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1. 发明申请

WO03010536A3 TNF-ALPHA MIMICS AND LEAD OPTIMISATION 审中-公开
标题翻译： TNF-ALPHA MIMICS和LEAD优化
公开(公告)号：WO03010536A3
公开(公告)日：2003-06-05
申请号：PCT/NL0200486
申请日：2002-07-19
申请人： PEPSCAN SYSTEMS BV , SLOOTSTRA JELLE WOUTER , PUIJK WOUTER CORNELIS , VAN DIJK EVERT
发明人： SLOOTSTRA JELLE WOUTER , PUIJK WOUTER CORNELIS , VAN DIJK EVERT
IPC分类号： G01N33/68
CPC分类号： G01N33/6863
摘要： The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites of TNF alpha or epitopes corresponding to a binding molecule, in particular in relation to protein-protein protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. The invention provides a synthetic molecular library allowing testing for, identification, characterisation or detection of a discontinuous binding site of TNF alpha capable of interacting with a binding molecule, said library having been provided with a plurality of molecules, each molecule of said molecules comprising at least one first segment linked to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site.
摘要翻译：本发明涉及分子识别或检测对应于结合分子的TNFα或表位的不连续或构象结合位点的领域，特别是涉及蛋白质 - 蛋白质 - 核酸，核酸 - 核酸或生物分子 - 配体互动。本发明提供合成分子文库，其允许测试，鉴定，表征或检测能与结合分子相互作用的TNFα的不连续结合位点，所述文库已经提供了多个分子，所述分子的每个分子包含连接到第二段的至少一个第一段，每个区段具有作为不连续结合位点的潜在单一部分的能力。

2. 发明申请

WO02066984A8 ARRAYS FOR DETERMINING BINDING OF BIOMOLECULES_____________ 审中-公开
标题翻译：确定生物分子结合的方法
公开(公告)号：WO02066984A8
公开(公告)日：2003-11-06
申请号：PCT/NL0200097
申请日：2002-02-15
申请人： PEPSCAN SYSTEMS BV , PUIJK WOUTER CORNELIS , VAN DIJK EVERT , SLOOTSTRA JELLE WOUTER
发明人： PUIJK WOUTER CORNELIS , VAN DIJK EVERT , SLOOTSTRA JELLE WOUTER
IPC分类号： G01N33/53 , B01J19/00 , C07K7/06 , C07K7/08 , C07K17/08 , C12Q1/00 , C12Q1/42 , C12Q1/68 , G01N21/78 , G01N33/544 , G01N33/545 , G01N33/566
CPC分类号： G01N33/544 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , G01N33/545
摘要： The invention relates to the detection of biomolecules or analogs thereof in micro-arrays and the supports used for said micro-arrays, in particular in methods for determining or testing binding of a first member molecule within an array or library of tentative first member binding molecules for binding with a second member binding molecule. The invention provides a support for a micro-array suitable for determining binding of a first member molecule within a library of spots of tentative first member binding molecules with a second member binding molecule said support provided with a support surface wherein surface patches are interspersed within surface areas that are materially distinct from said patches.
摘要翻译：本发明涉及在微阵列中的生物分子或其类似物的检测和用于所述微阵列的支持物，特别是用于确定或测试第一成员分子在暂定第一成员结合分子的阵列或文库内的结合的方法用于与第二成员结合分子结合。本发明提供了对于适合于确定临时第一成员结合分子的斑点的第一成员分子与第二成员结合分子的结合的微阵列的支持物，所述支持物具有支撑表面，其中表面斑块散布在表面内与所述贴片实质上不同的区域。

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