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1. 发明申请

WO2010149388A2 ADHERENCE INDICATION TOOL FOR CHRONIC DISEASE MANAGEMENT AND METHOD THEREOF 审中-公开
标题翻译：用于慢性疾病管理的干预指示工具及其方法
公开(公告)号：WO2010149388A2
公开(公告)日：2010-12-29
申请号：PCT/EP2010/003894
申请日：2010-06-25
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG
发明人： THUKRAL, Ajay , WEINERT, Stefan , WAGNER, Robin , ZIVITZ, Maury
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , G06F19/325 , G06F19/3475 , G06F19/3481 , G16H50/20
摘要： An adherence indication tool for chronic disease self-management and method thereof for measuring adherence or compliance to following or achieving prescribed therapy steps to achieve stated target goals for improved chronic disease self-management are disclosed.
摘要翻译：公开了一种用于慢性疾病自我管理的依从性指示工具及其方法，用于测量依从性或依从性以达到规定的治疗步骤，以达到改善慢性病自我管理的所述目标。

2. 发明申请

WO2006131288A1 A SYSTEM AND METHOD PROVIDING FOR USER INTERVENTION IN A DIABETES CONTROL ARRANGEMENT 审中-公开
标题翻译：一种用于糖尿病患者控制布置的用户干预的系统和方法
公开(公告)号：WO2006131288A1
公开(公告)日：2006-12-14
申请号：PCT/EP2006/005344
申请日：2006-06-03
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG
发明人： BOUSAMRA, Steven , CHITTAJALLU, Siva , GALLEY, Paul , THUKRAL, Ajay , WAGNER, Robin , WEINERT, Stefan
IPC分类号： G06F19/00 , A61B19/00 , A61M5/142
CPC分类号： A61M5/172 , A61M5/1723 , A61M2005/14208 , A61M2005/14296 , A61M2205/3569 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/50
摘要： A system providing for user intervention in a medical control arrangement may comprise a first user intervention mechanism responsive to user selection thereof to produce a first user intervention signal, a second user intervention mechanism responsive to user selection thereof to produce a second user intervention signal, and a processor executing a drug delivery algorithm forming part of the medical control arrangement. The processor may be responsive to the first user intervention signal to include an intervention therapy value in the execution of the drug delivery algorithm, and responsive to the second user intervention signal to exclude the intervention therapy value from the execution of the drug delivery algorithm. The medical control arrangement may be a diabetes control arrangement, the drug delivery algorithm may be an insulin delivery algorithm, and the intervention therapy value may be, for example, an intervention insulin quantity or an intervention carbohydrate quantity.
摘要翻译：提供用户干预医疗控制装置的系统可以包括响应于用户选择其以产生第一用户干预信号的第一用户干预机制，响应于用户选择以产生第二用户干预信号的第二用户干预机制，以及执行形成医疗控制装置的一部分的药物递送算法的处理器。所述处理器可以响应于所述第一用户干预信号，以在所述药物递送算法的执行中包括干预治疗值，并且响应于所述第二用户干预信号排除所述介入治疗值与所述药物递送算法的执行。医疗控制装置可以是糖尿病控制装置，药物递送算法可以是胰岛素递送算法，并且干预治疗值可以是例如干预胰岛素量或干预碳水化合物量。

3. 发明申请

WO2006066926A1 SYSTEM AND METHOD FOR DETERMINING INSULIN BOLUS QUANTITIES 审中-公开
标题翻译：用于确定胰岛素凝块数量的系统和方法
公开(公告)号：WO2006066926A1
公开(公告)日：2006-06-29
申请号：PCT/EP2005/013891
申请日：2005-12-22
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG
发明人： HELLWIG, Robert , WEINERT, Stefan
IPC分类号： G06F19/00
CPC分类号： G01N33/66 , A61M5/1413 , A61M2005/1405 , A61M2005/14208 , G01N33/74 , G01N2333/4745 , G01N2800/042 , G06F19/00 , G06F19/3468 , G16H50/50
摘要： A method of computing an insulin bolus quantity when a measured glucose value in a current time interval exceeds a target glucose value for the current time interval and when a time duration of glucose lowering action of the bolus to be administered spans the current and a number of the next adjacent time intervals, may comprise determining a corresponding number of percentages of insulin action of the recommended bolus quantity that will each be used lowering the glucose level during a respective one of the number of time intervals, and computing the recommended bolus quantity as a function of the measured glucose value, the target blood glucose level for a last one of the number of next adjacent time intervals, the insulin sensitivities for the current and each of the number of next adjacent time intervals, and the corresponding number of percentages.
摘要翻译：当当前时间间隔内的测量葡萄糖值超过当前时间间隔的目标葡萄糖值时，以及当要施用的推注的葡萄糖降低作用的持续时间跨越当前时间间隔和当前时间间隔的多个时，计算胰岛素推注量的方法下一个相邻的时间间隔可以包括确定推荐的推注剂量的胰岛素作用百分比的相应数量，其将在每个时间间隔的相应时间段内分别使用降低葡萄糖水平，并将推荐的推注量计算为测量的葡萄糖值的功能，下一个相邻时间间隔数量的最后一个的目标血糖水平，当前和下一个相邻时间间隔的数量的胰岛素敏感性以及相应的百分比数。

4. 发明申请

WO2010072386A2 STRUCTURED TESTING METHOD FOR DIAGNOSTIC OR THERAPY SUPPORT OF A PATIENT WITH A CHRONIC DISEASE AND DEVICES THEREOF 审中-公开
标题翻译：具有慢性疾病的患者的诊断或治疗支持的结构化测试方法及其装置
公开(公告)号：WO2010072386A2
公开(公告)日：2010-07-01
申请号：PCT/EP2009/009170
申请日：2009-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG
发明人： WALLING, P., Douglas , SONI, Abhishek, S. , RASCH-MENGES, Juergen , WEINERT, Stefan , BOUSAMRA, Steven , EISENHARDT, Christoph
IPC分类号： G06F19/00
CPC分类号： G06F17/30289 , G01N33/49 , G01N33/66 , G06F19/00 , G06F19/3418 , G16H10/20 , G16H40/63
摘要： A structured testing method (200, 300, 388) for diagnostic or therapy support of a patient (12) with a chronic disease and devices (18) thereof are disclosed, devices (18) implement the structured collection procedure (70) based on a medical use case and/or question which provides at least one or more parameters (220, 222, 224, 226, 228, 230, 232, 237, 238, 240) defining at least one entry criterion (226), a schedule of events (222), at least one adherence criterion (224), and at least one exit criterion (228). The entry criterion (226) establish conditions needed to be met prior to obtaining biomarker data (256) from the patient (12). Each event (237) in the schedule of events (222) can include at least one or more of a performance time (238), guidance (230) to perform the event (237), a request (240) for information from the patient (12), a request (240) for patient action, and a request (240) for collection of at least one type of biomarker data (256) from the patient (12). The adherence criterion (224) is used to assess qualitatively whether an event (237) performed according to the schedule of events (222) provided data (256, 170, 145) which is acceptable to addressing the medical use case and/or question, and the exit criterion (228) establishes conditions needed to be met prior to exiting the structured collection procedure (70).
摘要翻译：公开了一种用于具有慢性疾病的患者（12）及其装置（18）的诊断或治疗支持的结构化测试方法（200,300,388），装置（18）基于提供定义至少一个入口标准（226）的至少一个或多个参数（220,222,224,226,228,230,232,237,238,240）的医疗用例和/或问题，事件调度（222），至少一个遵守标准（224）和至少一个退出标准（228）。进入标准（226）建立在从患者（12）获得生物标志物数据（256）之前需要满足的条件。事件调度表（222）中的每个事件（237）可以包括执行事件（237）的执行时间（238），指导（230），来自患者的信息的请求（240））中的至少一个或多个（12），用于患者动作的请求（240）以及用于从患者（12）收集至少一种类型的生物标志物数据（256）的请求（240）。遵守标准（224）用于定性地评估根据事件调度表（222）执行的事件（237）是否提供了解决医疗用例和/或问题可接受的数据（256,170,145）并且退出标准（228）建立在退出结构化收集过程（70）之前需要满足的条件。

5. 发明申请

WO2013041156A1 SYSTEMS AND METHODS FOR HANDLING UNACCEPTABLE VALUES IN STRUCTURED COLLECTION PROTOCOLS 审中-公开
标题翻译：用于处理结构化收集协议中不可否认值的系统和方法
公开(公告)号：WO2013041156A1
公开(公告)日：2013-03-28
申请号：PCT/EP2012/001987
申请日：2012-05-09
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： BOUSAMRA, Steven A. , DUKE, David L. , GALLEY, Paul J. , Greenburg, Alan, M. , WEINERT, Stefan
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , G16H10/20
摘要： Embodiments of methods of querying a diabetic patient regarding compliance with adherence criteria comprises instructing the diabetic patient to collect at least one sample in a sampling set of biomarker data, wherein each sampling set comprises a sufficient plurality of samples recorded over a collection period, comparing the collected samples to an acceptable range, wherein the acceptable range encompasses biomarker values that would be expected upon compliance with the adherence criteria, and informing the diabetic patient if at least one sample is an unacceptable value which falls outside of the acceptable range, and performing at least one additional task after detecting the unacceptable value.
摘要翻译：对糖尿病患者询问遵守依从性标准的方法的实施方案包括指示糖尿病患者在生物标志物数据的采样组中收集至少一个样品，其中每个采样组包括在收集期间记录的足够多个样品，收集的样品到可接受的范围，其中可接受的范围包括根据遵守标准预期的生物标志物值，并且通知糖尿病患者，如果至少一个样品是不可接受的值，其不超出可接受的范围，并且在检测到不可接受的值后，再增加一项任务。

6. 发明申请

WO2012089318A1 METHODS OF SELECTING DIABETES THERAPY REGIMENS 审中-公开
标题翻译：选择糖尿病治疗方案的方法
公开(公告)号：WO2012089318A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/006506
申请日：2011-12-22
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： GALLEY, Paul, J. , HASKER, David , PORSCH, Ulrich , WEINERT, Stefan
IPC分类号： G06F19/00
CPC分类号： G06F19/325 , G06F19/00 , G06F19/3456 , G06F19/3468 , G06Q10/063112
摘要： Embodiments of methods of assessing a diabetes treatment protocol comprise determining a protocol complexity level corresponding to a degree of difficulty of completing the diabetes treatment protocol by utilizing the processor, determining a patient proficiency level corresponding to a skill set of the patient in conducting the diabetes treatment protocol by utilizing the processor, comparing the protocol complexity level to the patient proficiency level via the processor, and providing an output based on the comparison.
摘要翻译：评估糖尿病治疗方案的方法的实施方案包括通过利用处理器确定对应于完成糖尿病治疗方案的难度的方案复杂度水平，确定与进行糖尿病治疗的患者的技能组相对应的患者熟练度水平通过利用处理器协议，通过处理器将协议复杂度水平与患者熟练程度进行比较，并提供基于比较的输出。

7. 发明申请

WO2010149392A1 METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR PROVIDING BOTH AN ESTIMATED TRUE MEAN BLOOD GLUCOSE VALUE AND ESTIMATED GLYCATED HEMOGLOBIN (HBA1C) VALUE FROM STRUCTURED SPOT MEASUREMENTS OF BLOOD GLUCOSE 审中-公开
标题翻译：方法，系统和计算机程序产品，用于提供两种估计的平均血糖值和估计的糖化血红蛋白（HBA1C）价值从血液葡萄糖结构测量
公开(公告)号：WO2010149392A1
公开(公告)日：2010-12-29
申请号：PCT/EP2010/003929
申请日：2010-06-28
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： THUKRAL, Ajay , WEINERT, Stefan , PAN, Zhengzheng , AMANN-ZALAN, Ildiko , SCHWEITZER, Matthias, Axel
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , G06F19/00 , G06F19/3456
摘要： A method and system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements are disclosed. The bG measurements and associated context of the bG measurement are collected at daily times specified by a structured sampling schema, and the collected bG measurements are weighted based on the associated context. The estimated true mean bG value and the estimate HbA1C value are then determined from the weighted measurements of the collected bG measurements. A computer program for implementing the method for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements is also disclosed.
摘要翻译：公开了一种从点血糖（bG）测量中提供估计的真实平均血糖值和估计的糖化血红蛋白（HbA1C）值的方法和系统。 bG测量和bG测量的相关上下文在由结构化采样模式指定的每日时间收集，并且基于相关联的上下文对收集的bG测量进行加权。然后从所收集的bG测量的加权测量中确定估计的真实平均值bG值和估计HbA1C值。还公开了一种用于实现从斑点血糖（bG）测量提供估计的真实平均血糖值和估计的糖化血红蛋白（HbA1C）值的方法的计算机程序。

8. 发明申请

WO2011157372A2 STATUS REPORTING OF A STRUCTURED COLLECTION PROCEDURE 审中-公开
标题翻译：结构性收集程序的状态报告
公开(公告)号：WO2011157372A2
公开(公告)日：2011-12-22
申请号：PCT/EP2011/002809
申请日：2011-06-08
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： SONI, Abhishek S. , GALLEY, Paul J. , GREENBURG, Alan , BOUSAMRA, Steven , WEINERT, Stefan , DIEBOLD, Eric, R.
CPC分类号： G06F19/3456 , A61B5/0002 , A61B5/14532 , A61B5/4839 , A61B5/7275 , G06F19/00 , G06F19/3418 , G06F19/3468 , G06F19/3475 , G06F19/3481 , G06Q50/24 , G16H10/20 , G16H10/60 , G16H15/00
摘要： Embodiments related to a system and method managing the implementation, execution, data collection, data analysis and status reporting of a structured collection procedure running on a portable, hand-held collection device are disclosed. The collection device performing the structured collection procedure has program instructions that when executed by a processor cause the processor to initiate automatically a schedule of events of the structured collection procedure upon one or more entry criteria being met at some unknown time, store in memory patient data collected in accordance to the schedule of events, end automatically the structured collection procedure upon one or more exit criteria being met at some unknown time. Status reporting can be provided throughout the execution of the collection procedure.
摘要翻译：公开了涉及在便携式手持收集装置上运行的结构化收集过程的实现，执行，数据收集，数据分析和状态报告的系统和方法的实施例。执行结构化收集过程的收集装置具有当处理器执行时使得处理器在某个未知时间满足一个或多个入口标准时自动启动结构化收集过程的事件调度的程序指令，存储在存储器患者数据中根据事件进度收集，在一些未知时间满足一个或多个退出条件时自动结束结算收集程序。可以在整个执行收集过程中提供状态报告。

9. 发明申请

WO2011092133A1 METHODS AND SYSTEMS FOR PROCESSING GLUCOSE DATA MEASURED FROM A PERSON HAVING DIABETES 审中-公开
标题翻译：用于加工糖尿病患者测量的葡萄糖数据的方法和系统
公开(公告)号：WO2011092133A1
公开(公告)日：2011-08-04
申请号：PCT/EP2011/050888
申请日：2011-01-24
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , DUKE, David, L. , SONI, Abhishek, S. , WEINERT, Stefan
发明人： DUKE, David, L. , SONI, Abhishek, S. , WEINERT, Stefan
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/7221 , A61B5/725
摘要： Methods and systems are disclosed for estimating a glucose level of a person having diabetes. One method may comprise: receiving into a computing device a plurality of measured glucose results from a glucose sensor coupled to the person; using the computing device to analyze the plurality of measured glucose results with a probability analysis tool configured to determine a probability of glucose sensor accuracy based on the plurality of measured glucose results; and using the computing device to estimate a glucose level of the person with a recursive filter configured to estimate the glucose level based on the plurality of measured glucose results weighted with the probability of glucose sensor accuracy.
摘要翻译：公开了用于估计患有糖尿病的人的葡萄糖水平的方法和系统。一种方法可以包括：从计算设备接收来自耦合到人的葡萄糖传感器的多个测量的葡萄糖结果; 使用所述计算装置利用概率分析工具分析所述多个测量的葡萄糖结果，所述概率分析工具被配置为基于所述多个测量的葡萄糖结果来确定葡萄糖传感器精度的概率; 以及使用所述计算设备来估计具有递归滤波器的人的葡萄糖水平，该递归滤波器被配置为基于以葡萄糖传感器精度的概率加权的多个测量的葡萄糖结果来估计葡萄糖水平。

10. 发明申请

WO2010072387A3 MANAGEMENT METHOD AND SYSTEM FOR IMPLEMENTATION, EXECUTION, DATA COLLECTION, AND DATA ANALYSIS OF A STRUCTURED COLLECTION PROCEDURE WHICH RUNS ON A COLLECTION DEVICE 审中-公开
公开(公告)号：WO2010072387A3
公开(公告)日：2010-07-01
申请号：PCT/EP2009/009171
申请日：2009-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG
发明人： SONI, Abhishek, S. , RASCH-MENGES, Juergen , WEINERT, Stefan
IPC分类号： G06F19/00
摘要： Embodiments related to a system (41) and method (200, 300, 388, 400) managing the implementation, execution, data collection, and data analysis of a structured collection procedure (70) running on a portable, hand-held collection device (24) are disclosed. The collection device (24) performing the structured collection procedure (70) has program (34) instructions that when executed by a processor (102) causes the processor (102) to initiate automatically a schedule of events (222) of the structured collection procedure (70) upon one or more entry criterions (226) being met at some unknown time, store in memory (110) patient data (256, 170, 145) collected in accordance to the schedule of events (222), end automatically the structured collection procedure (70) upon one or more exit criterions (228) being met at some unknown time, and mark/indicate the structured collection procedure (70) as completed if no exception occurred during performance of an event (237) in the schedule of events (222).

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