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1. 发明申请

WO1997025073A2 CONTRAST MEDIA 审中-公开
标题翻译：对比媒体
公开(公告)号：WO1997025073A2
公开(公告)日：1997-07-17
申请号：PCT/GB1997000067
申请日：1997-01-09
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , GUNTHER, Wolfgang , KELLAR, Kenneth , FUJII, Dennis, Kiyoshi , DESAI, Vinay , BLACK, Christopher , BEEBER, Marshall , WELLONS, Jennifer , FAHLVIK, Anne, Kjersti , NAEVESTAD, Anne , NA, George , YUAN, Barbara , STEVENS, Jack , WEEKLEY, Brian , ENGELL, Torgrim , GACEK, Michel , LADD, David, Lee , SINGH, Jasbir , BACON, Edward, Richard , McINTIRE, Gregory, Lynn , SNOW, Robert, Alan
发明人： NYCOMED IMAGING A/S
IPC分类号： A61K49/00
CPC分类号： B82Y5/00 , A61K49/049 , A61K49/1842 , A61K49/186 , A61K49/1863
摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.
摘要翻译：本发明涉及用于磁共振成像的造影剂，其包含复合纳米粒子，所述粒子优选包含覆盖有氧化裂解淀粉涂层的超顺磁性氧化铁核，任选地与用于延长造影剂在血液中停留时间的聚环氧烷。

2. 发明申请

WO1997036617A2 METHOD OF T1-WEIGHTED MAGNETIC RESONANCE IMAGING OF RES ORGANS 审中-公开
标题翻译：方法采用T1加权磁共振成像方法
公开(公告)号：WO1997036617A2
公开(公告)日：1997-10-09
申请号：PCT/GB1997000886
申请日：1997-03-27
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , FAHLVIK, Anne, Kjersti
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian
IPC分类号： A61K49/00
CPC分类号： A61K49/186 , A61K49/1863
摘要： The invention provides a method of contrast enhanced MR angiography of the human or non-human animal body, said method comprising administering into the vasculature thereof a contrast effective amount of a contrast agent composition comprising magnetic particles having an r2/r1 ratio of no more than 5, and, at a time when sufficient of said magnetic particles remain in the vasculature to provide positive contrast enhancement thereof in a T1-weighted image while sufficient magnetic particles have been taken up into an organ of the reticuloendothelial system to provide negative contrast enhancement thereof in said T1-weighted image, generating a T1-weighted image magnetic resonance image of at least said organ.
摘要翻译：本发明提供了人或非人动物体的造影增强MR血管造影的方法，所述方法包括向其血管系统施用对比有效量的造影剂组合物，其包含r2 / r1比不超过并且在足够的磁性颗粒保留在脉管系统中以在T1加权图像中提供正对比度增强的时候，同时足够的磁性颗粒被吸收到网状内皮系统的器官中以提供其负对比度增强在所述T1加权图像中，产生至少所述器官的T1加权图像磁共振图像。

3. 发明申请

WO1997029782A1 THERMALLY STABILIZED CONTRAST AGENT 审中-公开
标题翻译：热稳定的对比剂
公开(公告)号：WO1997029782A1
公开(公告)日：1997-08-21
申请号：PCT/GB1997000458
申请日：1997-02-19
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , SWAERD-NORDMO, Marit , GULLIKSEN, Per, Helge , BRAENDEN, Jorunn, Undheim , FAHLVIK, Anne, Kjersti
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian
IPC分类号： A61K49/00
CPC分类号： A61K49/223 , A61K49/227
摘要： This invention relates to a freeze-dried vesicle containing ultrasound contrast agent containing a freeze-drying stabilizer and thermally stable at temperatures in excess of 20 DEG C.
摘要翻译：本发明涉及含有冷冻干燥稳定剂的超声造影剂的冷冻干燥囊泡，并且在超过20℃的温度下热稳定。

4. 发明申请

WO1996009840A1 CONTRAST AGENT 审中-公开
标题翻译：对比代理
公开(公告)号：WO1996009840A1
公开(公告)日：1996-04-04
申请号：PCT/GB1994002097
申请日：1994-09-27
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson , FAHLVIK, Anne, Kjersti , NÆVESTAD, Anne , GUNDERSEN, Helge , STRANDE, Per , KLAVENESS, Jo , JACOBSEN, Anne
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson
IPC分类号： A61K49/00
CPC分类号： A61K51/1258 , A61K49/1854 , A61K49/1863 , A61K49/1872
摘要： The invention relates to particulate contrast agents, especially contrast agents for MR imaging, having a metal oxide, preferably superparamagnetic iron oxide core provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.
摘要翻译：本发明涉及颗粒造影剂，特别是用于MR成像的造影剂，其具有金属氧化物，优选超顺磁性氧化铁芯，其具有选自结构多糖和合成聚合物，特别是聚氨基酸的聚电解质包被剂的低涂层密度。不同于传统的涂层颗粒，新的颗粒对心血管参数，血小板减少，补体活化和血液凝固具有降低或没有影响。

5. 发明申请

WO1997009633A1 A METHOD OF DETERMINING OXYGEN CONCENTRATION IN A SAMPLE 审中-公开
标题翻译：在样品中测定氧气浓度的方法
公开(公告)号：WO1997009633A1
公开(公告)日：1997-03-13
申请号：PCT/GB1996002198
申请日：1996-09-06
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson , ARDENKJAER-LARSEN, Jan, Henrik , LEUNBACH, Ib
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson
IPC分类号： G01R33/62
CPC分类号： A61K49/20 , G01R33/281 , G01R33/62
摘要： A method for determining the oxygen concentration of a sample using electron spin resonance enhanced magnetic resonance imaging.
摘要翻译：使用电子自旋共振增强磁共振成像确定样品的氧浓度的方法。

6. 发明申请

WO1996040274A3 CHELATING POLYMERS AS CONTRAST AGENTS FOR MEDICAL IMAGING 审中-公开
公开(公告)号：WO1996040274A3
公开(公告)日：1996-12-19
申请号：PCT/GB1996001308
申请日：1996-06-03
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian , HOLLISTER, Kenneth, Robert , KELLER, Kenneth, Edmond , WEI, Dong , PENG, Xin , LADD, David, Lee , SNOW, Robert, Allen
IPC分类号： A61K49/00

7. 发明申请

WO1997011683A2 STABILISED PHOSPHOLIPID COMPOSITIONS 审中-公开
标题翻译：稳定的磷脂组合物
公开(公告)号：WO1997011683A2
公开(公告)日：1997-04-03
申请号：PCT/GB1996002364
申请日：1996-09-25
申请人： NYCOMED IMAGING A/S , DAIICHI PHARMACEUTICAL CO., LTD. , COCKBAIN, Julian , DYVIK, Kari , DUGSTAD, Harald , SKURTVEIT, Roald , KLAVENESS, Jo , OSTENSEN, Jonny , YACHI, Kiyoto
发明人： NYCOMED IMAGING A/S , DAIICHI PHARMACEUTICAL CO., LTD. , COCKBAIN, Julian
IPC分类号： A61K09/127
CPC分类号： A61K49/0433 , A61K9/127
摘要： The stability of phospholipid compositions is enhanced by the inclusion of a buffer system comprising ammonia or a water soluble amine having a pH at 15 DEG C of less than or equal to 9.5.
摘要翻译：磷脂组合物的稳定性通过包含氨或包含pH在15℃下的水溶性胺小于或等于9.5的缓冲体系来增强。

8. 发明申请

WO1996028432A1 PROCESS FOR TETRAAZACYCLOALKANE PREPARATION 审中-公开
标题翻译：四氯化碳制剂的制备方法
公开(公告)号：WO1996028432A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000462
申请日：1996-03-01
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , SANDNES, Rolf, Wiggo , VASILEVSKIS, Janis , UNDHEIM, Kjell , GACEK, Michel
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian
IPC分类号： C07D257/02
CPC分类号： C07D257/02
摘要： The present invention provides a synthetic route for tetraazacycloalkane preparation which facilitates heteropoly-N-alkylation of the macrocyclic product, and is thereby beneficial for the production of chelating agents and chelates useful in diagnostic imaging. The process involves (i) reacting a tetraazaalkane with a bridging agent to couple for amine nitrogens of said tetraazaalkane to a bridging moiety to yield a fused tricyclic intermediate, (ii) reacting said intermediate to introduce an alkylene bridge between the secondary amine nitrogens in the outer rings of the fused tricyclic intermediate, optionally be decoupling an alkanediylidene bridging moiety from the tertiary amine nitrogens at the ring fusion sites of the fused tricyclic intermediate, and (iii) where necessary, decoupling said bridging moiety to yield a macrocyclic tetraazacycloalkane.
摘要翻译：本发明提供了促进大环杂多杂-N-烷基化的四氮杂环烷烃制备的合成路线，从而有利于制备可用于诊断成像的螯合剂和螯合物。该方法包括（i）使四氮杂链烷烃与桥连剂反应以将所述四氮杂烷的胺氮偶联至桥连部分以产生稠合的三环中间体，（ii）使所述中间体在仲胺氮中引入亚烷基桥，稠合三环中间体的外环任选地在稠合三环中间体的环融合位点处将烷二亚烷基桥连部分与叔胺氮键分离，和（iii）必要时将所述桥连部分解偶联以产生大环四氮杂环烷烃。

9. 发明申请

WO1995028392A1 CHELANT COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO1995028392A1
公开(公告)日：1995-10-26
申请号：PCT/GB1995000833
申请日：1995-04-12
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , VARADARAJAN, John , WATSON, Alan, David , BERG, Arne
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian
IPC分类号： C07D257/02
CPC分类号： A61K49/06 , C07C237/08 , C07D255/02 , C07D257/02 , C07D259/00 , C07D273/00
摘要： The invention provides amphiphilic compounds of the formula (I) Ch-(-L-Ar-(-AH)n)m (where Ch is a hydrophilic chelant moiety or a salt or a chelate thereof); each L is an optionally oxo substituted C2-25-alkylene linker wherein at least one CH2 moiety is replaced by a group X (e.g. L may include a chain sequence, an X (CH2CH2X )u (where u is a positive integer) such as X CH2CH2X , CH2X CH2CH2X CH2CH2X , CH2X CH2CH2X CH2CH2X CH2CH2X , etc.), and wherein L is optionally interrupted by a metabolizable group M but with the provisos that the terminus of L adjacent Ch is CH2 and that the terminus of L adjacent Ar is X or a CH2 group adjacent or separated by one CH2 from a group X (thus, for example the L-Ar linkage may be L -X -Ar, L -CH2-Ar, L -X CH2-Ar or L -X CH2CH2-Ar, where L is the residue of L; each Ar is an aryl ring optionally substituted by or having fused thereto a further aryl ring; each AH is a protic acid group, preferably an oxyacid, e.g. a carbon, sulphur or phosphorus oxyacid or a salt thereof; each X is O, S, NR or PR , preferably no more than 3 X groups being present in L; each R is hydrogen, alkyl or aryl; and m and n are positive integers, m being for example 1 to 4, especially 1 or 2 and n being for example 1, 2 or 3) which are especially suited for use in diagnostic imaging of the hepatobiliary system.
摘要翻译：本发明提供式（I）Ch - （ - L-Ar - （ - AH）n）m（其中Ch是亲水性螯合剂部分或其盐或螯合物）的两亲化合物; 每个L是任选氧代取代的C2-25-亚烷基接头，其中至少一个CH 2部分被基团X 1取代（例如L可以包括链序列，X 1（CH 2 CH 2 X 1）u（其中u是正整数），例如X 1 CH 2 CH 2 X 1，CH 2 X 1 CH 2 CH 2 X 1 CH 2 CH 2 X 1，CH 2 X 1 CH 2 CH 2 X 1 CH 2 CH 2 X 1 CH 2 CH 2 X 1等），并且其中L任选地被可代谢基团M中断，但条件是邻近Ch的L的末端是CH 2，并且L相邻的Ar的末端是X 1或与一个CH 2相邻或分隔的CH2基团基团X 1（因此，例如L-Ar键可以是L 1 -X 1 -Ar，L 1 -CH 2 -Ar，L 1 -X 1 CH 2 - Ar或L 1 -X 1 CH 2 CH 2 -Ar，其中L 1是L的残基;每个Ar是任选被另外的芳基环取代或与其稠合的芳基;每个AH是质子酸基团，优选含氧酸，例如碳，硫或磷的含氧酸或其盐;每个X 1为O，S，NR 1或PR 1，优选不超过3个X 1为存在于升; 每个R 1是氢，烷基或芳基; m和n为正整数，m为例如1至4，特别是1或2，n为例如1,2或3），其特别适用于肝胆系统的诊断成像。

10. 发明申请

WO1997030736A2 CONTRAST MEDIUM 审中-公开
标题翻译：对比媒介
公开(公告)号：WO1997030736A2
公开(公告)日：1997-08-28
申请号：PCT/GB1997000473
申请日：1997-02-20
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian , RAJAGOPALAN, Natarajan , OSTRANDER, Kevin, Darryl , GUSTOW, Evan , DOTY, Brian , HARNISH, Phillip
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian
IPC分类号： A61K49/04
CPC分类号： A61K49/0404 , A61K49/1806 , A61K49/226
摘要： The invention provides a contrast medium having good lower GI tract coating properties following oral administration. The medium comprises a diagnostically effective amount of a contrast agent together with a viscosity modifier and an osmotic modifier, said modifiers together being present at a weight ratio relative to said agent of at least 1:20.
摘要翻译：本发明提供口服给药后具有良好的较低GI道涂层性质的造影剂。介质包含诊断有效量的造影剂以及粘度调节剂和渗透调节剂，所述改性剂一起以相对于所述药剂的重量比存在至少1:20。

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