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1. 发明申请

WO2006060456A3 INDOLE DERIVATIVES FOR USE AS PPAR PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译：用作PPAR PPAR活性化合物的吲哚衍生物
公开(公告)号：WO2006060456A3
公开(公告)日：2006-09-21
申请号：PCT/US2005043271
申请日：2005-11-29
申请人： PLEXXIKON INC , LIN JACK , ARTIS DEAN R , IBRAHIM PRABHA N , ZHANG CHAO , ZUCKERMAN REBECCA , BREMER RYAN , SHI SHENGHUA , LEE BYUNGHUN
发明人： LIN JACK , ARTIS DEAN R , IBRAHIM PRABHA N , ZHANG CHAO , ZUCKERMAN REBECCA , BREMER RYAN , SHI SHENGHUA , LEE BYUNGHUN
IPC分类号： C07D209/36 , A61K31/404 , A61P3/04 , C07D209/30 , C07D209/40
CPC分类号： C07D209/36 , C07D209/30 , C07D209/40
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and /or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR?.
摘要翻译：描述了在PPARa，PPARd和PPARγ中的至少一种上具有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARγ中的至少一种的治疗和/或预防方法。

2. 发明申请

WO2007030567A3 PPARACTIVE COMPOUNDS 审中-公开
标题翻译： PPARACTIVE化合物
公开(公告)号：WO2007030567A3
公开(公告)日：2007-06-21
申请号：PCT/US2006034764
申请日：2006-09-06
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU , ZUCKERMAN REBECCA
发明人： LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU , ZUCKERMAN REBECCA
IPC分类号： C07C59/68 , A61K31/10 , A61K31/192 , A61K31/381 , A61K31/4155 , A61K31/427 , A61K31/4418 , A61P3/04 , A61P3/06 , C07C317/04 , C07D213/64 , C07D237/04 , C07D277/24 , C07D333/34 , C07D417/04
CPC分类号： C07C317/46 , B82Y15/00 , C07C51/08 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C61/39 , C07C69/734 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D213/64 , C07D231/12 , C07D231/24 , C07D239/54 , C07D261/08 , C07D263/32 , C07D263/46 , C07D277/24 , C07D277/36 , C07D333/32 , C07D333/34 , G01N33/588 , G01N33/6872 , C07C59/52
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR?.
摘要翻译：描述了对PPARα，PPARd和PPARα中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARα中的至少一种的治疗和/或预防方法。

3. 发明申请

WO2007030574A3 1 , 4 AND 1 , 5-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： 1,4,4和1,5-异构体吲哚衍生物用作PPAR活性化合物
公开(公告)号：WO2007030574A3
公开(公告)日：2007-05-10
申请号：PCT/US2006034780
申请日：2006-09-06
申请人： PLEXXIKON INC , LIN JACK , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , LEE BYUNGHUN
发明人： LIN JACK , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , LEE BYUNGHUN
IPC分类号： C07D409/12 , A61K31/405 , A61P3/10 , C07D209/08 , C07D409/14
CPC分类号： C07D409/12 , C07D209/08 , C07D409/14
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR? . wherein R 1 is selected from the group consisting of -C(O)OR 18 R 19 , and a carboxylic acid isostere.
摘要翻译：描述了对PPARα，PPARd和PPARγ中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARβ中的至少一种的治疗和/或预防方法。。其中R 1选自-C（O）OR 18 R 19和羧酸等价异构体。

4. 发明申请

WO2007030559A3 1, 3-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR MODULATORS 审中-公开
标题翻译：用作PPAR调节剂的1,3取代的吲哚衍生物
公开(公告)号：WO2007030559A3
公开(公告)日：2007-09-13
申请号：PCT/US2006034747
申请日：2006-09-06
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU
发明人： LIN JACK , WOMACK PATRICK , LEE BYUNGHUN , SHI SHENGHUA , ZHANG CHAO , ZUCKERMAN REBECCA , ARTIS DEAN R , IBRAHIM PRABHA N , WANG WEIRU
IPC分类号： C07D409/14 , A61K31/405 , A61P3/10 , C07D413/14
CPC分类号： C07D409/14 , C07D209/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPARa, PPAR? and PPARd. Also describe are methods of use of the compounds in treating various diseases.
摘要翻译：描述了对PPARs有活性的化合物，包括泛酸化合物和对PPARα，PPARα，和PPARd。还描述了化合物在治疗各种疾病中的使用方法。

5. 发明申请

WO2006060535A2 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：WO2006060535A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043412
申请日：2005-11-29
申请人： PLEXXIKON INC , LIN JACK , IBRAHIM PRABHA N , ARTIS DEAN R , ZHANG CHAO , WANG WEIRU , SHI SHENGHUA
发明人： LIN JACK , IBRAHIM PRABHA N , ARTIS DEAN R , ZHANG CHAO , WANG WEIRU , SHI SHENGHUA
IPC分类号： C07D209/30 , A61K31/405 , A61P3/04
CPC分类号： C07D209/30
摘要： Compounds are described that are active on at least one of PPARa, PPARd, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd, and PPAR?.
摘要翻译：描述了在PPARa，PPARd和PPARγ中的至少一种上具有活性的化合物，其可用于涉及调节PPARα，PPARd和PPARγ中的至少一种的治疗和/或预防方法。

6. 发明申请

WO2011079133A3 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2011079133A3
公开(公告)日：2011-11-17
申请号：PCT/US2010061601
申请日：2010-12-21
申请人： PLEXXIKON INC , IBRAHIM PRABHA N , WU GUOXIAN , LIN JACK , SPEVAK WAYNE , CHO HANNA , EWING TODD , ZHANG CHAO
发明人： IBRAHIM PRABHA N , WU GUOXIAN , LIN JACK , SPEVAK WAYNE , CHO HANNA , EWING TODD , ZHANG CHAO
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/519 , C07D519/00
摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.
摘要翻译：其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物，其形式在B-Raf，B-Raf V600E和c-Raf-1蛋白激酶中的每一个上都是活性的。在某些方面和实施方案中，所述化合物在抑制Ras突变细胞系的增殖中是有活性的。还描述了其用于治疗疾病和病症的方法，包括黑素瘤，神经胶质瘤，成胶质细胞瘤，纤维细胞性星形细胞瘤，肝癌，胆道癌，胆管癌，结肠直肠癌，肺癌，膀胱癌，胆囊癌，乳腺癌，胰腺癌，甲状腺癌，肾癌，卵巢癌，肾上腺皮质癌，前列腺癌，胃肠道间质瘤，甲状腺髓样癌，肿瘤血管生成，急性骨髓性白血病，慢性骨髓单核细胞白血病，儿童急性淋巴细胞性白血病，浆细胞白血病和多发性骨髓瘤。

7. 发明申请

WO2008109697A3 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：WO2008109697A3
公开(公告)日：2008-11-20
申请号：PCT/US2008055952
申请日：2008-03-05
申请人： PLEXXIKON INC , LIN JACK , WOMACK PATRICK , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN , IBRAHIM PRABHA , WANG WEIRU
发明人： LIN JACK , WOMACK PATRICK , SHI SHENGHUA , ZHANG CHAO , ARTIS DEAN , IBRAHIM PRABHA , WANG WEIRU
IPC分类号： C07C317/44 , A61K31/192 , A61P3/04 , C07C65/24 , C07C317/46 , C07D213/30 , C07D231/54 , C07D239/34
CPC分类号： C07C317/46 , C07C59/68 , C07C317/44 , C07D213/64 , C07D231/12 , C07D239/34
摘要： Compounds of Formula I, wherein Ar, L, m, R 1 , R 2 , R 3 , W, X, Y, Z are as defined in the claims, are described that are active on at least one of PPARa, PPARd and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa, PPARd and PPAR?.
摘要翻译：其中Ar，L，m，R 1，R 2，R 3，W，X，Y，Z的式I化合物是描述了权利要求中所定义的在PPARα，PPARd和PPARγ中的至少一种上有活性的，其可用于涉及调节PPARα，PPARd和PPARγ中的至少一种的治疗和/或预防方法。

8. 发明申请

WO0240114A3 RECREATIONAL EXERCISE DEVICE FOR SIMULATION OF SNOW BOARD ACTION ON SNOWLESS SURFACES 审中-公开
标题翻译：用于模拟无锡表面上的雪板动作的娱乐练习装置
公开(公告)号：WO0240114A3
公开(公告)日：2003-05-30
申请号：PCT/US0145030
申请日：2001-11-17
申请人： LIN JACK
发明人： LIN JACK
IPC分类号： A63C5/035 , A63C17/02 , A63C17/06 , A63C1/00
CPC分类号： A63C17/06 , A63C17/045
摘要： A recreational exercise device (Figure 1), consisting of at least one substantially horizontal member (12) having a top (14) and a bottom (16) surface and a sidewall (18) to define a body (19).The top and bottom surfaces are substantially planar and of equal length and width. The body is of substantially greater length than said height. The horizontal member having a longitudinal (52) and transverse axis (54). The horizontal member extending along the longitudinal axis a substantially longer distance than along the transverse axis. A foot support (26) is mounted on the top surface along the longitudinal axis at a point between a first and second end of the horizontal member. The horizontal member extending a predetermined distance beyond the foot support along the longitudinal axis toward the first and second ends. A first wheel (22) is mounted near the first end (23) on the horizontal member along the longitudinal axis, the first wheel extending below the bottom surface. A second wheel (24) is mounted near the second end (25) on the horizontal member along the longitudinal axis, the second wheel extending below the bottom surface.
摘要翻译：休闲运动装置（图1），由至少一个具有顶部（14）和底部（16）表面的基本水平的构件（12）和用于限定主体（19）的侧壁（18）组成。底表面基本上是平面的并且具有相同的长度和宽度。身体具有比所述高度大得多的长度。水平构件具有纵向（52）和横向轴线（54）。水平构件沿着纵向轴线延伸比沿着横向轴线大得多的距离。在水平构件的第一端和第二端之间的点处，脚支撑件（26）沿着纵向轴线安装在顶表面上。所述水平构件沿所述纵向轴线朝向所述第一端和所述第二端延伸超过所述脚支撑件的预定距离。第一轮（22）沿着纵向轴线安装在水平构件上的第一端（23）附近，第一轮在底面下方延伸。第二轮（24）沿着纵向轴线安装在水平构件上的第二端（25）附近，第二轮在底面的下方延伸。

9. 发明申请

WO2014039714A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2014039714A2
公开(公告)日：2014-03-13
申请号：PCT/US2013058320
申请日：2013-09-05
申请人： PLEXXIKON INC
发明人： LIN JACK , BUELL JOHN , CHAN KATRINA , EWING TODD , IBRAHIM PRABHA N , NESPI MARIKA , PHAM PHUONGLY , SHI SONGYUAN , SPEVAK WAYNE , WU GUOXIAN , ZHANG JIAZHONG , ZHANG YING
IPC分类号： C07D495/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D239/74 , C07D401/12 , C07D473/00 , C07D487/04 , C07D491/056
CPC分类号： C07D495/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D239/74 , C07D401/12 , C07D473/00 , C07D487/04 , C07D491/056 , C07D519/00
摘要： Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.
摘要翻译：描述了对具有任何突变的c-kit蛋白激酶或突变c-kit蛋白激酶有活性的化合物，以及制备和使用这些化合物治疗与c-kit蛋白激酶和突变体c的异常活性相关的疾病和病症的方法 -kit蛋白激酶。

10. 发明申请

WO2008064053A9 SYSTEMS AND METHODS FOR DIABETES MANAGEMENT USING CONSUMER ELECTRONIC DEVICES 审中-公开
标题翻译：使用消费电子设备进行糖尿病管理的系统和方法
公开(公告)号：WO2008064053A9
公开(公告)日：2008-08-07
申请号：PCT/US2007084769
申请日：2007-11-15
申请人： MEDTRONIC MINIMED INC , PATEL HIMANSHU , ISTOC EMIL , LIN JACK , NARANG AJIT
发明人： PATEL HIMANSHU , ISTOC EMIL , LIN JACK , NARANG AJIT
IPC分类号： G06F19/00
CPC分类号： G06F19/3418 , A61B5/6849 , G06F19/324 , G06F19/3456 , G06F19/3475 , G16H15/00 , G16H40/40
摘要： The invention is embodied in a system for diabetes management including a medical device (MD) and a consumer electronic device (CED). The CED may be used to monitor and/or control the MD. In particular embodiments, the system may include a connector that plugs into the CED to allow communication between the MD and the CED. The medical device may be an external infusion device, implantable pump, glucose meter, glucose monitor, continuous glucose monitoring system, or the like. The CED may be any type of consumer electronic device including, but not limited to, cellular phones, personal digital assistants (PDAs), BlackBerry, Smartphones, pocketpc phones, mp3 players, radios, CD players, and the like.
摘要翻译：本发明体现在包括医疗设备（MD）和消费电子设备（CED）在内的糖尿病管理系统中。 CED可用于监测和/或控制MD。在具体实施例中，系统可以包括插入到CED中以允许MD与CED之间的通信的连接器。医疗装置可以是外部输液装置，可植入泵，葡萄糖计，葡萄糖监测器，连续葡萄糖监测系统等。 CED可以是任何类型的消费电子设备，包括但不限于蜂窝电话，个人数字助理（PDA），黑莓手机，智能手机，袖珍手机，MP3播放器，无线电装置，CD播放器等。

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