06191
摘要： The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula (I) wherein R, R 1 , P 1 , P 2 and P 3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
摘要翻译：本发明涉及一系列式（I）的取代的3-氨基丙烷次膦酸衍生物，其中R，R 1，P 1，P 2和P 3如本文所定义。本发明的化合物可用于治疗各种疾病，包括但不限于抑郁，焦虑，某些精神症状，认知障碍和精神分裂症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式