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1. 发明申请

WO2007047015A3 DIGITAL TIME VARIABLE GAIN CIRCUIT FOR NON-DESTRUCTIVE TEST INSTRUMENT 审中-公开
公开(公告)号：WO2007047015A3
公开(公告)日：2007-04-26
申请号：PCT/US2006/036810
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS, Andrew , BESSER, Steven
发明人： THOMAS, Andrew , BESSER, Steven
IPC分类号： G01N29/36 , G01N29/38 , G01N29/44 , G01N29/46
摘要： In a non-destructive test instrument, there is provided a time variable gain (TVG) amplifier (28) wherein the gain of the amplifier is dynamically changed to optimize the amplitude of a flaw echo signal (11b) The TVG digital memory for a given TVG curve (343) specifies and controls not only the start gain value, and the end game value, but the gain rate of change slope as well to generate TVG curve line segments.

2. 发明申请

WO2007047018A2 ULTRASONIC FAULT DETECTION SYSTEM USING A HIGH DYNAMIC RANGE ANALOG TO DIGITAL CONVERSION SYSTEM 审中-公开
标题翻译：使用高动态范围模拟数字转换系统的超声波故障检测系统
公开(公告)号：WO2007047018A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/036908
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS, Andrew
发明人： THOMAS, Andrew
IPC分类号： G01N29/00
CPC分类号： G01N29/44 , G01N29/043 , G01N29/262 , G01N29/42 , G01N29/4463 , G01N2291/044 , G01N2291/102 , H03M1/188
摘要： A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults.
摘要翻译：用于实现物体的超声波探伤的方法和装置处理在至少三个信号通道中从被测试对象接收的回波信号，其中回波信号沿着每个通道被缩放到不同程度以增加和扩展一个相关的A / D转换器系统，其不需要使用大量模拟高通和低通滤波器和可变增益放大器。这降低了复杂性并避免了性能限制。数模转换器对不同比例的输入信号进行采样，并且选择电路选择从具有最高增益但尚未溢出的模数转换器获得的数字输出的输出。数字输出无缝合并，产生可显示为显示故障位置的扫描显示的输出。

3. 发明申请

WO2007047025A2 ULTRASONIC DETECTION MEASUREMENT SYSTEM USING A TUNABLE DIGITAL FILTER WITH 4X INTERPOLATOR 审中-公开
标题翻译：超声波检测测量系统使用带4X插入式的数字滤波器
公开(公告)号：WO2007047025A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/037110
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS, Andrew , BESSER, Steven , TOOMEY, Jason
发明人： THOMAS, Andrew , BESSER, Steven , TOOMEY, Jason
IPC分类号： G01N29/00
CPC分类号： G01N29/262 , G01N29/043 , G01N29/42 , G01N29/44 , G01N29/4463 , G01N29/449 , G01N2291/044 , G01N2291/102
摘要： An ultrasonic inspection system utilizes a tunable digital filter with 4X interpolation. The system is used for scanning objects to be tested and includes a transmit/receive device to generate a test signal and receive an echo signal. A signal processing circuit processes the echo signal with one or more digital to analog converters for converting an analog version of the echo signal to a digital echo signal in the form of streaming digital data which is stored in a memory. The data is stored at a first data rate and read out at the second, slower data rate. An averaging decimator receives and processes the data from the memory and supplies it to an IIR filter and subsequently to an FIR filter and ultimately to a box car filter to effect processing thereon which increases the perceived resolution of the data by a given factor, preferably by a factor of 4.
摘要翻译：超声波检测系统采用4X插值的可调数字滤波器。该系统用于扫描要测试的对象，并且包括发射/接收装置以产生测试信号并接收回波信号。信号处理电路用一个或多个数模转换器来处理回波信号，用于将回波信号的模拟版本转换成存储在存储器中的流式数字数据形式的数字回波信号。数据以第一数据速率存储，并以第二个较慢的数据速率读出。平均抽取器接收并处理来自存储器的数据并将其提供给IIR滤波器并随后提供给FIR滤波器并且最终提供给盒式汽车滤波器以对其进行处理，从而将数据的感知分辨率提高给定因子，优选地通过一个因素4。

4. 发明申请

WO2009023281A1 A MULTIPLE MODE DIGITIZATION SYSTEM FOR A NON-DESTRUCTIVE INSPECTION INSTRUMENT 审中-公开
标题翻译：非破坏性检查仪器的多模式数字化系统
公开(公告)号：WO2009023281A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/009832
申请日：2008-08-18
申请人： OLYMPUS NDT , DRUMMY, Michael , THOMAS, Andrew , LAQUERRE, Denys , LAROCHELLE, David , LANGLOIS, Pierre , BESSER, Steven
发明人： DRUMMY, Michael , THOMAS, Andrew , LAQUERRE, Denys , LAROCHELLE, David , LANGLOIS, Pierre , BESSER, Steven
IPC分类号： G01R27/28
CPC分类号： G01R19/2509 , G01N29/262 , G01N29/44
摘要： A multiple mode digitization system for a non-destructive inspection instrument which makes use of a multiplexing circuit and a single set of analog to digital converters to efficiently digitize analog test signals from a plurality of inputs. In the preferred embodiment, each of the analog to digital converters in the system is driven with an independent and separate clock signal, allowing for propagation delay compensation among the plurality of test signals as well as interleaved sampling such that custom sampling rates can be used for each input without the need for more than one clock frequency. In an alternate embodiment, phase adjustments on the sampling clocks are used only for interleave sampling, and digital filters are used to provide signal propagation delay compensation.
摘要翻译：一种用于非破坏性检查仪器的多模式数字化系统，其利用多路复用电路和单组模数转换器来有效地数字化来自多个输入的模拟测试信号。在优选实施例中，系统中的每个模数转换器都用独立和分离的时钟信号驱动，允许多个测试信号之间的传播延迟补偿以及交错采样，使得定制采样速率可用于每个输入不需要多于一个时钟频率。在替代实施例中，采样时钟上的相位调整仅用于交织采样，并且使用数字滤波器来提供信号传播延迟补偿。

5. 发明申请

WO2011101304A2 PIPERIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO2011101304A2
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052101
申请日：2011-02-14
申请人： F. HOFFMANN-LA ROCHE AG , BAUMANN, Karlheinz , FLOHR, Alexander , GOETSCHI, Erwin , GREEN, Luke , JOLIDON, Synese , KNUST, Henner , LIMBERG, Anja , LUEBBERS, Thomas , THOMAS, Andrew
发明人： BAUMANN, Karlheinz , FLOHR, Alexander , GOETSCHI, Erwin , GREEN, Luke , JOLIDON, Synese , KNUST, Henner , LIMBERG, Anja , LUEBBERS, Thomas , THOMAS, Andrew
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/4523 , A61P25/28
CPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04
摘要： The invention relates to compounds of formula (I). Hetaryl I is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N; hetaryl II is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, or is a two membered ring system containing 1 to 4 heteroatoms selected from S, O or N, wherein at least one ring is aromatic in nature; R 1 is lower alkyl, lower alkoxy, lower alkyl substituted by halogen, or halogen; R 2 is halogen, lower alkyl, lower alkoxy, hydroxy, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy or benzo[1,3]dioxolyl, or is -(CHR) p -phenyl, optionally substituted by halogen, lower alkyl, lower alkoxy, S(O) 2 -lower alkyl, cyano, nitro, lower alkoxy substituted by halogen, dimethylamino, -(CH 2 )P-NHC(O)O-Iower alkyl, or lower alkyl substituted by halogen, and R is hydrogen, halogen, hydroxy or lower alkoxy, or is cycloalkenyl or cycloalkyl, optionally substituted by hydroxy or lower alkyl substituted by halogen, or is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, which is optionally substituted by halogen, lower alkyl, lower alkoxy or dimethylamino, or is O-phenyl, optionally substituted by halogen, or is heterocycloalkyl, optionally substituted by halogen, hydroxy, lower alkyl substituted by halogen or C(O)O-lower alkyl; R 3 is hydrogen, lower alkyl, cyano or phenyl; R 4 is lower alkoxy, lower alkyl or halogen; p is 0 or 1; n is 0, 1 or 2; if n is 2 then R 4 may be the same or different; m is 0, 1 or 2; if m is 2 then R 1 may be the same or different; o is 0, 1, 2 or 3, if o is 2 or 3 then R 2 may be the same or different; or to pharmaceutically active acid addition salts thereof. The compounds of formula (I) are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
摘要翻译：本发明涉及式（I）的化合物。 Hetary11是含有1至3个选自O，S或N的杂原子的五元或六元杂芳基; 杂芳基II是含有1至3个选自O，S或N的杂原子的五元或六元杂芳基，或者是含有1至4个选自S，O或N的杂原子的二元环体系，其中至少一个环本质上是芳香的; R 1为低级烷基，低级烷氧基，被卤素取代的低级烷基或卤素; R 2是卤素，低级烷基，低级烷氧基，羟基，被卤素取代的低级烷基，被羟基或苯并[1,3]二氧杂环戊烯基取代的低级烷基，或者是 - （CHR）p 低级烷基，低级烷氧基，S（O）2 - 低级烷基，氰基，硝基，被卤素取代的低级烷氧基，二甲基氨基， - （CH 2）（O）O-低级烷基或被卤素取代的低级烷基，且R为氢，卤素，羟基或低级烷氧基，或者为环烯基或环烷基，任选被羟基或低级被卤素取代的烷基，或者是含有1至3个选自O，S或N的杂原子的五元或六元杂芳基，其任选被卤素，低级烷基，低级烷氧基或二甲基氨基取代，或者是O-苯基，任选被卤素取代，或者为任选被卤素，羟基，被卤素取代的低级烷基或C（O）O-低级烷基取代的杂环烷基; R 3是氢，低级烷基，氰基或苯基; R 4是低级烷氧基，低级烷基或卤素; p是0或1; n是0,1或2; 如果n是2，则R 4可以相同或不同; m是0,1或2; 如果m是2，则R 1可以相同或不同; o是0,1,2或3，如果o是2或3，则R 2可以相同或不同; 或其药学活性酸加成盐。式（I）化合物是β-淀粉样蛋白的调节剂，因此它们可用于治疗或预防与β-淀粉状蛋白在脑中沉积相关的疾病，特别是阿尔茨海默氏病和其他疾病，如脑具有淀粉样变性的遗传性脑出血，荷兰型（HCHWA-D），多发性梗塞型痴呆，拳击员痴呆和唐氏综合症。

6. 发明申请

WO2010127978A1 ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS 审中-公开
标题翻译：作为GABA调节剂的异噻唑衍生物
公开(公告)号：WO2010127978A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/055701
申请日：2010-04-28
申请人： F. HOFFMANN-LA ROCHE AG , BUETTELMANN, Bernd , JAKOB-ROETNE, Roland , KNUST, Henner , LUCAS, Matthew C. , THOMAS, Andrew
发明人： BUETTELMANN, Bernd , JAKOB-ROETNE, Roland , KNUST, Henner , LUCAS, Matthew C. , THOMAS, Andrew
IPC分类号： C07D413/12 , C07D413/14 , A61K31/4439 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention is concerned with novel isoxazole derivatives of formula (I) wherein X, R 1 , R 2 , R 3 and R 4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula (I), pharmaceutical compositions containing them and their use as medicaments.
摘要翻译：本发明涉及式（I）的新的异恶唑衍生物，其中X，R 1，R 2，R 3和R 4如本文所述，以及其药学上可接受的盐和酯。本发明的活性化合物对GABA A a5受体具有亲和性和选择性。此外，本发明涉及制备式（I）的活性化合物，含有它们的药物组合物及其作为药物的用途。

7. 发明申请

WO2010127975A1 ISOXAZOLE-PYRAZOLE DERIVATIVES 审中-公开
标题翻译：异噻唑衍生物
公开(公告)号：WO2010127975A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/055694
申请日：2010-04-28
申请人： F. HOFFMANN-LA ROCHE AG , JAKOB-ROETNE, Roland , LUCAS, Matthew, C. , THOMAS, Andrew
发明人： JAKOB-ROETNE, Roland , LUCAS, Matthew, C. , THOMAS, Andrew
IPC分类号： C07D413/12 , C07D413/14 , A61K31/4155 , A61P25/28
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention is concerned with isoxazole-pyrazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及式I的异恶唑 - 吡唑衍生物，其具有对GABA A a5受体的亲和性和选择性，它们的制备，含有它们的药物组合物及其作为药物的用途。本发明的活性化合物可用作认知增强剂或用于治疗和/或预防性治疗认知障碍如阿尔茨海默氏病。

8. 发明申请

WO2010097368A1 ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER 审中-公开
标题翻译：带有乙烯和乙烯基连接的异噻唑/ O-吡啶衍生物
公开(公告)号：WO2010097368A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052224
申请日：2010-02-23
申请人： F. HOFFMANN-LA ROCHE AG , BUETTELMANN, Bernd , LUCAS, Matthew C. , THOMAS, Andrew
发明人： BUETTELMANN, Bernd , LUCAS, Matthew C. , THOMAS, Andrew
IPC分类号： C07D413/06 , A61K31/4439 , A61P25/28
CPC分类号： C07D413/06 , C07D413/14
摘要： The present invention is concerned with novel isoxazole-pyridine derivatives of formula I wherein R 1 , R 2 , R 3 and L are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor.. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as medicaments.
摘要翻译：本发明涉及式I的新的异恶唑 - 吡啶衍生物，其中R 1，R 2，R 3和L如本文所述，以及其药学上可接受的盐和酯。本发明的活性化合物对GABA A a5受体具有亲和性和选择性。此外，本发明涉及制备式I的活性化合物，含有它们的药物组合物及其作为药物的用途。

9. 发明申请

WO2022020553A1 ULTRASONIC TESTING WITH SINGLE SHOT PROCESSING 审中-公开
公开(公告)号：WO2022020553A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042712
申请日：2021-07-22
申请人： THOMAS, Andrew
发明人： THOMAS, Andrew
IPC分类号： G01B17/02 , G01H11/00 , G01N29/22 , G01N29/26 , G01N29/27
摘要： Examples of the present subject matter provide techniques for measuring thicknesses of materials using one or more acquisition cycles. The data from the one or more acquisition cycles may be amplified using a specified gain across the signal response, converted to a digital signal, and stored in a memory. The digital signal may be retrieved from memory, and signal processing techniques using one or more time-variable threshold(s) may be used to calculate one or more thickness(es) of the testing object.

10. 发明申请

WO2012143112A1 SIDE TRIMMING APPARATUS FOR TRIMMING LONGITUDINAL EDGES OF A METAL STRIP 审中-公开
标题翻译：用于裁剪金属条的纵向边的侧面裁剪装置
公开(公告)号：WO2012143112A1
公开(公告)日：2012-10-26
申请号：PCT/EP2012/001634
申请日：2012-04-16
申请人： TATA STEEL UK LIMITED , THAMPI, Praveen Venugopalan , LOGAN, Christopher Ian , STIRLING, Paul Anthony , THOMAS, Andrew , BANFIELD, Carl Kevin , RAGOBAR, Brian Nicholas
发明人： THAMPI, Praveen Venugopalan , LOGAN, Christopher Ian , STIRLING, Paul Anthony , THOMAS, Andrew , BANFIELD, Carl Kevin , RAGOBAR, Brian Nicholas
IPC分类号： B23D33/02
CPC分类号： B23D19/06 , B23D33/02
摘要： The invention relates to a side trimming apparatus (10) for trimming longitudinal edges (22) of a metal strip (18) to provide a trimmed strip having a constant width (d), the apparatus comprising a conveyor means (14) for conveying the metal strip in a machine direction, a trimming means (26) for trimming both longitudinal edges by removing side scrap (30), a steering unit (36) for mutually displacing the strip and the trimming means in a direction perpendicular to the machine direction, a control means (34) for controlling movement of the steering unit, wherein the control means comprise a side scrap width measurement means (32) for measuring the width of either side scrap removed at the trimming means, and a computer means for conversion of width data received from the side scrap width measurement means into steering data for the steering unit.
摘要翻译：本发明涉及一种用于修剪金属条（18）的纵向边缘（22）的侧边修剪装置（10），以提供具有恒定宽度（d）的修剪条带，该装置包括一个输送装置（14）金属条带，用于通过去除侧边废料来修剪两个纵向边缘的修剪装置（26），用于在与机器方向垂直的方向上相互移位条带和修剪装置的转向单元（36）用于控制转向单元的运动的控制装置（34），其中控制装置包括用于测量在修剪装置上移除的任一侧废料的宽度的侧废料宽度测量装置（32）和用于转换宽度的计算机装置从侧面废料宽度测量装置接收的数据转换成转向单元的转向数据。

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