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1. 发明申请

WO2009115572A2 NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF 审中-公开
标题翻译：新型杂环化合物及其用途
公开(公告)号：WO2009115572A2
公开(公告)日：2009-09-24
申请号：PCT/EP2009/053245
申请日：2009-03-19
申请人： NOVARTIS AG , HUANG, Zilin , JIN, Jeff , MACHAJEWSKI, Timothy, D. , ANTONIOS-MCCREA, William, R. , MCKENNA, Maureen , POON, Daniel , RENHOWE, Paul, A. , SENDZIK, Martin , SHAFER, Cynthia, M. , SMITH, Aaron , XU, Yongjin , ZHANG, Qiong
发明人： HUANG, Zilin , JIN, Jeff , MACHAJEWSKI, Timothy, D. , ANTONIOS-MCCREA, William, R. , MCKENNA, Maureen , POON, Daniel , RENHOWE, Paul, A. , SENDZIK, Martin , SHAFER, Cynthia, M. , SMITH, Aaron , XU, Yongjin , ZHANG, Qiong
IPC分类号： C07D401/14
CPC分类号： C07D498/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译：提供了新的取代的杂环化合物，含有它们的组合物以及使用它们抑制Raf激酶活性的方法。新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用以治疗Raf激酶介导的疾病，例如癌症。

2. 发明申请

WO2011161216A1 HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的HETEROARYL化合物和组合物
公开(公告)号：WO2011161216A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060561
申请日：2011-06-23
申请人： NOVARTIS AG , MADERA, Ann Marie , POON, Daniel , SMITH, Aaron
发明人： MADERA, Ann Marie , POON, Daniel , SMITH, Aaron
IPC分类号： C07D417/04 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I): wherein R 1 , R 2 , R 3 , and X are as defined herein. The compounds of Formula (I) and pharmaceutical compositions thereof are useful for the treatment of cancer, and B- Raf-associated diseases.
摘要翻译：本发明提供式（I）的化合物：其中R 1，R 2，R 3和X如本文所定义。式（I）的化合物及其药物组合物可用于治疗癌症和B-Raf相关疾病。

3. 发明申请

WO2007084786A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS 审中-公开
标题翻译：用作PI-3激酶抑制剂的吡嗪衍生物
公开(公告)号：WO2007084786A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001708
申请日：2007-01-22
申请人： NOVARTIS AG , BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia
发明人： BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia , PICK, Teresa , BARSANTI, Paul , IWANOWICZ, Edwin , FANTL, Wendy , HENDRYCKSON, Tom , KNAPP, Mark , MERITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , XIN, Xiahua
IPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

4. 发明申请

WO2012004217A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：循环醚化合物作为激酶抑制剂有用
公开(公告)号：WO2012004217A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061198
申请日：2011-07-04
申请人： NOVARTIS AG , BURGER, Matthew , DING, Yu , HAN, Wooseok , LINDVALL, Mika , NISHIGUCHI, Gisele A. , RICO, Alice , SMITH, Aaron , TANNER, Huw , WAN, Lifeng
发明人： BURGER, Matthew , DING, Yu , HAN, Wooseok , LINDVALL, Mika , NISHIGUCHI, Gisele A. , RICO, Alice , SMITH, Aaron , TANNER, Huw , WAN, Lifeng
IPC分类号： C07D407/04 , C07D407/14 , C07D417/14 , C07D491/04 , A61K31/444
CPC分类号： C07D417/14 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/541 , A61K45/06 , C07D405/14 , C07D407/04 , C07D407/14 , C07D491/04 , A61K2300/00
摘要： The present invention provides a compound of Formula (I): and pharmaceutically acceptable salts thereof, as further described herein. Also provided are formulations comprising compounds of formula I, and a method to use such compounds for treating a disease or condition mediated by Provirus Integration of Maloney Maloney Kinase (PIM Kinase), GSK3, PKC, KDR, PDGFRa, FGFR3, FLT3, or cABL.
摘要翻译：本发明提供如本文进一步描述的式（I）化合物及其药学上可接受的盐。还提供了包含式I化合物的制剂和使用这些化合物治疗由Maloney Maloney激酶（PIM激酶），GSK3，PKC，KDR，PDGFRa，FGFR3，FLT3或cABL的Provirus整合介导的疾病或病症的方法。

5. 发明申请

WO2014151616A1 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS 审中-公开
标题翻译：二胺化合物作为激酶抑制剂
公开(公告)号：WO2014151616A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026107
申请日：2014-03-13
申请人： NOVARTIS AG , AVERSA, Robert , BARSANTI, Paul A. , BURGER, Matthew , DILLON, Michael Patrick , DIPESA, Alan , HU, Cheng , LOU, Yan , NISHIGUCHI, Gisele , PAN, Yue , POLYAKOV, Valery , RAMURTHY, Savithri , RICO, Alice , SETTI, Lina , SMITH, Aaron , SUBRAMANIAN, Sharadha , TAFT, Benjamin , TANNER, Huw , WAN, Lifeng , YUSUFF, Naeem
发明人： AVERSA, Robert , BARSANTI, Paul A. , BURGER, Matthew , DILLON, Michael Patrick , DIPESA, Alan , HU, Cheng , LOU, Yan , NISHIGUCHI, Gisele , PAN, Yue , POLYAKOV, Valery , RAMURTHY, Savithri , RICO, Alice , SETTI, Lina , SMITH, Aaron , SUBRAMANIAN, Sharadha , TAFT, Benjamin , TANNER, Huw , WAN, Lifeng , YUSUFF, Naeem
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D213/74 , C07D213/75 , C07D233/88 , C07D401/04 , C07D401/12 , C07D403/04 , C07D237/20 , C07D405/04 , C07D405/12 , C07D239/42 , C07D241/20
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译：本发明提供了本文所述的式（I）化合物及其盐，以及这些化合物治疗与Raf激酶活性相关的疾病的治疗用途。本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。

6. 发明申请

WO2007095588A1 PI-3 KINASE INHIBITORS AND METHODS OF THEIR USE 审中-公开
标题翻译： PI-3激酶抑制剂及其使用方法
公开(公告)号：WO2007095588A1
公开(公告)日：2007-08-23
申请号：PCT/US2007/062157
申请日：2007-02-14
申请人： NOVARTIS AG , NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
发明人： NI, Zhi-jie , PECCHI, Sabina , BURGER, Matthew , HAN, Wooseok , SMITH, Aaron , ATALLAH, Gordana , BARTULIS, Sarah , FRAZIER, Kelly , VERHAGEN, Joelle , ZHANG, Yanchen , IWANOWICZ, Ed , HENDRICKSON, Tom , KNAPP, Mark , MERRITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , LEGRAND, Darren Mark , BRUCE, Ian , DALE, James , LAN, Jiong , LEVINE, Barry , COSTALES, Abran , LIU, Jie , PICK, Teresa , MENEZES, Daniel
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/5025 , A61K31/428 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译：磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途受体和磷酸酶。

7. 发明申请

WO2003099818A1 SUBSTITUTED QUINAZOLINONE COMPOUNDS 审中-公开
标题翻译：替代喹唑啉酮化合物
公开(公告)号：WO2003099818A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/016442
申请日：2003-05-23
申请人： CHIRON CORPORATION , BOYCE, Rustum, S. , AURRECOECHEA, Natalia , CHU, Daniel , SMITH, Aaron
发明人： BOYCE, Rustum, S. , AURRECOECHEA, Natalia , CHU, Daniel , SMITH, Aaron
IPC分类号： C07D471/04
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译：提供了能够充当MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

8. 发明申请

WO2009114112A2 METHOD AND APPARATUS FOR PRECURSOR DELIVERY SYSTEM FOR IRRADIATION BEAM INSTRUMENTS 审中-公开
标题翻译：用于辐照光束仪器的前驱器传送系统的方法和装置
公开(公告)号：WO2009114112A2
公开(公告)日：2009-09-17
申请号：PCT/US2009/001480
申请日：2009-03-06
申请人： OMNIPROBE, INC. , KRUGER, Rocky , SMITH, Aaron , MOORE, Thomas
发明人： KRUGER, Rocky , SMITH, Aaron , MOORE, Thomas
IPC分类号： C23C16/455 , C23C16/48
CPC分类号： C23C16/4481 , C23C16/45561 , C23C16/48 , C23C16/52 , C23C16/54
摘要： A precursor delivery system for an irradiation beam instrument having a vacuum chamber includes an injection tube (340) for injecting gasses into the vacuum chamber of the instrument and a main gas line (290) having an inlet (295) and an outlet 335). The outlet (335)is connected to the injection tube, (340) and the inlet (295) is connected to a sequential pair of valves (120, 125) connected to a carrier gas source (150). A crucible (190) for holding precursor material is selectively connected to the main gas line (290) at a location between the pair of valves (120, 125) and the injection tube (340). The source (150) of carrier gas may be selectively connected to the inlet (295) by sequential operation of the pair of carrier gas valves (120, 125), so that pulses of carrier gas assist the flow of precursor material to the injection tube (340). Rapid purging of the system between precursors is enabled by a valve (110) selectively connecting the main line (290) to an envelope (300) in communication with the instrument vacuum. Methods of CVD and etching using the system are also disclosed.
摘要翻译：用于具有真空室的照射束仪器的前体输送系统包括用于将气体注入仪器的真空室中的注入管（340）和具有入口（295）和出口335的主气体管线（290）。出口（335）连接到注射管（340），并且入口（295）连接到连接到载气源（150）的顺序一对阀（120,125）。用于保持前体材料的坩埚（190）在一对阀（120,125）和注射管（340）之间的位置处选择性地连接到主气体管线（290）。载气的源（150）可以通过一对载气阀（120,125）的顺序操作选择性地连接到入口（295），使得载气的脉冲帮助前体材料流到注射管（340）。通过选择性地将主线（290）连接到与仪器真空连通的封套（300）的阀门（110）能够快速清洗前体之间的系统。还公开了使用该系统的CVD和蚀刻的方法。

9. 发明申请

WO2004112793A1 GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS 审中-公开
标题翻译：甘氨酸取代的喹唑啉酮化合物作为MC4-R AGONISTS
公开(公告)号：WO2004112793A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/015959
申请日：2004-05-21
申请人： CHIRON CORPORATION , GLAXOSMITHKLINE , BOYCE, Rustum, S. , AURRECOECHEA, Natalia , CHU, Daniel , SMITH, Aaron , CONLEE, Christopher, R. , THOMPSON, Brian, D. , DE ARMAS KUNTZ, Judith , MUSSO, David, L. , BARVIAN, Kevin, K. , THOMSON, Stephen, A. , SWAIN, William, R. , DU, Kien, S. , CHAUDER, Brian, A. , SPEAKE, Jason, D. , BISHOP, Michael, J.
发明人： BOYCE, Rustum, S. , AURRECOECHEA, Natalia , CHU, Daniel , SMITH, Aaron , CONLEE, Christopher, R. , THOMPSON, Brian, D. , DE ARMAS KUNTZ, Judith , MUSSO, David, L. , BARVIAN, Kevin, K. , THOMSON, Stephen, A. , SWAIN, William, R. , DU, Kien, S. , CHAUDER, Brian, A. , SPEAKE, Jason, D. , BISHOP, Michael, J.
IPC分类号： A61K31/517
CPC分类号： C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种小分子，含胍分子。当施用于受试者时，这些化合物可用于治疗MC4-R介导的疾病。这些化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

10. 发明申请

WO2002098273A2 METHOD AND APPARATUS FOR ELECTROMAGNETIC NAVIGATION OF A SURGICAL PROBE NEAR A METAL OBJECT 审中-公开
标题翻译：邻近金属物体外科手术电磁导管的方法与装置
公开(公告)号：WO2002098273A2
公开(公告)日：2002-12-12
申请号：PCT/US2002/017228
申请日：2002-06-03
申请人： SURGICAL NAVIGATION TECHNOLOGIES, INC. , JASCOB, Bradley , SIMON, David , KESSMAN, Paul , SMITH, Aaron
发明人： JASCOB, Bradley , SIMON, David , KESSMAN, Paul , SMITH, Aaron
IPC分类号： A61B
CPC分类号： A61B90/36 , A61B34/20 , A61B2017/00725 , A61B2034/2051 , A61B2034/2072 , A61B2090/0481 , A61B2090/376
摘要： A method and apparatus for electromagnetic navigation of a surgical probe near a metal object. The electromagnetic navigation system includes a transmitter coil array and a shield. The transmitter coil array has a plurality of transmitter coils and is operable to generate the electromagnetic field to navigate the probe. The shield is positioned adjacent the metal object and is operable to shield the metal object from the electromagnetic field generated by the transmitter coil array, such that the field substantially reduces distortion of the electromagnetic field by the metal object.
摘要翻译：一种用于金属物体附近的外科探针（20）的电磁导航的方法和装置。电磁导航系统包括发射器线圈阵列（12）和屏蔽（54）。线圈发射器线圈阵列（12）具有多个发射器线圈（62），并且可操作以产生电磁场以导航探针。屏蔽件位于金属物体附近，并且可操作以将金属物体与发射器线圈阵列产生的电磁场屏蔽，使得屏蔽件（54）基本上减少金属物体的电磁场的变形。

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