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1. 发明申请

WO2017080669A1 PHARMACEUTICAL PREPARATION EFFECTIVE IN AGE-RELATED DISORDERS 审中-公开
标题翻译：药物制剂对与年龄有关的疾病有效
公开(公告)号：WO2017080669A1
公开(公告)日：2017-05-18
申请号：PCT/EP2016/001888
申请日：2016-11-14
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/16 , A61P29/00 , A61P17/00 , A61P17/18 , A61P39/00
CPC分类号： A61K35/14 , A61K35/16
摘要： The present invention provides a pharmaceutical preparation for use by injection into the skin, wherein the pharmaceutical preparation is preparable by a production method comprising the steps of providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, providing a vessel or containment means, said vessel or containment means having an internal surface, and contacting said liquid with said vessel or containment means, wherein (a) said production method further comprises the step of incubating said liquid in said vessel or containment means for an incubation time, and optionally removing cellular constituents of said liquid after said incubation, (b) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (c) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means.
摘要翻译：本发明提供通过注射到皮肤中使用的药物制剂，其中所述药物制剂可通过包括以下步骤的生产方法制备：提供从生物体收集的液体，所述液体包含细胞组分（a）所述生产方法还包括在所述容器中培养所述液体的步骤，或者（b）所述容器或容器装置具有内表面，（b）所述液体包含外泌体，并且所述生产方法还包括以下步骤：浓缩所述外泌体并任选地在所述浓缩后除去所述液体的细胞组分或分离所述外泌体的步骤，或（c）所述生产方法进一步c 包括避免所述液体温育的步骤，以及除去与所述容器或容器装置接触的所述液体的细胞组分的步骤。

2. 发明申请

WO2006013069A2 VERFAHREN UND MITTEL ZUR GEWINNUNG VON THROMBOCYTENREICHEM PLASMA 审中-公开
标题翻译：获得血细胞可复制等离子体的方法和手段
公开(公告)号：WO2006013069A2
公开(公告)日：2006-02-09
申请号：PCT/EP2005/008252
申请日：2005-07-29
申请人： ORTHOGEN AG , WEHLING, Peter , REINECKE, Julio
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61M1/02 , A61K35/16 , A61L27/38 , A61L24/10 , A61F2/00
CPC分类号： A61M1/029 , A61L24/108 , A61M1/0209 , A61M1/3693 , A61M2202/0415 , A61M2202/0427
摘要： Verfahren und Mittel zur Gewinnung von thrombocytenreichem Plasma (“platelet rich plasma“, PRP), welches insbesondere einen hohen Gehalt an insbesondere aktivierten Thrombocyten aufweist und welches insbesondere leicht coagulierbar ist, aus Vollblut.
摘要翻译：
方法和装置，用于获得富血小板血浆（“富血小板血浆”，PRP），其特别地具有特定活化的血小板的含量高，并且是特别容易coagulierbar，从全血中。

3. 发明申请

WO2005054279A1 DELIVERY PEPTIDES, THEIR CONSTRUCTS WITH ACTIVE AGENTS AND USE 审中-公开
标题翻译：交付肽，他们的结构与主动代理和使用
公开(公告)号：WO2005054279A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013203
申请日：2004-11-19
申请人： ORTHOGEN AG , MEIJER, Hans , WEHLING, Peter , STURM, Barbara , REINECKE, Julio
发明人： MEIJER, Hans , WEHLING, Peter , STURM, Barbara , REINECKE, Julio
IPC分类号： C07K7/06
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/665 , C07K7/06
摘要： The present invention refers to delivery proteins, protein-cargo complexes, methods, and means for the enhanced delivery or transport of drugs, biologically active agents or other compounds as cargo or cargo molecules onto, into, or across biological membranes or tissues forming a biological barrier.
摘要翻译：本发明涉及递送蛋白质，蛋白质 - 载体复合物，方法和用于将药物，生物活性剂或作为货物或货物分子的其它化合物递送或输送到形成生物屏障。

4. 发明申请

WO2018036657A1 COMBINATION THERAPY USING A BLOOD PREPARATION AND A HELMINTHIC PREPARATION 审中-公开
标题翻译：使用血液制备和有用的制剂的组合疗法
公开(公告)号：WO2018036657A1
公开(公告)日：2018-03-01
申请号：PCT/EP2017/001010
申请日：2017-08-25
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/62 , A61P19/00
CPC分类号： A61K35/62 , A61K35/14 , A61P19/00 , A61P19/02 , A61K2300/00
摘要： The present invention relates to a combination of a blood preparation and a helminthic preparation for use as a medicament, wherein the blood preparation is preparable by a production method comprising the following steps: providing a blood sample collected from an organism and a vessel or container, contacting said blood sample with said vessel or a container, and incubating said blood sample in said vessel or container, wherein said blood sample is (1) a whole blood sample or (2) a whole blood sample from which certain or all cells have been depleted. Moreover, the present invention relates to the non-therapeutic use of a blood preparation in combination with a helminthic preparation, wherein the helminthic preparation comprises helminths which are incapable of reproducing in the organism and/or which do not infect the organism and particularly do not chronically infect the organism, and wherein the blood preparation is preparable by a production method as described above. In addition, the present invention relates to a kit for use as a medicament or for improving a human's quality of life, wherein the kit comprises a blood preparation and a helminthic preparation, wherein the blood preparation is preparable by a production method as described above.
摘要翻译：本发明涉及用作药物的血液制剂和蠕虫制剂的组合，其中所述血液制剂可通过包括以下步骤的制备方法制备：提供从生物体和容器或容器，使所述血液样品与所述容器或容器接触，并将所述血液样品在所述容器或容器中孵育，其中所述血液样品是（1）全血样品或（2）全血样品某些细胞或全部细胞已经从中消失。此外，本发明涉及血液制剂与蠕虫制剂组合的非治疗用途，其中蠕虫制剂包含不能在生物体中繁殖和/或不感染生物体的蠕虫，特别是不能感染生物体长期感染生物体，并且其中血液制剂可通过如上所述的生产方法制备。此外，本发明涉及用作药物或改善人类生活质量的试剂盒，其中所述试剂盒包含血液制剂和蠕虫制剂，其中所述血液制剂可通过如上所述的制备方法制备。

5. 发明申请

WO2018033227A1 ANTI-AGEING PHARMACEUTICAL PREPARATION 审中-公开
标题翻译：抗衰老药物制剂
公开(公告)号：WO2018033227A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/000581
申请日：2017-05-12
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/16 , A61P29/00 , A61P17/00 , A61P17/18 , A61P39/00
摘要： The present invention relates a pharmaceutical preparation for use in the treatment of ageing or as an anti-ageing agent, which is preparable by a production method comprising the following steps: providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, and a vessel or containment means and contacting said liquid with said vessel or containment means, wherein (i) said production method further comprises the step of incubating said liquid in said vessel or containment means, and optionally removing cellular constituents of said liquid after said incubation, (ii) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (iii) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means.
摘要翻译：本发明涉及用于治疗衰老的药物制剂或作为抗衰老剂，其可通过包括以下步骤的生产方法制备：提供从生物体收集的液体，所述液体包含血液的细胞成分，以及容器或容器装置，并使所述液体与所述容器或容器装置接触，其中（i）所述制造方法还包括在所述容器或容器装置中培养所述液体的步骤，（ii）所述液体包含外泌体，并且所述生产方法还包括以下步骤：浓缩所述外泌体并任选地除去所述浓缩后的所述液体的细胞成分，或者分离所述外泌体的步骤，或者（iii）所述生产方法还包括避免所述液体培养的步骤以及去除细胞的步骤所述液体的多种组分与所述容器或容器装置接触。

6. 发明申请

WO2007090569A1 KONDITIONIERTE BLUTZUSAMMENSETZUNG UND VERFAHREN ZU DEREN HERSTELLUNG 审中-公开
标题翻译： CONDITIONED血液成分和方法及其
公开(公告)号：WO2007090569A1
公开(公告)日：2007-08-16
申请号：PCT/EP2007/000903
申请日：2007-02-02
申请人： ORTHOGEN AG , REINECKE, Julio , WEHLING, Peter
发明人： REINECKE, Julio , WEHLING, Peter
IPC分类号： A61K35/14 , A61P37/00
CPC分类号： A61K35/14 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/191 , A61K38/20 , A61K38/2006 , A61K38/2026 , A61K38/204 , A61K38/2066 , A61K38/2086 , A61K38/30 , A61M1/0209 , A61K2300/00
摘要： Die vorliegende Erfindung betrifft Verfahren zur Herstellung konditionierte Blut Zusammensetzungen, die induzierte Faktoren und Cytokine, insbesondere Interleukin-6, enthalten, sowie konditionierte Blutzusammensetzungen, herstellbar durch das Verfahren, und deren Verwendung zur Behandlung oder Vorbeugung eines Leidens des menschlichen oder tierischen Körpers.
摘要翻译：本发明涉及到用于生产诱导因子和细胞因子调节的血液组合物的方法，特别地，包括白介素-6，以及调节血液组合物通过该方法生产并且其用于人或动物体的疾病的治疗或预防的用途。

7. 发明申请

WO2018033249A1 COMBINATION THERAPY EFFECTIVE IN THE TREATMENT OF AGEING AND AGE-RELATED DISORDERS 审中-公开
标题翻译：联合治疗有效治疗老年和年龄相关性疾病
公开(公告)号：WO2018033249A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/000994
申请日：2017-08-17
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/16 , A61P29/00 , A61P17/00 , A61P17/18 , A61P39/00 , A61K31/728
摘要： The present invention provides a pharmaceutical preparation and in particular a combination of a pharmaceutical preparation and hyaluronic acid for use as a medicament, wherein the pharmaceutical preparation is injected into an intact skin and is preparable by a production method comprising the steps of providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, providing a vessel or containment means, said vessel or containment means having an internal surface, and contacting said liquid with said vessel or containment means, wherein (a) said production method further comprises the step of incubating said liquid in said vessel or containment means for an incubation time, and optionally removing cellular constituents of said liquid after said incubation, or (b) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means. Preferably, the pharmaceutical preparation and in particular a combination of a pharmaceutical preparation and hyaluronic acid is for use in the treatment of ageing or as an anti-ageing agent. Also disclosed is the non-medical use of the aforementioned pharmaceutical preparation and in particular of the combination of a pharmaceutical preparation and hyaluronic acid.
摘要翻译：本发明提供药物制剂，特别是用作药物的药物制剂和透明质酸的组合，其中所述药物制剂被注射到完整的皮肤中并且可通过制备方法制备包括提供从生物体收集的液体的步骤，所述液体包含血液的细胞成分，提供容器或容器装置，所述容器或容器装置具有内表面，并使所述液体与所述容器或容器装置接触，其中（ a）所述生产方法还包括在所述容器或容器装置中温育所述液体达孵育时间并任选地在所述温育后除去所述液体的细胞成分的步骤，或（b）所述液体包含外泌体，并且所述生产方法进一步包括浓缩所述外泌体和任选地去除所述细胞成分的步骤所述浓缩后的液体或分离所述外泌体的步骤，或所述生产方法还包括避免所述液体温育的步骤，以及除去与所述容器或容器装置接触的所述液体的细胞成分的步骤。优选地，药物制剂并且特别是药物制剂和透明质酸的组合用于治疗衰老或作为抗衰老剂。还公开了上述药物制剂的非医学用途，特别是药物制剂和透明质酸的组合。

8. 发明申请

WO2003080122A1 VERFAHREN UND MITTEL ZUR HERSTELLUNG THERAPEUTISCH WIRKSAMER BLUTZUSAMMENSETZUNGEN 审中-公开
标题翻译：方法及装置，用以产生治疗组合物有效血药
公开(公告)号：WO2003080122A1
公开(公告)日：2003-10-02
申请号：PCT/EP2003/002969
申请日：2003-03-21
申请人： ORTHOGEN AG , MEIJER, Hans , REINECKE, Julio , WEHLING, Peter
发明人： MEIJER, Hans , REINECKE, Julio , WEHLING, Peter
IPC分类号： A61K48/00
CPC分类号： A61K35/14 , A61K38/00 , A61K48/00 , A61K48/0091 , C07K14/54 , C12N15/895
摘要： Verfahren zur Herstellung induzierter Blutzusammensetzungen aus Blut, wobei die Blutzellen transient oder stabil ein oder mehrere therapeutisch und/oder diagnostisch bedeutsame Protein und/oder Effektormoleküle exprimieren und gegebenenfalls sezernieren.
摘要翻译：一种用于从血液制备血诱导组合物，其中所述血液细胞中瞬时或稳定表达一种或多种治疗和/或诊断显著蛋白质和/或效应分子，和任选地分泌过程。

9. 发明申请

WO2018033227A8 ANTI-AGEING PHARMACEUTICAL PREPARATION 审中-公开
公开(公告)号：WO2018033227A8
公开(公告)日：2018-02-22
申请号：PCT/EP2017/000581
申请日：2017-05-12
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/16 , A61P29/00 , A61P17/00 , A61P17/18 , A61P39/00
摘要： The present invention relates a pharmaceutical preparation for use in the treatment of ageing or as an anti-ageing agent, which is preparable by a production method comprising the following steps: providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, and a vessel or containment means and contacting said liquid with said vessel or containment means, wherein (i) said production method further comprises the step of incubating said liquid in said vessel or containment means, and optionally removing cellular constituents of said liquid after said incubation, (ii) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (iii) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means.

10. 发明申请

WO2017080668A1 PHARMACEUTICAL PREPARATION EFFECTIVE IN AGE-RELATED DISORDERS 审中-公开
标题翻译：药物制剂对与年龄有关的疾病有效
公开(公告)号：WO2017080668A1
公开(公告)日：2017-05-18
申请号：PCT/EP2016/001887
申请日：2016-11-14
申请人： ORTHOGEN AG
发明人： WEHLING, Peter , REINECKE, Julio
IPC分类号： A61K35/14 , A61K35/16 , A61P29/00 , A61P17/00 , A61P17/18 , A61P39/00
CPC分类号： A61K35/14 , A61K35/16
摘要： The present invention relates a pharmaceutical preparation for the treatment of age- related disorders, which is preparable by a production method comprising the following steps: providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, and a vessel or containment means and contacting said liquid with said vessel or containment means, wherein (i) said production method further comprises the step of incubating said liquid in said vessel or containment means, and optionally removing cellular constituents of said liquid after said incubation, (ii) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (iii) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means.
摘要翻译：本发明涉及一种用于治疗年龄相关疾病的药物制剂，其可通过包括以下步骤的生产方法制备：提供从生物体收集的液体，所述液体包含细胞成分血液和容器或容器装置中，并使所述液体与所述容器或容器装置接触，其中（i）所述制造方法还包括在所述容器或容器装置中培养所述液体并任选地除去所述液体后的细胞组分（ii）所述液体包含外泌体，并且所述生产方法还包括以下步骤：浓缩所述外泌体并任选地除去所述浓缩后的所述液体的细胞成分，或分离所述外泌体的步骤，或（iii）所述生产方法进一步包括避免所述液体孵育的步骤，以及除去细胞成分o的步骤 f所述液体与所述容器或容器装置接触。

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