专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010084402A3 HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS 审中-公开
公开(公告)号：WO2010084402A3
公开(公告)日：2010-07-29
申请号：PCT/IB2010/000094
申请日：2010-01-21
申请人： ORCHID RESEARCH LABORATORIES LTD. , BALASUBRAMANIAN, Gopalan , NARAYANAN, Sukunath , SHARMA, Ganapavarapu, vEERA, rAGHAVA , ANDIAPPAN, Lavanya , NARAYANAN, Shridhar , SAXENA, Sanjeev , RAJAGOPAL, Sridharan , VISHWAKARMA, Lolaknath, Santosh , THIRUNAVUKKARASU, Saravanan
发明人： BALASUBRAMANIAN, Gopalan , NARAYANAN, Sukunath , SHARMA, Ganapavarapu, vEERA, rAGHAVA , ANDIAPPAN, Lavanya , NARAYANAN, Shridhar , SAXENA, Sanjeev , RAJAGOPAL, Sridharan , VISHWAKARMA, Lolaknath, Santosh , THIRUNAVUKKARASU, Saravanan
IPC分类号： C07D413/04 , C07D417/04 , C07D417/14
摘要： Described are compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

2. 发明申请

WO2009095773A2 NOVEL HETEROCYCLES 审中-公开
标题翻译：新型杂环
公开(公告)号：WO2009095773A2
公开(公告)日：2009-08-06
申请号：PCT/IB2009/000157
申请日：2009-01-30
申请人： ORCHID RESEARCH LABORATORIES LIMITED , ORCHID RESEARCH LABORATORIES LIMITED , SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
发明人： SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
IPC分类号： C07D403/04 , C07D401/04 , C07D239/26
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 动脉粥样硬化; 癌症; 恶病质; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 哮喘; 慢性阻塞性肺病; 骨吸收疾病; 多发性硬化症败血症; 败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

3. 发明申请

WO2008110891A2 NEW HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新的杂环化合物
公开(公告)号：WO2008110891A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/000536
申请日：2008-03-07
申请人： ORCHID RESEARCH LABORATORIES LIMITED, , SHARMA, Ganapavarapu, Veera, Raghava , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , RAMACHANDRAN, Uma , NARAYANAN, Sukunath , PICHIKA, Nagalakshmi , NEMMARA VISWANATHAN, Venkatesh , ANDIAPPAN, Lavanya , THIRUNAVUKKARASU, Saravanan
发明人： SHARMA, Ganapavarapu, Veera, Raghava , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , RAMACHANDRAN, Uma , NARAYANAN, Sukunath , PICHIKA, Nagalakshmi , NEMMARA VISWANATHAN, Venkatesh , ANDIAPPAN, Lavanya , THIRUNAVUKKARASU, Saravanan
IPC分类号： C07D401/12
CPC分类号： C07D239/24 , C07D413/14
摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).
摘要翻译：本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。本文进一步描述的是通过在患者中给予一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂来治疗各种疾病和病症的式（I）的杂环化合物。本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症败血症; 败血性休克中毒性休克综合征由于HIV-1介导的感染和疾病引起的发热和肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒; 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

4. 发明申请

WO2007004041A2 NEW COMPOUNDS AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：新化合物及其药物用途
公开(公告)号：WO2007004041A2
公开(公告)日：2007-01-11
申请号：PCT/IB2006/001843
申请日：2006-07-04
申请人： ORCHID RESEARCH LABORATORIES LIMITED , SHARMA, Ganapavarapu, Veera, Raghava , NARAYANAN, Sukunath , THIRUNAVUKKARASU, Saravanan , NAGALAKSHMI, Pichika , RAJAGOPAL, Sriram , KAMARAJ, Mani
发明人： SHARMA, Ganapavarapu, Veera, Raghava , NARAYANAN, Sukunath , THIRUNAVUKKARASU, Saravanan , NAGALAKSHMI, Pichika , RAJAGOPAL, Sriram , KAMARAJ, Mani
IPC分类号： C07D403/08
CPC分类号： C07D403/06 , C07D401/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel compounds of the general formula (I), their analogs, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel compounds of the general formula (I).
摘要翻译：本发明涉及通式（I）的新化合物，它们的类似物，它们的立体异构体，它们的多晶型物，它们的水合物，它们的溶剂合物，其药学上可接受的盐和组合物。本发明更具体地提供了通式（I）的新化合物。

5. 发明申请

WO2007007161A2 NOVEL BIO-ACTIVE DERIVATIVES 审中-公开
标题翻译：新型生物活性衍生物
公开(公告)号：WO2007007161A2
公开(公告)日：2007-01-18
申请号：PCT/IB2006/001895
申请日：2006-07-10
申请人： ORCHID RESEARCH LABORATORIES LIMITED , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , NATARAJAN, Manikandan , KOPPOLU, Kesavan
发明人： TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , NATARAJAN, Manikandan , KOPPOLU, Kesavan
IPC分类号： C07D239/54 , A61K31/513
CPC分类号： C07D239/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D413/06 , C07D417/12
摘要： The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel compounds of the general formula (I).
摘要翻译：本发明涉及通式（I）的新化合物，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的水合物，它们的溶剂化物，它们的药学上可接受的盐和含有它们的药学可接受组合物本发明更具体地提供了通式（I）的新型化合物。

6. 发明申请

WO2007083182A2 NOVEL HETEROCYCLES 审中-公开
标题翻译：新颖的杂项
公开(公告)号：WO2007083182A2
公开(公告)日：2007-07-26
申请号：PCT/IB2006/003468
申请日：2006-12-01
申请人： ORCHID RESEARCH LABORATORIES LIMITED , SRINIVAS, Visweswara, Akella, Staya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , THIRUNAVUKKARASU, Sappanimuthu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARSIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , REEDY, Gaddam, Om , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan
发明人： SRINIVAS, Visweswara, Akella, Staya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , THIRUNAVUKKARASU, Sappanimuthu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARSIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , REEDY, Gaddam, Om , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan
IPC分类号： C07D233/96
CPC分类号： C07D239/42 , C07D213/30 , C07D239/32 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和组合物，代谢物和前药。本发明更具体地提供了新的通式（I）的杂环。还包括治疗免疫性疾病，炎症，疼痛病症，类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤; uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊椎炎; 痛风性关节炎; 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎; 过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症; 败血症; 感染性休克; 中毒性休克综合症发热和由于哺乳动物感染引起的肌痛，包括施用有效量的如上所述的式（I）化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式