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1. 发明申请

WO2010058572A1 METHODS FOR DIAGNOSING OR TREATING PROSTATE CANCER 审中-公开
标题翻译：用于诊断或治疗前列腺癌的方法
公开(公告)号：WO2010058572A1
公开(公告)日：2010-05-27
申请号：PCT/JP2009/006201
申请日：2009-11-18
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TSUNODA, Takuya
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TSUNODA, Takuya
IPC分类号： C12N15/09 , A61K31/713 , A61K48/00 , A61P35/00 , C12N15/113 , C12Q1/68 , G01N33/15
CPC分类号： C12Q1/6886 , C12N15/1136 , C12N2310/14 , C12N2310/531 , C12Q2600/112 , C12Q2600/136 , G01N33/57434 , G01N2500/04
摘要： The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer. Moreover, the present invention provides double-stranded molecules targeting the STC2 gene, which are suggested to be useful in the treatment of cancer. The compositions and methods of the present invention find particular applicability to prostate cancer, more specifically, castration-resistant prostate cancer and aggressive prostate cancer.
摘要翻译：本发明提供了通过确定STC2基因的表达水平来检测和/或诊断癌症的方法。发现该基因能够将癌细胞与正常细胞区分开来。此外，本发明提供筛选用于治疗癌症的治疗剂的方法，用于治疗癌症的方法。此外，本发明提供靶向STC2基因的双链分子，其被认为可用于治疗癌症。本发明的组合物和方法特别适用于前列腺癌，更具体地说，抗阉割抗性前列腺癌和侵袭性前列腺癌。

2. 发明申请

WO2010023855A1 C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译： C12ORF48作为癌症治疗和诊断的靶基因
公开(公告)号：WO2010023855A1
公开(公告)日：2010-03-04
申请号：PCT/JP2009/004020
申请日：2009-08-21
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TOGASHI, Akira
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TOGASHI, Akira
IPC分类号： C12N15/09
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57438 , G01N33/57484 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them.
摘要翻译：本文描述了用于诊断发展胰腺癌和前列腺癌，特别是胰腺导管腺癌（PDAC）和去势抗性前列腺癌的倾向的客观方法。在一个实施方案中，诊断方法包括使用靶向C12ORF48基因的siRNA确定C12ORF48的表达水平的步骤。本发明还包括诸如siRNA的产物以及含有它们的组合物。本发明还提供筛选用于治疗C12ORF48相关疾病（例如癌症）的治疗剂的方法。胰腺癌和前列腺癌，以及抑制细胞生长和治疗或减轻一种或多种疾病症状的方法。本发明还包括诸如双链分子的产物，以及含有它们的载体和组合物。

3. 发明申请

WO2005090398A1 GENES AND POLYPEPTIDES RELATING TO PROSTATE CANCERS 审中-公开
标题翻译：与前列腺癌相关的基因和多肽
公开(公告)号：WO2005090398A1
公开(公告)日：2005-09-29
申请号：PCT/JP2005/004860
申请日：2005-03-11
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5011 , G01N33/57434
摘要： The present application provides novel human gene CCDC4 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
摘要翻译：本申请提供了新的人基因CCDC4，其表达在前列腺癌中显着升高。由该基因编码的基因和多肽可用于例如前列腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻前列腺癌的细胞生长。

4. 发明申请

WO2010023856A1 PANCREATIC CANCER RELATED GENE TTLL4 审中-公开
标题翻译：胰腺癌相关基因TTLL4
公开(公告)号：WO2010023856A1
公开(公告)日：2010-03-04
申请号：PCT/JP2009/004031
申请日：2009-08-21
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TOGASHI, Akira
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , TOGASHI, Akira
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/57438 , C12N9/93 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y603/02025
摘要： The present invention relates to the roles played by TTLL4 genes in pancreatic cancer carcinogenesis and features a method for treating or preventing pancreatic cancer by administering a double-stranded molecule against one or more of the TTLL4 genes or a composition, vector or cell containing such a double stranded molecule. Also, disclosed are methods of identifying compounds for treating and preventing pancreatic cancer, using as an index their effect on the over-expression of TTLL4 in the pancreatic cancer cell.
摘要翻译：本发明涉及TTLL4基因在胰腺癌发生中的作用，其特征在于通过对一种或多种TTLL4基因施用双链分子或含有这样一种或多种的TTLL4基因的组合物，载体或细胞来治疗或预防胰腺癌的方法双链分子。此外，公开了鉴定用于治疗和预防胰腺癌的化合物的方法，其作为对胰腺癌细胞中TTLL4的过表达的影响的指标。

5. 发明申请

WO2007013360A3 PANCREATIC CANCER RELATED GENE CST6 AND GABRP 审中-公开
公开(公告)号：WO2007013360A3
公开(公告)日：2007-02-01
申请号：PCT/JP2006/314444
申请日：2006-07-14
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C12N15/11 , C12Q1/68 , G01N33/574
摘要： Objective methods of detecting and diagnosing pancreatic cancer (PDAC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of CST6 or GABRP that discriminates between PDAC cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

6. 发明申请

WO2008020596A2 TREATING OR PREVENTING CANCERS OVER-EXPRESSING REG4 OR KIAA0101 审中-公开
标题翻译：治疗或预防癌症超过REG4或KIAA0101
公开(公告)号：WO2008020596A2
公开(公告)日：2008-02-21
申请号：PCT/JP2007/065873
申请日：2007-08-08
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C12N15/11 , A61K31/7088 , A61K39/395 , C07K16/32 , C07K14/475 , A61K38/00 , A61P35/00 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/1135 , A61K38/00 , C07K14/47 , C07K16/18 , C07K2317/56 , C07K2317/565 , C12N2310/111 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of an siRNA that inhibits expression of REG4 or KIAA0101. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, prostatic cancer cell, breast cancer cell, and bladder cancer cell, particularly pancreatic ductal adenocarcinoma (PDAC) by inhibiting REG4 gene. The present invention also relates to methods of treating or preventing PDAC in a subject comprising the step of administering to said subject a pharmaceutically effective amount of an antibody or fragment thereof that binds to a protein encoded by REG4. The present invention also relates to methods of diagnosing chemo-radiation therapeutic resistance of a cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises polypeptide which comprises QKGIGEFF/SEQ ID NO: 21. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine.
摘要翻译：本发明的特征在于通过使细胞与抑制REG4或KIAA0101表达的siRNA的组合物接触来抑制癌细胞生长的方法。治疗癌症的方法也在本发明的范围内。本发明还包括可用于所提供的方法的产品，包括核酸序列和载体以及包含它们的组合物。本发明还提供通过抑制REG4基因来抑制肿瘤细胞的方法，例如胰腺癌细胞，前列腺癌细胞，乳腺癌细胞和膀胱癌细胞，特别是胰腺导管腺癌（PDAC）。本发明还涉及在受试者中治疗或预防PDAC的方法，其包括向所述受试者施用结合由REG4编码的蛋白质的药学有效量的抗体或其片段的步骤。本发明还涉及诊断癌症的化学放射治疗抗性的方法。本发明还提供了使用多肽治疗癌症的治疗剂或方法。本发明的多肽由包含QKGIGEFF / SEQ ID NO：21的多肽的氨基酸序列组成。本发明的多肽可以通过用转染试剂如多聚精氨酸修饰多肽而导入癌细胞。

7. 发明申请

WO2008018625A2 PROSTATE CANCER RELATED GENE STYK1 审中-公开
标题翻译：前列腺癌相关基因STYK1
公开(公告)号：WO2008018625A2
公开(公告)日：2008-02-14
申请号：PCT/JP2007/065895
申请日：2007-08-08
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C12Q1/68 , A61K39/00 , C12N15/11
CPC分类号： C12Q1/6886 , A61K39/0011 , C12N9/1205 , C12N15/1137 , C12N2310/14 , C12N2310/53 , C12Q2600/136 , C12Y207/10002
摘要： The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer, and methods for vaccinating a subject against cancer. Moreover, the present invention provides siRNAs targeting the STYK1 gene, which are suggested to be useful in the treatment of cancer.
摘要翻译：本发明提供了检测和诊断癌症的方法，该方法涉及确定STYK1基因的表达水平。发现该基因能够将癌细胞与正常细胞区分开来。此外，本发明提供筛选可用于治疗癌症的治疗剂的方法，用于治疗癌症的方法，以及用于接种受试者接种癌症的方法。此外，本发明提供靶向STYK1基因的siRNA，其被认为可用于治疗癌症。

8. 发明申请

WO2004031414A2 METHOD FOR DIAGNOSING PROSTATE CANCER 审中-公开
标题翻译：诊断前列腺癌的方法
公开(公告)号：WO2004031414A2
公开(公告)日：2004-04-15
申请号：PCT/JP2003/012073
申请日：2003-09-22
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
摘要翻译：本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。在一个实施方案中，诊断方法涉及确定区分PRC或PIN与正常细胞的PRC相关基因的表达水平。本发明进一步提供筛选用于治疗PRC和PIN之一或两者的治疗剂的方法，治疗PRC和PIN之一或二者的方法以及针对PRC和PIN之一或二者接种受试者的方法。 / p>

9. 发明申请

WO2009113295A1 C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译： C2ORF18作为靶基因治疗癌症和诊断
公开(公告)号：WO2009113295A1
公开(公告)日：2009-09-17
申请号：PCT/JP2009/001057
申请日：2009-03-10
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： A61K49/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： G01N33/57438 , A61K48/005 , C07K16/303 , C12N15/113 , C12N2310/14 , G01N2500/02
摘要： Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.
摘要翻译：本文描述了用于检测或诊断发展中的癌症，特别是胰腺癌的易感性的客观方法。在一个实施方案中，诊断方法包括使用抗C2orf18抗体确定C2orf18的表达水平的步骤。本发明还提供筛选用于治疗C2orf18相关疾病（例如癌症）的治疗剂的方法。胰腺癌，抑制细胞生长和治疗或缓解其症状的方法。本发明还包括产物，例如多核苷酸，多肽和载体双链分子，抗体，载体和由其组成的组合物。

10. 发明申请

WO2009028521A1 PKIB AND NAALADL2 FOR TARGET GENES OF PROSTATE CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译：前列腺癌治疗和诊断目标基因的PKIB和NAALADL2
公开(公告)号：WO2009028521A1
公开(公告)日：2009-03-05
申请号：PCT/JP2008/065234
申请日：2008-08-20
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , NAKAGAWA, Hidewaki , NAKATSURU, Shuichi
IPC分类号： C12N15/00 , A61K31/70 , A61K48/00 , A61P35/00
CPC分类号： A61K31/70 , A61K48/00 , C07K14/47 , C12N15/113 , C12N2310/111 , C12N2310/14
摘要： The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expresion of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
摘要翻译：本发明的特征在于检测前列腺癌特别是激素难治性前列腺癌（HRPC）或去势抗性前列腺癌（CRPC）的方法，通过检测与正常器官相比较的PKIB或NAALADL2的过表达。还公开了基于前列腺癌中PKIB或NAALADL2的过度表达，PKIB或NAALADL2的细胞增殖功能，PKIB或NAALADL2的细胞内定位或相互作用的鉴定，鉴定用于治疗和预防前列腺癌包括HRPC的化合物的方法 PKIB和PKA-C之间。此外，提供了通过对PKIB或NAALADL2基因施用双链分子来治疗前列腺癌的方法。本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。

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