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1. 发明申请

WO2021079306A1 ACCOUNTING FOR ERRORS IN OPTICAL MEASUREMENTS 审中-公开
公开(公告)号：WO2021079306A1
公开(公告)日：2021-04-29
申请号：PCT/IB2020/059925
申请日：2020-10-22
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： PECKER, Sharon , ESHEL, Yochay Shlomo , ZAIT, Amir , GLUCK, Dan , YORAV-RAPHAEL, Noam , HOURI YAFIN, Arnon , LEVY SCHREIER, Sarah , POLLAK, Joseph Joel , LEVNER, Daniel , HALPERIN, Yonatan , LEZMY, Natalie , WEISS, Itamar
IPC分类号： G06K9/00 , G01N33/49
摘要： Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

2. 发明申请

WO2017195205A1 SAMPLE CARRIER FOR OPTICAL MEASUREMENTS 审中-公开
标题翻译：样品载体用于光学测量
公开(公告)号：WO2017195205A1
公开(公告)日：2017-11-16
申请号：PCT/IL2017/050523
申请日：2017-05-11
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： POLLAK, Joseph Joel , LEVY SCHREIER, Sarah , ESHEL, Yochay Shlomo , ZAIT, Amir , PECKER, Sharon
IPC分类号： G01N21/03 , G01N33/49
摘要： Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
摘要翻译：描述了用于确定生物样品的性质的设备和方法。样本载体（22）包括限定至少第一区域（42）和第二区域（44）的一个或多个样本室（40），一个或多个样本室的高度在第一和第二区域预定义的方式。计算机处理器（28）接收与第一光学测量有关的数据，所述第一光学测量对布置在第一区域内的样品的一部分执行，接收与第二光学测量有关的数据，所述第二光学测量是对样品的一部分设置在所述第二区域内，并通过使用所述第一光学测量，所述第二光学测量和所述区域之间的所述预定高度变化之间的关系来确定所述样本的性质。还介绍了其他应用程序。

3. 发明申请

WO2021116957A1 OFF-FOCUS MICROSCOPIC IMAGES OF A SAMPLE 审中-公开
公开(公告)号：WO2021116957A1
公开(公告)日：2021-06-17
申请号：PCT/IB2020/061728
申请日：2020-12-10
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： GLUCK, Dan , ZAIT, Amir , HOURI YAFIN, Arnon , HALPERIN, Yonatan , ESHEL, Yochay Shlomo , LEVY, Sarah , POLLAK, Joseph Joel , PECKER, Sharon , YAFIN, Peretz , BENNASSAT, Dana , BRAILOVSKY, David , PUMERANTZ, Uriyah
IPC分类号： G01N15/14
摘要： Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.

4. 发明申请

WO2017195208A1 PERFORMING OPTICAL MEASUREMENTS ON A SAMPLE 审中-公开
标题翻译：在样品上进行光学测量
公开(公告)号：WO2017195208A1
公开(公告)日：2017-11-16
申请号：PCT/IL2017/050526
申请日：2017-05-11
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ZAIT, Amir , HOURI YAFIN, Arnon , GLUCK, Dan , PECKER, Sharon , ESHEL, Yochay Shlomo , LEVY SCHREIER, Sarah , POLLAK, Joseph Joel
IPC分类号： G01N33/50 , G01N33/49 , G01N21/49
摘要： Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.
摘要翻译：描述了与血液样品（48,50）一起使用的设备和方法，包括通过对血液进行第一次测量来测量血液样品的至少一部分（48）内的血红蛋白浓度样品。通过对血液样本（48,50）进行第二次测量，测量血液样本（48,50）中的平均血球血红蛋白。基于血红蛋白浓度与平均红细胞血红蛋白之间的关系确定血液样品的参数。还介绍了其他应用程序。

5. 发明申请

WO2021116959A1 ANALYZING AN ANALYTE DISPOSED WITHIN A MEDIUM 审中-公开
公开(公告)号：WO2021116959A1
公开(公告)日：2021-06-17
申请号：PCT/IB2020/061731
申请日：2020-12-10
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ESHEL, Yochay Shlomo , PECKER, Sharon , LEVY, Sarah , POLLAK, Joseph Joel
IPC分类号： G01N21/31
摘要： Apparatus and methods are described for use with a bodily sample that contains an analyte disposed within water. The bodily sample is placed within a sample chamber a height of which is unknown. Light is directed through the sample at a first wavelength band, at which absorption of light by the analyte is relatively high, and at a second wavelength band that is centered around a wavelength of between 1,200 nm and 3,000 nm. The light that passes through the sample at each of the first and second wavelength bands is detected, and, based upon the detected light at each of the first and second wavelength bands, a concentration of the analyte within the bodily sample is determined, without directly measuring the height of the sample chamber. Other applications are also described.

6. 发明申请

WO2021079305A1 ACCOUNTING FOR ERRORS IN OPTICAL MEASUREMENTS 审中-公开
公开(公告)号：WO2021079305A1
公开(公告)日：2021-04-29
申请号：PCT/IB2020/059924
申请日：2020-10-22
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： PECKER, Sharon , ESHEL, Yochay Shlomo , ZAIT, Amir , GLUCK, Dan , YORAV-RAPHAEL, Noam , HOURI YAFIN, Arnon , LEVY SCHREIER, Sarah , POLLAK, Joseph Joel , LEVNER, Daniel , HALPERIN, Yonatan , LEZMY, Natalie , WEISS, Itamar
IPC分类号： G06K9/03
摘要： Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.

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