会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • APO B-SECRETION/MTP INHIBITORY AMIDES
    • APO B分泌/ MTP抑制剂
    • WO1998023593A1
    • 1998-06-04
    • PCT/IB1997001368
    • 1997-11-03
    • PFIZER INC.CHANG, GeorgeQUALLICH, George, Joseph
    • PFIZER INC.
    • C07D217/04
    • C07D401/04C07D217/04C07D401/06C07D405/04C07D405/06C07D409/06C07D417/06
    • This invention is directed to compounds of formula (I) or the stereoisomers, pharmaceutically acceptable salts and hydrates thereof. The compounds are Apo B/MTP inhibitors and are useful in the treatment of various disorders and conditions such as atherosclerosis, pancreatitis, obesity, hypercholesteremia, hypertriglyceridemia, hyperlipidemia, and diabetes. The compounds of this invention are also useful in combination with other pharmaceutical agents including cholesterol biosynthesis inhibitors and cholesterol absorption inhibitors, especially HMG-CoA reductase inhibitors and HMG-CoA synthase inhibitors; HMG-CoA reductase gene expression inhibitors; CETP inhibitors; bile acid sequestrants; fibrates; cholesterol absorption inhibitors; ACAT inhibitors, squalene synthetase inhibitors, ion-exchange resins, anti-oxidants and niacin. This invention is also directed to intermediates and processes useful in the preparation of compounds of formula (I).
    • 本发明涉及式(I)化合物或其立体异构体,其药学上可接受的盐和水合物。 这些化合物是Apo B / MTP抑制剂,可用于治疗各种疾病和病症如动脉粥样硬化,胰腺炎,肥胖症,高胆固醇血症,高甘油三酯血症,高脂血症和糖尿病。 本发明的化合物还可与其它药剂组合使用,包括胆固醇生物合成抑制剂和胆固醇吸收抑制剂,特别是HMG-CoA还原酶抑制剂和HMG-CoA合成酶抑制剂; HMG-CoA还原酶基因表达抑制剂; CETP抑制剂; 胆汁酸螯合剂 贝特类药物; 胆固醇吸收抑制剂; ACAT抑制剂,角鲨烯合成酶抑制剂,离子交换树脂,抗氧化剂和烟酸。 本发明还涉及可用于制备式(I)化合物的中间体和方法。