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1. 发明申请

WO2019227063A1 METHODS, ASSAYS, AND KITS FOR EVALUATING THE PERFORMANCE OF ENGINEERED LIVER TISSUE CONSTRUCTS 审中-公开
公开(公告)号：WO2019227063A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/034031
申请日：2019-05-24
申请人： ORGANOVO, INC.
发明人： DAVIS, Scott , PRESNELL, Sharon C.
IPC分类号： A61B10/00 , A61B5/15 , C12Q1/68
摘要： The disclosure provides methods, assays, and kits for evaluating performances of engineered liver tissue constructs, such as three-dimensional bioprinted liver tissue constructs, including in vitro, pre-implantation, and post-implantation performances. In some embodiments, the performances are evaluated using exosomal RNAs as biomarkers and in vitro sandwich culture assays.

2. 发明申请

WO2018064323A1 USE OF ENGINEERED RENAL TISSUES IN ASSAYS 审中-公开
标题翻译：在测定中使用工程化的肾脏组织
公开(公告)号：WO2018064323A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053997
申请日：2017-09-28
申请人： ORGANOVO, INC.
发明人： KING, Shelby Marie , NGUYEN, Deborah Lynn Greene , PRESNELL, Sharon C.
IPC分类号： C12N5/07 , C12N5/09 , G01N33/50
摘要： Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three- dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
摘要翻译：公开了使用三维工程化生物打印的生物肾小管模型来评估候选治疗剂逆转，减少或预防潜在毒性剂引起的肾损伤的能力的方法。还公开了评估药剂对肾功能的作用的方法，所述方法包括使所述药剂与三维工程化生物打印的生物肾小管模型接触。还公开了肾病的模型。在一个实施方案中，公开了包含三维工程化生物打印的生物肾小管模型的肾纤维化模型。还公开了制造肾病模型的方法。在一个实施方案中公开了制备肾纤维化模型的方法，其包括使三维工程化生物打印的生物肾小管模型与能够诱导间质纤维化组织形成的药剂接触。

3. 发明申请

WO2018035138A1 THREE DIMENSIONAL BIOPRINTED TUMOR MODELS FOR DRUG TESTING 审中-公开
标题翻译：用于药物检测的三维生物打印肿瘤模型
公开(公告)号：WO2018035138A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/046983
申请日：2017-08-15
申请人： ORGANOVO, INC. , OREGON HEALTH & SCIENCE UNIVERSITY , PRESNELL, Sharon C. , KING, Shelby Marie , NGUYEN, Deborah Lynn Greene , JO, Minji , PELZ, Rosalie Sears , ALLEN-PETERSEN, Brittany , LANGER, Ellen
发明人： PRESNELL, Sharon C. , KING, Shelby Marie , NGUYEN, Deborah Lynn Greene , JO, Minji , PELZ, Rosalie Sears , ALLEN-PETERSEN, Brittany , LANGER, Ellen
IPC分类号： A61L27/36 , C12N5/00 , C12N5/071 , C12N5/09 , A01K67/027 , C12N5/077 , G01N33/50
摘要： Described are three-dimensional, engineered, biological cancer models, methods of producing the same, and methods of identifying a therapeutic agent for cancer in an individual utilizing the three-dimensional, engineered, biological cancer models.
摘要翻译：描述了利用三维工程化生物癌症模型的三维工程化生物癌症模型，其生产方法，以及鉴定个体中癌症治疗剂的方法。

4. 发明申请

WO2017083402A1 IMPROVED METHODS FOR TISSUE FABRICATION 审中-公开
标题翻译：改进的组织制造方法
公开(公告)号：WO2017083402A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061156
申请日：2016-11-09
申请人： ORGANOVO, INC.
发明人： RETTING, Kelsey Nicole , NGUYEN, Deborah Lynn Greene , PRESNELL, Sharon C. , KING, Shelby Marie
IPC分类号： C12N5/07 , C12N5/02 , B41J2/01
CPC分类号： C12N5/0698 , C12N5/0656 , C12N5/0697 , C12N2502/091 , C12N2502/094 , C12N2533/54
摘要： Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
摘要翻译：本文公开了用于制造生物打印的三维生物组织的改进方法。这些方法涉及暴露于低温，在各种持续时间的低温下孵育，以及在没有结构交联处理的环境中制造。

5. 发明申请

WO2016073782A1 ENGINEERED THREE-DIMENSIONAL SKIN TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：工程三维皮肤组织，其阵列及其制造方法
公开(公告)号：WO2016073782A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059327
申请日：2015-11-05
申请人： ORGANOVO, INC.
发明人： RETTING, Kelsey Nicole , O'NEILL, Colin M. , NGUYEN, Deborah Lynn Greene , PRESNELL, Sharon C.
IPC分类号： C12N5/07 , C12N5/0735 , C12N5/074 , C12N5/078 , C12N5/09 , C12Q1/02 , G01N33/50
CPC分类号： C12N5/0698 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2503/06 , C12N2533/54 , C12N2533/74 , C12N2533/90 , C12N2535/00
摘要： Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
摘要翻译：公开了生物印迹，三维生物皮肤组织，其包括：包含真皮成纤维细胞的真皮层; 以及表皮层，其包含角质形成细胞，所述表皮层与真皮层接触以形成三维，工程化的生物皮肤组织。还公开了工程化皮肤组织的阵列和制备工程皮肤组织的方法。

6. 发明申请

WO2016057571A1 ENGINEERED RENAL TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：工程化肾组织，其阵列及其制备方法
公开(公告)号：WO2016057571A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054315
申请日：2015-10-06
申请人： ORGANOVO, INC.
发明人： NGUYEN, Deborah Lynn Greene , KING, Shelby Marie , PRESNELL, Sharon C.
IPC分类号： C12N5/07 , C12N5/09 , G01N33/50
CPC分类号： G01N33/5014 , C12N5/0684 , C12N5/0697 , C12N2502/1323 , C12N2502/256 , C12N2502/28 , G01N33/5044 , G01N2500/02 , G01N2500/10
摘要： Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
摘要翻译：公开了肾组织及其阵列，其包括肾间质组织层，肾间质组织包含肾成纤维细胞和内皮细胞; 和一层肾上皮组织，肾上皮组织包含肾小管上皮细胞，肾上皮组织与肾间质组织层接触形成三维，工程化的生物肾组织。还公开了制造和使用它们的方法。

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