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1. 发明申请

WO9850530A9 ENZYMATIC NUCLEIC ACID TREATMENT OF DISEASES OR CONDITIONS RELATED TO LEVELS OF EXPRESSION OF C-RAF 审中-公开
标题翻译：与C-RAF表达水平相关的疾病或病症的酶促核酸治疗
公开(公告)号：WO9850530A9
公开(公告)日：1999-03-25
申请号：PCT/US9809249
申请日：1998-05-05
申请人： RIBOZYME PHARM INC , JARVIS THALE , MATULIC ADAMIC JASENKA , REYNOLDS MARK , KISICH KEVIN , BELLON LAURENT , PARRY TOM , BEIGELMAN LEONID , MCSWIGGEN JAMES A , KARPEISKY ALEXANDER , BURGIN ALEX , THOMPSON JAMES , WORKMAN CHRISTOPHER T , BEAUDRY AMBER , SWEEDLER DAVID
发明人： JARVIS THALE , MATULIC-ADAMIC JASENKA , REYNOLDS MARK , KISICH KEVIN , BELLON LAURENT , PARRY TOM , BEIGELMAN LEONID , MCSWIGGEN JAMES A , KARPEISKY ALEXANDER , BURGIN ALEX , THOMPSON JAMES , WORKMAN CHRISTOPHER T , BEAUDRY AMBER , SWEEDLER DAVID
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61P17/06 , A61P29/00 , A61P35/00 , C12N5/10 , C12N9/12 , C12N15/113 , C12Q1/68 , C12N9/00
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Nucleic acid catalysts which modulate the expression of Raf gene; method of delivery, screening, identification, synthesis, deprotection, purification, of nucleic acid catalysts and processes for identification of nucleic acid molecules is described.
摘要翻译：调节Raf基因表达的核酸催化剂; 描述了核酸分子的递送，筛选，鉴定，合成，脱保护，纯化和鉴定核酸分子的方法。

2. 发明申请

WO9850530A3 ENZYMATIC NUCLEIC ACIDS: SYNTHESIS, SELECTION AND USE 审中-公开
标题翻译：酶促核酸：合成，选择和使用
公开(公告)号：WO9850530A3
公开(公告)日：1999-07-29
申请号：PCT/US9809249
申请日：1998-05-05
申请人： RIBOZYME PHARM INC , JARVIS THALE , MATULIC ADAMIC JASENKA , REYNOLDS MARK , KISICH KEVIN , BELLON LAURENT , PARRY TOM , BEIGELMAN LEONID , MCSWIGGEN JAMES A , KARPEISKY ALEXANDER , BURGIN ALEX , THOMPSON JAMES , WORKMAN CHRISTOPHER T , BEAUDRY AMBER , SWEEDLER DAVID
发明人： JARVIS THALE , MATULIC-ADAMIC JASENKA , REYNOLDS MARK , KISICH KEVIN , BELLON LAURENT , PARRY TOM , BEIGELMAN LEONID , MCSWIGGEN JAMES A , KARPEISKY ALEXANDER , BURGIN ALEX , THOMPSON JAMES , WORKMAN CHRISTOPHER T , BEAUDRY AMBER , SWEEDLER DAVID
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61P17/06 , A61P29/00 , A61P35/00 , C12N5/10 , C12N9/12 , C12N15/113 , C12Q1/68 , C12N9/00 , C07H19/04 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/10
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Nucleic acid catalysts which modulate the expression of Raf gene; method of delivery, screening, identification, synthesis, deprotection, purification, of nucleic acid catalysts and processes for identification of nucleic acid molecules is described.
摘要翻译：调节Raf基因表达的核酸催化剂; 描述了核酸分子的递送，筛选，鉴定，合成，脱保护，纯化和鉴定核酸分子的方法。

3. 发明申请

WO0017346A3 HAIRPIN HYBRIDIZER MOLECULES FOR MODULATION OF GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的发夹式杂交分子
公开(公告)号：WO0017346A3
公开(公告)日：2000-08-03
申请号：PCT/US9921865
申请日：1999-09-20
申请人： RIBOZYME PHARM INC , HARTMANN THOMAS , ZWICK MICHAEL , THOMPSON JAMES , JARVIS THALE
发明人： HARTMANN THOMAS , ZWICK MICHAEL , THOMPSON JAMES , JARVIS THALE
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/7125 , A61K35/76 , A61K38/00 , A61K48/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/113 , C12Q1/68 , C12N15/11 , A61K31/70 , C07H21/00
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： The invention features novel hairpin hybridizer nucleic acid molecules which are able to modulate gene expression; useful in target validation, gene function identification and in human therapeutics.
摘要翻译：本发明的特征在于能够调节基因表达的新型发夹杂交物核酸分子; 用于靶标验证，基因功能鉴定和人类治疗。

4. 发明申请

WO0211674A2 METHOD AND REAGENT FOR THE INHIBITION OF CALCIUM ACTIVATED CHLORIDE CHANNEL-1 (CLCA-1) 审中-公开
标题翻译：激活氯化钙通道1（CLCA-1）的抑制方法和试剂
公开(公告)号：WO0211674A2
公开(公告)日：2002-02-14
申请号：PCT/US0124970
申请日：2001-08-09
申请人： RIBOZYME PHARM INC , SYNTEX LLC , THOMPSON JAMES , MCSWIGGEN JAMES , MCKENZIE TIMOTHY , AYERS DAVID , SZYMKOWSKI DAVID E , GRUPE ANDREW
发明人： THOMPSON JAMES , MCSWIGGEN JAMES , MCKENZIE TIMOTHY , AYERS DAVID , SZYMKOWSKI DAVID E , GRUPE ANDREW
IPC分类号： A61K38/00 , C12N15/113 , C12N15/12 , A61K
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121
摘要： Nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, and GeneBlocs, which modulate the expression of calcium activated chloride channels (CLCA1, CLCA2, CLCA3, and CLCA4).
摘要翻译：核酸分子，包括反义和酶核酸分子，如锤头核酶，DNA酶和GeneBlocs，其调节钙活化氯化物通道（CLCA1，CLCA2，CLCA3和CLCA4）的表达。

5. 发明申请

WO2013058889A3 BRAIDING MECHANISM AND METHODS OF USE 审中-公开
标题翻译：制动机制及使用方法
公开(公告)号：WO2013058889A3
公开(公告)日：2014-05-08
申请号：PCT/US2012054517
申请日：2012-09-10
申请人： SEQUENT MEDICAL INC , MARCHAND PHILIPPE , NOLTING JOHN , KENT DARRIN , DINH TAN , TRAN HUNG , MILBURN JAMES , THOMPSON JAMES , COX BRIAN , ROSENBLUTH ROBERT
发明人： MARCHAND PHILIPPE , NOLTING JOHN , KENT DARRIN , DINH TAN , TRAN HUNG , MILBURN JAMES , THOMPSON JAMES , COX BRIAN , ROSENBLUTH ROBERT
IPC分类号： D04C3/40
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments are described. In one embodiment, the braiding machine includes a disc with a mandrel extending from the center in a perpendicular direction and a plurality of catch mechanisms arranged circumferentially around the edge of the disc. A plurality of filaments are temporarily affixed to the mandrel, each filament extending from the mandrel toward the edge of the disc and engaging the edge of the disc at a discrete point of engagement. The plurality of catch mechanisms are attached to actuators adapted to move the catch mechanisms in a generally radial direction relative to the edge of the disc to allow the catch mechanism to engage a subset of the filaments and move the engaged filaments beyond the circumferential edge of the disc.
摘要翻译：描述了用于形成包括多根细丝的管状编织物的装置和方法。在一个实施例中，编织机包括具有在垂直方向上从中心延伸的心轴的盘和围绕盘的边缘周向布置的多个捕获机构。许多细丝临时固定在心轴上，每根细丝从心轴向盘的边缘延伸并且在离散的接合点处与盘的边缘接合。多个捕捉机构附接到致动器，其适于相对于盘的边缘在大致径向方向上移动捕获机构，以允许捕获机构接合细丝的一部分并且将所接合的细丝移动超过所述纤维的圆周边缘光盘。

6. 发明申请

WO2011049896A2 SILICONE COMPOSITIONS COMPRISING A SWOLLEN SILICONE GEL 审中-公开
标题翻译：含硅酮硅胶的硅胶组合物
公开(公告)号：WO2011049896A2
公开(公告)日：2011-04-28
申请号：PCT/US2010053112
申请日：2010-10-19
申请人： DOW CORNING , AHN DONGCHAN , SCHULZ WILLIAM , THOMPSON JAMES
发明人： AHN DONGCHAN , SCHULZ WILLIAM , THOMPSON JAMES
IPC分类号： A61K8/89
CPC分类号： C08G77/442 , A61K8/042 , A61K8/893 , A61K2800/546 , A61Q15/00 , A61Q19/00 , C08L83/10
摘要： In various embodiments, provided are substantially homogenous swollen silicone gels, powders, pastes, and compositions thereof; methods of preparing the same; and personal care and healthcare products comprising the same.
摘要翻译：在各种实施方案中，提供基本均匀的溶胀硅氧烷凝胶，粉末，糊剂及其组合物; 制备方法; 以及包含其的个人护理和保健产品。

7. 发明申请

WO2007053424A3 SILICONE VESICLES CONTAINING ACTIVES 审中-公开
标题翻译：含有活性的硅胶
公开(公告)号：WO2007053424A3
公开(公告)日：2007-06-28
申请号：PCT/US2006041831
申请日：2006-10-25
申请人： DOW CORNING , LIN SHAOW BURN , NEWTON JOANNA , POSTIAUX STEPHANIE , THOMPSON JAMES
发明人： LIN SHAOW BURN , NEWTON JOANNA , POSTIAUX STEPHANIE , THOMPSON JAMES
IPC分类号： A61K8/894 , A61K8/14 , A61K9/127
CPC分类号： A61K8/894 , A61K8/14 , A61K9/107 , A61K9/1075 , A61K47/24 , A61Q1/02 , A61Q1/06 , A61Q17/04 , A61Q19/00
摘要： Processes are disclosed for preparing silicone vesicle compositions and emulsions containing silicone vesicles, the compositions prepared therefrom, and formulated personal and healthcare products containing the silicone vesicles and emulsions compositions.
摘要翻译：公开了制备硅树脂囊泡组合物和含有硅酮囊泡的乳液的方法，由其制备的组合物以及含有硅酮泡沫和乳液组合物的配制的个人和保健产品。

8. 发明申请

WO0232221A2 SYSTEM FOR PROTECTING TREES AND STRUCTURES AGAINST INFESTATION 审中-公开
标题翻译：防止感染的物种和结构的系统
公开(公告)号：WO0232221A2
公开(公告)日：2002-04-25
申请号：PCT/CA0101460
申请日：2001-10-18
申请人： THOMPSON JAMES
发明人： THOMPSON JAMES
IPC分类号： A01M29/00 , A01G13/10 , A01M1/02
CPC分类号： A01G13/105
摘要： A system for protecting trees (1) and structures from infestation by crawling or climbing insects by attaching an insect barrier to the wall surface of the object to be protected. The barrier consists of a belt means (2), which may be made from a plastic sheet material and may be wrapped around the object to be protected, including a contact means that engages the surface of the object. The contact means may have a deformable thickness, such as provided by a layer of a non-woven fabric, to prent the passage of insects between the barrier and the surface of the objet. The free ends of the belt means are secured to each other to retain the belt means against the surface of the tree and engage the contact means against the tree surface. The belt means has slippery surface means (3), having a low coefficient of friction with respect to insects, that prevents the travel of insects on the belt means, preventing them from proceeding over the belt means and infesting the tree or structure to be protected. The slippery surface means may be provided by application of a coating of a fluoro-polymer, such as poly-tetra-fluoro ethylene (PTFE), to the belt means or may be otherwise suitably attached to or integrally formed with the belt means.
摘要翻译：通过将昆虫屏障附着在待保护对象的墙壁表面上，通过爬行或爬行昆虫来保护树木（1）和结构免遭侵扰的系统。阻挡层包括带状装置（2），其可以由塑料片材制成并且可以缠绕在待保护物体周围，包括接合物体表面的接触装置。接触装置可以具有可变形的厚度，例如由无纺布层提供的厚度，以预防昆虫在阻挡层和对象表面之间的通过。带装置的自由端彼此固定，以将带装置保持抵靠树的表面，并将接触装置接合在树面上。皮带装置具有光滑的表面装置（3），其具有相对于昆虫的低摩擦系数，其防止昆虫在皮带装置上行进，防止它们进入皮带装置并侵染被保护的树或结构。可以通过将诸如聚四氟乙烯（PTFE）的氟聚合物的涂层施加到带装置来提供光滑表面装置，或者可以以其它方式适当地附接到带装置或与带装置一体形成。

9. 发明申请

WO2009001144A3 PHARMACEUTICAL AEROSOL COMPOSITIONS COMPRISING FLUTICASONE 审中-公开
标题翻译：含有FLUTICASONE的药用气溶胶组合物
公开(公告)号：WO2009001144A3
公开(公告)日：2009-03-19
申请号：PCT/GB2008050518
申请日：2008-06-27
申请人： GENERICS UK LTD , FLANDERS PAUL , THOMPSON JAMES
发明人： FLANDERS PAUL , THOMPSON JAMES
IPC分类号： A61K9/12 , A61K31/56 , A61K47/32 , A61P11/06
CPC分类号： A61K47/32 , A61K9/0078
摘要： The present invention relates to pharmaceutical compositions and in particular to suspension aerosol pharmaceutical compositions, processes to obtain them and their use in inhalation therapy.
摘要翻译：本发明涉及药物组合物，特别涉及悬浮气雾剂药物组合物，获得它们的方法及其在吸入治疗中的用途。

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