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1. 发明申请

WO2011161220A1 HYPEROSMOTIC PREPARATIONS COMPRISING 5 -AMINO LEVULINIC ACID OR DERIVATIVE AS PHOTOSENSITIZING AGENT 审中-公开
标题翻译：包含5亚氨基酸或衍生物作为光敏剂的高效制剂
公开(公告)号：WO2011161220A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060574
申请日：2011-06-23
申请人： PHOTOCURE ASA , HEGLUND, Inger Ferner , GODAL, Aslak , KLAVENESS, Jo
发明人： HEGLUND, Inger Ferner , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K41/00 , A61K9/00 , A61P35/00
CPC分类号： A61K41/0061 , A61B5/0071 , A61B5/0084 , A61K9/0031 , A61K47/10 , A61K47/26
摘要： Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer.
摘要翻译：本文提供了光动力学治疗和诊断胃肠道中的癌症和非癌性病症的改进方法，例如。在结肠中，特别是用于这些方法的高渗灌肠剂。灌肠制剂包含5-氨基乙酰丙酸（5-ALA）或其前体或衍生物的光敏剂，例如5-氨基乙酰丙酸。 5-ALA酯，与至少一种高渗剂组合。本文描述的方法和制剂特别适用于治疗和/或诊断结肠直肠癌的光动力学方法。

2. 发明申请

WO2006051269A1 TREATMENT OF ACNE USING DERIVATIVES OF 5-AMINOLEVULINIC ACID 审中-公开
标题翻译：使用5-氨基乙酸的衍生物治疗ACNE
公开(公告)号：WO2006051269A1
公开(公告)日：2006-05-18
申请号：PCT/GB2005/004253
申请日：2005-11-04
申请人： PHOTOCURE ASA , GOLDING, Louise , GODAL, Aslak , KLAVENESS, Jo , MORRIS, Hilde
发明人： GODAL, Aslak , KLAVENESS, Jo , MORRIS, Hilde
IPC分类号： A61K31/197
CPC分类号： A61N5/0616 , A61K31/197 , A61K41/0061
摘要： The invention provides use of a photosensitiser, which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the prevention or treatment of acne.
摘要翻译：本发明提供了在制备用于预防或治疗痤疮的药物中使用光敏剂，其是5-氨基乙酰丙酸（5-ALA）的衍生物（例如酯）或其药学上可接受的盐）。

3. 发明申请

WO2009074811A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2009074811A2
公开(公告)日：2009-06-18
申请号：PCT/GB2008/004113
申请日：2008-12-12
申请人： PHOTOCURE ASA , GOLDING, Louise , KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
发明人： KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K9/02 , A61K9/28 , A61K9/48 , A61K31/197
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non¬ cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
摘要翻译：本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。本发明还涉及用于这些方法的固体药物产品，例如。栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症，例如，在结直肠癌或宫颈癌的治疗或诊断中。

4. 发明申请

WO2005092838A1 ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES 审中-公开
标题翻译： 5-氨基酸或其衍生物的酸添加量
公开(公告)号：WO2005092838A1
公开(公告)日：2005-10-06
申请号：PCT/GB2005/001236
申请日：2005-03-29
申请人： PHOTOCURE ASA , BRAENDEN, Jon, Erik , GODAL, Aslak , NILSEN, Nils, Olav , KLAVENESS, Jo
发明人： BRAENDEN, Jon, Erik , GODAL, Aslak , NILSEN, Nils, Olav , KLAVENESS, Jo
IPC分类号： C07C229/22
CPC分类号： A61K41/0061 , C07C229/22
摘要： The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.
摘要翻译：本发明提供5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与酸的加成盐，所述酸的pKa为约5或更小，优选约3或较少，条件是酸不是盐酸。特别优选的盐是衍生自选自磺酸及其衍生物，氢溴酸，硫酸，硝酸和磷酸的酸的酸。根据本发明的盐特别适用于诊断和光化学治疗身体的外表面或内表面的病症或异常的光敏剂。

5. 发明申请

WO2007132234A1 PHARMACEUTICAL COMPOSITIONS COMPRISING 5-AMINOLEVULINIC ACID 审中-公开
标题翻译：包含5-氨基酸的药物组合物
公开(公告)号：WO2007132234A1
公开(公告)日：2007-11-22
申请号：PCT/GB2007/001791
申请日：2007-05-16
申请人： PHOTOCURE ASA , GORDON, Kirsteen , GODAL, Aslak , KLAVENESS, Jo
发明人： GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K31/197 , A61K31/22 , A61K31/222 , A61P31/00 , A61P35/00 , A61K45/06
CPC分类号： A61K31/197 , A61K31/22 , A61K31/222 , A61K45/06 , A61K2300/00
摘要： This invention provides a pharmaceutical product comprising a photosensitiser which is 5-ALA or a precursor or derivative thereof and a non-photosensitising therapeutic agent, for example 5-fluorouracil, mitromycin, metronidazole etc.
摘要翻译：本发明提供一种药物产品，其包含5-ALA或其前体或衍生物的光敏剂和非感光治疗剂，例如5-氟尿嘧啶，霉素，甲硝唑等。

6. 发明申请

WO2010142456A1 SOLID COMPOSITIONS COMPRISING 5-AMINOLEVULINIC ACID 审中-公开
标题翻译：包含5-氨基酸的固体组合物
公开(公告)号：WO2010142456A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003531
申请日：2010-06-11
申请人： PHOTOCURE ASA , HELLAND, Oddveig Sellaeg , STENSRUD, Gry , KLEM, Bjorn , BRAENDEN, Jon Erik , GODAL, Aslak , KLAVENESS, Jo
发明人： HELLAND, Oddveig Sellaeg , STENSRUD, Gry , KLEM, Bjorn , BRAENDEN, Jon Erik , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K9/20 , A61K9/48 , A61K9/02 , A61K47/14 , A61K31/197
CPC分类号： A61K31/197 , A61K9/0009 , A61K9/4858 , A61K41/0061 , A61K49/0036
摘要： This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.
摘要翻译：本发明涉及用于癌症的光动力学诊断方法，胃肠系统下部癌前和非癌症病症的固体组合物和固体药物产品。固体药物组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。本发明还涉及癌症的光动力学诊断方法，下胃肠道的癌前和非癌症状况，其中使用固体药物组合物和药物产品。

7. 发明申请

WO2010072419A3 ENEMA PREPARATIONS AND THEIR USE 审中-公开
公开(公告)号：WO2010072419A3
公开(公告)日：2010-07-01
申请号：PCT/EP2009/009293
申请日：2009-12-23
申请人： PHOTOCURE ASA , GODAL, Aslak , KLAVENESS, Jo
发明人： GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K9/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/34 , A61K47/38 , A61K41/00
摘要： This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.

8. 发明申请

WO2008084241A3 USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 审中-公开
公开(公告)号：WO2008084241A3
公开(公告)日：2008-07-17
申请号：PCT/GB2008/000086
申请日：2008-01-11
申请人： PHOTOCURE ASA , GOLDING, Louise , WULF, Hans, Christian , GODAL, Aslak , KLAVENESS, Jo
发明人： WULF, Hans, Christian , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K31/221 , A61K41/00 , A61K31/197 , A61P17/10 , A61P35/00
摘要： The invention provides the use of a photosensitiser which is 5- aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10 % wt (e.g. 0.5 to 8 %wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm 2 (e.g. 5 to 40 mW/cm 2 ), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).

9. 发明申请

WO2003045893A1 DOUBLE ESTERS 审中-公开
标题翻译：双胞胎
公开(公告)号：WO2003045893A1
公开(公告)日：2003-06-05
申请号：PCT/GB2002/005305
申请日：2002-11-22
申请人： PHOTOCURE ASA , COCKBAIN, Julian , KLAVENESS, Jo
发明人： KLAVENESS, Jo
IPC分类号： C07C69/50
CPC分类号： A61K31/225 , A61K31/23 , C07C69/34 , C07C69/48 , C07C69/96
摘要： The invention provides acyloxymethyl esters of C 6-14 alkane-dicarboxylic acids, or physiologically tolerable salts or esters thereof, for use in medicine as therapeutic or prophylactic agents.
摘要翻译：本发明提供了用作医药或预防药物的C 6-14烷烃二羧酸或其生理上可耐受的盐或酯的酰氧基甲基酯。

10. 发明申请

WO2003011265A2 METHOD 审中-公开
标题翻译： 5-氨基酸和酯，与其他光敏剂组合使用，作为光致变色剂中的光敏剂，以及它们在治疗伤口中的用途
公开(公告)号：WO2003011265A2
公开(公告)日：2003-02-13
申请号：PCT/GB2002/003386
申请日：2002-07-25
申请人： PHOTOCURE ASA , GOLDING, Louise , KLAVENESS, Jo , HANSSON, Vidar
发明人： KLAVENESS, Jo , HANSSON, Vidar
IPC分类号： A61K31/00
CPC分类号： A61K41/0061
摘要： The method relates to the use of a photosensitizer selected from 5-aminolevulinic acid (5-ALA) and 5-ALA derivatives, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in treating a wound. Examples of wounds which may be treated in accordance with the invention include those resulting from non-physiological processes, e.g. from surgery or from physical injury, abrasions, lacerations, and wounds arising from a thermal injury (e.g. a burn or a wound arising from any cryo-based treatment). Ulcers, e.g. leg ulcers, venous ulcers and gastric ulcers, may also be successfully treated in accordance with the methods of the invention.
摘要翻译：该方法涉及在制备用于治疗伤口的药物中使用选自5-氨基乙酰丙酸（5-ALA）和5-ALA衍生物的光敏剂及其药学上可接受的盐。根据本发明可以治疗的伤口的实例包括由非生理过程产生的伤口。来自手术或来自身体伤害，擦伤，撕裂和由热损伤引起的伤口（例如，由任何基于冷冻的治疗产生的烧伤或伤口）。溃疡，例如还可以根据本发明的方法成功治疗腿部溃疡，静脉溃疡和胃溃疡。

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