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1. 发明申请

WO2010140973A1 RECOMBINANTLY PRODUCED ALLERGENS 审中-公开
标题翻译：重新生产过敏原
公开(公告)号：WO2010140973A1
公开(公告)日：2010-12-09
申请号：PCT/SE2010/050623
申请日：2010-06-04
申请人： PHADIA AB , MATTSSON, Lars , LIDHOLM, Jonas , LUNDGREN, Thomas
发明人： MATTSSON, Lars , LIDHOLM, Jonas , LUNDGREN, Thomas
IPC分类号： C07K14/47 , A61K39/35 , A61P11/06 , A61P37/08 , G01N33/53 , G01N33/68 , C12N15/63 , C12N15/86
CPC分类号： A61K39/35 , A61K39/001 , C07K14/47 , G01N33/6854 , G01N2800/24
摘要： The present invention refers to the field of allergy. More specifically, the invention relates to the identification of new allergens from mammals and to diagnosis and treatment of allergy towards mammals. In particular the invention relates to a recombinantly produced canine allergen, Can f 4, or bovine allergen, Bos d 23k, or variants or fragments thereof sharing epitopes with the wildtype allergen, and the use thereof for the manufacture of a diagnostic composition as well as methods for in vitro diagnosis and treatment of allergy.
摘要翻译：本发明涉及过敏领域。更具体地，本发明涉及鉴定哺乳动物的新过敏原以及对哺乳动物的过敏的诊断和治疗。特别地，本发明涉及重组产生的犬变应原Can f 4或牛变应原，Bos d 23k，或其与野生型变应原共有表位的变体或片段，以及其用于制造诊断组合物的用途以及用于体外诊断和治疗过敏症的方法。

2. 发明申请

WO2008079095A1 NOVEL PROSTATE KALLIKREIN ALLERGEN 审中-公开
标题翻译：新的PROSTATE KALLIKREIN过敏原
公开(公告)号：WO2008079095A1
公开(公告)日：2008-07-03
申请号：PCT/SE2007/051080
申请日：2007-12-21
申请人： PHADIA AB , MATTSSON, Lars , EVERBERG, Henrik , LIDHOLM, Jonas
发明人： MATTSSON, Lars , EVERBERG, Henrik , LIDHOLM, Jonas
IPC分类号： A61K39/35 , G01N33/531 , A61P37/00
CPC分类号： G01N33/573 , A61K39/35 , C07K16/18 , G01N33/6854 , G01N2333/47 , G01N2333/96455
摘要： Prostatic kallikrein for the manufacture of a diagnostic or pharmaceutical composition for diagnosis/treatment of type 1 allergy, especially allergy to dogs.
摘要翻译：前列腺激肽释放酶用于制造用于诊断/治疗1型过敏的诊断或药物组合物，特别是对狗的过敏。

3. 发明申请

WO2003080658A1 NOVEL ALLERGEN 审中-公开
公开(公告)号：WO2003080658A1
公开(公告)日：2003-10-02
申请号：PCT/SE2003/000499
申请日：2003-03-26
申请人： PHARMACIA DIAGNOSTICS AB , MARKNELL DEWITT, Åsa , NIEDERBERGER, Verena , LEHTONEN, Pirjo , SPITZAUER, Susanne , SPERR, Wolfgang , VALENT, Peter , VALENTA, Rudolf , LIDHOLM, Jonas
发明人： MARKNELL DEWITT, Åsa , NIEDERBERGER, Verena , LEHTONEN, Pirjo , SPITZAUER, Susanne , SPERR, Wolfgang , VALENT, Peter , VALENTA, Rudolf , LIDHOLM, Jonas
IPC分类号： C07K14/415
CPC分类号： C07K14/415 , A61K39/00
摘要： The present invention relates to a novel allergen from timothy grass (Phleum pratense) pollen, Phl p11 as disclosed in SEQ ID NO 1, and use thereof as a reagent and in a diagnostic kit as well as for immunotherapy.
摘要翻译：本发明涉及如SEQ ID NO 1所公开的斜方草（Phleum pratense）花粉，Phl p11的新型变应原及其作为试剂的用途，以及在诊断试剂盒中以及用于免疫治疗。

4. 发明申请

WO2021004885A1 NOVEL ALLERGEN 审中-公开
公开(公告)号：WO2021004885A1
公开(公告)日：2021-01-14
申请号：PCT/EP2020/068670
申请日：2020-07-02
申请人： PHADIA AB
发明人： LIDHOLM, Jonas , MATTSSON, Lars , EHRENBERG, Angelica , LARSSON, Håkan , ÖSTLING, Jonas
IPC分类号： C07K14/415 , A61K39/35 , G01N33/68
摘要： The present invention relates to the field of allergens and more specifically to a novel isolated allergen from the species Cupressaceae shown to be a primary sensitizer for severe peach allergy mediated by the protein Pru p7. The allergen is homologous with Pru P7 in peach, a protein belonging to the Gibberelin Regulating Proteins (GRPs). The novel allergen also5 shares high sequence homology among other species from the Cupressaceae family and there is therefore also provided additional novel allergens in two other species of the Cupressaceae family. The novel allergens find use in the in vitro diagnosis of, treatment and/or prevention of Type 1 Cupressaceace pollen allergy and Cupressaceace pollen- associated food allergies.

5. 发明申请

WO2022152803A1 NOVEL ALLERGEN ISOFORM VARIANTS 审中-公开
公开(公告)号：WO2022152803A1
公开(公告)日：2022-07-21
申请号：PCT/EP2022/050663
申请日：2022-01-13
申请人： PHADIA AB
发明人： LIDHOLM, Jonas , MATTSSON, Lars , LARSSON, Håkan , EHRENBERG, Angelica , ÖSTLING, Jonas
IPC分类号： G01N33/68 , A61K39/35 , C07K14/415
摘要： The present invention relates to the field of allergens and more specifically to novel allergen isoform variants of Cup s 7 and related allergens containing an isoleucine in position 23. The novel allergen isoform variants find use in the in vitro diagnosis of, treatment and/or prevention of Type 1 Cupressaceace pollen allergy and Cupressaceace pollen-associated food allergies.

6. 发明申请

WO2016013971A1 NOVEL ALLERGEN 审中-公开
公开(公告)号：WO2016013971A1
公开(公告)日：2016-01-28
申请号：PCT/SE2015/050828
申请日：2015-07-20
申请人： PHADIA AB
发明人： MATTSSON, Lars , OLSSON, Ulrica , LUNDGREN, Thomas , LIDHOLM, Jonas , LARSSON, Håkan
IPC分类号： A61K39/35
CPC分类号： G01N33/6854 , C07K14/47
摘要： The invention relates to a novel horse allergen consisting of a heterodimeric protein having a first peptide chain and a second peptide chain together having an overall sequence identity of at least 70 % with the combined sequences of SEQ ID NO:3 and SEQ ID NO: 4, as well as a single chain protein having an overall sequence identity of at least 70%, such as 75%, 80%, 85%, 90%, 95%, or 98%, with the combined amino acid sequences according to SEQ ID NO: 3 and SEQ ID NO: 4.The invention further relates to the use of the protein in methods of diagnosis and therapy of Type I allergy, and kits and compositions for use in such methods.
摘要翻译：本发明涉及由具有第一肽链和第二肽链的异二聚体蛋白组成的新型马过敏原，其总序列同一性与SEQ ID NO：3和SEQ ID NO：4的组合序列具有至少70％的总体序列同一性，以及具有至少70％，例如75％，80％，85％，90％，95％或98％的总体序列同一性的单链蛋白，其中根据SEQ ID NO.3和SEQ ID NO：4。本发明还涉及该蛋白在诊断和治疗I型变态反应的方法中的用途，以及用于此类方法的试剂盒和组合物。

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