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1. 发明申请

WO2007109571A2 METHODS OF PREDICTING AND MONITORING TYROSINE KINASE INHIBITOR THERAPY 审中-公开
标题翻译：预测和监测酪氨酸激酶抑制剂治疗的方法
公开(公告)号：WO2007109571A2
公开(公告)日：2007-09-27
申请号：PCT/US2007064217
申请日：2007-03-16
申请人： PROMETHEUS LAB INC , HARVEY JEANNE , NERI BRUCE , SINGH SHARAT
发明人： HARVEY JEANNE , NERI BRUCE , SINGH SHARAT
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/24
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57484 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G06F19/24
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析生物标志物组合以在诊断患有癌症的患者中个体化酪氨酸激酶抑制剂治疗的方法。具体而言，本发明的测定方法可用于预测，鉴定或监测肿瘤，肿瘤细胞或患者对酪氨酸激酶抑制剂治疗的应答，其使用基于生物标志物分析的算法。本发明的测定方法也可用于预测患者是否具有发生毒性或对酪氨酸激酶抑制剂治疗抗性的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会对药物产生耐药性。此外，本发明的测定方法可用于优化接受药物的患者中酪氨酸激酶抑制剂的剂量以实现治疗功效和/或减少毒副作用。

2. 发明申请

WO2009012140A3 DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS 审中-公开
标题翻译：使用基于抗体的阵列进行肺癌治疗的药物选择
公开(公告)号：WO2009012140A3
公开(公告)日：2009-03-05
申请号：PCT/US2008069764
申请日：2008-07-11
申请人： PROMETHEUS LAB INC , SINGH SHARAT , HARVEY JEANNE
发明人： SINGH SHARAT , HARVEY JEANNE
IPC分类号： G01N33/574 , C12N5/08 , C12Q1/00
CPC分类号： G01N33/57423 , G01N33/5041 , G01N33/5044 , G01N33/5082 , G01N2500/10 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供了用于检测肿瘤细胞中信号转导途径组分的活化状态的组合物和方法。关于源自使用本发明的信号转导途径组分的活化状态的信息可用于癌症诊断，预后和癌症治疗的设计。

3. 发明申请

WO2008036802A3 ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS 审中-公开
标题翻译：用于检测罕见循环细胞中多个信号转导体的基于抗体的阵列
公开(公告)号：WO2008036802A3
公开(公告)日：2008-05-08
申请号：PCT/US2007079002
申请日：2007-09-20
申请人： PROMETHEUS LAB INC , HARVEY JEANNE , SINGH SHARAT , KIM PHILLIP , LIU XINJUN , BARHAM ROBERT , LIU LIMIN
发明人： HARVEY JEANNE , SINGH SHARAT , KIM PHILLIP , LIU XINJUN , BARHAM ROBERT , LIU LIMIN
IPC分类号： G01N33/543
CPC分类号： G01N33/57484 , G01N33/54306
摘要： The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.
摘要翻译：本发明提供用于检测稀有循环细胞中多个信号转导分子的活化状态和/或总量的基于抗体的阵列及其用于促进癌症预后和诊断以及个性化靶向治疗的设计的方法。

4. 发明申请

WO2011088149A3 METHODS FOR PREDICTING RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER TO THERAPY 审中-公开
标题翻译：预防三阴性乳腺癌治疗反应的方法
公开(公告)号：WO2011088149A3
公开(公告)日：2011-10-27
申请号：PCT/US2011021026
申请日：2011-01-12
申请人： PROMETHEUS LAB INC , LIU XINJUN , KIM PHILLIP , KIRKLAND RICHARD , LEE TANI , YBARRONDO BELEN , SINGH SHARAT
发明人： LIU XINJUN , KIM PHILLIP , KIRKLAND RICHARD , LEE TANI , YBARRONDO BELEN , SINGH SHARAT
IPC分类号： G01N33/574 , A61P35/00 , C12Q1/68 , G01N33/15
CPC分类号： G01N33/57415 , G01N2333/71 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。

5. 发明申请

WO2011066458A3 NOVEL GENOMIC BIOMARKERS FOR IRRITABLE BOWEL SYNDROME DIAGNOSIS 审中-公开
标题翻译：新型基因组生物标志物用于肠易激综合征的诊断
公开(公告)号：WO2011066458A3
公开(公告)日：2011-12-22
申请号：PCT/US2010058099
申请日：2010-11-24
申请人： PROMETHEUS LAB INC , GONG HUA , SINGH SHARAT , HOE NICHOLAS
发明人： GONG HUA , SINGH SHARAT , HOE NICHOLAS
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/6893 , G01N2800/065
摘要： The invention provides novel biomarkers, kits, and methods of diagnosing, prognosing, and subtyping IBS. In one aspect, the invention provides novel genomic biomarkers for diagnosing, classifying, providing a prognosis for, and assigning therapy for IBS in a subject in need thereof. In another aspect, the present invention provides novel algorithms for the diagnosis and prognosis of IBS.
摘要翻译：本发明提供了诊断，预后和亚型IBS的新型生物标志物，试剂盒和方法。一方面，本发明提供了新的基因组生物标志物，用于诊断，分类，提供预后和指定对有此需要的受试者的IBS的治疗。另一方面，本发明提供了用于IBS的诊断和预后的新算法。

6. 发明申请

WO2010117694A2 CITRULLINATED PEPTIDES FOR DIAGNOSING AND PROGNOSING RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于诊断和预防流感嗜血杆菌的化学物质
公开(公告)号：WO2010117694A2
公开(公告)日：2010-10-14
申请号：PCT/US2010028946
申请日：2010-03-26
申请人： PROMETHEUS LAB INC , LING NICHOLAS CHI-KWAN , WANG SHUI LONG , WANG DUNRUI , SINGH SHARAT
发明人： LING NICHOLAS CHI-KWAN , WANG SHUI LONG , WANG DUNRUI , SINGH SHARAT
IPC分类号： C07K14/47
CPC分类号： G01N33/564 , C07K14/4713
摘要： TThe present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods for detecting rheumatoid factor (RF) using novel RF detection reagents as a means to aid, assist, improve, or facilitate the diagnosis or prognosis of rheumatic diseases such as RA. Kits comprising at least one of the novel citrullinated peptides and/or RF detection reagents of the present invention are also provided.
摘要翻译：本发明提供新颖的瓜氨酸肽，其用于帮助，协助，改善或促进风湿性疾病如类风湿性关节炎（RA）的诊断或预后的方法，以及用于鉴定与抗瓜氨酸化免疫反应的新型瓜氨酸肽蛋白质抗体（ACPA）。本发明还提供使用新的RF检测试剂检测类风湿因子（RF）的方法，以帮助，协助，改善或促进风湿性疾病如RA的诊断或预后。还提供了包含本发明的新颖瓜氨酸肽和/或RF检测试剂中的至少一种的试剂盒。

7. 发明申请

WO2011153501A9 METHODS FOR IMPROVING INFLAMMATORY BOWEL DISEASE DIAGNOSIS 审中-公开
标题翻译：用于改善炎症性腹膜疾病诊断的方法
公开(公告)号：WO2011153501A9
公开(公告)日：2012-04-05
申请号：PCT/US2011039174
申请日：2011-06-03
申请人： PROMETHEUS LAB INC , PRINCEN FRED , SINGH SHARAT
发明人： PRINCEN FRED , SINGH SHARAT
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156

8. 发明申请

WO2005019470A2 DETECTING AND PROFILING MOLECULAR COMPLEXES 审中-公开
标题翻译：检测和分析分子配合物
公开(公告)号：WO2005019470A2
公开(公告)日：2005-03-03
申请号：PCT/US2004025945
申请日：2004-08-10
申请人： ACLARA BIOSCIENCES INC , CHAN-HUI PO-YING , SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN
发明人： CHAN-HUI PO-YING , SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN
IPC分类号： C07K16/46 , C12N7/02 , C12Q20060101 , G01N33/53 , G01N33/542 , G01N33/566 , C12Q
CPC分类号： G01N33/566 , G01N33/542 , Y10S436/824
摘要： Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.
摘要翻译：提供了用于检测样品（例如细胞或组织裂解物）中分子（特别是蛋白质）复合物形成的方法。在一个方面，提供了对复合物中的第一种蛋白质特异的切割探针和对复合物中的一种或多种第二蛋白质特异的一种或多种结合化合物。在结合后，诱导裂解探针产生活性物质，例如单线态氧，其仅在裂解探针的局部区域中裂解连接至结合化合物的分子标签。释放的分子标签与测定混合物分离并彼此分离以提供与复合物中存在的蛋白质的数量和类型相关的读数。

9. 发明申请

WO03018753A3 MULTIPLE-SITE SAMPLE-HANDLING APPARATUS AND METHOD 审中-公开
标题翻译：多站点样品处理设备和方法
公开(公告)号：WO03018753A3
公开(公告)日：2003-10-09
申请号：PCT/US0226767
申请日：2002-08-23
申请人： ACLARA BIOSCIENCES INC , HOOPER HERBERT H , SINGH SHARAT , BOONE TRAVIS D , ANDERSON ROLFE , ALBAGLI DAVID , RICCO ANTONIO J
发明人： HOOPER HERBERT H , SINGH SHARAT , BOONE TRAVIS D , ANDERSON ROLFE , ALBAGLI DAVID , RICCO ANTONIO J
IPC分类号： B01J19/00 , B01L3/00 , G01N1/40 , G01N33/543 , C12Q1/00 , C12M1/34
CPC分类号： G01N33/54366 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00891 , B01J2219/00936 , B01J2219/00945 , B01J2219/0095 , B01L3/5027 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2200/16 , B01L2400/0415 , B01L2400/0487 , G01N1/40
摘要： A microchannel apparatus (322) and method for processing a sample or performing a plurality of small-volume reactions simultaneously with components in a bulk phase medium are disclosed. The apparatus includes a device (320) having an elongate or planar channel (324) providing a plurality of discrete small-volume reaction regions within the channel, each communicating with supply and hold reservoirs (326, 328) from which material can be introduced into the regions, and to which material can be transferred from the reaction regions. The channel or the fluid communication between a reaction region and an associated region-specific region is dimensioned to substantially prevent convective fluid flow among the reaction regions during such reactions, thus confining the reaction in each region. The apparatus also includes structure for moving solvent or solvent components from or to a selected region-specific reservoir, to or from the associated reaction region, and a control unit (334) for controlling such reservoir-to channel and channel-to-reservoir movement.
摘要翻译：公开了一种微通道设备（322）以及用于处理样品或与体相介质中的组分同时进行多个小体积反应的方法。该设备包括具有细长或平面通道（324）的装置（320），其在通道内提供多个分立的小体积反应区域，每个通道与供应和保持储存器（326,328）连通，材料可从该储存器引入区域，并且可以从反应区域转移到哪些材料。反应区域和相关区域特定区域之间的通道或流体连通的尺寸被设计成基本上防止在这种反应期间反应区域之间的对流流体流动，从而将反应限制在每个区域中。该设备还包括用于将溶剂或溶剂组分从选定的区域特定的储存器移动到相关联的反应区域或从相关联的反应区域移动的结构，以及用于控制这种储存器到通道和通道至储存器运动的控制单元（334）。

10. 发明申请

WO2006052788A3 DETECTION OF ACTIVATION OF ENDOTHELIAL CELLS AS SURROGATE MARKER FOR ANGIOGENESIS 审中-公开
标题翻译：检测内源性细胞作为血管生成的标志物的活化
公开(公告)号：WO2006052788A3
公开(公告)日：2007-10-04
申请号：PCT/US2005040099
申请日：2005-11-04
申请人： MONOGRAM BIOSCIENCES INC , MOORE SEAN C , SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN , CAO LICHING , SPERINDE JEFF
发明人： MOORE SEAN C , SINGH SHARAT , SALIMI-MOOSAVI HOSSEIN , CAO LICHING , SPERINDE JEFF
IPC分类号： G01N33/53 , C12Q1/24 , G01N33/541 , G01N33/557 , G01N33/58 , G01N33/96
CPC分类号： G01N33/5041 , G01N33/5064 , G01N33/5091 , G01N33/574 , G01N2333/515 , G01N2333/71 , G01N2800/52 , Y10S436/824
摘要： Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells. The methods can be used for assessing status of diseases associated with undesirable angiogenesis, such as the likelihood of developing the disease, presence or absence of the disease, prognosis of the disease and the likelihood of response or resistance to a particular anti-angiogenic therapy. The methods can also be used to guide the design of effective therapeutic regimens targeting a specific angiogenic signaling pathway, as well as in conjunction with therapeutic intervention of diseases or conditions associated with undesirable angiogenesis.
摘要翻译：提供了方法，组合物和试剂盒，用于通过敏感，直接检测分子水平的内皮细胞活化来评估血管发生。通常，通过测量参与内皮细胞中特异性血管生成信号传导途径的细胞成分及其蛋白质复合物的水平来检测内皮细胞的活化。该方法可用于评估与不期望的血管生成相关的疾病的状态，例如发展疾病的可能性，疾病的存在或不存在，疾病的预后以及对特定抗血管生成疗法的反应或抗性的可能性。该方法还可用于指导针对特定血管生成信号通路的有效治疗方案的设计，以及与不期望的血管发生相关的疾病或病症的治疗干预。

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