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1. 发明申请

WO2007019462A2 SYSTEM AND METHOD FOR THE IDENTIFICATION AND QUANTIFICATION OF A BIOLOGICAL SAMPLE SUSPENDED IN A LIQUID 审中-公开
标题翻译：用于鉴定和定量悬浮在液体中的生物样品的系统和方法
公开(公告)号：WO2007019462A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030765
申请日：2006-08-08
申请人： POCARED DIAGNOSIS, LTD. , BARNES, Russell, H. , INGBER, Gal , GURFINKEL, Jonathan
发明人： BARNES, Russell, H. , INGBER, Gal , GURFINKEL, Jonathan
IPC分类号： C12Q1/00 , G06F19/00 , C12M1/34 , G01J3/42
CPC分类号： G01N21/6486 , G01N21/21 , G01N21/31 , G01N21/51 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6482 , G01N2021/6491 , G01N2201/0612 , G01N2201/129 , G01N2201/1293
摘要： A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at least one excitation light source; a fluorescence emission module optically coupled to the sample interface module and comprising at least one detection device for detecting fluorescence excitation-emission matrices of the biological sample; and a computer module operatively coupled to the fluorescence emission module. The computer module performs multivariate analysis on the fluorescence excitation-emission matrices of the biological sample to identify and quantify the biological sample. The multivariate analysis may comprise extended partial least squared analysis for identification and quantification of the biological sample. A method for the identification and quantification of a biological sample suspended in a liquid is also provided.
摘要翻译：用于鉴定和量化悬浮在液体中的生物样品的系统包括具有至少一个激发光源的荧光激发模块; 样品接口模块，其光学耦合到所述荧光激发模块，用于定位生物样品以接收来自所述至少一个激发光源的激发光; 荧光发射模块，其光学耦合到所述样本界面模块并且包括用于检测所述生物样本的荧光激发发射矩阵的至少一个检测装置; 以及可操作地耦合到荧光发射模块的计算机模块。计算机模块对生物样品的荧光激发发射矩阵进行多变量分析以识别和量化生物样品。多变量分析可以包括用于生物样品的鉴定和定量的扩展偏最小二乘分析。还提供了一种识别和量化悬浮在液体中的生物样品的方法。

2. 发明申请

WO2009049171A3 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN URINE 审中-公开
公开(公告)号：WO2009049171A3
公开(公告)日：2009-04-16
申请号：PCT/US2008/079533
申请日：2008-10-10
申请人： POCARED DIAGNOSTICS LTD. , INGBER, Gal , ATTERBURY, William, G. , BARNES, Russell, H. , BOYD, Douglas, E. , DENNIS, Joseph, D. , GURFINKEL, Jonathan , HOLLEY, Dave , HUCKABY, Steven, E. , KLAUSING, Thomas, A. , LAUDO, John, S. , SADESKI, Kevin , SCHAEFER, Jason, A. , SCOTT, K., Bryan , STILLMAN, Carol , TALBERT, Sherwood , TALLARICO, John
发明人： INGBER, Gal , ATTERBURY, William, G. , BARNES, Russell, H. , BOYD, Douglas, E. , DENNIS, Joseph, D. , GURFINKEL, Jonathan , HOLLEY, Dave , HUCKABY, Steven, E. , KLAUSING, Thomas, A. , LAUDO, John, S. , SADESKI, Kevin , SCHAEFER, Jason, A. , SCOTT, K., Bryan , STILLMAN, Carol , TALBERT, Sherwood , TALLARICO, John
IPC分类号： C12Q1/04 , G01N33/493
摘要： A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

3. 发明申请

WO2008107881A2 ANTIBIOTIC SENSITIVITY TESTING METHOD 审中-公开
标题翻译：抗生素敏感性测试方法
公开(公告)号：WO2008107881A2
公开(公告)日：2008-09-12
申请号：PCT/IL2008/000283
申请日：2008-03-05
申请人： POCARED DIAGNOSTICS LTD. , INGBER, Gal , GURFINKEL, Jonathan
发明人： INGBER, Gal , GURFINKEL, Jonathan
IPC分类号： C12Q1/18
CPC分类号： G01N33/9446
摘要： The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing the set of antibiotics; determining concentration of bacteria in the respective antibiotic solutions; determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration; and comparing the growth curves for the respective antibiotic solutions with a growth curve determined from the control sample. An identification and quantification system may be used to select the set of antibiotics, and further may be used in the steps of determining concentration of bacteria in the respective antibiotic solutions and determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration.
摘要翻译：该方法包括获得细菌样品的几个步骤; 鉴定细菌样品中细菌的类型; 根据细菌样本中细菌的特征选择一组抗生素; 从细菌样品获得对照样品; 将细菌样品置于含有该组抗生素的溶液中; 确定各抗生素溶液中细菌的浓度; 基于确定的细菌浓度确定各抗生素溶液的生长曲线; 并将各抗生素溶液的生长曲线与从对照样品测定的生长曲线进行比较。可以使用鉴定和定量系统来选择该组抗生素，并且还可以用于确定各抗生素溶液中的细菌浓度并基于确定的细菌浓度确定各抗生素溶液的生长曲线的步骤。

4. 发明申请

WO2012061451A2 OPTICAL CUP 审中-公开
标题翻译：光学杯
公开(公告)号：WO2012061451A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/058881
申请日：2011-11-02
申请人： POCARED DIAGNOSTICS INC. , INGBER, Gal
发明人： INGBER, Gal
IPC分类号： C12M1/34 , C12M1/24 , C12M1/18 , C12Q1/04
CPC分类号： G01N21/0303 , B01L3/508 , B01L3/5085 , B01L2200/025 , B01L2200/028 , B01L2200/12 , B01L2300/0809 , B01L2300/0851 , B01L2300/0858 , B01L2300/168 , C12M41/36 , G01N21/6452 , G01N35/025 , G01N2021/0321 , G01N2021/0382 , G01N2021/6469 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译：本发明涉及一种用于对微生物（例如生物样品中的细菌）进行鉴定和定量的系统。更具体地说，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色皿的系统; 其中所述壁成角度以允许更好的涂层和更好的光线条纹，光学系统包括光学读取器和热控制器; 光学分析仪; 一个冷却系统; 和一个改进的光谱仪。该系统可以使用样品处理器中的一次性盒和光学分析仪中的光学杯或比色皿。

5. 发明申请

WO2010089749A1 OPTICAL MEASUREMENT ARRANGEMENT 审中-公开
标题翻译：光学测量装置
公开(公告)号：WO2010089749A1
公开(公告)日：2010-08-12
申请号：PCT/IL2010/000108
申请日：2010-02-07
申请人： Pocared Diagnostics Ltd. , INGBER, Gal
发明人： INGBER, Gal
IPC分类号： G01J3/42
CPC分类号： G01J1/32 , G01J3/42 , G01J2003/2866 , G01N21/031 , G01N21/253 , G01N2201/0415 , G01N2201/0469 , G01N2201/0692
摘要： A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.
摘要翻译：一种用于增强光学测量装置中的光学测量的功率校正的方法和装置，所述步骤包括：提供用于产生光束的光源; 将光束分成两束; 将第一分裂光束引导通过询问区并进入光学分离装置; 引导来自光学分离装置的光束和将光源的主光束的照明强度表示为检测器阵列的单元的第二分裂光束; 测量和评估细胞中获得的信息; 并且使用该信息来计算接收来自光学分离装置的光束的单元的校正值，以便调整光源的光束强度的功率和/或校正来自光源的光束的强度询问区。

6. 发明申请

WO2012103174A3 IRIS CONTROL SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2012103174A3
公开(公告)日：2012-08-02
申请号：PCT/US2012/022488
申请日：2012-01-25
申请人： POCARED DIAGNOSTICS INC. , INGBER, Gal
发明人： INGBER, Gal
IPC分类号： C12M1/34 , C12M1/42 , C12M1/12 , C12Q1/04
摘要： A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical cup for measuring the intensity level of the excitation wavelength, and feeding this information to an iris having an iris setting control device such that the iris setting may be adjusted based upon the measured intensity level to control and optimize the level of light fed to the filter wheel from the lamp. The iris setting can be adjusted so that the level of light fed to the filter wheel remains constant during the lifetime of the lamp and to ensure that the level of light fed to the sample remains below the level at which photo-bleaching occurs.

7. 发明申请

WO2011035304A2 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：在生物样品中鉴定细菌的系统
公开(公告)号：WO2011035304A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049658
申请日：2010-09-21
申请人： POCARED DIAGNOSTICS LTD. , INGBER, Gal , ATTERBURY, William, G. , HOLLEY, Dave , KLAUSING, Thomas, A. , LAUDO, John, S. , SCHAEFER, Jason, A. , TALBERT, Sherwood , TALLARICO, John
发明人： INGBER, Gal , ATTERBURY, William, G. , HOLLEY, Dave , KLAUSING, Thomas, A. , LAUDO, John, S. , SCHAEFER, Jason, A. , TALBERT, Sherwood , TALLARICO, John
IPC分类号： G01N35/02 , C12M1/38 , C12Q1/04 , C12Q1/06
CPC分类号： G01N35/025 , B04B9/14 , G01N2035/00504 , G01N2035/0434 , G01N2035/0458
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
摘要翻译：本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。更具体地，本发明涉及一种包括用于在测试期间保持样品的预定最适温度的冷却，加热和风扇装置的系统; 用于使转盘内的样品对准的视觉，圆周和轴向对准系统; 用于将样品从转盘转移到离心机的转移系统; 使离心机的旋转振动最小化的平衡系统; 采样系统的安全系统和防倾翻设计; 用于分配缓冲盐溶液的液体分配臂; 以及用于将从样品去除的液体排放和处置到系统外部的位置的排出口。

8. 发明申请

WO2009100197A2 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：在生物样品中鉴定细菌的系统
公开(公告)号：WO2009100197A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/033186
申请日：2009-02-05
申请人： POCARED DIAGNOSTICS LTD. , INGBER, Gal , ATTERBURY, William, G. , HOLLEY, Dave , LAUDO, John, S. , SCHAEFER, Jason, A. , TALBERT, Sherwood , TALLARICO, John , KLAUSING, Thomas, A.
发明人： INGBER, Gal , ATTERBURY, William, G. , HOLLEY, Dave , LAUDO, John, S. , SCHAEFER, Jason, A. , TALBERT, Sherwood , TALLARICO, John , KLAUSING, Thomas, A.
IPC分类号： G01N35/02 , G01N21/03
CPC分类号： G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译：本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。

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