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1. 发明申请

WO0222659A3 DISCRIMINATION BETWEEN GnRH-I AND GnRH-II 审中-公开
标题翻译： GnRH-I和GnRH-II之间的分化
公开(公告)号：WO0222659A3
公开(公告)日：2003-01-23
申请号：PCT/NL0100666
申请日：2001-09-11
申请人： PEPSCAN SYSTEMS BV , MELOEN ROBERT HANS , OONK HENDRICA BERENDINA , TURKSTRA JOUWERT ANNE
发明人： MELOEN ROBERT HANS , OONK HENDRICA BERENDINA , TURKSTRA JOUWERT ANNE
IPC分类号： A61K39/00 , A61K38/00 , A61P15/00 , A61P35/00 , C07K14/00 , C07K14/575 , C07K14/72 , C07K16/00 , C07K16/26 , C07K7/23 , A61K38/09
CPC分类号： C07K14/723 , A61K39/00
摘要： A peptide that comprises a modified GnRH decapeptide sequence which allows for a testosterone level that is essentially non-detectable after vaccination with the peptide in a suitable dosage and/or allows for a immunogenic response that allows for the effective discrimination between GnRH-I and GnRH-II and a method for the immunocastration of pigs and for the treatment of prostate cancers of humans
摘要翻译：一种肽，其包含修饰的GnRH十肽序列，其允许在以适合剂量接种肽后接种疫苗时基本上不可检测的睾酮水平和/或允许允许有效区分GnRH-I和GnRH的免疫原性应答 -II和用于免疫接种猪和治疗人类前列腺癌的方法

2. 发明申请

WO2005078450A3 METHOD FOR THE DETECTION OF EARLY B CELL POPULATIONS IN VACCINE DEVELOPMENT 审中-公开
标题翻译：检测疫苗发展中早期B细胞群体的方法
公开(公告)号：WO2005078450A3
公开(公告)日：2006-08-03
申请号：PCT/NL2005000101
申请日：2005-02-11
申请人： PEPSCAN SYSTEMS BV , UNIV UTRECHT HOLDING BV , ARKESTEIJN GERARDUS JOSEPHUS A , HENSEN EVERARD JOHANNES , SCIBELLI ANTONIO , VAN DER MOST ROBBERT GERRIT , MELOEN ROBERT HANS , TURKSTRA JOUWERT ANNE
发明人： ARKESTEIJN GERARDUS JOSEPHUS A , HENSEN EVERARD JOHANNES , SCIBELLI ANTONIO , VAN DER MOST ROBBERT GERRIT , MELOEN ROBERT HANS , TURKSTRA JOUWERT ANNE
IPC分类号： G01N33/50 , G01N33/543 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56972 , G01N33/54306 , G01N33/54313 , G01N33/54393
摘要： The present invention discloses an affinity-binding assay comprising a particle having at least four copies of a target molecule and at least two binding molecules specific for said target molecule, wherein a first of said binding molecules is associated with a first label and a second of said binding molecules is associated with a second label, wherein a particle having said first label and a particle having said second label are distinguishable from a particle having both said first and said second label, wherein said first and said second binding molecule each comprise at least two binding regions specific for said target molecule. The present invention also discloses a composition comprising a first binding molecule associated with a first label and a second binding molecule associated with a second label, wherein the signal obtained from said first label and said second label is distinguishable from the combined signal of said first and second label, characterised in that said first and said second binding molecule each comprise at least two binding regions specific for essentially the same target molecule, preferably for essentially the same epitope on said target molecule and a method for selecting a synthetic antigen from a collection of at least three antigens comprising using the disclosed composition and method. The invention further discloses an antigen obtainable by above described method and capable of inducing an early immune response, a kit of parts to perform said method, the use of antigens selected by said methods for use as a vaccine, and the use of antibodies and antigens as a medicament.
摘要翻译：本发明公开了一种亲和力结合测定法，其包含具有至少四个拷贝的靶分子和至少两个对所述靶分子特异性的结合分子的颗粒，其中所述结合分子中的第一个与第一个标记相关联，第二个所述结合分子与第二标记相关联，其中具有所述第一标记的颗粒和具有所述第二标记的颗粒与具有所述第一和所述第二标记两者的颗粒区分开，其中所述第一和所述第二结合分子各自至少包含对于所述靶分子具有特异性的两个结合区。本发明还公开了一种组合物，其包含与第一标记相关联的第一结合分子和与第二标记相关联的第二结合分子，其中从所述第一标记和所述第二标记获得的信号与所述第一标记和所述第二标记的组合信号区分开，第二标记，其特征在于所述第一和所述第二结合分子各自包含至少两个对基本上相同的靶分子特异性的结合区，优选用于所述靶分子上基本相同的表位，以及从所述靶分子的集合中选择合成抗原的方法包括使用所公开的组合物和方法的至少三种抗原。本发明还公开了可以通过上述方法获得并且能够诱导早期免疫应答的抗原，用于进行所述方法的一部分试剂盒，使用由所述方法选择的抗原用作疫苗，以及使用抗体和抗原作为药物。

3. 发明申请

WO2004077062B1 METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND 审中-公开
标题翻译：选择候选药物化合物的方法
公开(公告)号：WO2004077062B1
公开(公告)日：2005-02-24
申请号：PCT/NL2004000146
申请日：2004-02-26
申请人： PEPSCAN SYSTEMS BV , TIMMERMAN PETER , BELD JORIS , MELOEN ROBERT HANS , PUIJK WOUTER CORNELIS
发明人： TIMMERMAN PETER , BELD JORIS , MELOEN ROBERT HANS , PUIJK WOUTER CORNELIS
IPC分类号： A61K31/00 , A61K31/03 , A61K38/00 , C07K1/00 , C07K1/02 , C07K19/00 , C40B30/04 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54306 , C07K17/02 , C40B30/04 , G01N33/54353
摘要： The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, said method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with said at least first and second reactive group; contacting said scaffold with said at least one molecule to form at least two linkages between said scaffold and said at least one molecule in a coupling reaction, whereby the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein said coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound, comprising providing a library of compounds according to the invention and determining the binding of a target molecule to said compounds.
摘要翻译：本发明涉及候选药物测试和药物开发领域。提供了一种用于提供由至少一个通过至少两个连接键与分子支架连接的分子组成的化合物的方法，所述方法包括提供包含至少第一和第二反应基的支架; 提供至少一种能够与所述至少第一和第二反应性基团反应的分子; 使所述支架与所述至少一种分子接触以在偶联反应中在所述支架和所述至少一种分子之间形成至少两个连接，由此形成连接加速形成连续连接，优选其中进行所述偶联反应在溶液中，更优选在水溶液中。此外，提供了用于选择候选药物化合物的方法，包括提供根据本发明的化合物文库并确定靶分子与所述化合物的结合。

4. 发明申请

WO2004077062A3 METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND 审中-公开
标题翻译：选择候选药物化合物的方法
公开(公告)号：WO2004077062A3
公开(公告)日：2005-01-13
申请号：PCT/NL2004000146
申请日：2004-02-26
申请人： PEPSCAN SYSTEMS BV , TIMMERMAN PETER , BELD JORIS , MELOEN ROBERT HANS , PUIJK WOUTER CORNELIS
发明人： TIMMERMAN PETER , BELD JORIS , MELOEN ROBERT HANS , PUIJK WOUTER CORNELIS
IPC分类号： A61K31/00 , A61K31/03 , A61K38/00 , C07K1/00 , C07K1/02 , C07K19/00 , C40B30/04 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54306 , C07K17/02 , C40B30/04 , G01N33/54353
摘要： The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, said method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with said at least first and second reactive group; contacting said scaffold with said at least one molecule to form at least two linkages between said scaffold and said at least one molecule in a coupling reaction, whereby the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein said coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound, comprising providing a library of compounds according to the invention and determining the binding of a target molecule to said compounds.
摘要翻译：本发明涉及候选药物检测和药物开发领域。提供了一种提供由至少一个分子通过至少两个键连接到分子支架构成的化合物的方法，所述方法包括提供包含至少第一和第二反应性基团的支架; 提供至少一个能够与所述至少第一和第二反应性基团反应的分子; 使所述支架与所述至少一个分子接触以在偶联反应中在所述支架和所述至少一个分子之间形成至少两个键，由此形成连接加速连续键的形成，优选其中所述偶联反应进行在溶液中，更优选在水溶液中。此外，提供了用于选择候选药物化合物的方法，其包括提供根据本发明的化合物文库并确定靶分子与所述化合物的结合。

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