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1. 发明申请

WO2007022305A3 2-AMINOIMIDAZOPYRIDINES FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经病变性疾病的2-氨基咪唑吡啶
公开(公告)号：WO2007022305A3
公开(公告)日：2007-04-12
申请号：PCT/US2006032040
申请日：2006-08-16
申请人： PHARMACOPEIA DRUG DISCOVERY , COLE ANDREW G , MCGUINNESS BRIAN F , BRESCIA MARC-RALEIGH , SHAO YUEFEI , DONG GUIZHEN , HENDERSON IAN
发明人： COLE ANDREW G , MCGUINNESS BRIAN F , BRESCIA MARC-RALEIGH , SHAO YUEFEI , DONG GUIZHEN , HENDERSON IAN
IPC分类号： C07D471/04 , A61K31/4188 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to 2-aminoimidazopyridine derivatives useful in treating disorders that are mediated by A 2a receptor function, including neurodegenerative diseases including Parkinson's disease and inflammation. The compounds have general formula (I).
摘要翻译：本发明涉及可用于治疗由A 2A受体功能介导的疾病的2-氨基咪唑并吡啶衍生物，包括神经变性疾病，包括帕金森病和炎症。该化合物具有通式（I）。

2. 发明申请

WO2007030438A3 AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的氨基嘌呤衍生物
公开(公告)号：WO2007030438A3
公开(公告)日：2007-05-31
申请号：PCT/US2006034517
申请日：2006-09-06
申请人： PHARMACOPEIA DRUG DISCOVERY , COLE ANDREW G , BRESCIA MARC-RALEIGH , AHMED GULZAR , HENDERSON IAN
发明人： COLE ANDREW G , BRESCIA MARC-RALEIGH , AHMED GULZAR , HENDERSON IAN
IPC分类号： C07D473/32 , A61K31/52 , A61P25/16
CPC分类号： C07D473/32
摘要： The invention relates to aminopurine derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation. The compounds are of the general formula (I).
摘要翻译：本发明涉及可用于治疗由腺苷受体功能介导的疾病（包括神经变性疾病和炎症）的氨基嘌呤衍生物。化合物具有通式（I）。

3. 发明申请

WO2007133983A3 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的2-氨基苯并咪唑
公开(公告)号：WO2007133983A3
公开(公告)日：2008-03-20
申请号：PCT/US2007068318
申请日：2007-05-07
申请人： PHARMACOPEIA INC , COLE ANDREW G , MCGUINNESS BRIAN F , DONG GUIZHEN , HENDERSON IAN
发明人： COLE ANDREW G , MCGUINNESS BRIAN F , DONG GUIZHEN , HENDERSON IAN
IPC分类号： C07D239/74 , A61K31/4184 , A61P25/00 , A61P27/02 , C07D401/06 , C07D413/06
CPC分类号： C07D239/74 , C07D401/06 , C07D413/06
摘要： There are disclosed 2-aminobenzimidazoles useful in treating disorders that are mediated by A2a receptor function, including neurodegenerative diseases including Parkinson's disease and inflammation. The compounds have general formula : (I) Other embodiments are also disclosed.
摘要翻译：公开了用于治疗由A2a受体功能介导的疾病的2-氨基苯并咪唑，包括神经变性疾病，包括帕金森病和炎症。该化合物具有通式：（I）其它实施方案也被公开。

4. 发明申请

WO2007022415A2 SUBSTITUTED 2-AMINOTHIAZOLES FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经退行性疾病的取代2-氨基噻唑
公开(公告)号：WO2007022415A2
公开(公告)日：2007-02-22
申请号：PCT/US2006032311
申请日：2006-08-18
申请人： PHARMACOPEIA DRUG DISCOVERY , COLE ANDREW G , METZGER AXEL , HENDERSON IAN
发明人： COLE ANDREW G , METZGER AXEL , HENDERSON IAN
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention relates to substituted 2-aminothiazole derivatives useful in treating disorders that are mediated by A 2a receptor function, including neurodegenerative diseases including Parkinson's disease and inflammation. The compounds have general formula (I):
摘要翻译：本发明涉及用于治疗由A 2a受体功能介导的疾病的取代的2-氨基噻唑衍生物，所述疾病包括神经退行性疾病，包括帕金森病和炎症。该化合物具有通式（I）：

5. 发明申请

WO2009158309A3 BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：联苯磺隆作为双血管内皮素受体拮抗剂
公开(公告)号：WO2009158309A3
公开(公告)日：2010-04-22
申请号：PCT/US2009048136
申请日：2009-06-22
申请人： LIGAND PHARM INC , COLE ANDREW G , JOKIEL PATRICK A , BRESCIA MARC-RALEIGH , QIN LANYING , HENDERSON IAN
发明人： COLE ANDREW G , JOKIEL PATRICK A , BRESCIA MARC-RALEIGH , QIN LANYING , HENDERSON IAN
IPC分类号： C07D487/04 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/519 , A61K31/53 , A61K31/5365 , A61P7/00 , A61P7/04 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P15/00 , A61P25/06 , A61P35/00 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D471/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04
摘要： The present invention provides novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists useful in the treatment of conditions such as hypertension and other diseases.
摘要翻译：本发明提供了可用于治疗诸如高血压等疾病的病症的组合血管紧张素和内皮素受体拮抗剂的新型联苯磺酰胺化合物。

6. 发明申请

WO2007104053A3 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译： 8-HETEROARYLPURINE MNK2用于治疗代谢性疾病的抑制剂
公开(公告)号：WO2007104053A3
公开(公告)日：2007-11-01
申请号：PCT/US2007063699
申请日：2007-03-09
申请人： PHARMACOPEIA INC , COLE ANDREW G , BRESCIA MARC-RALEIGH , ZHANG JOAN J , HUSSAIN ZAHID , DILLER DAVID J , METZGER AXEL , AHMED GULZAR , HENDERSON IAN
发明人： COLE ANDREW G , BRESCIA MARC-RALEIGH , ZHANG JOAN J , HUSSAIN ZAHID , DILLER DAVID J , METZGER AXEL , AHMED GULZAR , HENDERSON IAN
IPC分类号： C07D473/32 , A61K31/52 , A61P3/00
CPC分类号： C07D473/32
摘要： This invention relates to 8-Heteroarylpurine Mnk2 Inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要翻译：本发明涉及可用于治疗和预防代谢性疾病如肥胖症和糖尿病的8-杂芳基嘌呤Mnk2抑制剂。

7. 发明申请

WO2010135350A3 BIPHENYL INTERMEDIATE COMPOUNDS AND METHODS FOR THE PREPARATION OF A DUAL ANGIOTENSIN II AND ENDOTHELIN A RECEPTOR ANTAGONIST 审中-公开
标题翻译：联苯胺中间体化合物和制备双抗血管素II和内皮素受体拮抗剂的方法
公开(公告)号：WO2010135350A3
公开(公告)日：2011-03-31
申请号：PCT/US2010035294
申请日：2010-05-18
申请人： PHARMACOPEIA LLC , ZHI LIN , PICKENS JASON , VAN OEVEREN CORNELIUS A , HENDERSON IAN
发明人： ZHI LIN , PICKENS JASON , VAN OEVEREN CORNELIUS A , HENDERSON IAN
IPC分类号： C07C309/86 , C07C43/174 , C07C309/87 , C07D233/70 , C07D327/08
CPC分类号： C07D413/12 , C07C43/1786 , C07C309/32 , C07C309/42 , C07C309/66 , C07C309/73 , C07D235/02 , C07D327/02
摘要： Disclosed herein are methods and compounds useful in preparing N-(3,4-dimethyl-5-isoxazolyl)-2-(4-(2-butyl-4-oxo-l,3-diazospiro[4.4]non-l-en-3yl)methyl-2-ethoxymethylphenyl)phenylsulfonamide.
摘要翻译：本文公开了可用于制备N-（3,4-二甲基-5-异恶唑基）-2-（4-（2-丁基-4-氧代-1,3-二氮杂螺环[4.4]壬-1-烯 -3yl）甲基-2-乙氧基甲基苯基）苯磺酰胺。

8. 发明申请

WO0134205A3 USE OF LYTIC TOXINS AND TOXIN CONJUGATES 审中-公开
标题翻译： LYTIC TOXINS和TOXIN CONJUGATES的使用
公开(公告)号：WO0134205A3
公开(公告)日：2002-07-11
申请号：PCT/GB0004329
申请日：2000-11-13
申请人： MICROBIOLOGICAL RES AUTHORITY , PURDY DESMOND , CHARLTON SUSAN , HENDERSON IAN
发明人： PURDY DESMOND , CHARLTON SUSAN , HENDERSON IAN
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61P17/00 , A61P17/06 , A61P19/02 , A61P31/04 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K14/245
CPC分类号： B82Y5/00 , A61K47/6415 , A61K47/67 , A61K47/6829
摘要： Agents are provided which are capable of inhibiting the cell division cycle in a target cell of interest. The agents comprise first and second components, wherein the first component is a targetting moiety which is capable of directing the second component to the target cell of interest. The second component is capable of inhibiting the cell division cycle in the target cell of interest. The agents are preferably provided in the form of conjugates, and the second component is preferably a cytolethal distending toxin. Methods for the preparation of the agents, and the use thereof for treating proliferative cell disorders and intracellular pathogens are also provided.
摘要翻译：提供能够抑制感兴趣的靶细胞中的细胞分裂周期的试剂。所述试剂包含第一和第二组分，其中第一组分是靶向部分，其能够将第二组分引导至感兴趣的靶细胞。第二组分能够抑制感兴趣的靶细胞中的细胞分裂周期。试剂优选以缀合物的形式提供，第二组分优选为细胞致死的扩张毒素。还提供了制备药剂的方法及其用于治疗增殖性细胞病症和细胞内病原体的用途。

9. 发明申请

WO2010026394A3 INSTALLING FENCING 审中-公开
标题翻译：安装FENCING
公开(公告)号：WO2010026394A3
公开(公告)日：2010-04-29
申请号：PCT/GB2009002140
申请日：2009-09-04
申请人： LEGACY HABITAT MAN LTD , DIXON MATTHEW , HENDERSON IAN
发明人： DIXON MATTHEW , HENDERSON IAN
IPC分类号： A01K3/00 , E04H17/00
CPC分类号： A01K3/00 , A01K2003/007 , E04H17/26
摘要： Apparatus for, and a method of, installing partially buried fencing material. A plough is configured to receive a length of fencing material having a depth and to dispense received fencing material from a delivery end. A guide element is configured to act on received fencing material as it is passes through the plough. The guide element presents a guide edge that is profiled to bend a first portion of the depth of received fencing material at an angle to a second portion of the depth of received fencing material to provide an under lap. A guide element that presents a guide edge that is profiled to present a bend for bending a first portion of the depth of fencing material at an angle to a second portion of the depth of said fencing material to provide an under lap. A guide element having a guide edge that presents a curvature.
摘要翻译：用于安装部分掩埋的围栏材料的装置和方法。犁被构造成接收具有深度的一定长度的围栏材料并且从递送端分配所接收的围栏材料。引导元件被构造成当其接收的围栏材料穿过犁时作用于所接收的围栏材料。引导元件具有引导边缘，该引导边缘被成形为将接收到的围栏材料的深度的第一部分以一定角度弯曲到接收到的围栏材料的深度的第二部分以提供下搭接。引导元件呈现引导边缘，所述引导边缘被成形为呈现弯曲以用于将所述围栏材料的深度的第一部分弯曲成与所述围栏材料的深度的第二部分成一定角度以提供下搭接。引导元件具有呈现曲率的引导边缘。

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