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1. 发明申请

WO2020124274A1 MODIFIED ORTHOPOXVIRUS VECTORS 审中-公开
公开(公告)号：WO2020124274A1
公开(公告)日：2020-06-25
申请号：PCT/CA2019/051899
申请日：2019-12-20
申请人： OTTAWA HOSPITAL RESEARCH INSTITUTE , TURNSTONE BIOLOGICS CORP.
发明人： BELL, John C. , HUH, Michael S. , TANG, Matthew Y. , PELIN, Adrian , BREITBACH, Caroline J. , BURGESS, Michael F. , BERNSTEIN, Steven H.
IPC分类号： C12N15/863 , A61K35/768 , A61P35/00 , C07K14/07 , C07K14/54 , C07K14/575 , C07K16/28 , C12N15/12 , C12N15/13 , C12N15/24 , C12N15/39 , C12N5/10 , C12N7/01
摘要： The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

2. 发明申请

WO2020124273A1 MODIFIED ORTHOPOXVIRUS VECTORS 审中-公开
公开(公告)号：WO2020124273A1
公开(公告)日：2020-06-25
申请号：PCT/CA2019/051898
申请日：2019-12-20
申请人： OTTAWA HOSPITAL RESEARCH INSTITUTE , TURNSTONE BIOLOGICS CORP.
发明人： BELL, John C. , HUH, Michael S. , TANG, Matthew Y. , PELIN, Adrian , BREITBACH, Caroline J. , BURGESS, Michael F. , BERNSTEIN, Steven H.
IPC分类号： C12N15/863 , A61K35/768 , A61P35/00 , C07K14/065 , C07K16/28 , C12N15/12 , C12N15/13 , C12N15/19 , C12N15/24 , C12N15/39 , C12N15/52 , C12N5/10 , C12N7/01
摘要： The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

3. 发明申请

WO2016119052A1 COMPOSITIONS AND METHODS FOR ENHANCING ONCOLYTIC VIRUS EFFICACY 审中-公开
标题翻译：增强溶瘤病毒效力的组合物和方法
公开(公告)号：WO2016119052A1
公开(公告)日：2016-08-04
申请号：PCT/CA2016/050062
申请日：2016-01-26
申请人： OTTAWA HOSPITAL RESEARCH INSTITUTE , UNIVERSITY OF OTTAWA
发明人： DIALLO, Jean-simon , BODDY, Christopher Noyce , DORNAN, Mark , KRISHNAN, Ramya , LE BOEUF, Fabrice , BELL, John C. , MACKLIN, Andrew , SMITH, Jeffrey
IPC分类号： A61K31/4015 , A61K31/341 , A61K31/36 , A61K31/365 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4745 , A61K31/50 , A61K35/76 , A61K35/00 , C07D207/38 , C07D207/40 , C07D237/14 , C07D307/60 , C07D307/66
CPC分类号： C12N7/00 , A61K31/4015 , A61K31/402 , C07D207/36 , C07D207/38 , C07D207/456 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
摘要翻译：提供了通过增加病毒在细胞中的扩散，增加病毒在细胞中的滴度或增加病毒对细胞的细胞毒性来增强病毒功效的化合物。还提供了其他用途，组合物和使用它们的方法。

4. 发明申请

WO2010020056A1 ENGINEERED SYNERGISTIC ONCOLYTIC VIRAL SYMBIOSIS 审中-公开
标题翻译：工程协同毒理学病毒学意义
公开(公告)号：WO2010020056A1
公开(公告)日：2010-02-25
申请号：PCT/CA2009/001176
申请日：2009-08-20
申请人： OTTAWA HOSPITAL RESEARCH INSTITUTE , BELL, John C. , LE BOEUF, Fabrice
发明人： BELL, John C. , LE BOEUF, Fabrice
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K38/162 , A61K35/76 , A61K35/766 , A61K38/193 , C12N2710/24132 , C12N2760/20232 , A61K2300/00
摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.
摘要翻译：一方面，本发明提供了通过用两种或多种病毒株感染宿主组织来优先杀死宿主例如癌细胞中的靶增殖细胞的方法。可以选择病毒株以提供协同和共生作用，其涉及目标增殖细胞中的同时溶解感染。在选择的实施方案中，选择病毒使得第一毒力因子在被第一病毒感染的增殖细胞中的表达增加了第二病毒的溶解作用; 并且第二种毒力因子在用第二种病毒感染的增殖细胞中的表达增加了第一种病毒的溶解作用。可以选择第一和第二病毒的基因组，使得它们与宿主细胞中的病毒基因组之间的重组不相容。

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