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1. 发明申请

WO2012097427A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：化合物和组合物治疗癌症
公开(公告)号：WO2012097427A1
公开(公告)日：2012-07-26
申请号：PCT/CA2011/001179
申请日：2011-10-26
申请人： PROMETIC BIOSCIENCES INC. , GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , LAURIN, Pierre , PENNEY, Christopher , ZACHARIE, Boulos
发明人： GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , LAURIN, Pierre , PENNEY, Christopher , ZACHARIE, Boulos
IPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61P35/00 , C07C217/84 , C07C229/18 , C07C229/42 , C07C229/60 , C07C323/20 , C07C323/52 , C07C323/62 , C07C57/30 , C07C59/52 , C07C59/64 , C07C59/76
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

2. 发明申请

WO2008131547A1 "TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES" 审中-公开
标题翻译： “TRIAZINE衍生物，含有这些衍生物的组合物，以及使用这种衍生物治疗癌症和自身免疫疾病的方法”
公开(公告)号：WO2008131547A1
公开(公告)日：2008-11-06
申请号：PCT/CA2008/000796
申请日：2008-04-25
申请人： PROMETIC BIOSCIENCES INC. , ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , ABBOTT, Shaun, D.
发明人： ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , ABBOTT, Shaun, D.
IPC分类号： C07D251/70 , A61K31/53 , A61P35/00 , A61P37/00 , C07D251/18
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译：我们描述下列通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或甲酰胺基团或其N-甲基或N-二甲基类似物; m为2〜6的整数，n为0〜2的整数。该化合物可用于治疗某些癌症和自身免疫性疾病。

3. 发明申请

WO2012055014A1 PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：苯甲酮羧酸酯化合物及其药物用途
公开(公告)号：WO2012055014A1
公开(公告)日：2012-05-03
申请号：PCT/CA2011/001176
申请日：2011-10-26
申请人： PROMETIC BIOSCIENCES INC. , ZACHARIE, Boulos , PENNEY, Christopher , ABBOTT, Shaun , GAGNON, Lyne , GROUIX, Brigitte , LAURIN, Pierre
发明人： ZACHARIE, Boulos , PENNEY, Christopher , ABBOTT, Shaun , GAGNON, Lyne , GROUIX, Brigitte , LAURIN, Pierre
IPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C217/84 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92
CPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C2602/08
摘要： Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH( OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A snd B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=l-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.
摘要翻译：式I的苯甲酮羧酸酯化合物，其中n = 2-6; R = C（0）; -OC（O） - 或-CH（OH） - ; 当B是Ft B是（CH2）mCOOH，W（CH2）mCOOH或YCH（COOH）（（CH2）pCH3）时，A是（CH2）mCOOH，W（CH2）mCOOH或YCH 当A为Ft或A snd B时，形成被COOFt W = 0，S或NFt Y = 0，S，NH或CH 2取代的5-7元环烷基; M = 0-2; p值= 1-7; 已经准备好了这些化合物及其药学上可接受的盐具有有益的治疗效果，以预防或治疗与（l）血液病症有关的病症，（ii）炎症相关疾病，（iii）肾脏疾病和/或肾脏疾病并发症，或（iv）纤维化 - 相关器官功能障碍。

4. 发明申请

WO2010127440A1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：取代的芳香化合物及其药物用途
公开(公告)号：WO2010127440A1
公开(公告)日：2010-11-11
申请号：PCT/CA2010/000677
申请日：2010-05-03
申请人： PROMETIC BIOSCIENCES INC. , ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , BIENVENU, Jean-François , PERRON, Valérie , GROUIX, Brigitte
发明人： ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , BIENVENU, Jean-François , PERRON, Valérie , GROUIX, Brigitte
IPC分类号： C07C57/30 , A61K31/192 , A61K31/41 , A61K31/44 , A61P13/12 , A61P29/00 , C07C57/58 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula (I) and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译：本发明涉及取代的式（I）芳族化合物及其药物用途。本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。

5. 发明申请

WO2010127448A1 SALTS OF 3-PENTYLPHENYLACETIC ACID AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译： 3-戊基苯甲酸的盐及其药物用途
公开(公告)号：WO2010127448A1
公开(公告)日：2010-11-11
申请号：PCT/CA2010/000691
申请日：2010-05-03
申请人： PROMETIC BIOSCIENCES INC. , ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , BIENVENU, Jean-François , PERRON, Valérie , GROUIX, Brigitte
发明人： ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , BIENVENU, Jean-François , PERRON, Valérie , GROUIX, Brigitte
IPC分类号： C07C57/30 , A61K31/192 , C07C51/353 , C07C51/36 , C07C51/41
CPC分类号： A61K31/192 , C07C51/412 , C07C57/30 , C07C67/303 , C07C67/343 , C07C69/612 , C07C69/618
摘要： The present invention relates to salts of 3-pentylphenylacetic acid and their pharmaceutical uses. Particular aspects of the invention relate to the use of those salts in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention and treatment of (i) blood disorders, (ii) renal disorders and renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译：本发明涉及3-戊基苯乙酸的盐及其药物用途。本发明的特定方面涉及这些盐在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防和治疗（i）血液病症，（ii）肾脏疾病和肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。

6. 发明申请

WO2009055932A1 SUBSTITUTED PHENYLPROPIONIC ACIDS AS STIMULATORS OF HEMATOPOIESIS AND ERYTHROPOIESIS 审中-公开
标题翻译：取代的苯丙酸作为HEMATOPOIESIS和ERYTHROPOIESIS的刺激物
公开(公告)号：WO2009055932A1
公开(公告)日：2009-05-07
申请号：PCT/CA2008/001929
申请日：2008-11-03
申请人： PROMETIC BIOSCIENCES INC. , GAGNON, Lyne , LAGRAOUI, Mouna , GROUIX, Brigitte , CAMERON, Alan, D. , ALLAM, Mustapha , PENNEY, Christopher , ZACHARIE, Boulos
发明人： GAGNON, Lyne , LAGRAOUI, Mouna , GROUIX, Brigitte , CAMERON, Alan, D. , ALLAM, Mustapha , PENNEY, Christopher , ZACHARIE, Boulos
IPC分类号： A61K31/19 , A61K31/192 , A61K31/196 , A61P7/06
CPC分类号： A61K31/192 , A61K31/19 , A61K31/196
摘要： Compounds, or pharmaceutically acceptable derivatives thereof, of the following general formula (I): n = 0-4, X = O, NH, S, Z = H, C 1 -C 4 (alky I, alkenyl, alkynyl), (II), (III), (IV), Y = OH, C 1 -C 4 (alky!, branched or straight chain), (V), Y = CH 3 , (VI), A = Oalkyl (branched or straight chain), OH, Oaryl, halogen (F, Cl, Br), CF 3 , phenyl, B = halogen (F, Cl, Br), CF 3 , phenyl may be used at least to treat anemia or neutropenia. They may be used as stimulators of at least hematopoiesis or erythropoiesis. They may also be used in combination therapy.
摘要翻译：（I）的化合物或其药学上可接受的衍生物：n = 0-4，X = O，NH，S，Z = H，C 1 -C 4（烷基I，链烯基，炔基），（II），（IV），Y = OH，C1-C4（支链或直链），（V），Y = CH3，（VI），A = O烷基（支链或直链）芳基，卤素（F，Cl，Br），CF 3，苯基，B =卤素（F，Cl，Br），CF 3，苯基可至少用于治疗贫血或中性白细胞减少。它们可以用作至少造血或红细胞生成的刺激剂。它们也可以用于联合治疗。

7. 发明申请

WO2006024175A1 2,4,6-TRIAMINO-S-TRIAZINE-BASED COMPOUNDS WHICH BIND TO THE TAIL (Fc) PORTION OF IMMUNOGLOBULINS AND THEIR USE 审中-公开
标题翻译： 2,4,6-TRIAMINO-S-TRIAZINE的化合物，其结合到免疫球蛋白的尾部（Fc）部分及其使用
公开(公告)号：WO2006024175A1
公开(公告)日：2006-03-09
申请号：PCT/CA2005/001344
申请日：2005-09-02
申请人： PROMETIC BIOSCIENCES INC. , PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
发明人： PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
IPC分类号： C07D251/54
CPC分类号： C07D251/70 , A61M1/3679 , C07K16/00 , C07K2317/52
摘要： The present invention comprises new compounds described by the following general formula:(I) NH 2 where R is a straight chain or cyclic alkyl group, X is oxygen or sufur or an imino group or is absent, R' is an amino or metoxy group, or fluorine or chlorine atom and n is 0, 1 or 2. These compounds are useful for binding to tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases.
摘要翻译：本发明包括由以下通式描述的新化合物：（I）NH 2其中R是直链或环状烷基，X是氧或磺酰基或亚氨基或不存在，R “是氨基或甲氧基，或氟或氯原子，n是0,1或2.这些化合物可用于结合免疫球蛋白的尾部或Fc部分，因此在需要非共价结合相互作用的那些应用中有用的具有免疫球蛋白Fc部分的分子。这些应用包括免疫球蛋白的检测和纯化以及某些自身免疫性疾病的治疗。

8. 发明申请

WO2005049607A1 TRIAZINE DIMERS FOR THE TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译：治疗自发性疾病的TRIAZINE DIMERS
公开(公告)号：WO2005049607A1
公开(公告)日：2005-06-02
申请号：PCT/CA2004/002003
申请日：2004-11-22
申请人： PROMETIC BIOSCIENCES INC. , PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
发明人： PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
IPC分类号： C07D403/14
CPC分类号： C07D401/14 , C07D251/70
摘要： Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo .
摘要翻译：含有通过有机接头共价连接但不直接相互连接的两个单取代或二取代的三嗪环的化合物可用于治疗自身免疫性疾病。适合用本发明化合物治疗的自身免疫性疾病包括类风湿性关节炎，系统性红斑狼疮（SLE），特发性（免疫性）血小板减少症（ITP），肾小球性肾炎和血管炎。本发明还涉及通常伴随传统治疗自身免疫性疾病的药物毒性降低。化合物也可用于体外或离体结合抗体。

9. 发明申请

WO2012097428A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USES IN DIABETES 审中-公开
标题翻译：用于糖尿病的化合物和药物组合物
公开(公告)号：WO2012097428A1
公开(公告)日：2012-07-26
申请号：PCT/CA2011/001180
申请日：2011-10-26
申请人： PROMETIC BIOSCIENCES INC. , GAGNON, Lyne , GROUIX, Brigitte , LAURIN, Pierre
发明人： GAGNON, Lyne , GROUIX, Brigitte , LAURIN, Pierre
IPC分类号： A61K31/192 , A61P3/00 , A61P3/10
CPC分类号： A61K31/192 , A61K31/155 , A61K31/20 , A61K31/426
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I, IA, IB and IC, and their pharmaceutical acceptable salts are described for prevention or treatment of diabetes or a diabetes-related disorder in a subject in need thereof. Diabetes and diabetes-related disorder include Type I diabetes, Type II diabetes, maturity-onset diabetes of the young, latent autoimmune diabetes of adults (LADA), gestational diabetes, diabetic nephropathy, proteinuria, ketonuria, obesity, hyperglycemia, glucose intolerance, insulin resistance, hyperinsulinemia, hypercholesterolemia, hypertension, hyperlipoproteinemia, hyperlipidemia, hypertriglyceridemia, dyslipidemia, metabolic syndrome, syndrome X, diabetic neuropathy, diabetic retinopathy, hypoglycemia, cardiovascular disease, atherosclerosis, diabetic kidney disease, ketoacidosis, thrombotic disorders, sexual dysfunction, dermatopathy, edema, metabolic syndrome and renal disorders. The related pharmaceutical compositions and methods are also described. These compounds can be used in combination with comprising a therapeutic agent for lowering or controlling blood glucose level such as metformin or a thiazolidinedione.
摘要翻译：描述了用于预防或治疗有需要的受试者中的糖尿病或糖尿病相关疾病的式I，式I，IA，IB和IC的苯甲酮羧酸酯化合物和取代的芳族化合物及其药学上可接受的盐的新用途。糖尿病和糖尿病相关疾病包括I型糖尿病，II型糖尿病，年龄成熟期糖尿病，成人潜伏性自身免疫性糖尿病（LADA），妊娠糖尿病，糖尿病肾病，蛋白尿，酮尿症，肥胖症，高血糖，葡萄糖不耐受，胰岛素高胰岛素血症，高胆固醇血症，高血压，高脂蛋白血症，高脂血症，高甘油三酯血症，血脂异常，代谢综合征，综合征X，糖尿病性神经病，糖尿病性视网膜病，低血糖，心血管疾病，动脉粥样硬化，糖尿病肾病，酮症酸中毒，血栓性疾病，性功能障碍，皮肤病，水肿，代谢综合征和肾功能障碍。还描述了相关的药物组合物和方法。这些化合物可以与降低或控制血糖水平的治疗剂如二甲双胍或噻唑烷二酮组合使用。

10. 发明申请

WO2016054726A1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DIABETES 审中-公开
标题翻译：用于预防和治疗糖尿病的替代芳香化合物和药物组合物
公开(公告)号：WO2016054726A1
公开(公告)日：2016-04-14
申请号：PCT/CA2015/000531
申请日：2015-10-08
申请人： PROMETIC BIOSCIENCES INC.
发明人： GAGNON, Lyne , GROUIX, Brigitte
IPC分类号： A61K31/192 , A61K31/155 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/50 , C07C59/84 , C07C59/88 , C07C59/90
CPC分类号： A61K31/192 , A61K9/0053 , A61K31/155 , A61K45/06 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/50 , A61K2300/00
摘要： The present invention concerns the use of compounds for preventing and/or treating diabetes, for modulating glucose, insulin, and/or triglyceride levels; for reducing blood glucose level; for maintaining or increasing insulin level; for increasing insulin secretion; increasing insulin sensitivity; or decreasing insulin resistance in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts. wherein A is C 5 alkyl, C 6 alkyl, C 5 alkenyl, C 6 alkenyl, C(0)-(CH 2 ) n -CH 3 or CH(OH)-(CH 2 ) n -CH 3 wherein n is 3 or 4; R 1 is H, F or OH; R 2 is C 5 alkyl, C 6 alkyl, C 5 alkenyl, C 6 alkenyl, C(0)-(CH 2 ) n -CH 3 or CH(OH)-(CH 2 ) n -CH 3 wherein n is 3 or 4; R 3 is H, F, OH or CH 2 Ph; R 4 is H, F or OH; Q is 1) (CH 2 ) m C(O)OH wherein m is 1 or 2, 2) CH(CH 3 )C(O)OH, 3) C(CH 3 ) 2 C(O)OH, 4) CH(F)- C(O)OH, 5) CF 2 - C(O)OH, or 6) C(O)- C(O)OH.
摘要翻译：本发明涉及化合物用于预防和/或治疗糖尿病，调节葡萄糖，胰岛素和/或甘油三酯水平的用途; 用于降低血糖水平; 用于维持或增加胰岛素水平; 用于增加胰岛素分泌; 增加胰岛素敏感性; 或降低受试者的胰岛素抵抗。已经发现了由式I表示的化合物和其药学上可接受的盐的这些新用途。其中A为C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（OH） - （CH 2）n -CH 3，其中n为3或4; R1是H，F或OH; R 2是C 5烷基，C 6烷基，C 5烯基，C 6烯基，C（O） - （CH 2）n -CH 3或CH（OH） - （CH 2）n -CH 3，其中n是3或4; R3是H，F，OH或CH2Ph; R4是H，F或OH; Q是1）（CH 2）m C（O）OH，其中m是1或2，2）CH（CH 3）C（O）OH，3）C（CH 3）2 C（O）OH，4）CH（F） -C（O）OH，5）CF 2 -C（O）OH或6）C（O）-C（O）OH。

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