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1. 发明申请

WO2018098223A1 SEALABLE TRAY SYSTEM AND METHODS OF USING SAME 审中-公开
公开(公告)号：WO2018098223A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/062941
申请日：2017-11-22
申请人： OSIRIS THERAPEUTICS, INC.
发明人： SINCLAIR, Steven Michael , DUAN-ARNOLD, Yi , GYURDIEVA, Alexandra , JOHNSON, Amy Elizabeth , UVEGES, Thomas Edward , GERAGHTY, Sandra D. , KUANG, Jin-Qiang , DANILKOVITCH, Alla
IPC分类号： B65D81/18 , A61B17/06 , C12M3/00
CPC分类号： A01N1/0273 , A61B17/06 , B65D25/10 , B65D51/18 , B65D77/046 , B65D81/027 , B65D2251/0018 , B65D2251/0081 , C12M45/22
摘要： A sealable tray system for sealing a product in a transport-ready position. The sealable tray system has an insert, a first lid, an outer basin, and a second lid. The insert has a well portion with a base surface that extends upwardly to support the product. The insert also has a flange portion that extends outwardly from the well portion and is sealingly engaged by the first lid. The outer basin receives the insert in the transport-ready position, and the second lid engages a top surface of the outer basin. Methods of sealing a product in a transport-ready position are also disclosed.

2. 发明申请

WO2017053701A1 UMBILICAL TISSUE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：脐带组织及其使用方法
公开(公告)号：WO2017053701A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/053309
申请日：2016-09-23
申请人： OSIRIS THERAPEUTICS, INC.
发明人： DANILKOVITCH, Alla , DUAN-ARNOLD, Yi , MOORMAN, Matthew , LERCH, Anne , KUANG, Jin-Qiang
IPC分类号： A61K35/50 , A61K38/17
CPC分类号： A61K35/51 , A01N1/021 , A61K35/50
摘要： Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue,; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.
摘要翻译：公开了包含脐带组织的组合物，其中脐带组织包含一个或多个工程化通道。还公开了包含先前冷冻保存的脐带组织的组合物，其中在冷冻保存和随后解冻之后，脐带组织包含：a）脐带组织天然存活的细胞; b）天然脐带组织的组织完整性; c）对于脐带组织是天然的一种或多种生长因子; 和d）一种或多种类型的功能性免疫原性细胞的耗尽量。公开了生产包含脐带组织的组合物的方法，其中脐带组织包含一个或多个工程化通道。还公开了治疗受损组织的方法，包括向所述部位施用包含脐带组织的受损组织组合物，其中所述脐带组织包含一个或多个工程化通道。

3. 发明申请

WO2015138935A1 SUPPORT AND PACKAGING FOR MEMBRANES 审中-公开
标题翻译：膜的支撑和包装
公开(公告)号：WO2015138935A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020502
申请日：2015-03-13
申请人： OSIRIS THERAPEUTICS, INC.
发明人： DUAN-ARNOLD, Yi , DANILKOVITCH, Alla , GYURDIEVA, Alexandra , KUANG, Jinqiang , SINCLAIR, Steven Michael
IPC分类号： A61F13/00
CPC分类号： B65D77/26 , A61B2090/0815 , A61B2090/0816 , A61F2/0095 , A61F2/105 , A61F15/001 , B65B5/04 , B65B55/22 , B65D65/02 , B65D85/70
摘要： A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
摘要翻译：用于在可操作位置支撑生物制品（例如膜）的支撑组件。支撑组件具有底座和盖子。基座的膜接收部分限定了在产品接收部分的顶表面和底表面之间延伸的多个穿孔。盖子在产品覆盖位置可释放地联接到基座，在该产品覆盖位置，盖子覆盖在基座的产品接收部分上。在操作位置，生物制品接合产品接收部分的顶表面和盖的底表面。

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