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1. 发明申请

WO2003027246A2 ANTAGONISTS 审中-公开
标题翻译：拮抗剂
公开(公告)号：WO2003027246A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030412
申请日：2002-09-24
申请人： NOVO NORDISK A/S , DGI BIOTECHNOLOGIES , PILLUTLA, Renuka , DEDOVA, Olga , BLUME, Arthur, J. , GOLDSTEIN, Neil, I. , BRISSETTE, Renee , WANG, Pinger , LIU, Hao , HSIAO, Ku-chuan , LENNICK, Michael , FLETCHER, Paul
发明人： PILLUTLA, Renuka , DEDOVA, Olga , BLUME, Arthur, J. , GOLDSTEIN, Neil, I. , BRISSETTE, Renee , WANG, Pinger , LIU, Hao , HSIAO, Ku-chuan , LENNICK, Michael , FLETCHER, Paul
IPC分类号： C12N
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译：公开了能够结合具有激动剂或拮抗剂活性的胰岛素和/或胰岛素样生长因子受体并从各种肽文库鉴定的肽序列。本发明还鉴定至少两个不同的结合位点，其存在于胰岛素和胰岛素样生长因子受体上，并选择性结合本发明的肽。作为激动剂，本发明的肽可用于开发作为补充或替代内源性肽激素的治疗剂。拮抗剂肽也可以开发为治疗剂。

2. 发明申请

WO2003070747A3 INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开
公开(公告)号：WO2003070747A3
公开(公告)日：2003-08-28
申请号：PCT/US2002/030312
申请日：2002-09-24
申请人： NOVO NORDISK A/S , DGI BIOTECHNOLOGIES , PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
发明人： PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
IPC分类号： A61K38/28
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.

3. 发明申请

WO2003070747A2 INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：胰岛素和IGF-1受体激动剂和拮抗剂
公开(公告)号：WO2003070747A2
公开(公告)日：2003-08-28
申请号：PCT/US2002/030312
申请日：2002-09-24
申请人： NOVO NORDISK A/S , DGI BIOTECHNOLOGIES , PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
发明人： PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
IPC分类号： C07K
CPC分类号： C07K14/65 , C07K14/62
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译：公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。拮抗剂也可以作为治疗剂开发。

4. 发明申请

WO2003035839A3 TARGET SPECIFIC SCREENING ANDITS USE FOR IDENTIFYING TARGET BINDERS 审中-公开
公开(公告)号：WO2003035839A3
公开(公告)日：2003-05-01
申请号：PCT/US2002/034021
申请日：2002-10-24
申请人： DGI BIOTECHNOLOGIES, INC. , PILLUTLA, Renuka, C. , BRISSETTE, Renee , SPRUYT, Michael , DEDOVA, Olga , BLUME, Arthur , PRENDERGAST, John , GOLDSTEIN, Neil
发明人： PILLUTLA, Renuka, C. , BRISSETTE, Renee , SPRUYT, Michael , DEDOVA, Olga , BLUME, Arthur , PRENDERGAST, John , GOLDSTEIN, Neil
IPC分类号： C07K19/00
摘要： The present invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages, one comprising a target or target library and the other comprising a target-binder library, and selecting to eliminate the non-paired targets and binders. Also related are complexes comprising target and target binders, as well as antibodies that bind to these complexes. Additionally, the present invention also relates to nucleic acids encoding target and target binders peptides. The invention also relates to the use of the sequence information inherent in the targets and target binders for target validation using in silico approaches. In addition, the invention also relates to diagnostics and therapeutics employing the disclosed target and target binder pepetides or polynucleotides and their use in small molecule drug discovery. In particular, the present invention relates to diagnostic and therapeutic applications directed to cancers and similar disorders and the isolation of small molecule drugs by using the target and target binders to generate site directed assays for high throughput drug screening.

5. 发明申请

WO2003035839A2 TARGET SPECIFIC SCREENING ANDITS USE FOR IDENTIFYING TARGET BINDERS 审中-公开
标题翻译：目标特异性筛选和用于识别目标粘结剂
公开(公告)号：WO2003035839A2
公开(公告)日：2003-05-01
申请号：PCT/US2002/034021
申请日：2002-10-24
申请人： DGI BIOTECHNOLOGIES, INC. , PILLUTLA, Renuka, C. , BRISSETTE, Renee , SPRUYT, Michael , DEDOVA, Olga , BLUME, Arthur , PRENDERGAST, John , GOLDSTEIN, Neil
发明人： PILLUTLA, Renuka, C. , BRISSETTE, Renee , SPRUYT, Michael , DEDOVA, Olga , BLUME, Arthur , PRENDERGAST, John , GOLDSTEIN, Neil
IPC分类号： C12N
CPC分类号： C12N15/1037 , C40B30/04 , C40B40/02 , G01N33/6845 , G01N2333/71
摘要： The present invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages, one comprising a target or target library and the other comprising a target-binder library, and selecting to eliminate the non-paired targets and binders. Also related are complexes comprising target and target binders, as well as antibodies that bind to these complexes. Additionally, the present invention also relates to nucleic acids encoding target and target binders peptides. The invention also relates to the use of the sequence information inherent in the targets and target binders for target validation using in silico approaches. In addition, the invention also relates to diagnostics and therapeutics employing the disclosed target and target binder pepetides or polynucleotides and their use in small molecule drug discovery. In particular, the present invention relates to diagnostic and therapeutic applications directed to cancers and similar disorders and the isolation of small molecule drugs by using the target and target binders to generate site directed assays for high throughput drug screening.
摘要翻译：本发明涉及一种用于检测和鉴定目标和靶标结合物的修饰的噬菌体展示方法。修饰的方法包括用两个单独的噬菌体转化宿主细胞，一个包含靶标或靶标文库，另一个包含靶 - 结合物文库，并选择去除非配对目标和结合物。还涉及包含靶和靶结合物的复合物，以及结合这些复合物的抗体。另外，本发明还涉及编码靶标和靶结合肽的核酸。本发明还涉及在计算机方法中使用目标和目标结合物固有的序列信息进行目标验证。此外，本发明还涉及使用所公开的靶和靶结合物肽或多核苷酸的诊断和治疗及其在小分子药物发现中的用途。特别地，本发明涉及针对癌症和类似病症的诊断和治疗应用以及通过使用靶标和靶标结合物产生用于高通量药物筛选的位点定向测定来分离小分子药物。

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