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1. 发明申请

WO2008134331A8 MATS FOR USE IN PAVED SURFACES 审中-公开
公开(公告)号：WO2008134331A8
公开(公告)日：2008-11-06
申请号：PCT/US2008/061204
申请日：2008-04-23
申请人： OWENS CORNING INTELLECTUAL CAPITAL, LLC , HUANG, Helen, Y. , JONES, David, R., IV , CHEN, Liang , SMITH, Jeffrey, W. , MILLER, Timothy, A. , HERNANDEZ-TORRES, Jesus, Manuel , SAMUELOFF, Michael, D. , TAZI, Mohammed , GILBERT, Timothy, R.
发明人： HUANG, Helen, Y. , JONES, David, R., IV , CHEN, Liang , SMITH, Jeffrey, W. , MILLER, Timothy, A. , HERNANDEZ-TORRES, Jesus, Manuel , SAMUELOFF, Michael, D. , TAZI, Mohammed , GILBERT, Timothy, R.
IPC分类号： E01C11/16
摘要： A paving mat (14) for use in a paved surface (10) includes a fibrous mat in the form of a paving mat. The fibrous mat includes a fibrous matrix containing a mixture of polymer fibers, first mineral fibers having a first median length, and second mineral fibers having a second median length that is different from the first median length. In another embodiment, the paving mat includes a fibrous mat including a fibrous matrix which is bonded together by a binder. In one embodiment, the binder is a mixture of different binders. The fibrous matrix includes a mixture of mineral fibers in an amount within a range of from 61 wt% to 85 wt% and polymer fibers in an amount within a range of from 15 wt% to 39 wt%. The polymer fibers have a melting point greater than 320°F (160°C). The mat has a stiffness in the machine direction within a range of from 65 g-cm to HO g- cm. The mat has a load-elongation behavior such that when the mat is subject to tensile stress, the mat achieves at least 90% of its ultimate load at an elongation not greater than 5% of the specimen length in the direction of applied stress. Another embodiment of the paving mat is made with a carboxy-modified acrylic binder.

2. 发明申请

WO2007143044A1 ASPHALT-FILLED POLYMERS 审中-公开
标题翻译：沥青填充聚合物
公开(公告)号：WO2007143044A1
公开(公告)日：2007-12-13
申请号：PCT/US2007/012857
申请日：2007-05-31
申请人： OWENS CORNING INTELLECTUAL CAPITAL, LLC , VERMILION, Donn, R. , QUINN, Robert, E. , PONN, Frderick, H. , O'BRIEN-BERNINI, Frank, C. , SMITH, Jeffrey, W. , UHL, Fawn, M. , OLANG, Nassreen , BARGABOS, Sheree , RYND, Joseph, P. , FABIAN, Barbara, A. , WEEKLY, Mitchell, Z. , HULLS, Byron, J. , LOH, Roland
发明人： VERMILION, Donn, R. , QUINN, Robert, E. , PONN, Frderick, H. , O'BRIEN-BERNINI, Frank, C. , SMITH, Jeffrey, W. , UHL, Fawn, M. , OLANG, Nassreen , BARGABOS, Sheree , RYND, Joseph, P. , FABIAN, Barbara, A. , WEEKLY, Mitchell, Z. , HULLS, Byron, J. , LOH, Roland
IPC分类号： C08L25/04 , C08L101/00 , C08L95/00
CPC分类号： C08L25/06 , C08J9/0061 , C08J2325/06 , C08J2495/00 , C08L25/04 , C08L95/00 , C08L101/00 , C08L2207/22 , C08L2666/72
摘要： The present invention relates to asphalt generally, and more particularly to polymeric products containing asphalt-based additives to achieve various properties and/or reduce cost. In one embodiment, this invention relates the use of asphalt as a resin replacement and/or a colorant in a plastic product. In one such embodiment it relates to rigid foamed polymeric board wherein asphalt is added to increase insulating capability of the polymeric foamed board.
摘要翻译：本发明通常涉及沥青，更具体地涉及含有沥青基添加剂以实现各种性能和/或降低成本的聚合物。在一个实施方案中，本发明涉及在塑料制品中沥青作为树脂替代物和/或着色剂的用途。在一个这样的实施方案中，其涉及刚性泡沫聚合物板，其中添加沥青以增加聚合物泡沫板的绝缘能力。

3. 发明申请

WO2008006113A3 NOVEL BELACTOSIN DERIVATIVES AS THERAPEUTIC AGENTS/BIOLOGICAL PROBES AND THEIR SYNTHESIS 审中-公开
公开(公告)号：WO2008006113A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/073077
申请日：2007-07-09
申请人： THE TEXAS A & M UNIVERSITY SYSTEM , ROMO, Daniel , CHO, Sung, Wook , SMITH, Jeffrey, W. , RICHARDSON, Robyn, D.
发明人： ROMO, Daniel , CHO, Sung, Wook , SMITH, Jeffrey, W. , RICHARDSON, Robyn, D.
IPC分类号： C07D305/12 , C07D407/12 , A61K31/365 , A61P35/00
摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or autoimmune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.

4. 发明申请

WO2003023355A2 SERINE/THREONINE HYDROLASE PROTEINS AND SCREENING ASSAYS 审中-公开
标题翻译：丝氨酸/螺旋蛋白水解蛋白和筛选测定
公开(公告)号：WO2003023355A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028438
申请日：2002-09-04
申请人： THE BURNHAM INSTITUTE , SMITH, Jeffrey, W. , KRIDEL, Steven, J. , AXELROD, Fumiko, T.
发明人： SMITH, Jeffrey, W. , KRIDEL, Steven, J. , AXELROD, Fumiko, T.
IPC分类号： G01N
CPC分类号： C12N9/6445 , C07K2319/00 , C12N9/48
摘要： Proteins specific for prostate epithelial cells, normal or neoplastic, are identified and used for diagnosis, development of antibodies, and for evaluating drugs that react with the neoplastic specific proteins. Affinity based probes are used that react specifically with the active site to provide a measure of the enzyme activity of the cells. Prostate epithelial neoplastic cells can be used in screening candidate drugs for their effect in changing the proteome profile as to the serine-threonine hydrolase enzymes, using the affinity based probes for determining the profile.
摘要翻译：鉴定用于前列腺上皮细胞（正常或肿瘤）的蛋白质，用于诊断，开发抗体，并用于评价与肿瘤特异性蛋白质反应的药物。使用与活性位点特异性反应的亲和性探针，以提供细胞酶活性的量度。前列腺上皮肿瘤细胞可用于筛选候选药物，以改变蛋白质组分析与丝氨酸 - 苏氨酸水解酶的作用，使用基于亲和性的探针确定分布。

5. 发明申请

WO2003025125A2 SELECTIVE SUBSTRATES FOR MATRIX METALLOPROTEINASES 审中-公开
标题翻译：用于基质金属蛋白酶的选择性底物
公开(公告)号：WO2003025125A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029060
申请日：2002-09-13
申请人： THE BURNHAM INSTITUTE , SMITH, Jeffrey, W. , CHEN, Emily, I. , KRIDEL, Steven, J.
发明人： SMITH, Jeffrey, W. , CHEN, Emily, I. , KRIDEL, Steven, J.
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K47/64
摘要： The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetrics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.
摘要翻译：本发明提供分离的MMP-2，MMP-9和MT1-MMP选择性底物多肽或功能性肽测定。选择性底物多肽含有以下序列：MMP-2选择性底物多肽含有SEQ ID NO：1-27，MMP-9选择性底物多肽含有SEQ ID NO：28-35，并且MT1-MMP选择性底物多肽含有SEQ ID NO ：36-40。另外，本发明提供了通过向受试者施用有效量的分离的MMP-2选择性底物多肽，该多肽含有与部分连接的SEQ ID NOS：45-47，从而优先将部分指向MMP-2活性部位的方法。还提供了通过向受试者施用有效量的分离的含有与部分连接的SEQ ID NO：44的MMP-9选择性底物多肽并且优选地指导一种部分至MMP-9活性部位的方法通过向受试者施用有效量的与部分连接的含有SEQ ID NOS：36-40的分离的MT1-MMP选择性底物多肽来实现MT1-MMP活性位点。

6. 发明申请

WO2009059046A1 BETA-LACTONE COMPOUNDS 审中-公开
标题翻译： BETA-LACTONE化合物
公开(公告)号：WO2009059046A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/081857
申请日：2008-10-30
申请人： BURNHAM INSTITUTE FOR MEDICAL RESEARCH , THE TEXAS A & M UNIVERSITY SYSTEM , SMITH, Jeffrey, W. , ROMO, Daniel , MA, Gil , ZANCANELLA, Manuel
发明人： SMITH, Jeffrey, W. , ROMO, Daniel , MA, Gil , ZANCANELLA, Manuel
IPC分类号： C07D305/00
CPC分类号： C07D305/12
摘要： The present invention provides compounds having the general structure A3 or a pharmaceutically acceptable derivatives thereof: wherein R is an alkyl group, and Ri comprises at least one moiety selected from a group consisting of an alkyl, an alkenyl, an aryl, a heterocycle, hydroxyl, ester, amido, aldehyde, and a halogen.
摘要翻译：本发明提供具有通式结构A3或其药学上可接受的衍生物的化合物：其中R是烷基，R 1包含至少一个选自烷基，烯基，芳基，杂环，羟基，酯，酰氨基，醛和卤素。

7. 发明申请

WO2008088836A2 COMPOSITIONS AND METHODS FOR TREATMENT OF COLORECTAL CANCER 审中-公开
标题翻译：用于治疗大肠癌的组合物和方法
公开(公告)号：WO2008088836A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/000590
申请日：2008-01-16
申请人： THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH , SMITH, Jeffrey, W. , FANG, Changming
发明人： SMITH, Jeffrey, W. , FANG, Changming
IPC分类号： A61K48/00
CPC分类号： A61K48/0058 , C12N15/113 , C12N2310/11 , C12N2310/14 , G01N33/5011 , G01N2500/02
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N- terminal sequence that is not found in the IBABP protein. The present invention provides, for example, compositions and methods for diagnosing and treating colorectal cancer.
摘要翻译：我们已鉴定了回肠胆汁酸结合蛋白（IBABP）的新变体，命名为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的转录本来自另一起始位点，包括IBABP中缺失的三个外显子。 IBABP-L也与IBABP共享第四个外显子的一部分。由IBABP-L编码的蛋白质包含在IBABP蛋白质中未发现的推定的49个残基的N-末端序列。本发明提供了例如用于诊断和治疗结直肠癌的组合物和方法。

8. 发明申请

WO2007058704A3 COMPOSITIONS AND METHODS FOR DETECTION OF COLORECTAL CANCER 审中-公开
公开(公告)号：WO2007058704A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/037103
申请日：2006-09-21
申请人： THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH , SMITH, Jeffrey, W. , FANG, Changming
发明人： SMITH, Jeffrey, W. , FANG, Changming
IPC分类号： C07H21/00
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N- terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.

9. 发明申请

WO2003023355A3 SERINE/THREONINE HYDROLASE PROTEINS AND SCREENING ASSAYS 审中-公开
公开(公告)号：WO2003023355A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028438
申请日：2002-09-04
申请人： THE BURNHAM INSTITUTE , SMITH, Jeffrey, W. , KRIDEL, Steven, J. , AXELROD, Fumiko, T.
发明人： SMITH, Jeffrey, W. , KRIDEL, Steven, J. , AXELROD, Fumiko, T.
IPC分类号： A61K38/54
摘要： Proteins specific for prostate epithelial cells, normal or neoplastic, are identified and used for diagnosis, development of antibodies, and for evaluating drugs that react with the neoplastic specific proteins. Affinity based probes are used that react specifically with the active site to provide a measure of the enzyme activity of the cells. Prostate epithelial neoplastic cells can be used in screening candidate drugs for their effect in changing the proteome profile as to the serine-threonine hydrolase enzymes, using the affinity based probes for determining the profile.

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