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1. 发明申请

WO2011116125A3 MULTILAYERED VASCULAR TUBES 审中-公开
标题翻译：多层血管
公开(公告)号：WO2011116125A3
公开(公告)日：2012-01-19
申请号：PCT/US2011028713
申请日：2011-03-16
申请人： ORGANOVO INC , KHATIWALA CHIRAG , MURPHY KEITH , SHEPHERD BENJAMIN
发明人： KHATIWALA CHIRAG , MURPHY KEITH , SHEPHERD BENJAMIN
IPC分类号： A61F2/06 , A61L27/38 , A61L27/40 , C12N5/071
CPC分类号： A61F2/06 , A61L27/3808 , A61L27/3813 , A61L27/3826 , A61L27/507 , C12N5/0691 , C12N2502/1323 , C12N2533/76
摘要： Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1 : 99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.
摘要翻译：本文描述的是包含至少一层分化成体成纤维细胞，至少一层分化成年平滑肌细胞的工程多层血管，其中任何层还包含分化的成体内皮细胞，其中所述管具有以下特征：（a）内皮细胞与平滑肌细胞的比例约为1:99至约45:55; （b）管是顺从的; （c）管的内径约为6mm或更小; （d）管的长度高达约30厘米; 和（e）管的厚度沿管的区域基本均匀; 条件是工程化多层血管管不含任何预先形成的支架。本文还描述了形成所述管的方法和用于所述管的方法，包括用于治疗患者的方法，包括将这种管提供给有需要的患者。

2. 发明申请

WO2013040078A3 ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于体外研究用途的工程组织，其阵列以及制备该组合物的方法
公开(公告)号：WO2013040078A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054923
申请日：2012-09-12
申请人： ORGANOVO INC , MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON , ROBBINS JUSTIN
发明人： MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON , ROBBINS JUSTIN
IPC分类号： C12N5/07 , A61L27/54 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5088 , A61L27/34 , A61L27/38 , A61L27/3891 , A61L27/50 , C12N5/0691 , C12N5/0697 , C12N2502/27 , C12N2502/28 , C12N2513/00 , G01N33/5082
摘要： Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
摘要翻译：公开了用于体外科学和医学研究的活体三维组织构建体，其阵列以及制造所述组织和阵列的方法。

3. 发明申请

WO2013040087A3 PLATFORM FOR ENGINEERED IMPLANTABLE TISSUES AND ORGANS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：工程可植入组织和机构的平台及其制造方法
公开(公告)号：WO2013040087A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054935
申请日：2012-09-12
申请人： ORGANOVO INC , MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON
发明人： MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON
IPC分类号： A61F2/02 , A61F2/08 , A61L27/54
CPC分类号： A61L27/3826 , A61L27/3891 , A61L2430/22 , B33Y10/00
摘要： Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.
摘要翻译：公开的工程组织和器官包括一层或多层肌肉，工程组织或器官基本上由细胞材料组成，条件是工程组织或器官可植入脊椎动物受试者而不是血管内。

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