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1. 发明申请

WO2009011500A2 METHODS FOR DECREASING FALSE SIGNALS IN IMMUNOASSAY TO DETECT A MULTIMERIC FORM FROM A MONOMERIC FORM OF MULTIMER-FORMING POLYPEPTIDES 审中-公开
标题翻译：减少免疫检测中的错误信号以从多聚形式的多肽的单体形式检测多形式的方法
公开(公告)号：WO2009011500A2
公开(公告)日：2009-01-22
申请号：PCT/KR2008003532
申请日：2008-06-20
申请人： PEOPLEBIO INC , OH HYUN-JUNG , LIM KUN-TAEK
发明人： OH HYUN-JUNG , LIM KUN-TAEK
IPC分类号： G01N33/53
CPC分类号： G01N33/54393
摘要： The present invention provides a method for decreasing false signals in immunoassay to detect a multimeric form of multimer-forming polypeptides with an antibody, which comprises the step of contacting a biosample with NADPH (Nicotiamide adenine dinucleotide phosphate (reduced form)) and a method for differentially detecting a multimeric form from a monomeric form of multimer- forming polypeptides in a biosample. The present invention may differentially detect a multimeric form from a monomeric form of multimer-forming polypeptides easily in a high-throughput manner. The present invention may detect a multimeric form of multimer-forming polypeptides associated with various diseases in a high-throughput manner and particularly is very efficient to detect a scrapie form of prion.
摘要翻译：本发明提供了在免疫测定中减少假信号以用抗体检测多聚体形式多肽的方法，该方法包括使生物样品与NADPH（烟酰胺腺嘌呤二核苷酸磷酸（还原形式））接触的步骤和用于从生物样品中单体形式的多聚体形成多肽差异检测多聚体形式。本发明可以容易地以高通量方式差异检测来自多聚体形成多肽的单体形式的多聚体形式。本发明可以以高通量方式检测与多种疾病相关的多聚体形成多肽的多聚体形式，并且特别是对于检测瘙痒症形式的朊病毒是非常有效的。

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