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2. 发明申请

WO1995002046A1 BORONIC ACID OR BORINIC ACID DERIVATIVES AS ENZYME STABILIZERS 审中-公开
标题翻译：硼酸或硼酸衍生物作为酶稳定剂
公开(公告)号：WO1995002046A1
公开(公告)日：1995-01-19
申请号：PCT/DK1994000249
申请日：1994-06-22
申请人： NOVO NORDISK A/S , BORAX CONSOLIDATED LTD. , NIELSEN, Lone, Kierstein , DEANE-WRAY, Allison
发明人： NOVO NORDISK A/S , BORAX CONSOLIDATED LTD.
IPC分类号： C12N09/96
CPC分类号： C11D3/166 , C11D3/38663 , C12N9/96
摘要： This invention relates to a liquid composition comprising an enzyme and a boronic acid or borinic acid derivative enzyme stabilizer of formula (I), where R1 is an optionally substituted fused aromatic ring structure containing 14 or 18 carbon atoms in the ring, or an optionally substituted monocyclic or fused aromatic heterocyclic ring structure containing up to 17 carbon atoms in the ring, or an optionally substituted monocyclic or fused quinonoid ring structure containing up to 18 carbon atoms in the ring; R2 has formula (II) where X is the same or different and selected from hydrogen, C1-C6 alkyl, substituted C1-C6 alkyl, aryl substituted aryl, hydroxy, hydroxyl derivative, halogen, amine, alkylated amine, amine derivative, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate, an o,p and q may be the same or different and may each be 0, 1 or 2; n and m may be the same or different and may each be 0 or 1; R3 is the same or different as R1 and selected from R1, or R3 is a hydroxyl group, or R1 and R3 are both optionally substituted monocyclic or dicyclic aromatic ring structures.
摘要翻译：本发明涉及包含式（I）的酶和硼酸或硼酸衍生物酶稳定剂的液体组合物，其中R1是在环中含有14或18个碳原子的任选取代的稠合芳环结构，或任选取代的在环中含有至多17个碳原子的单环或稠合芳族杂环结构，或在环中含有至多18个碳原子的任选取代的单环或稠合的醌类环结构; R2具有式（II），其中X相同或不同，选自氢，C1-C6烷基，取代的C1-C6烷基，芳基取代的芳基，羟基，羟基衍生物，卤素，胺，烷基化胺，胺衍生物，硝基，硫醇，硫醇衍生物，醛，酸，酸盐，酯，磺酸盐或膦酸盐，o，p和q可以相同或不同，并且各自可以是0,1或2; n和m可以相同或不同，并且各自可以是0或1; R 3与R 1相同或不同，选自R 1，或R 3为羟基，或R 1和R 3均为任选取代的单环或二环芳环结构。

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