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1. 发明申请

WO2012075045A2 RELEASE FACTOR 1 (RF1) IN ESCHERICHIA COLI 审中-公开
标题翻译：释放因子1（RF1）在ESCHERICHIA COLI
公开(公告)号：WO2012075045A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062466
申请日：2011-11-29
申请人： SALK INST FOR BIOLOGICAL STUDI , WANG LEI
发明人： WANG LEI
IPC分类号： C12N1/21 , C12N15/31 , C12N15/70 , C12P21/00
CPC分类号： C12N15/70 , C07K14/195 , C07K14/245 , C12N15/67 , C12P21/00 , C12P21/02
摘要： Provided herein are release factor 1 (RF1) deficient bacteria, methods of using the bacteria to reassign the UAG codon, and generate mutant polypeptides.
摘要翻译：本文提供了释放因子1（RF1）缺陷细菌，使用细菌重新分配UAG密码子并产生突变多肽的方法。

2. 发明申请

WO2011119771A3 METHODS AND COMPOSITIONS FOR DETECTING PROTEIN MODIFICATIONS 审中-公开
标题翻译：检测蛋白质修饰的方法和组合物
公开(公告)号：WO2011119771A3
公开(公告)日：2012-02-23
申请号：PCT/US2011029680
申请日：2011-03-23
申请人： SALK INST FOR BIOLOGICAL STUDI , WANG LEI , LACEY VANESSA K , PARRISH ANGELA R
发明人： WANG LEI , LACEY VANESSA K , PARRISH ANGELA R
IPC分类号： G01N33/68 , C12Q1/48 , G01N33/58
CPC分类号： C12Q1/485
摘要： Methods and compositions for detecting a protein modification in vitro and in vivo are disclosed. In certain embodiments, the protein modification detected is phosphorylation.
摘要翻译：公开了用于检测体外和体内蛋白质修饰的方法和组合物。在某些实施方案中，检测到的蛋白质修饰是磷酸化。

3. 发明申请

WO2011053998A3 TARGETING OF MODIFYING ENZYMES FOR PROTEIN EVOLUTION 审中-公开
标题翻译：修饰酶对蛋白质进化的靶向作用
公开(公告)号：WO2011053998A3
公开(公告)日：2011-11-24
申请号：PCT/US2010055161
申请日：2010-11-02
申请人： SALK INST FOR BIOLOGICAL STUDI , TAKIMOTO JEFFREY K , WANG LEI
发明人： TAKIMOTO JEFFREY K , WANG LEI
IPC分类号： C12N15/54 , C12N9/12 , C12N15/85
CPC分类号： C12N15/1024
摘要： Methods and compositions for producing variants of a polypeptide are disclosed. Variants are generated using modifying enzymes specifically targeted to the polypeptide through the interaction of a T7 polymerase with a T7 polymerase promoter.
摘要翻译：公开了用于产生多肽变体的方法和组合物。通过T7聚合酶与T7聚合酶启动子的相互作用，使用修饰酶特异性地靶向多肽来产生变体。

4. 发明申请

WO2014078027A3 METHOD TO DETECT DRILLING DYSFUNCTIONS 审中-公开
标题翻译：检测钻孔功能的方法
公开(公告)号：WO2014078027A3
公开(公告)日：2014-07-10
申请号：PCT/US2013066210
申请日：2013-10-22
申请人： EXXONMOBIL UPSTREAM RES CO , WANG LEI , BAILEY JEFFREY R , O'DONNELL BRIAN J , CHANG DAR-LON , PAYETTE GREGORY S
发明人： WANG LEI , BAILEY JEFFREY R , O'DONNELL BRIAN J , CHANG DAR-LON , PAYETTE GREGORY S
IPC分类号： E21B7/06
CPC分类号： E21B45/00 , E21B10/00 , E21B44/00 , G01M99/005 , G01M99/008
摘要： Methods and systems for detecting downhole bit dysfunction in a drill bit penetrating a subterranean formation comprising receiving a plurality of drilling parameters characterizing a wellbore drilling operation and calculating bit aggressiveness (μ) at each of a plurality of points during drilling, wherein each point corresponds to time, depth, or both. A depth-of-cut (DOC), time derivative of bit aggressiveness (µ̇), calculated as dμ/dt, or both, is calculated at each of the plurality of points. A two-dimensional data representation of the plurality of points, comprising μ in one dimension and DOC, μ̇, or both, in another dimension is created. Data features are extracted from the two-dimensional data representation and downhole bit dysfunction is identified by comparing the extracted data features with predefined criteria.
摘要翻译：用于检测穿透地下地层的钻头中井下钻头功能障碍的方法和系统，包括接收表征井眼钻井操作的多个钻孔参数并在钻孔期间在多个点的每一点计算钻头侵蚀性（μ），其中每个点对应于时间，深度或两者兼而有之。在多个点中的每个点处计算深度切割（DOC），位攻击性（μ̇）的时间导数（以dμ/ dt计算）或两者。创建多个点的二维数据表示，在另一个维度上包括一维中的μ和DOC，μ̇或两者。从二维数据表示中提取数据特征，并通过将提取的数据特征与预定标准进行比较来识别井下位功能障碍。

5. 发明申请

WO2012092144A3 TRACKING MOVING OBJECTS USING A CAMERA NETWORK 审中-公开
标题翻译：使用摄像机网络跟踪移动对象
公开(公告)号：WO2012092144A3
公开(公告)日：2012-11-15
申请号：PCT/US2011066956
申请日：2011-12-22
申请人： PELCO INC , MILLAR GREG , AGHDASI FARZIN , WANG LEI
发明人： MILLAR GREG , AGHDASI FARZIN , WANG LEI
IPC分类号： G08B25/10 , G08B13/196 , H04N5/262 , H04N7/18
CPC分类号： H04N7/181 , G08B13/19608
摘要： Techniques are described for tracking moving objects using a plurality of security cameras. Multiple cameras may capture frames that contain images of a moving object. These images may be processed by the cameras to create metadata associated with the images of the objects. Frames of each camera's video feed and metadata may be transmitted to a host computer system. The host computer system may use the metadata received from each camera to determine whether the moving objects imaged by the cameras represent the same moving object. Based upon properties of the images of the objects described in the metadata received from each camera, the host computer system may select a preferable video feed containing images of the moving object for display to a user.
摘要翻译：描述了使用多个安全摄像机跟踪移动物体的技术。多个相机可以捕获包含移动物体的图像的帧。这些图像可以由相机处理以创建与对象的图像相关联的元数据。每个摄像机的视频馈送和元数据的帧可以被发送到主机系统。主计算机系统可以使用从每个摄像机接收的元数据来确定由摄像机成像的移动物体是否表示相同的移动物体。基于从每个摄像机接收到的元数据中描述的对象的图像的属性，主计算机系统可以选择包含用于显示给用户的移动物体的图像的优选视频馈送。

6. 发明申请

WO2012103282A2 METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的方法和组合物
公开(公告)号：WO2012103282A2
公开(公告)日：2012-08-02
申请号：PCT/US2012022646
申请日：2012-01-26
申请人： ZHONG YI , CHIANG HSUEH-CHENG , WANG LEI
发明人： ZHONG YI , CHIANG HSUEH-CHENG , WANG LEI
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28
CPC分类号： A61K31/5377 , A61K31/517
摘要： This disclosure relates to methods and compositions useful for treating Alzheimer's disease. In particular, the disclosure relates to pharmaceutical compositions containing an EGFR-inhibitory compound suitable for administration to treat Alzheimer's disease, as well as to related therapeutic methods. In addition, this disclosure relates to screening methods for identifying compounds useful for treating Alzheimer's disease based on the ability to inhibit the activity of EGFR.
摘要翻译：本公开涉及可用于治疗阿尔茨海默氏病的方法和组合物。具体而言，本公开涉及含有适于施用以治疗阿尔茨海默氏病的EGFR抑制性化合物的药物组合物，以及相关的治疗方法。另外，本公开涉及基于抑制EGFR活性的能力来鉴定用于治疗阿尔茨海默病的化合物的筛选方法。

7. 发明申请

WO2010105254A2 METHOD AND APPARATUS FOR CARRIER ASSIGNMENT, CONFIGURATION AND SWITCHING FOR MULTICARRIER WIRELESS COMMUNICATIONS 审中-公开
标题翻译：用于多媒体无线通信的载波分配，配置和切换的方法和装置
公开(公告)号：WO2010105254A2
公开(公告)日：2010-09-16
申请号：PCT/US2010027304
申请日：2010-03-15
申请人： INTERDIGITAL PATENT HOLDINGS , TERRY STEPHEN E , ZHANG GUODONG , WANG JIN , WANG LEI
发明人： TERRY STEPHEN E , ZHANG GUODONG , WANG JIN , WANG LEI
IPC分类号： H04L5/00
CPC分类号： H04W72/0406 , H04B7/0626 , H04B7/0632 , H04L1/0023 , H04L1/1812 , H04L5/003 , H04W36/0016
摘要： As part of carrier assignment and configuration for multicarrier wireless communications, a single uplink (UL) primary carrier may provide control information for multiple concurrent downlink (DL) carriers. Optionally, control information for each DL carrier may be transmitted over paired UL carriers. Carrier switching of UL and/or DL carriers, including primary and anchor carriers, may occur during normal operation or during handover, and may occur in only the UL or only the DL direction. A unidirectional handover is performed when only an UL carrier or only a DL carrier is switched as part of a handover. Switching of UL and/or DL carriers may be from one component carrier or a subset of carriers to another component carrier, another subset of carriers, or all carriers in the same direction.
摘要翻译：作为用于多载波无线通信的载波分配和配置的一部分，单个上行链路（UL）主载波可以为多个并行下行链路（DL）载波提供控制信息。可选地，可以通过成对的UL载波来传送每个DL载波的控制信息。包括主载波和锚载波的UL和/或DL载波的载波切换可以在正常操作期间或在切换期间发生，并且可以仅发生在UL或仅DL方向上。当只有一个UL载波或仅一个DL载波被切换作为切换的一部分时，执行单向切换。 UL和/或DL载波的切换可以是来自一个分量载波或载波的子集到另一个分量载波，载波的另一个子集或相同方向上的所有载波。

8. 发明申请

WO2006059788A9 OPTIMIZATION PROCESSING METHOD USING A DISTRIBUTED GENETIC ALGORITHM 审中-公开
公开(公告)号：WO2006059788A9
公开(公告)日：2007-07-12
申请号：PCT/JP2005022499
申请日：2005-12-01
申请人： MATSUSHITA ELECTRIC IND CO LTD , WANG LEI
发明人： WANG LEI
IPC分类号： G06N3/12
CPC分类号： G06N3/126
摘要： An optimization processing method comprises forming a plurality of islands each having a plurality of individuals and repeating crossover, mutation, evaluation and selection on the individuals until the desired condition has been satisfied by applying a genetic algorithm to each of the plurality of islands thereby obtaining an optimized solution, in which the optimized solution is obtained by migrating individuals to other islands.

9. 发明申请

WO2004035743A8 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS 审中-公开
标题翻译： KETO氨基酸在蛋白质中的位点特异性引入
公开(公告)号：WO2004035743A8
公开(公告)日：2005-06-09
申请号：PCT/US0332576
申请日：2003-10-15
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , WANG LEI
发明人： SCHULTZ PETER G , WANG LEI
IPC分类号： C07K14/47 , C12N9/00 , C12N15/10 , C12N15/67 , C12P21/00 , C12N
CPC分类号： C12N15/67 , C12N9/93 , C12N15/10 , C12P21/005
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
摘要翻译：提供了生产蛋白质生物合成机器组分的组合物和方法，所述组合物包括正交tRNA，正交氨酰-tRNA合成酶和正交配对的tRNA /合成酶，其将酮氨基酸掺入蛋白质中。还提供了用于鉴定这些正交配对的方法以及使用这些正交配对产生具有酮基氨基酸的蛋白质的方法。

10. 发明申请

WO2012092451A3 SEARCHING RECORDED VIDEO 审中-公开
标题翻译：搜索录制的视频
公开(公告)号：WO2012092451A3
公开(公告)日：2013-01-24
申请号：PCT/US2011067769
申请日：2011-12-29
申请人： PELCO INC , MILLAR GREG , AGHDASI FARZIN , WANG LEI
发明人： MILLAR GREG , AGHDASI FARZIN , WANG LEI
IPC分类号： H04N7/18 , H04N5/76
CPC分类号： G06F17/3079
摘要： Embodiments of the disclosure provide for systems and methods for creating metadata associated with a video data. The metadata can include data about objects viewed within a video scene and/or events that occur within the video scene. Some embodiments allow users to search for specific objects and/or events by searching the recorded metadata. In some embodiments, metadata is created by receiving a video frame and developing a background model for the video frame. Foreground object(s) can then be identified in the video frame using the background model. Once these objects are identified they can be classified and/or an event associated with the foreground object may be detected. The event and the classification of the foreground object can then be recorded as metadata.
摘要翻译：本公开的实施例提供了用于创建与视频数据相关联的元数据的系统和方法。元数据可以包括关于在视频场景内观看的对象的数据和/或在视频场景内发生的事件。一些实施例允许用户通过搜索记录的元数据来搜索特定对象和/或事件。在一些实施例中，通过接收视频帧并开发视频帧的背景模型来创建元数据。然后可以使用背景模型在视频帧中识别前景对象。一旦识别出这些对象，就可以对它们进行分类和/或可以检测与前景对象相关联的事件。然后可以将事件和前景对象的分类记录为元数据。

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