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1. 发明申请

WO2008115566A3 GUIDANCE AND IMPLANTATION OF CATHETERS 审中-公开
标题翻译：导管的指导和植入
公开(公告)号：WO2008115566A3
公开(公告)日：2009-12-23
申请号：PCT/US2008003711
申请日：2008-03-20
申请人： PEAK BIOSCIENCES INC , DALKE WILLIAM D , GERBER MICHAEL J , JELLISON THOMAS A , LILLEHEI KEVIN O , MATSUURA JAMES E , WARREN STEPHEN L
发明人： DALKE WILLIAM D , GERBER MICHAEL J , JELLISON THOMAS A , LILLEHEI KEVIN O , MATSUURA JAMES E , WARREN STEPHEN L
IPC分类号： A61M25/18
CPC分类号： A61K51/0491 , Y10T137/0402
摘要： A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum.
摘要翻译：提供了一种导管系统，其适于在病人组织内的空间限定的植入物中导航，引导和植入导管或多个导管。该系统可以包括组织导航系统和探针，以通知导航系统来引导导管在目标组织内的位置。探针可以提供诸如光学视觉图像或超声图像的图像，或者可以提供无线电定位数据来引导导管放置。导管提供包括生物活性剂的加压液体，例如可用于治疗癌症，例如123I-或125I-IUDR。提供的系统和方法可用于局部晚期肿瘤的治疗，如脑，头颈部，食管，前列腺，卵巢，肝，胰腺，膀胱或直肠癌。

2. 发明申请

WO2008020931A3 DEVICE FOR DELIVERY OF ANTI-CANCER AGENTS TO TISSUE 审中-公开
标题翻译：用于将抗癌药物递送到组织的装置
公开(公告)号：WO2008020931A3
公开(公告)日：2008-11-06
申请号：PCT/US2007015549
申请日：2007-07-06
申请人： PEAK BIOSCIENCES INC , UNIV COLORADO , WARREN STEPHEN L , GOULD GREGORY A , LILLEHEI KEVIN O
发明人： WARREN STEPHEN L , GOULD GREGORY A , LILLEHEI KEVIN O
IPC分类号： A61F13/00 , A61F2/00
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/70 , A61K51/0491 , A61K51/1282 , A61N5/1007 , A61N2005/1024
摘要： A filament comprising a biocompatible material and a bioactive agent, adapted for implantation within the tissue of a patient wherein the bioactive agent is released over a period of time, is provided. An array of a plurality of the filaments implanted within the tissue of a patient, an array assembler, and a matrix comprising a plurality of filaments and a base adapted for implantation within the tissue of a patient, are further provided. A method for treatment of a malcondition in a patient comprises implantation of a filament, an array of filaments, or a matrix. The bioactive agent can be a chemotherapeutic agent or a radiotherapeutic agent. A radiotherapeutic agent is 123I- or 125I-IUDR, for example in treatment of an advanced stage localized brain tumor such as glioblastoma multiforme.
摘要翻译：提供了包含生物相容性材料和生物活性剂的长丝，其适于植入患者组织内，其中生物活性剂在一段时间内释放。还提供了植入患者组织内的多个细丝的阵列，阵列组装器，以及包括多个细丝的基质和适于植入患者组织内的基底。用于治疗患者病情的方法包括将细丝植入，细丝阵列或基质。生物活性剂可以是化学治疗剂或放射治疗剂。放射治疗剂是123I-或125I-IUDR，例如在治疗晚期局部脑肿瘤如多形性成胶质细胞瘤中。

3. 发明申请

WO2008020967A3 CATHETER AND ARRAY FOR ANTICANCER THERAPY 审中-公开
标题翻译：用于抗癫痫治疗的导管和阵列
公开(公告)号：WO2008020967A3
公开(公告)日：2008-11-20
申请号：PCT/US2007016701
申请日：2007-07-25
申请人： PEAK BIOSCIENCES INC , MATSUURA JAMES E , WARREN STEPHEN L
发明人： MATSUURA JAMES E , WARREN STEPHEN L
IPC分类号： A61M5/00
CPC分类号： A61M25/0662 , A61M25/0021 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/008 , A61M25/0084 , A61M2025/0036 , A61M2025/0081 , A61M2025/0175
摘要： A catheter array system adapted for implanting a plurality of catheters within the tissue of a patient in a spatially defined array, comprising a plurality of catheters, a catheter guide template adapted to guide the implantation of catheters, and a liquid supply system including a pressurizer and a manifold, is provided. A method of treatment of a malcondition in a patient comprises implantation of a spatially definted array of catheters using the system is also provided. The bioactive agent can be a radiotherapeutic agent, a chemotherapeutic agent, a protein, an antibody, an oligonucleotide-based therapeutic agent such as siRNA, or a combination of agents. A preferred radiotherapeutic agent is 123 I- or 125 I-IUDR, for example in the treatment of locally advanced tumors, such as glioblastoma multiforme.
摘要翻译：适于以空间限定阵列将多个导管植入患者组织内的导管阵列系统包括多个导管，适于引导导管植入的导管引导模板以及包括加压器的液体供应系统和提供歧管。还提供了一种治疗患者恶化的方法，该方法包括使用该系统植入空间限定的导管阵列。生物活性剂可以是放射治疗剂，化学治疗剂，蛋白质，抗体，基于寡核苷酸的治疗剂例如siRNA，或者药剂的组合。优选的放射治疗剂是例如用于局部晚期肿瘤如多形性成胶质细胞瘤的治疗中的I-123或I-IUDR。

4. 发明申请

WO2006065951A3 SUSTAINED DELIVERY FORMULATIONS OF OCTREOTIDE COMPOUNDS 审中-公开
标题翻译：化合物的持续递送配方
公开(公告)号：WO2006065951A3
公开(公告)日：2006-10-19
申请号：PCT/US2005045346
申请日：2005-12-15
申请人： QLT USA INC , WARREN STEPHEN L , DADEY ERIC , DUNN RICHARD L , DOWNING JOHN MILTON , LI ELLEN QI
发明人： WARREN STEPHEN L , DADEY ERIC , DUNN RICHARD L , DOWNING JOHN MILTON , LI ELLEN QI
IPC分类号： A61K9/14
CPC分类号： A61K38/31 , A61K9/0021 , A61K9/19 , A61K47/34
摘要： The present invention relates to an octreotide sustained release delivery system for treatment of diseases relating to somatotropin and/or somatostatin. The sustained release delivery system of the invention includes a flowable composition containing an octreotide compound, and an implant containing the octreotide compound. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and an octreotide compound.
摘要翻译：本发明涉及用于治疗与生长激素和/或生长抑素有关的疾病的奥曲肽缓释递送系统。本发明的持续释放递送系统包括含有奥曲肽化合物的可流动组合物和含有奥曲肽化合物的植入物。可流动组合物可以注射到组织中，随后凝结成为固体或凝胶，整体式植入物。可流动组合物包括可生物降解的热塑性聚合物，有机液体和奥曲肽化合物。

5. 发明申请

WO2006041942A2 OCULAR DELIVERY OF POLYMERIC DELIVERY FORMULATIONS 审中-公开
标题翻译：全面交付聚合物交付配方
公开(公告)号：WO2006041942A2
公开(公告)日：2006-04-20
申请号：PCT/US2005035865
申请日：2005-10-04
申请人： QLT USA INC , DADEY ERIC , LINDEMANN CHRISTOPHER M , WARREN STEPHEN L , NORTON RICHARD L
发明人： DADEY ERIC , LINDEMANN CHRISTOPHER M , WARREN STEPHEN L , NORTON RICHARD L
IPC分类号： A61F9/00
CPC分类号： A61K9/0051 , A61F9/0008 , A61F9/0017 , A61F2210/0004
摘要： The present invention provides a flowable composition suitable for use as a controlled release implant. The flowable composition can be administered into the ocular region of a mammal. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides methods of medical treatment that include administering the flowable composition into the ocular region of a mammal.
摘要翻译：本发明提供适合用作控释剂的可流动组合物。可流动组合物可以施用于哺乳动物的眼部区域。组合物包括：（a）可生物降解的生物相容性热塑性聚合物，其至少基本上不溶于水性介质，水或体液; （b）生物制剂，其代谢物，生物学上可接受的盐或其前药; 和（c）在标准温度和压力下的热塑性聚合物可溶的生物相容性有机液体。本发明还提供了包括将可流动组合物施用到哺乳动物的眼部区域中的药物治疗方法。

6. 发明申请

WO2004081196A3 FORMULATIONS FOR CELL- SCHEDULE DEPENDENT ANTICANCER AGENTS 审中-公开
标题翻译：细胞依赖性抗原代谢物的制剂
公开(公告)号：WO2004081196A3
公开(公告)日：2004-12-23
申请号：PCT/US2004007650
申请日：2004-03-11
申请人： ATRIX LAB INC , WARREN STEPHEN L , DADEY ERIC J , ZHOU MINGXING , DUNN RICHARD L
发明人： WARREN STEPHEN L , DADEY ERIC J , ZHOU MINGXING , DUNN RICHARD L
IPC分类号： A61F2/02 , C12N20060101
CPC分类号： A61L27/54 , A61K9/0024 , A61K31/7072 , A61L27/18 , A61L27/50 , A61L27/58 , A61L2300/416 , A61L2300/426 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2400/06 , C08L67/04
摘要： The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides a method of treating cancer in a mammal. The present invention also provides a method of blocking, impeding, or otherwise interfering with cell cycle progression at the G1-phase, G1/S interphase, S-phase, G2/M interface or M-phase of the cell cycle in a mammal. The methods includes administering to a mammal an effective amount of a flowable composition of the present invention.
摘要翻译：本发明提供适合用作控释剂的可流动组合物。组合物包括：（a）可生物降解的生物相容性热塑性聚合物，其至少基本上不溶于水性介质，水或体液; （b）细胞周期依赖性生物制剂，计划依赖性生物制剂，其代谢物，其药学上可接受的盐或其前药; 和（c）在标准温度和压力下的热塑性聚合物可溶的生物相容性有机液体。本发明还提供了一种治疗哺乳动物癌症的方法。本发明还提供在哺乳动物的细胞周期的G1期，G1 / S间期，S期，G2 / M界面或M期，阻断，阻碍或以其他方式干扰细胞周期进程的方法。所述方法包括向哺乳动物施用有效量的本发明的可流动组合物。

7. 发明申请

WO9720031A2 RNA POLYMERASE II CARBOXYL TERMINAL DOMAIN-DERIVED PEPTIDES 审中-公开
标题翻译： RNA聚合酶II羧基末端衍生的肽
公开(公告)号：WO9720031A2
公开(公告)日：1997-06-05
申请号：PCT/US9619038
申请日：1996-11-29
申请人： UNIV YALE , WARREN STEPHEN L
发明人： WARREN STEPHEN L
IPC分类号： A61K38/00 , A61K47/48 , C12N9/12 , C12N15/62 , C12N
CPC分类号： C12N9/1247 , A61K38/00 , A61K47/62 , C07K2319/09 , C07K2319/43 , C07K2319/90 , C12N15/62
摘要： The targeting molecules described herein are derived from the RNA polymerase II carboxyl terminus, consisting of at least two to three hexapeptide repeats of the structure: YX1PX2X3PX4, where Y is tyrosine, P is proline, X can be any amino acid, and X1, X2 and X3 are most preferably serine or threonine, covalently conjugated to a bioactive molecule, most preferably an oligonucleotide, preferably via a linker consisting of one to two amino acids or a carbon chain of equivalent length attached using amide or disulfide chemistry to the tyrosine at the N-terminus of the peptide, leaving a free carboxyl. The peptide can be phosphorylated to alter the association with certain molecules in the nucleus, such as proteins having a serine/arginine motif and Sm snRNPs. For example, it is demonstrated that phosphorylated CTD-derived peptides bind to these nuclear proteins associated with transcription and splicing.
摘要翻译：本文描述的靶向分子衍生自RNA聚合酶II羧基末端，由至少两个至三个以下结构的六肽重复序列组成：YX1PX2X3PX4，其中Y是酪氨酸，P是脯氨酸，X可以是任何氨基酸，X 1，X 2 和X3最优选是丝氨酸或苏氨酸，共价结合生物活性分子，最优选寡核苷酸，优选通过由一至两个氨基酸组成的接头或使用酰胺或二硫化物化学连接到本发明的酪氨酸的等同长度的碳链肽的N-末端，留下游离羧基。肽可以被磷酸化以改变与核中的某些分子的关联，例如具有丝氨酸/精氨酸基序和Sm snRNP的蛋白质。例如，证明磷酸化CTD衍生的肽与转录和剪接相关的这些核蛋白结合。

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