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1. 发明申请

WO2012119203A1 GENE EXPRESSION AND ERADICATION SYSTEM IN HELICOBACTER PYLORI 审中-公开
标题翻译： HELICOBACTER PYLORI的基因表达和排除系统
公开(公告)号：WO2012119203A1
公开(公告)日：2012-09-13
申请号：PCT/AU2012/000245
申请日：2012-03-09
申请人： ONDEK PTY LTD , BENGHEZAL, Mohammed , DEBOWSKI, Aleksandra Weronika , SEHNAL, Miriam , DIEYE, Yakhya , PARK, Se-Hoon , MARSHALL, Barry
发明人： BENGHEZAL, Mohammed , DEBOWSKI, Aleksandra Weronika , SEHNAL, Miriam , DIEYE, Yakhya , PARK, Se-Hoon , MARSHALL, Barry
IPC分类号： C12N15/74 , A61K35/74
CPC分类号： C12N15/74 , A61K2035/11
摘要： The present invention relates to a gene expression and eradication system for Helicobacter pylori ( H. pylori ). In particular, the present invention relates to a genetic construct comprising, in the 5'-3' direction: (a) a promoter sequence and (b) a DNA sequence of interest, wherein the promoter sequence comprises a polynucleotide sequence capable of regulating expression of the DNA sequence of interest in Helicobacter pylori and wherein said promoter sequence is modified to comprise a tetracycline (tet) operator sequence.
摘要翻译：本发明涉及幽门螺杆菌（H.pylori）的基因表达和根除系统。特别地，本发明涉及包含在5'-3'方向上的（a）启动子序列和（b）感兴趣的DNA序列的遗传构建体，其中启动子序列包含能够调节表达的多核苷酸序列的幽门螺杆菌感兴趣的DNA序列，其中所述启动子序列被修饰为包含四环素（tet）操纵子序列。

2. 发明申请

WO2010148459A1 SYNTHETIC OPERON 审中-公开
标题翻译：合成操作
公开(公告)号：WO2010148459A1
公开(公告)日：2010-12-29
申请号：PCT/AU2010/000806
申请日：2010-06-25
申请人： ONDEK PTY LTD , BENGHEZAL, Mohammed , DIEYE, Yakhya , SCHWANN, Carola , SEHNAL, Miriam , FULURIJA, Alma , MARSHALL, Barry
发明人： BENGHEZAL, Mohammed , DIEYE, Yakhya , SCHWANN, Carola , SEHNAL, Miriam , FULURIJA, Alma , MARSHALL, Barry
IPC分类号： C12N15/09 , C12N15/62 , A61P37/02 , C12N15/74
CPC分类号： C12N15/68 , C12N9/80 , C12N15/52 , C12N15/74 , C12Y305/01005
摘要： The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.
摘要翻译：本发明涉及合成操纵子。特别地，本发明涉及用于整合到细菌细菌染色体中的合成操纵子，其包含与至少两个基因可操作地连接的启动子，其中至少一个基因是目的基因，并且至少一个基因是基因对所述细菌至关重要。

3. 发明申请

WO2010139018A1 NOVEL STRAINS OF HELICOBACTER PYLORI AND USES THEREOF 审中-公开
标题翻译： HELICOBACTER PYLORI的新颖菌株及其用途
公开(公告)号：WO2010139018A1
公开(公告)日：2010-12-09
申请号：PCT/AU2010/000689
申请日：2010-06-03
申请人： ONDEK PTY LTD , BENGHEZAL, Mohammed , FULURIJA, Alma , LU, Wei , NILSSON, Hans-Olof , MARSHALL, Barry
发明人： BENGHEZAL, Mohammed , FULURIJA, Alma , LU, Wei , NILSSON, Hans-Olof , MARSHALL, Barry
IPC分类号： C12N1/20 , G01N33/48
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/52
摘要： The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
摘要翻译：本发明涉及可用于递送生物活性剂的幽门螺杆菌菌株。特别地，本发明提供了幽门螺杆菌的分离菌株，其具有：（a）低致病性; （b）自然转化的能力; 和（c）没有宿主适应的定殖小鼠胃粘膜的能力。

4. 发明申请

WO2011160182A1 MEANS OF CONTROLLING INFECTION PERSISTENCE OF HELICOBACTER PYLORI 审中-公开
标题翻译：控制HELICOBACTER PYLORI感染持续性的手段
公开(公告)号：WO2011160182A1
公开(公告)日：2011-12-29
申请号：PCT/AU2011/000771
申请日：2011-06-24
申请人： ONDEK PTY LTD , BENGHEZAL, Mohammed , SCHOEP, Tobias , FULURIJA, Alma , BERG, Doug , MARSHALL, Barry
发明人： BENGHEZAL, Mohammed , SCHOEP, Tobias , FULURIJA, Alma , BERG, Doug , MARSHALL, Barry
IPC分类号： C12N1/21 , A61K39/02
CPC分类号： A61K39/105 , A61K2039/522 , C12N1/36 , C12N9/80 , C12Y305/01005 , Y02A50/412 , Y02A50/466 , Y02A50/467
摘要： The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori) . In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
摘要翻译：本发明涉及一种控制幽门螺杆菌（幽门螺杆菌）感染持久性的方法。特别地，本发明涉及一种分离的经遗传修饰的幽门螺杆菌，其包含功能性脲酶，其中SEQ ID NO：1的氨基酸529和氨基酸555之间的连续氨基酸序列被改变以产生所述修饰的幽门螺杆菌无法建立或维持持续感染。

5. 发明申请

WO2014201525A1 IMMUNOTHERAPY COMPOSITION AND USE THEREOF 审中-公开
标题翻译：免疫组织化学及其用途
公开(公告)号：WO2014201525A1
公开(公告)日：2014-12-24
申请号：PCT/AU2014/050087
申请日：2014-06-20
申请人： ONDEK PTY LTD
发明人： BENGHEZAL, Mohammed , MARSHALL, Barry , FULURIJA, Alma , WALTON, Senta
IPC分类号： A61K35/74 , A61K39/02 , A61P11/06 , A61P37/08
CPC分类号： A61K39/35 , A23L33/135 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0073 , A61K9/20 , A61K35/74 , A61K39/105 , A61K39/36 , A61K2039/521 , A61K2039/523 , A61K2039/542 , A61K2039/544 , A61K2039/545 , A61K2039/55 , A61K2039/57 , A61K2039/575 , A61K2039/58
摘要： The present invention relates to the field of preventing or reducing incidence or severity of an allergic immune response, and compositions for preventing or reducing incidence or severity of an allergic immune response. For example, the present invention provides compositions comprising inactivated and/or killed cells of Helicobacter pylori or a cell lysate thereof, and methods and/or uses thereof for delaying or preventing or interrupting or slowing onset of one or more allergic conditions in a subject.
摘要翻译：本发明涉及预防或减少过敏性免疫应答的发生率或严重程度的领域，以及用于预防或降低过敏性免疫应答的发生率或严重程度的组合物。例如，本发明提供包含幽门螺杆菌的灭活和/或杀死细胞或其细胞裂解物的组合物，以及用于延迟或预防或阻止或减缓受试者中一种或多种过敏症状发作的方法和/或用途。

6. 发明申请

WO2007026128A2 COMPUTER APPARATUS 审中-公开
标题翻译：电脑装置
公开(公告)号：WO2007026128A2
公开(公告)日：2007-03-08
申请号：PCT/GB2006/003165
申请日：2006-08-24
申请人： COJAC LIMITED , JACKSON, Rodney , MARSHALL, Barry
发明人： JACKSON, Rodney , MARSHALL, Barry
IPC分类号： G06F3/033
CPC分类号： G06F3/0354 , G06F3/03543 , G06F2203/0333
摘要： A computer input apparatus, comprising: a base provided with a socket; a ball segment located in the socket and rotatable in the socket, the ball segment being shaped to support a wrist of a user; a handle attached to and extending away from the ball segment and configured such that when the user's wrist is supported by the ball segment, the handle is adjacent to the user's hand and maybe held by the user.
摘要翻译：一种计算机输入装置，包括：设置有插座的基座; 位于所述插座中并可在所述插座中旋转的球段，所述球段被成形为支撑使用者的手腕; 手柄附接到球部并且远离球段延伸，并且构造成使得当用户的手腕被球段支撑时，手柄与用户的手相邻并且可能被使用者握住。

7. 发明申请

WO2004111265A1 A KIT FOR THE DETECTION OF UREASE 审中-公开
标题翻译：用于检测UREASE的工具包
公开(公告)号：WO2004111265A1
公开(公告)日：2004-12-23
申请号：PCT/AU2004/000731
申请日：2004-05-31
申请人： TRI-MED INTERNATIONAL PTY LTD , MARSHALL, Barry , MENDIS, Arundi
发明人： MARSHALL, Barry , MENDIS, Arundi
IPC分类号： C12Q1/58
CPC分类号： C12Q1/58 , C12Q1/04 , G01N2333/205
摘要： The present invention relates to a kit for the detection of an agent in a sample by a chemical reaction comprising a labile reagent. In particular, the present invention relates to a kit for the detection of the presence of urease in a sample comprising dried labile urea, non-labile reagent(s) and an indicator, wherein the urea is provided separately to the non-labile reagent(s). The kit may be used to detect the presence of Helicobacter pylori in a sample or to diagnose peptide ulcers.
摘要翻译：本发明涉及一种用于通过包含不稳定试剂的化学反应来检测样品中的试剂的试剂盒。特别地，本发明涉及用于检测包含干燥的不稳定尿素，非不稳定试剂和指示剂的样品中脲酶存在的试剂盒，其中将尿素分开提供给非不稳定试剂（ S）。试剂盒可用于检测样品中幽门螺杆菌的存在或诊断肽溃疡。

8. 发明申请

WO2003093580A1 RAILWAY RAIL FASTENING CLIP 审中-公开
标题翻译：铁路固定夹
公开(公告)号：WO2003093580A1
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001480
申请日：2003-04-04
申请人： PANDROL LIMITED , MARSHALL, Barry , SOMERSET, Martin
发明人： MARSHALL, Barry , SOMERSET, Martin
IPC分类号： E01B9/30
CPC分类号： E01B9/303 , E01B9/483
摘要： In a resilient railway rail fastening clip (9) comprising firstly a substantially straight first portion (1), then a bent second portion (2), then a substantially straight third portion (3) the axis of which makes an angle substantially more than 45° with the axis of the first portion (1), the two axes lying in the same plane as one another, then a fourth portion (4) which is a reverse bend, then a fifth portion (5), then a sixth portion (6) which is another reverse bend and finally a seventh portion (7), the first portion (1) is formed so as to comprise a region (1B) having a generally cylindrical surface extending along its entire length and a longitudinally-extending part (1A) having a surface which is less convex than the generally cylindrical surface region (1B) of the first portion (1). At least part of the second portion (2) and at least part of the third portion (3) are preferably manufactured with substantially flat surfaces (2A, 3A) on respective lateral regions thereof which contact the rail when the clip (9) is in use.
摘要翻译：在弹性的铁路轨道紧固夹（9）中，首先包括基本上直的第一部分（1），然后是弯曲的第二部分（2），然后是基本上直的第三部分（3），其轴线基本上大于45° °与第一部分（1）的轴线相同，两个轴彼此相同的平面，然后是第四部分（4），其是反向弯曲的，然后是第五部分（5），然后是第六部分 6），其是另一个反向弯曲部分，最后是第七部分（7），第一部分（1）形成为包括具有沿其整个长度延伸的大致圆柱形表面的区域（1B）和纵向延伸部分 1A）具有比第一部分（1）的大致圆柱形表面区域（1B）更小的表面。第二部分（2）的至少一部分和第三部分（3）的至少一部分优选地在夹子（9）处于其中的与其相接触的横向区域上具有基本平坦的表面（2A，3A）使用。

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