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    • 8. 发明申请
    • MICRONEEDLE APPARATUS USED FOR MARKING SKIN AND FOR DISPENSING SEMI-PERMANENT SUBCUTANEOUS MAKEUP
    • 用于标记皮肤的MICRONEEDLE设备和用于分配半永久性半成品
    • WO0191846A3
    • 2002-03-28
    • PCT/US0117188
    • 2001-05-24
    • PROCTER & GAMBLE
    • YUZHAKOV VADIM VLADIMIROVICHGARTSTEIN VLADIMIROWENS GROVER DAVID
    • A45D34/04A61M37/00A61N1/30B29C51/00B81C1/00
    • B29C51/00A45D34/04A45D2200/1018A61M37/0015A61M37/0076A61M2037/003A61M2037/0053A61N1/30B81B2201/055B81C1/00111B81C2201/036
    • An array of microneedles is provided to apply semi-permanent or permanent markings to skin, or to apply semi-permanent subcutaneous makeup or other cosmetic compounds to skin. The microneedles can apply identifications or other tattoo-like graphics, and will not enter into the dermal layer of the skin so that the application procedure is painless. The markings can be made permanent or semi-permanent, and can be applied with monochrome or multi-color inks, or even inks that are not visible at human eye wavelengths. The preferred inks contain particles of a certain minimum size that will not diffuse too far through the skin, thereby maintaining a high resolution, and if placed into the epidermis, the marking will disappear from the skin after a time period. The microneedle array is also useful for delivering specific compounds or actives into the skin, such as cosmetic compounds or nutrients, or various skin structure modifiers that can be delivered subcutaneously without having to visit a cosmetic surgery clinic. In addition, color cosmetics could also be delivered subcutaneously to provide long-term benefits for the skin, and even makeup or lipstick-type coloring compounds can be delivered by use of the microneedle patches described hereinabove. The color cosmetics are delivered into the epidermis, where they remain in place for at least one or two months. Since the epidermis is renewable, the color makeup or color cosmetics that are delivered would eventually wear out, since the epidermis is renewable; the delivered color pigment or dye, or skin structure support actives (such as polymers) will remain in the epidermis for only a finite time (e.g., 1-3 months), and then will be expunged from the body. This allows a person to change their "look" according to changes in fashion and style, which typically change every season.
    • 提供一系列微针,以将半永久性或永久性标记施用于皮肤,或将半永久性皮下化妆或其他化妆品化合物施用于皮肤。 微针可以应用标识或其他纹身图形,并且不会进入皮肤的真皮层,使得应用程序是无痛的。 标记可以制成永久性或半永久性,并且可以应用于单色或多色油墨,或甚至在人眼波长处不可见的油墨。 优选的油墨含有一定的最小尺寸的颗粒,其不会通过皮肤扩散太远,从而保持高分辨率,并且如果放置在表皮中,则标记将在一段时间后从皮肤消失。 微针阵列还可用于将特定的化合物或活性物质递送到皮肤中,例如化妆品化合物或营养物,或可以皮下递送而不必访问整容手术诊所的各种皮肤结构修饰剂。 此外,彩色化妆品也可以皮下递送以为​​皮肤提供长期的益处,甚至可以通过使用上述微针补片递送化妆或口红型着色化合物。 彩色化妆品被运送到表皮中,在那里保持至少一到两个月。 由于表皮是可再生的,由于表皮是可再生的,所以交付的颜色化妆品或彩色化妆品最终会磨损, 递送的彩色颜料或染料或皮肤结构支持活性物质(例如聚合物)将仅在有限时间(例如1-3个月)内保留在表皮中,然后将从身体中清除。 这允许一个人根据时尚和风格的变化来改变他们的“外观”,这通常每个季节都会改变。