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1. 发明申请

WO2006099871A1 POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：多糖和核酸编码它们
公开(公告)号：WO2006099871A1
公开(公告)日：2006-09-28
申请号：PCT/DK2006/000162
申请日：2006-03-22
申请人： NOVOZYMES A/S , OESTERGAARD, Peter, Rahbek , ANDERSEN, Lene, Nonboe , SEON, Aurelia , SIMOES-NUNES, Carlos , KLÜNTER, Anna-Maria , DE MARIA, Leonardo , CHRISTENSEN, Bjørn, Eggert
发明人： OESTERGAARD, Peter, Rahbek , ANDERSEN, Lene, Nonboe , SEON, Aurelia , SIMOES-NUNES, Carlos , KLÜNTER, Anna-Maria , DE MARIA, Leonardo , CHRISTENSEN, Bjørn, Eggert
IPC分类号： C07K14/32 , C12N9/00 , C12N15/31 , C12N15/52 , A23K1/00
CPC分类号： C07K14/32 , A23K10/18 , A23K20/174 , A23K20/30
摘要： The present invention relates to isolated polypeptides and isolated nucleic acid sequences encoding the polypeptides, as well as methods for producing and using the polypeptides in animal feed. An example of a polypeptide of the invention is the so-called L12 protein from Bacillus licheniformis ATCC 14580 which improves the Feed Conversion Ratio (FCR) and/or acts as a gut microflora modulator. The invention furthermore relates to the probiotic use of strains of Bacillus which produce proteins related to L12.
摘要翻译：本发明涉及编码多肽的分离的多肽和分离的核酸序列，以及在动物饲料中产生和使用多肽的方法。本发明的多肽的实例是来自地衣芽孢杆菌ATCC 14580的所谓的L12蛋白，其改进饲料转化率（FCR）和/或作为肠道微生物调节剂。本发明还涉及产生与L12有关的蛋白质的芽孢杆菌菌株的益生菌用途。

2. 发明申请

WO2004072221A2 PROTEASES 审中-公开
标题翻译：蛋白酶
公开(公告)号：WO2004072221A2
公开(公告)日：2004-08-26
申请号：PCT/DK2004/000090
申请日：2004-02-09
申请人： NOVOZYMES A/S , OESTERGAARD, Peter, Rahbek , DE MARIA, Leonardo
发明人： OESTERGAARD, Peter, Rahbek , DE MARIA, Leonardo
IPC分类号： C12N
CPC分类号： C12N9/58 , A01K2217/05 , C12N9/52 , C12N2310/111
摘要： The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent. Structural features of potential relevance for this effect are also disclosed. This class of proteases includes proteases derived from Brachysporiella gayana, Nocardiopsis dassonvillei subsp. dassonvillei, Nocardiopsis prasina, and Nocardiopsis alba, but excludes the known proteases derived from Metarhizium anisopliae and Nocardiopsis sp. NRRL 18262. The invention also relates to DNA encoding such proteases, the expression thereof in a host cell, includiThe invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent. Structural features of potential relevance for this effect are also disclosed. This class of proteases includes proteases derived from Brachysporiella gayana, Nocardiopsis dassonvillei subsp. dassonvillei, Nocardiopsis prasina, and Nocardiopsis alba, but excludes the known proteases derived from Metarhizium anisopliae and Nocardiopsis sp. NRRL 18262. The invention also relates to DNA encoding such proteases, the expression thereof in a host cell, including animal and plant cells, as well as to the use thereof, e.g. in animal feed and in detergents. In particular, the invention relates to animal feed and animal feed additives, such as premix, incorporating these proteases together with 1-500 ppm Cu (in-feed-concentration).
摘要翻译：本发明涉及肽类家族S2A或S1E的新一类丝氨酸蛋白酶，其在铜（Cu 2+）存在下是稳定的，和/或仅在有限程度上被铜抑制。还揭示了与此相关的结构特征。这类蛋白酶包括衍生自Brachysporiella gayana，Nocardiopsis dassonvillei subsp。的蛋白酶。 dassonvillei，Nocardiopsis prasina和Nocardiopsis alba，但不包括来源于Metarhizium anisopliae和Nocardiopsis sp的已知蛋白酶。本发明还涉及编码这种蛋白酶的DNA，其在宿主细胞中的表达，包括本发明涉及肽类家族S2A或S1E的新一类丝氨酸蛋白酶，其在铜（Cu 2+）和/ 或仅在有限程度上被铜抑制。还揭示了与此相关的结构特征。这类蛋白酶包括衍生自Brachysporiella gayana，Nocardiopsis dassonvillei subsp。的蛋白酶。 dassonvillei，Nocardiopsis prasina和Nocardiopsis alba，但不包括来源于Metarhizium anisopliae和Nocardiopsis sp的已知蛋白酶。本发明还涉及编码这种蛋白酶的DNA，其在宿主细胞中的表达，包括动物和植物细胞，以及其用途，例如，在动物饲料和洗涤剂中。特别地，本发明涉及动物饲料和动物饲料添加剂，例如预混物，将这些蛋白酶与1-500ppm Cu（进料中浓度）一起掺入。

3. 发明申请

WO2011117406A1 THERMOSTABLE PHYTASE VARIANTS 审中-公开
标题翻译：热稳定的植物变种
公开(公告)号：WO2011117406A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054652
申请日：2011-03-25
申请人： NOVOZYMES A/S , DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
发明人： DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
IPC分类号： C12N9/16 , C12N15/82 , C12N15/55 , A01H5/00
CPC分类号： C12N9/16 , A23K20/147 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/75 , A23K50/80 , A23L33/10 , A23L33/15 , A23L33/16 , A23V2002/00 , C12N15/8243 , C12P7/06 , Y02A40/818 , Y02E50/17
摘要： The present invention relates to a phytase which has at least 70% identity to a phytase derived from E. coli and comprises at least one modification as compared to this phytase. These phytase variants have modified, preferably improved,properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及与源自大肠杆菌的植酸酶具有至少70％同一性的植酸酶，并且与该植酸酶相比包含至少一种修饰。这些植酸酶变体具有修饰的，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

4. 发明申请

WO2011117396A2 THERMOSTABLE PHYTASE VARIANTS 审中-公开
标题翻译：热稳定的植物变种
公开(公告)号：WO2011117396A2
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054639
申请日：2011-03-25
申请人： NOVOZYMES A/S , SKOV, Lars Kobberoee , DE MARIA, Leonardo , MATSUI, Tomoko
发明人： SKOV, Lars Kobberoee , DE MARIA, Leonardo , MATSUI, Tomoko
IPC分类号： C12N9/16 , C12N15/82 , C12N15/55 , A01H5/00
CPC分类号： C12N9/96 , A23K10/16 , A23L33/195 , A61K38/46 , C12N9/16 , C12N15/8243 , C12P7/00 , C12P7/14 , C12P21/00 , C12Y301/03008 , C12Y301/03026 , C12Y301/03072
摘要： The present invention relates to a method for producing phytase variants which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least two additional disulfide bonds as compared to this phytase. These phytase variants have modified, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to the variants produced, DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及一种生产植酸酶变体的方法，所述植酸酶变体与来自柠檬酸杆菌（Citrobacter braakii）的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少两个另外的二硫键。这些植酸酶变体具有修饰的，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及所生产的变体，编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

5. 发明申请

WO2009106488A1 METHOD FOR INCREASING EXPRESSION YIELD OF A PROTEIN OF INTEREST 审中-公开
标题翻译：增加蛋白质表达的方法
公开(公告)号：WO2009106488A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052056
申请日：2009-02-20
申请人： NOVOZYMES A/S , HANSEN, Mogens Trier , RAVN, Birthe Marie , DE MARIA, Leonardo
发明人： HANSEN, Mogens Trier , RAVN, Birthe Marie , DE MARIA, Leonardo
IPC分类号： C07K14/38 , C12P21/02
CPC分类号： C12P21/02 , C07K14/38 , C12N15/80
摘要： The present invention relates to a method of producing a protein of interest comprising: (a) cultivating a mutant cell under conditions conducive for production of the protein wherein the mutant has a reduced or no expression of an endogenous polypeptide shown in SEQ ID NO: 2 compared to a parent host cell grown under the same conditions; and optionally (b) recovering the protein of interest.
摘要翻译：本发明涉及产生感兴趣的蛋白质的方法，包括：（a）在有助于产生蛋白质的条件下培养突变细胞，其中突变体具有SEQ ID NO：2所示的内源性多肽的减少或不表达与在相同条件下生长的亲本宿主细胞相比; 和（b）回收目的蛋白质。

6. 发明申请

WO2007112739A1 PHYTASE VARIANTS 审中-公开
公开(公告)号：WO2007112739A1
公开(公告)日：2007-10-11
申请号：PCT/DK2007/000135
申请日：2007-03-19
申请人： NOVOZYMES A/S , DE MARIA, Leonardo , ANDERSEN, Carsten , SKOV, Lars, Kobberoee , SOERENSEN, Mikael, Blom
发明人： DE MARIA, Leonardo , ANDERSEN, Carsten , SKOV, Lars, Kobberoee , SOERENSEN, Mikael, Blom
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A23K20/189 , C12Y301/03
摘要： The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少一个改变。这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

7. 发明申请

WO2013053801A1 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：木糖酶变体和编码它们的多核苷酸
公开(公告)号：WO2013053801A1
公开(公告)日：2013-04-18
申请号：PCT/EP2012/070127
申请日：2012-10-11
申请人： NOVOZYMES A/S , FRIIS, Esben Peter , DE MARIA, Leonardo , VIND, Jesper , POULSEN, Thomas A. , SVENDSEN, Allan , DANIELSEN, Steffen , LENHARD, Rolf T. , FRIIS-MADSEN, Henrik , SKOV, Lars K.
发明人： FRIIS, Esben Peter , DE MARIA, Leonardo , VIND, Jesper , POULSEN, Thomas A. , SVENDSEN, Allan , DANIELSEN, Steffen , LENHARD, Rolf T. , FRIIS-MADSEN, Henrik , SKOV, Lars K.
IPC分类号： C12N9/24
CPC分类号： C12N9/2428 , C12N9/242 , C12P5/002 , C12P5/02 , C12P7/06 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/20 , C12P19/20 , C12P37/00 , C12Y302/01001 , C12Y302/01003 , Y02E50/17
摘要： The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及具有改善的热稳定性的葡糖淀粉酶变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

8. 发明申请

WO2011104339A1 VARIANTS OF A LYSOZYME AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译： LYSOZYME和编码它们的多核苷酸的变体
公开(公告)号：WO2011104339A1
公开(公告)日：2011-09-01
申请号：PCT/EP2011/052812
申请日：2011-02-25
申请人： NOVOZYMES A/S , DE MARIA, Leonardo
发明人： DE MARIA, Leonardo
IPC分类号： C12N9/36 , A23K1/165 , C11D3/386
CPC分类号： C11D3/38636 , A23C19/11 , A23K20/189 , A23L3/3571 , A61K8/66 , A61Q1/04 , A61Q1/06 , A61Q11/00 , A61Q17/005 , A61Q19/00 , C12N9/2462 , C12Y302/01017
摘要： The present invention relates to variant lysozymes. The present invention also relates to polynucleotides encoding the variant lysozymes and to nucleic acid constructs, vectors, and host cells comprising the polynucleotide.
摘要翻译：本发明涉及变体溶菌酶。本发明还涉及编码变体溶菌酶的多核苷酸以及包含多核苷酸的核酸构建体，载体和宿主细胞。

9. 发明申请

WO2011009747A1 CARBOHYDRATE OXIDASES 审中-公开
标题翻译：碳酸氢氧化物
公开(公告)号：WO2011009747A1
公开(公告)日：2011-01-27
申请号：PCT/EP2010/059939
申请日：2010-07-09
申请人： NOVOZYMES A/S , OESTERGAARD, Lars Henrik , DE MARIA, Leonardo
发明人： OESTERGAARD, Lars Henrik , DE MARIA, Leonardo
IPC分类号： C12N9/04 , C12N15/53 , A21D8/04
CPC分类号： C12N9/0006 , A21D8/042
摘要： The present invention relates to carbohydrate oxidases. The present invention also relates to polynucleotides encoding the variant carbohydrate oxidases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes, such as, in preparing dough and dough product compositions.
摘要翻译：本发明涉及碳水化合物氧化酶。本发明还涉及编码变体碳水化合物氧化酶的多核苷酸和包含多核苷酸的核酸构建体，载体和宿主细胞，以及使用变体酶的方法，例如在制备面团和面团产品组合物中。

10. 发明申请

WO2009127702A3 LACCASE VARIANTS 审中-公开
公开(公告)号：WO2009127702A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054554
申请日：2009-04-16
申请人： NOVOZYMES A/S , OESTERGAARD, Lars Henrik , DE MARIA, Leonardo , TOSCANO, Miguel Duarte
发明人： OESTERGAARD, Lars Henrik , DE MARIA, Leonardo , TOSCANO, Miguel Duarte
IPC分类号： C12N9/02 , C11D3/386
摘要： The present invention relates to variants of a parent laccase. The present invention also relates to polynucleotides encoding the variant laccasesand to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.

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