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1. 发明申请

WO02062973A3 LIPASE VARIANTS 审中-公开
标题翻译：脂肪变种
公开(公告)号：WO02062973A3
公开(公告)日：2002-12-27
申请号：PCT/DK0200084
申请日：2002-02-07
申请人： NOVOZYMES AS , MUNK SIGNE , VIND JESPER , BORCH KIM , PATKAR SHAMKANT ANANT , GLAD SANNE O SCHROEDER , SVENDSEN ALLAN
发明人： MUNK SIGNE , VIND JESPER , BORCH KIM , PATKAR SHAMKANT ANANT , GLAD SANNE O SCHROEDER , SVENDSEN ALLAN
IPC分类号： C12N15/09 , C07H21/04 , C11D3/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/00 , C12N9/20 , C12P21/02
CPC分类号： C11D3/38627
摘要： Attaching a peptide extension to the C-terminal amino acid of a lipase re-duces the tendency to form odor. This may lead to lipase variants with a reduced odor generation when washing textile soiled with fat which includes relatively short-chain fatty acyl groups (e.g. up to C8) such as dairy stains containing butter fat or tropical oils such as coconut oil or palm kernel oil.
摘要翻译：将肽延伸到脂肪酶的C末端氨基酸，导致形成气味的倾向。这可能导致脂肪酶变体，当洗涤含有脂肪的纺织品的纺织物（例如高达C8）时，具有减少的气味产生，例如含有黄油脂肪或热带油的椰子油或棕榈仁油。

2. 发明申请

WO02055679A3 THERMOSTABLE LIPOLYTIC ENZYME VARIANT 审中-公开
标题翻译：耐热脂肪酶变体
公开(公告)号：WO02055679A3
公开(公告)日：2003-05-01
申请号：PCT/DK0200016
申请日：2002-01-10
申请人： NOVOZYMES AS , MINNING STEFAN , VIND JESPER , GLAD SANNE O SCHROEDER , DANIELSEN STEFFEN , BORCH KIM
发明人： MINNING STEFAN , VIND JESPER , GLAD SANNE O SCHROEDER , DANIELSEN STEFFEN , BORCH KIM
IPC分类号： C12N15/09 , A21D8/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/20 , D06M16/00 , D21C9/08 , D21H21/02
CPC分类号： C12N9/20
摘要： Lipolytic enzyme variants with improved thermostability are obtained by substituting certain specified amino acid residues in a fungal lipolytic enzyme. The thermostable lipolytic enzyme variants are useful, e.g., for controlling pitch troubles in a process for the production of mechanical pulp or a paper-making process using mechanical pulp.
摘要翻译：通过用真菌脂肪分解酶中的某些特定的氨基酸残基取代具有改善的热稳定性的脂肪分解酶变体。热稳定性脂肪分解酶变体是有用的，例如用于控制用于生产机械纸浆的方法中的沥青混合料或使用机械纸浆的造纸方法。

3. 发明申请

WO0206442A2 CELL-WALL DEGRADING ENZYME VARIANTS 审中-公开
标题翻译：细胞壁降解酶变异
公开(公告)号：WO0206442A2
公开(公告)日：2002-01-24
申请号：PCT/DK0100505
申请日：2001-07-17
申请人： NOVOZYMES AS , GLAD SANNE O SCHROEDER , ANDERSEN CARSTEN , FRANDSEN TORBEN PETER
发明人： SCHUELEIN MARTIN DI , GLAD SANNE O SCHROEDER , ANDERSEN CARSTEN , FRANDSEN TORBEN PETER
IPC分类号： C12N9/88 , C12N
CPC分类号： C12N9/88
摘要： A variant of a cell-wall degrading enzyme having a beta-helix structure, which variant holds at least one substituent in a position determined by identifying all residues potentially belonging to a stack; characterising the stack as interior or exterior; characterising the stack as polar, hydrophobic or aromatic/heteroaromatic based on the dominating characteristics of the parent or wild-type enzyme stack residues and/or its orientation relative to the beta-helix (interior or exterior); optimising all stack positions of a stack either to hydrophobic aliphatic amino acids, hydrophobic aromatic or polar amino acids by allowing mutations within one or all positions to amino acids belonging to one of these groups; measuring thermostability of the variants by DSC or an application-related assay such as a Pad-Steam application test; and selecting the stabilized variants. Variant of a wild-type parent pectate lyase (EC 4.2.2.2) having the conserved amino acid residues D111, D141 or E141, D145, K165, R194 and R199 when aligned with the pectate lyase comprising the amino acid sequence of SEQ ID NO: 2 are preferred.
摘要翻译：具有β-螺旋结构的细胞壁降解酶的变体，该变体保持在通过鉴定潜在属于堆叠的所有残基而确定的位置中的至少一个取代基; 将堆栈表征为内部或外部; 基于母体或野生型酶堆残基的主导特性和/或其相对于β-螺旋（内部或外部）的取向，将所述叠层表征为极性，疏水性或芳族/杂芳族; 通过在属于这些基团之一的氨基酸的一个或所有位置内允许突变将堆叠的所有堆叠位置优化为疏水性脂族氨基酸，疏水性芳族或极性氨基酸; 通过DSC测量变体的热稳定性或应用相关测定，例如Pad-Steam应用测试; 并选择稳定的变体。当与包含SEQ ID NO：1的氨基酸序列的果胶酸裂解酶比对时，具有保守氨基酸残基D111，D141或E141，D145，K165，R194和R199的野生型亲本果胶酸裂合酶（EC 4.2.2.2） 2是优选的。

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