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1. 发明申请

WO2012078519A3 3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2 审中-公开
公开(公告)号：WO2012078519A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/063312
申请日：2011-12-05
申请人： NUMERATE, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GRIFFIN, John , RAIMUNDO, Brian , MADRID, Peter , KHOSLA, Chaitan , JIN, Xi , KLOECK, Cornelius
发明人： GRIFFIN, John , RAIMUNDO, Brian , MADRID, Peter , KHOSLA, Chaitan , JIN, Xi , KLOECK, Cornelius
IPC分类号： C07D209/34 , C07D401/12 , C07D401/04 , C07D401/14 , A61K31/403 , A61K31/4725 , A61P25/00
摘要： Provided herein are acylidene oxoindole derivatives, compositions including them, and methods of inhibiting transglutaminase 2 and treating diseases mediated by transglutaminase 2 by administering such derivatives and compositions.

2. 发明申请

WO2018049324A1 MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS 审中-公开
标题翻译：用作GPR120调节剂的单环化合物
公开(公告)号：WO2018049324A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050956
申请日：2017-09-11
申请人： NUMERATE, INC.
发明人： RAIMUNDO, Brian , KOLTUN, Elena S. , GRIFFIN, John , STANGELAND, Eric
IPC分类号： A61K31/4035 , A61K31/423 , C07D261/20
摘要： Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.
摘要翻译：本文提供化合物，包含它们的组合物，以及通过施用此类化合物和组合物来调节GPR120活性和治疗由GPR120介导的疾病的方法。

3. 发明申请

WO2018049328A1 BICYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS 审中-公开
标题翻译：可用作GPR120调节剂的双环化合物
公开(公告)号：WO2018049328A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050964
申请日：2017-09-11
申请人： NUMERATE, INC.
发明人： RAIMUNDO, Brian , KOLTUN, Elena S. , GRIFFIN, John , STANGELAND, Eric
IPC分类号： A61K31/4035 , A61K31/423 , C07D261/20
摘要： Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.
摘要翻译：本文提供化合物，包含它们的组合物，以及通过施用此类化合物和组合物来调节GPR120活性和治疗由GPR120介导的疾病的方法。

4. 发明申请

WO2010028160A1 METHODS FOR THE DETECTION OF CIRCULATING TUMOR CELLS 审中-公开
标题翻译：检测循环肿瘤细胞的方法
公开(公告)号：WO2010028160A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055906
申请日：2009-09-03
申请人： THE SCRIPPS RESEARCH INSTITUTE , KUHN, Peter , GRIFFIN, John , BETHEL, Kelly , MARRINUCCI, Dena
发明人： KUHN, Peter , GRIFFIN, John , BETHEL, Kelly , MARRINUCCI, Dena
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , G01N33/57488 , G01N2800/52
摘要： The present invention provides methods for revealing, detecting, and analyzing circulating tumor cells in the blood of a subject. Revealing detectable circulating tumor cells allows for early stage detection and diagnosis in addition to long term prognosis in subjects with cancer. Additionally, enrichment allows for robust detection and clinically meaningful analysis of low volume samples for use in clinical settings as well as innovative methods for the treatment of cancers.
摘要翻译：本发明提供用于揭示，检测和分析受试者血液中的循环肿瘤细胞的方法。揭示可检测的循环肿瘤细胞除了癌症患者的长期预后之外，还允许进行早期检测和诊断。此外，富集可以对临床环境中使用的低体积样品进行强大的检测和临床意义的分析，以及治疗癌症的创新方法。

5. 发明申请

WO2005115397A2 COMPOSITIONS AND TREATMENTS FOR MODULATING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于调节激酶和/或HMG-COA还原酶的组合物和治疗剂
公开(公告)号：WO2005115397A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/014833
申请日：2005-04-29
申请人： PHARMIX CORPORATION , GRIFFIN, John
发明人： GRIFFIN, John
IPC分类号： A61K31/506
CPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating immuno-compromised and/or cardiovascular conditions in an animal subject by modulating one or more MAP kinase(s) and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of modulators of MAP kinases, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过调节一种或多种MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的免疫受损和/或心血管病症的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶或两者的调节剂的合理设计的方法。

6. 发明申请

WO2013009330A1 WALL-MOUNTABLE VACUUM CLEANER AND BRACKET COMBINATION 审中-公开
标题翻译：可安装的真空清洁器和支架组合
公开(公告)号：WO2013009330A1
公开(公告)日：2013-01-17
申请号：PCT/US2011/049626
申请日：2011-08-30
申请人： SHOP VAC CORPORATION , WOLFE, Melvin, E. , FRY, Kevin , GOTTSCHALL, Jason , GRIFFIN, John
发明人： WOLFE, Melvin, E. , FRY, Kevin , GOTTSCHALL, Jason , GRIFFIN, John
IPC分类号： A47L5/00 , A47L9/00
CPC分类号： A47L5/00 , A47L9/0063
摘要： A new wall-mountable vacuum cleaner and bracket combination provides easy locking. Both the vacuum cleaner and the bracket have mounting rims. When the vacuum cleaner is on the bracket, a support surface on a proximal end of one of the two mounting rims engages a terminal edge of the other of the two mounting rims. The vacuum cleaner can be secured in place by moving a movable arm from an extended position to a retracted position in which the vacuum cleaner is locked in place. To accommodate the required movement of the movable arm, the bracket has a deflectable locking edge that moves between a rest position and a deflected position. In the rest position, the distance between the locking edge and the terminal edge of the bracket mounting rim exceeds the distance between the terminal edge of the vacuum mounting rim and the base surface, but is less than the distance from the terminal edge of the vacuum mounting rim to the part of the vacuum cleaner that lies directly beneath the locking edge when the vacuum cleaner is stored on the bracket.
摘要翻译：一个新的壁挂式真空吸尘器和支架组合提供了方便的锁定。吸尘器和支架都具有安装边缘。当真空吸尘器在支架上时，两个安装轮圈之一的近端上的支撑表面接合两个安装轮圈中另一个的末端边缘。通过将可移动臂从延伸位置移动到缩回位置，真空吸尘器被锁定在适当位置，可以将真空吸尘器固定在适当位置。为了适应可动臂的所需运动，支架具有可偏转的锁定边缘，其在静止位置和偏转位置之间移动。在静止位置，锁定边缘和支架安装边缘的终端边缘之间的距离超过真空安装边缘的终端边缘与基面之间的距离，但小于距离真空终端边缘的距离当真空吸尘器存放在支架上时，将安装边缘安装到真空吸尘器的直接位于锁定边缘下方的部分。

7. 发明申请

WO2007050795A2 TRANSGLUTAMINASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007050795A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041849
申请日：2006-10-25
申请人： ALVINE PHARMACEUTICALS, INC. , PHARMIX CORPORATION , GRIFFIN, John , LANZA, Guido , BOARDMAN, Paul , SPENCER, Andrew
发明人： GRIFFIN, John , LANZA, Guido , BOARDMAN, Paul , SPENCER, Andrew
IPC分类号： A61K31/53 , A61K31/404
CPC分类号： A61K31/404 , A61K31/53
摘要： Transglutaminase inhibitors and methods of use thereof are provided.

8. 发明申请

WO2006016348A1 A METHOD AND SYSTEM FOR GENERATING A SURGICAL TRAINING MODULE 审中-公开
标题翻译：一种用于产生手术训练模块的方法和系统
公开(公告)号：WO2006016348A1
公开(公告)日：2006-02-16
申请号：PCT/IE2005/000081
申请日：2005-08-12
申请人： HAPTICA LIMITED , LACEY, Gerard , RYAN, Donncha, Mary , CASSIDY, Derek , GRIFFIN, John , GRIFFIN, Laurence
发明人： LACEY, Gerard , RYAN, Donncha, Mary , CASSIDY, Derek , GRIFFIN, John , GRIFFIN, Laurence
IPC分类号： G09B7/00
CPC分类号： G09B23/28 , G09B7/00 , G09B9/00
摘要： A system (1) comprises a physical surgical simulator (11) which transmits data concerning physical movement of training devices to an analysis engine (12). The engine (12) automatically generates rules for a rule base (13a) in a learning system (13). The learning system (13) also comprises content objects (13b) and 3D scenario objects (13c). A linked set of a 3D scenario object (13c), a rule base (13a), and a content object (13b) are together a lesson (10). Another simulator (14) is operated by a student. This transmits data concerning physical movement of training devices by a student to a verification engine (15). The verification engine (15) interfaces with the rule base (13a) to display the lesson in the manner defined by the lesson rule base (13a). It calculates performance measures defined in the lesson rule base (13a). It also records the performance measures into a lesson record (18) and it adapts the display of the lesson in line with the parameters defined in the lesson rule base (13a).
摘要翻译：系统（1）包括物理外科模拟器（11），其将关于训练装置的物理运动的数据发送到分析引擎（12）。引擎（12）在学习系统（13）中自动生成规则库（13a）的规则。学习系统（13）还包括内容对象（13b）和3D场景对象（13c）。一个3D场景对象（13c），一个规则库（13a）和一个内容对象（13b）的链接集合在一起（10）。另一个模拟器（14）由学生操作。这将有关学生的训练装置的身体移动的数据发送到验证引擎（15）。验证引擎（15）与规则库（13a）接口以由课程规则库（13a）定义的方式显示课程。它计算课程规则库（13a）中定义的绩效指标。它还将性能测量记录到课程记录（18）中，并且使课程的显示符合课程规则库（13a）中定义的参数。

9. 发明申请

WO2004068371A1 METHOD AND SYSTEM OF MEASURING AND RECORDING USER DATA IN A COMMUNICATIONS NETWORK 审中-公开
标题翻译：在通信网络中测量和记录用户数据的方法和系统
公开(公告)号：WO2004068371A1
公开(公告)日：2004-08-12
申请号：PCT/AU2004/000098
申请日：2004-01-29
申请人： RED SHERIFF LIMITED , GRIFFIN, John , LONG, Mark
发明人： GRIFFIN, John , LONG, Mark
IPC分类号： G06F17/40
CPC分类号： G06Q30/02 , H04L29/06 , H04L67/02 , H04L67/306 , H04L69/329
摘要： A system (2) for measuring and recording user data in a communications network and associating the user data with demographic data of the user, the user being able to access a user computer processing means (6) having browser means (18). The system comprises data processing means (4) for receiving from the browser means a measurement record after the user accesses a part of the network having a portion of measurement code embedded therein. The data processing means determines from the received measurement record whether a survey identified by a survey identifier has been presented to the user. The system further comprises first electronic storage means (12) for receiving survey response data of the user and the measurement record of the user.
摘要翻译：一种用于在通信网络中测量和记录用户数据并将用户数据与用户的人口统计数据相关联的系统（2），用户能够访问具有浏览器装置（18）的用户计算机处理装置（6）。该系统包括数据处理装置（4），用于在用户访问具有嵌入其中的测量码的一部分的网络的一部分之后从浏览器装置接收测量记录。数据处理装置根据所接收的测量记录确定是否向用户呈现由勘测标识符识别的调查。该系统还包括用于接收用户的测量响应数据和用户的测量记录的第一电子存储装置（12）。

10. 发明申请

WO2009120855A1 S-SHAPED INTERSPINOUS PROCESS SPACER HAVING TIGHT ACCESS OFFSET HOOKS 审中-公开
标题翻译： S型形状的间隙工艺间隔件，具有接近偏心钩
公开(公告)号：WO2009120855A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038382
申请日：2009-03-26
申请人： DEPUY SPINE, INC. , REYNOLDS, Martin, A. , GILMAN, Lisa , GRIFFIN, John , SERHAN, Hassan , HAWKINS, John, Riley , KWAK, Seungkyu, Daniel , GRACIA, Mark
发明人： REYNOLDS, Martin, A. , GILMAN, Lisa , GRIFFIN, John , SERHAN, Hassan , HAWKINS, John, Riley , KWAK, Seungkyu, Daniel , GRACIA, Mark
IPC分类号： A61B17/70
CPC分类号： A61B17/7062 , A61B17/7053 , A61B17/7065
摘要： An S-shaped interspinous spacer having a pair of hooks that, upon lateral insertion between opposed spinous process, bear upon the opposed spinous processes.
摘要翻译：具有一对钩的S形棘突间间隔物，其在相对的棘突之间的横向插入时承受相对的棘突。

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