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    • 2. 发明申请
    • BONE MORPHOGENETIC PROTEIN (BMP) 2A AND USES THEREOF
    • 骨形态蛋白(BMP)2A及其用途
    • WO2005041857A2
    • 2005-05-12
    • PCT/IL2004/000924
    • 2004-10-06
    • QUARK BIOTECH, INC.FUJIWAWA PHARMACEUTICAL CO., LTD.FEINSTEIN, ElenaMETT, IgorGORODIN, SvetlanaSHTUTMAN, Michael
    • FEINSTEIN, ElenaMETT, IgorGORODIN, SvetlanaSHTUTMAN, Michael
    • A61K
    • C12N15/1136C12N2310/11C12N2310/111C12N2310/14
    • The present invention provides compositions and methods for alleviation or reduction of the symptoms and signs associated with damaged neuronal tissues whether resulting from tissue trauma, or from chronic or acute degenerative changes. In particular, some embodiments of the present invention provide one or more pharmaceutical compositions comprising as an active ingredient a BMP2A inhibitor further comprising a pharmaceutically acceptable diluent or carrier. An additional embodiment provides a method for reducing damage to the central nervous system in a patient who has suffered an injury to the central nervous system, comprising administering to the patient a pharmaceutical composition in a dosage sufficient to reduce the damage. Yet another embodiment provides of the use of a BMP2A inhibitor for the preparation of a medicament for promoting or enhancing recovery in a patient who has suffered an injury to the central nervous system. Preferable inhibitors according to some embodiments of the invention are siRNA molecules and neutralizing antibodies. An additional embodiment provides a method for identifying a chemical compound that modulates apoptosis. Further, a process for diagnosing a neurodegenrative disease or an ischemic event in a subject is provided. The preferred methods, materials, and examples that will now be described are illustrative only and are not intended to be limiting; materials and methods similar or equivalent to those described herein can be used in practice or testing of the invention. Other features and advantages of the invention will be apparent from the following detailed description, and from the claims.
    • 本发明提供用于缓解或减少与损伤的神经元组织相关的症状和体征的组合物和方法,无论是由组织创伤引起的,还是由慢性或急性退行性变化引起。 特别地,本发明的一些实施方案提供一种或多种药物组合物,其包含作为活性成分的进一步包含药学上可接受的稀释剂或载体的BMP2A抑制剂。 另外的实施方案提供了减轻对中枢神经系统损伤的患者中的中枢神经系统的损伤的方法,包括以足以减少损伤的剂量向患者施用药物组合物。 另一个实施方案提供了BMP2A抑制剂用于制备用于促进或增强患有中枢神经系统损伤的患者的恢复的药物的用途。 根据本发明一些实施方案的优选的抑制剂是siRNA分子和中和抗体。 另外的实施方案提供了鉴定调节凋亡的化合物的方法。 此外,提供了用于诊断受试者中的神经发生性疾病或缺血事件的方法。 现在将要描述的优选方法,材料和实施例仅是说明性的而不是限制性的; 可以在本发明的实践或测试中使用与本文所述类似或等同的材料和方法。 从以下详细描述和权利要求书中,本发明的其它特征和优点将变得显而易见。