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1. 发明申请

WO2013104540A1 NEW C5A BINDING NUCLEIC ACIDS 审中-公开
标题翻译：新C5A结合核酸
公开(公告)号：WO2013104540A1
公开(公告)日：2013-07-18
申请号：PCT/EP2013/000056
申请日：2013-01-10
申请人： NOXXON PHARMA AG
发明人： HÖHLIG, Kai , VATER, Axel , BUCHNER, Klaus , MAASCH, Christian , KLUSSMANN, Sven
IPC分类号： C12N15/115 , A61K31/7088 , A61P29/00
CPC分类号： C12N15/115 , A61K31/7088 , C07K14/472 , C12N2310/16 , C12N2310/344 , G01N2333/4716 , C12N2310/322 , C12N2310/3531
摘要： The present invention is related to a nucleic acid molecule capable of binding to human C5a, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5' AUGn 1 GGUGKUn 2 n 3 RGGGHUGUKGGGn 4 Gn 5 CGACGCA 3' [SEQ ID NO: 61], wherein n 1 is U or dU, n 2 is G or dG, n 3 is A or dA, n 4 is U or dU, n 5 is U or dU and G, A, U, C, H, K, and R are ribonucleotides, and dU, dG and dA are 2'-deoxyribonucleotides.
摘要翻译：本发明涉及能够结合人C5a的核酸分子，其中核酸分子包含核苷酸中心区，其中核苷酸序列包含5'AUGn1GGUGKUn2n3RGGGHUGUKGGGn4Gn5CGACGCA 3'的核苷酸序列[SEQ ID NO： 61]，其中n1为U或dU，n2为G或dG，n3为A或dA，n4为U或dU，n5为U或dU，G，A，U，C，H，K和R为核糖核苷酸，dU，dG和dA是2'-脱氧核糖核苷酸。

2. 发明申请

WO2012095303A1 NUCLEIC ACID MOLECULE HAVING BINDING AFFINITY TO A TARGET MOLECULE AND A METHOD FOR GENERATING THE SAME 审中-公开
标题翻译：具有结合亲和性的目标分子的核酸分子及其产生方法
公开(公告)号：WO2012095303A1
公开(公告)日：2012-07-19
申请号：PCT/EP2012/000089
申请日：2012-01-10
申请人： NOXXON PHARMA AG , JAROSCH, Florian , KLUSSMANN, Sven , SELL, Simone , PURSCHKE, Werner , MAASCH, Christian , VATER, Axel , HÖHLIG, Kai
发明人： JAROSCH, Florian , KLUSSMANN, Sven , SELL, Simone , PURSCHKE, Werner , MAASCH, Christian , VATER, Axel , HÖHLIG, Kai
IPC分类号： C12N15/11 , C12N15/115
CPC分类号： C12N15/115 , C12N15/102 , C12N15/111 , C12N2310/16 , C12N2310/32 , C12N2320/13 , C12N2330/31 , G01N33/5308 , G01N2400/10 , G01N2500/04
摘要： The present invention is related to a method for generating a nucleic acid molecule capable of binding to a target molecule comprising the following steps: a) providing a reference nucleic acid molecule, wherein the reference nucleic acid molecule is capable of binding to the target molecule and wherein the reference nucleic acid molecule comprises a sequence of nucleotides, wherein the sequence of nucleotides comprises n nucleotides; b) preparing a first level derivative of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule differs from the reference nucleic acid molecule at one nucleotide position, wherein the first level derivative is prepared by replacing the ribonucleotide at the one nucleotide position by a 2'-deoxyribonucleotide in case the reference nucleic acid has a ribonucleotide at the nucleotide position and wherein the first level derivative is prepared by replacing the 2'-deoxyribonucleotide at the one nucleotide position by a ribonucleotide in case the reference nucleic acid has a 2'-deoxyribonucleotide at the nucleotide position and wherein the nucleotide position at which the replacement is made is the modified nucleotide position; and c) repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the group of first level derivatives of the reference nucleic acid molecule consists of n first level derivatives, wherein each of the first level derivatives of the reference nucleic acid molecule differs from the reference nucleic acid molecule by a single nucleotide replacement and wherein each of the first level derivatives of the reference nucleic acid molecule has a single modified nucleotide position which is different from the single modified nucleotide of all of the single modified nucleotide positions of the other first level derivatives of the group of first level derivatives of the reference nucleic acid molecule.
摘要翻译：本发明涉及产生能够结合靶分子的核酸分子的方法，该方法包括以下步骤：a）提供参照核酸分子，其中参考核酸分子能够结合靶分子和其中所述参考核酸分子包含核苷酸序列，其中所述核苷酸序列包含n个核苷酸; b）制备参考核酸分子的一级衍生物，其中参考核酸分子的第一级衍生物在一个核苷酸位置与参考核酸分子不同，其中第一级衍生物通过将核糖核酸在参考核酸在核苷酸位置具有核糖核苷酸的情况下，通过2'-脱氧核糖核苷酸的一个核苷酸位置，并且其中第一级衍生物是通过核糖核苷酸替换核糖核苷酸的2'-脱氧核糖核苷酸而制备的，酸在核苷酸位置具有2'-脱氧核糖核苷酸，其中进行置换的核苷酸位置是修饰的核苷酸位置; 和c）对参考核酸分子的每个核苷酸位置重复步骤b），从而制备参考核酸分子的一级第一级衍生物，其中参考核酸分子的一级衍生物组由n个第一其中参考核酸分子的每个第一级衍生物通过单核苷酸替换与参考核酸分子不同，并且其中参考核酸分子的每个第一级衍生物具有单个修饰的核苷酸位置，其为与参考核酸分子的第一级衍生物组的其他第一级衍生物的所有单一修饰的核苷酸位置的单个修饰的核苷酸不同。

3. 发明申请

WO2011131371A1 LIPID BINDING NUCLEIC ACIDS 审中-公开
标题翻译：脂肪结合核酸
公开(公告)号：WO2011131371A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/002068
申请日：2011-04-21
申请人： NOXXON PHARMA AG , PURSCHKE, Werner , KLUSSMANN, Sven , BUCHNER, Klaus , SCHWÖBEL, Frank , HÖHLIG, Kai
发明人： PURSCHKE, Werner , KLUSSMANN, Sven , BUCHNER, Klaus , SCHWÖBEL, Frank , HÖHLIG, Kai
IPC分类号： C12N15/115 , A61K31/7088
CPC分类号： C12N15/115 , C12N2310/16 , G01N33/92
摘要： The present invention is related to a nucleic acid molecule capable of binding to a lipid.
摘要翻译：本发明涉及能够结合脂质的核酸分子。

4. 发明申请

WO2013104539A1 NUCLEIC ACIDS SPECIFICALLY BINDING CGRP 审中-公开
标题翻译：核酸特异性结合CGRP
公开(公告)号：WO2013104539A1
公开(公告)日：2013-07-18
申请号：PCT/EP2013/000055
申请日：2013-01-10
申请人： NOXXON PHARMA AG
发明人： SCHÜLZCHEN, Simone , PURSCHKE, Werner , JAROSCH, Florian , HÖHLIG, Kai , MAASCH, Christian , KLUSSMANN, Sven
IPC分类号： C12N15/115 , A61K31/7088 , A61P25/06
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/344 , C12N2310/351 , C12N2320/10 , C12N2320/30 , C12Q1/6876 , C12N2310/321 , C12N2310/3531 , C12N2310/322
摘要： The present invention is related to a nucleic acid molecule capable of binding to CGRP, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5 ' HWn 1 n 2 YGGAn 3 An 4 UMn 5 n 6 Yn 7 n 8 n 9 n 10 n 11 Kn 12 Rn 13 ADn 14 n 15 ARn 16 Un 17 Cn 18 n 19 Un 20 n 21 3 ' [SEQ ID NO: 99], wherein H, W, Y, G, A, U, M, B, K, R, D, C are ribonucleotides, and n 1 is R or dG, n 2 is U or dT, n 3 is K or dG, n 4 is C or dC, n 5 is M or dC, n 6 is B or dU, n 7 is N or dG, n 8 is Y or dT, n 9 is N or dC, n 10 is R or dG, n 11 is V or dA, n 12 is K or dT or dU, n 13 is G or dG, n 14 is A or dA, n 15 is U or dT, n 16 is R or dG, n 17 is Y or dC, n 18 is C or dC, n 19 is B or dC, n 20 is C or dC, n 21 is C or dC, and dG, dT, dC, dA and dU are 2'-deoxyribonucleotides.
摘要翻译：本发明涉及能够结合CGRP的核酸分子，其中所述核酸分子包含核苷酸中心区，其中核苷酸序列包含5'端的核苷酸序列，包含5'端的核苷酸序列，其中包含5'端的核苷酸序列，包含5'端， 99，其中H，W，Y，G，A，U，M，B，K，R，D，C为核糖核苷酸，n1为R或dG，n2为U或dT，n3为K或dG，n4 是C或dC，n5是M或dC，n6是B或dU，n7是N或dG，n8是Y或dT，n9是N或dC，n10是R或dG，n11是V或dA，n12是K 或dT或dU，n13为G或dG，n14为A或dA，n15为U或dT，n16为R或dG，n17为Y或dC，n18为C或dC，n19为B或dC，n20为C 或dC，n21为C或dC，dG，dT，dC，dA和dU为2'-脱氧核糖核苷酸。

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