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1. 发明申请

WO2009015142A8 SMOKELESS TOBACCO COMPOSITIONS AND METHODS FOR TREATING TOBACCO FOR USE THEREIN 审中-公开
标题翻译：无烟烟草组合物及其用途处理烟草的方法
公开(公告)号：WO2009015142A8
公开(公告)日：2010-01-28
申请号：PCT/US2008070755
申请日：2008-07-22
申请人： REYNOLDS TOBACCO CO R , MUA JOHN-PAUL , MONSALUD LUIS ROSETE JR , HOLTON DARRELL EUGENE JR , FIGLAR JAMES NEIL , BRINKLEY PAUL ANDREW , MCCLANAHAN DAVID NEIL , FLINCHUM JACK GRAY JR , DUBE MICHAEL FRANCIS , CANTRELL DANIEL VERDIN , STOKES CYNTHIA STEWART
发明人： MUA JOHN-PAUL , MONSALUD LUIS ROSETE JR , HOLTON DARRELL EUGENE JR , FIGLAR JAMES NEIL , BRINKLEY PAUL ANDREW , MCCLANAHAN DAVID NEIL , FLINCHUM JACK GRAY JR , DUBE MICHAEL FRANCIS , CANTRELL DANIEL VERDIN , STOKES CYNTHIA STEWART
IPC分类号： A24B13/00 , A24B15/00 , A24B15/28 , A24B15/30
CPC分类号： A24B15/283 , A24B13/00 , A24B15/183 , A24B15/28 , A24B15/30
摘要： A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product (10) including a water-permeable pouch (12) containing a tobacco formulation, the tobacco formulation including a tobacco material (14) and a plurality of microcapsules (16) dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. The invention also provides processes for preparing a tobacco composition suitable for use as a smokeless tobacco composition, the processes including a heat treatment step for pasteurization of the tobacco composition.
摘要翻译：提供了构造成用于插入产品使用者口中的无烟烟草产品，烟草制品（10）包括含有烟草制剂的透水袋（12），烟草制剂包括烟草材料（14）和分散在烟草材料内的多个微胶囊（16），所述多个微胶囊包括封装内部净荷的外壳。内部有效载荷可以包括添加剂，例如水，调味剂，粘合剂，着色剂，pH调节剂，缓冲剂，填充剂，崩解助剂，保湿剂，抗氧化剂，口腔护理成分，防腐剂，来自草药或植物来源的添加剂，及其混合物。本发明还提供了制备适合用作无烟烟草组合物的烟草组合物的方法，该方法包括用于烟草组合物巴氏杀菌的热处理步骤。

2. 发明申请

WO2009015142A2 SMOKELESS TOBACCO COMPOSITIONS AND METHODS FOR TREATING TOBACCO FOR USE THEREIN 审中-公开
标题翻译：无烟烟草组合物及其用途处理烟草的方法
公开(公告)号：WO2009015142A2
公开(公告)日：2009-01-29
申请号：PCT/US2008070755
申请日：2008-07-22
申请人： REYNOLDS TOBACCO CO R , MUA JOHN-PAUL , MONSALUD LUIS ROSETE , HOLTON DARRELL EUGENE , FIGLAR JAMES NEIL , BRINKLEY PAUL ANDREW , MCCLANAHAN DAVID NEIL , FLINCHUM JACK GRAY , DUBE MICHAEL FRANCIS , CANTRELL DANIEL VERDIN , STOKES CYNTHIA STEWART
发明人： MUA JOHN-PAUL , MONSALUD LUIS ROSETE , HOLTON DARRELL EUGENE , FIGLAR JAMES NEIL , BRINKLEY PAUL ANDREW , MCCLANAHAN DAVID NEIL , FLINCHUM JACK GRAY , DUBE MICHAEL FRANCIS , CANTRELL DANIEL VERDIN , STOKES CYNTHIA STEWART
IPC分类号： A24B13/00 , A24B15/00
CPC分类号： A24B15/283 , A24B13/00 , A24B15/183 , A24B15/28 , A24B15/30
摘要： A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product including a water-permeable pouch containing a tobacco formulation, the tobacco formulation including a tobacco material and a plurality of microcapsules dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. The invention also provides processes for preparing a tobacco composition suitable for use as a smokeless tobacco composition, the processes including a heat treatment step for pasteurization of the tobacco composition.
摘要翻译：提供了构造成用于插入产品使用者的口中的无烟烟草产品，烟草制品包括含有烟草制剂的透水袋，烟草制剂包括烟草材料和分散在烟草材料内的多个微胶囊，所述多个微胶囊包括封装内部净荷的外壳。内部有效载荷可以包括添加剂，例如水，调味剂，粘合剂，着色剂，pH调节剂，缓冲剂，填充剂，崩解助剂，保湿剂，抗氧化剂，口腔护理成分，防腐剂，来自草药或植物来源的添加剂，及其混合物。本发明还提供了制备适合用作无烟烟草组合物的烟草组合物的方法，该方法包括用于烟草组合物巴氏杀菌的热处理步骤。

3. 发明申请

WO2012021683A3 THERMAL TREATMENT PROCESS FOR TOBACCO MATERIALS 审中-公开
标题翻译：烟草材料热处理工艺
公开(公告)号：WO2012021683A3
公开(公告)日：2012-05-31
申请号：PCT/US2011047385
申请日：2011-08-11
申请人： REYNOLDS TOBACCO CO R , CHEN GONG , GERARDI ANTHONY RICHARD , MUA JOHN-PAUL , HOLTON JR DARRELL EUGENE , CANTRELL DANIEL VERDIN , ST CHARLES FRANK KELLEY , MOLDOVEANU SERBAN C , BRINKLEY PAUL ANDREW
发明人： CHEN GONG , GERARDI ANTHONY RICHARD , MUA JOHN-PAUL , HOLTON JR DARRELL EUGENE , CANTRELL DANIEL VERDIN , ST CHARLES FRANK KELLEY , MOLDOVEANU SERBAN C , BRINKLEY PAUL ANDREW
IPC分类号： A24B15/20 , A24B15/30
CPC分类号： A24B15/18 , A24B3/12 , A24B13/00 , A24B15/20 , A24B15/30 , A24B15/306 , A24B15/307 , A24C5/00 , A24D3/00
摘要： A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.
摘要翻译：提供一种制备用于吸烟制品的烟草材料的方法，包括（i）将烟草材料，水和选自赖氨酸，甘氨酸，组氨酸，丙氨酸，甲硫氨酸，谷氨酸，天冬氨酸的添加剂混合酸，脯氨酸，苯丙氨酸，缬氨酸，精氨酸，二价和三价阳离子，天冬酰胺酶，糖类，酚类化合物，还原剂，具有游离巯基的化合物，氧化剂，氧化催化剂，植物提取物及其组合; （ii）加热混合物; 和（iii）将热处理的混合物并入作为吸烟材料的吸烟制品中。还提供了一种卷烟形式的吸烟制品，其包括预处理以抑制天冬酰胺在主流烟气中形成丙烯酰胺的反应的烟草材料。吸烟时，吸烟制品的特征在于主流烟雾的丙烯酰胺含量相对于未处理的对照吸烟制品而减少。

4. 发明申请

WO2010014506A2 SMOKELESS TOBACCO PRODUCTS AND PROCESSES 审中-公开
标题翻译：无烟烟草制品和工艺
公开(公告)号：WO2010014506A2
公开(公告)日：2010-02-04
申请号：PCT/US2009051641
申请日：2009-07-24
申请人： REYNOLDS TOBACCO CO R , ARZONICO BARBARA WALKER , BOVENDER DAVID CHARLES , BRINKLEY PAUL ANDREW , COLEMAN WILLIAM MONROE , DOOLITTLE DAVID JAMES , GIRARDI ANTHONY RICHARD , PHILLIPS PERCY DENOID , PATEL PANKAJ , ST CHARLES FRANK K , STOKES CYNTHIA STEWART
发明人： ARZONICO BARBARA WALKER , BOVENDER DAVID CHARLES , BRINKLEY PAUL ANDREW , COLEMAN WILLIAM MONROE , DOOLITTLE DAVID JAMES , GIRARDI ANTHONY RICHARD , PHILLIPS PERCY DENOID , PATEL PANKAJ , ST CHARLES FRANK K , STOKES CYNTHIA STEWART
IPC分类号： A24B15/30 , A24B13/00 , A24F23/00 , A24F23/02 , B65B1/36 , B65B9/00
CPC分类号： A24B15/302 , A24B13/00 , A24F23/00 , B65B25/02 , B65B37/10
摘要： A smokeless tobacco product is provided. A tobacco product configured for insertion into the mouth of a user of that product comprises a water-permeable pouch containing a tobacco formulation that includes a granular tobacco composition and miraculin.
摘要翻译：提供无烟烟草制品。构造成用于插入该产品的使用者的口中的烟草制品包括含有烟草制剂的透水袋，其包含颗粒状烟草组合物和miraculin。

5. 发明申请

WO2011139684A3 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：含NICOTINE的药物组合物
公开(公告)号：WO2011139684A3
公开(公告)日：2012-03-08
申请号：PCT/US2011033928
申请日：2011-04-26
申请人： NICONOVUM USA INC , BRINKLEY PAUL ANDREW , BORSCHKE AUGUST JOSEPH
发明人： BRINKLEY PAUL ANDREW , BORSCHKE AUGUST JOSEPH
IPC分类号： A61K9/00 , A61K31/19 , A61K31/465 , A61M15/00 , B65D83/52
CPC分类号： A61K9/0056 , A61K9/0058 , A61K9/006 , A61K31/19 , A61K31/465 , A61K31/787 , A61M15/009 , A61M15/0091
摘要： A composition intended to be employed for therapeutic purposes incorporates a source of nicotine and at least one levulinate moiety. Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) or nicotine polacrilex. The levulinate moiety can have the form of an acid (e.g., levulinic acid), a levulinate salt (e.g., sodium levulinate), or an ester of levulinic acid (e.g., methyl levulinate or ethyl levulinate). The composition can incorporate nicotine and levulinic acid in a salt form (e.g., nicotine levulinate). The composition can be composed of at least two forms of nicotine, and one of the forms of nicotine is in the form of nicotine levulinate. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and as a nicotine replacement therapy.
摘要翻译：旨在用于治疗目的的组合物包含尼古丁来源和至少一个乳酸部分。尼古丁的代表性形式包括游离碱（例如，作为尼古丁和微晶纤维素的混合物），尼古丁盐（例如，作为烟碱酒石酸氢盐）或尼古丁polacrilex。乙酰丙酸部分可以具有酸（例如乙酰丙酸），乙酰丙酸盐（例如乙酰丙酸钠）或乙酰丙酸（例如乙酰丙酸甲酯或乙酰丙酸乙酯）的酯的形式。组合物可以加入盐形式的尼古丁和乙酰丙酸（例如，乙酰丙酸烟碱）。组合物可以由至少两种形式的尼古丁组成，其中一种形式的尼古丁是烟酰胺酸盐的形式。该组合物可用于治疗中枢神经系统疾病和疾病，以及作为尼古丁替代疗法。

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