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1. 发明申请

WO2007053781A2 COMPOSITIONS WITH ANTIGENS ADSORBED TO CALCIUM PHOSPHATE 审中-公开
标题翻译：磷酸钙吸附抗原的组合物
公开(公告)号：WO2007053781A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/043162
申请日：2006-11-01
申请人： NOVARTIS AG , CONTORNI, Mario , SINGH, Manmohan , O'HAGAN, Derek
发明人： CONTORNI, Mario , SINGH, Manmohan , O'HAGAN, Derek
IPC分类号： C07K14/295 , C12N15/31 , C07K16/12 , A61K39/118
CPC分类号： A61K39/02 , A61K39/095 , A61K2039/55505
摘要： Calcium phosphate is used as an adjuvant, with a high degree of antigen adsorption to the adjuvant. The invention is particularly useful for adjuvanting conjugated capsular saccharide antigens. Buffers, such as phosphate or histidine buffers, can advantageously be used in combination with the calcium phosphate, and compositions may have a pH in the range of 5.5 to 7.5.
摘要翻译：使用磷酸钙作为佐剂，对佐剂高度吸附抗原。本发明对佐剂化偶联的荚膜糖抗原特别有用。缓冲液如磷酸盐或组氨酸缓冲液可以有利地与磷酸钙组合使用，并且组合物可以具有5.5至7.5的pH。

2. 发明申请

WO2009050586A1 MENINGOCOCCAL VACCINE FORMULATIONS 审中-公开
标题翻译： MENINGOCOCCAL VACCINE配方
公开(公告)号：WO2009050586A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/003283
申请日：2008-10-17
申请人： NOVARTIS AG , CONTORNI, Mario , KAZZAZ, Jina , O'HAGAN, Derek , SINGH, Manmohan , UGOZZOLI, Mildred
发明人： CONTORNI, Mario , KAZZAZ, Jina , O'HAGAN, Derek , SINGH, Manmohan , UGOZZOLI, Mildred
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K9/107 , A61K9/19 , A61K2039/55566
摘要： A dual formulation for vaccines against Neisseria meningitidis serogroup B ('Men-B') comprises (i) an oil-in-water emulsion adjuvant and (ii) a Men-B immunogenic component in lyophilised form. The lyophilised Men-B antigens can be reconstituted into liquid adjuvanted form at the time of use ready for administration to a patient. This formulation has been found to give excellent result in terms of both stability and immunogenicity. The lyophilised component can also include one or more conjugated saccharides from N. meningitidis in serogroups A, C, W135 and/or Y.
摘要翻译：针对脑膜炎奈瑟氏球菌血清群B（'Men-B'）的疫苗的双重配方包括（i）水包油乳剂佐剂和（ii）冻干形式的Men-B免疫原性组分。冻干的Men-B抗原可以在使用时重建成液体佐剂形式，准备用于给予患者。已经发现这种配方在稳定性和免疫原性方面都得到了优异的结果。冻干组分还可以包含一种或多种血清群A，C，W135和/或Y中脑膜炎奈瑟氏球菌的共轭糖。

3. 发明申请

WO2010092479A2 INFLUENZA VACCINES WITH REDUCED AMOUNTS OF SQUALENE 审中-公开
标题翻译：具有降低血浆浓度的流感疫苗
公开(公告)号：WO2010092479A2
公开(公告)日：2010-08-19
申请号：PCT/IB2010/000312
申请日：2010-02-10
申请人： NOVARTIS AG , CONTORNI, Mario , O'HAGAN, Derek , GROTH, Nicola
发明人： CONTORNI, Mario , O'HAGAN, Derek , GROTH, Nicola
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/545 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16234
摘要： Influenza vaccines include hemagglutinin from at least one influenza A virus strain and at least one influenza B virus strain. They also include an oil-in-water emulsion adjuvant with submicron oil droplets, comprising squalene. In some embodiments the hemagglutinin concentration is >12μg/ml per strain. In some embodiments the squalene concentration is
摘要翻译：流感疫苗包括来自至少一种甲型流感病毒株和至少一种乙型流感病毒株的血凝素。它们还包括含有亚微米油滴的包含角鲨烯的水包油乳剂佐剂。在一些实施方案中，血凝素浓度为每个菌株>12μg/ ml。在一些实施方案中，角鲨烯浓度<19mg / ml。在一些实施方案中，疫苗是无汞的。在一些实施方案中，疫苗的单位剂量体积在0.2-0.3mL之间。在一些实施方案中，角鲨烯浓度为9.75mg / mL或4.88mg / mL。在一些实施方案中，疫苗包括来自两个甲型流感病毒株和两种乙型流感病毒株的抗原。

4. 发明申请

WO2010067202A2 MIXING LYOPHILISED MENINGOCOCCAL VACCINES WITH NON-HIB VACCINES 审中-公开
标题翻译：用非HIB疫苗混合LYOPHILISED MENINGOCOCCAL VACCINES
公开(公告)号：WO2010067202A2
公开(公告)日：2010-06-17
申请号：PCT/IB2009/007928
申请日：2009-12-11
申请人： NOVARTIS AG , CONTORNI, Mario
发明人： CONTORNI, Mario
IPC分类号： A61K39/095 , A61K39/116 , A61K39/295 , A61P31/04 , A61P31/12
CPC分类号： A61K39/095 , A61K39/12 , A61K39/13 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , C12N2770/32634 , Y02A50/466
摘要： An aqueous immunogen formulation is used to reconstitute a lyophilised component including conjugates of capsular saccharides from Neisseria meningitidis serogroups A, C, W135 and Y, thereby producing a combined vaccine. The aqueous formulation can include various immunogens but does not include a Hib conjugate.
摘要翻译：使用含水免疫原制剂来重建冻干组分，包括脑膜炎奈瑟氏球菌血清群A，C，W135和Y的荚膜糖结合物，从而产生组合疫苗。水性制剂可以包括各种免疫原，但不包括Hib缀合物。

5. 发明申请

WO2013092985A1 STABLE COMPOSITIONS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：稳定的组合物，用于免疫印刷油菜
公开(公告)号：WO2013092985A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/076609
申请日：2012-12-21
申请人： NOVARTIS AG , CONTORNI, Mario , TARLI, Lorenzo , COSLOVI, Anna , SOTGIU, Michele
发明人： CONTORNI, Mario , TARLI, Lorenzo , COSLOVI, Anna , SOTGIU, Michele
IPC分类号： A61K39/085
CPC分类号： A61K39/085
摘要： Adding stabilizing additives to immunogenic compositions is effective in enhancing antigen stability. Suitable stabilizing additives include EDTA (ethylenediaminetetraacetic acid), sucrose, arginine, protease inhibitors, glycerol and/or citrate.
摘要翻译：向免疫原性组合物中加入稳定添加剂对提高抗原稳定性是有效的。合适的稳定添加剂包括EDTA（乙二胺四乙酸），蔗糖，精氨酸，蛋白酶抑制剂，甘油和/或柠檬酸盐。

6. 发明申请

WO2012035519A1 IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2012035519A1
公开(公告)日：2012-03-22
申请号：PCT/IB2011/054069
申请日：2011-09-16
申请人： NOVARTIS AG , BERTI, Francesco , CONTORNI, Mario , COSTANTINO, Paolo , FINCO, Oretta , GRANDI, Guido , MAIONE, Domenico , TELFORD, John
发明人： BERTI, Francesco , CONTORNI, Mario , COSTANTINO, Paolo , FINCO, Oretta , GRANDI, Guido , MAIONE, Domenico , TELFORD, John
IPC分类号： A61K39/385 , A61P31/04
CPC分类号： A61K39/385 , A61K39/092 , A61K47/646 , A61K2039/6037 , A61K2039/627
摘要： The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype la conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype lb conjugated to a carrier protein; and c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein. The invention also provides a method for immunising a patient against infection by GBS comprising the step of administering to the patient a conjugate that is a capsular saccharide from GBS conjugated to a diphtheria toxoid or derivative thereof, wherein the patient has been pre-immunised with a diphtheria toxoid or derivative thereof.
摘要翻译：本发明提供免疫原性组合物，其包含：a）缀合物，其是来自与载体蛋白质缀合的GBS血清型1a的荚膜糖; b）缀合物，其是与载体蛋白缀合的GBS血清型1b的荚膜糖; 和c）缀合物，其是与载体蛋白质缀合的GBS血清型III的荚膜糖。本发明还提供了一种用于免疫患者免受GBS感染的方法，包括向患者施用作为与白喉类毒素或其衍生物缀合的GBS的荚膜糖的缀合物的步骤，其中所述患者已经用白喉类毒素或其衍生物。

7. 发明申请

WO2010067201A2 MIXING LYOPHILISED MENINGOCOCCAL VACCINES WITH D-T-Pa VACCINES 审中-公开
标题翻译：用D-T-Pa疫苗混合LYOPHILISED MENINGOCOCCAL VACCINES
公开(公告)号：WO2010067201A2
公开(公告)日：2010-06-17
申请号：PCT/IB2009/007926
申请日：2009-12-11
申请人： NOVARTIS AG , CONTORNI, Mario
发明人： CONTORNI, Mario
IPC分类号： A61K39/05 , A61K39/095 , A61K39/116 , A61K39/10 , A61P31/04
CPC分类号： A61K39/099 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/095 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , Y02A50/466
摘要： A liquid D-T-Pa component is used to reconstitute a lyophilised meningococcal component, thereby producing a combined vaccine.
摘要翻译：使用液体D-T-Pa组分重构冻干的脑膜炎球菌成分，从而产生组合疫苗。

8. 发明申请

WO2010109323A1 ADJUVANTING MENINGOCOCCAL FACTOR H BINDING PROTEIN 审中-公开
公开(公告)号：WO2010109323A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/000733
申请日：2010-03-24
申请人： NOVARTIS AG , CONTORNI, Mario , TARLI, Lorenzo
发明人： CONTORNI, Mario , TARLI, Lorenzo
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K47/02 , A61K2039/55505 , A61K2039/55583 , A61K2039/6018 , A61K2039/70
摘要： Factor H binding protein (fHBP) has been proposed for use in immunising against serogroup B meningococcus ('MenB'). This antigen can be efficiently adsorbed to an aluminium hydroxyphosphate adjuvant by (i) ensuring that adsorption takes place at a pH which is equal to or below the adjuvant's point of zero charge (PZC), and/or (ii) selecting a fHBP and adjuvant with an isoelectric point/PZC within the range of 5.0 to 7, and/or (iii) selecting a fHBP with an isoelectric point above the adjuvant's PZC and using a buffer to bring the pH to within 1.2 pH units of the PZC. The adsorption is particularly useful for compositions which include multiple fHBP variants, and also in situations where an aluminium hydroxide adjuvant should be avoided. Buffered pharmaceutical compositions can include at least two different meningococcal fHBP antigens, both of which are at least 85% adsorbed to aluminium hydroxyphosphate adjuvant.
摘要翻译：已经提出因子H结合蛋白（fHBP）用于免疫血清群B脑膜炎球菌（'MenB'）。（i）确保在等于或低于佐剂点零点（PZC）的pH下进行吸附，和/或（ii）选择fHBP和佐剂，可以有效地将该抗原吸附到羟基磷酸铝佐剂上等电点/ PZC在5.0至7范围内，和/或（iii）选择具有等电点高于佐剂PZC的fHBP，并使用缓冲液使pH达到PZC的1.2pH单位内。该吸附对于包含多种fHBP变体的组合物以及在应避免使用氢氧化铝佐剂的情况下特别有用。缓冲的药物组合物可以包括至少两种不同的脑膜炎球菌fHBP抗原，两者都至少85％被羟基磷酸羟丙酯佐剂吸附。

9. 发明申请

WO2008149238A2 FORMULATION OF MENINGITIS VACCINES 审中-公开
标题翻译：男性阴道炎的制剂
公开(公告)号：WO2008149238A2
公开(公告)日：2008-12-11
申请号：PCT/IB2008/002121
申请日：2008-06-04
申请人： NOVARTIS AG , CONTORNI, Mario , COSTANTINO, Paolo
发明人： CONTORNI, Mario , COSTANTINO, Paolo
CPC分类号： A61K39/102 , A61K39/02 , A61K39/095 , A61K47/646 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , Y02A50/466 , A61K2300/00
摘要： A liquid Hib component is used to reconstitute a lyophilised meningococcal component, thereby producing a combined meningitis vaccine. A lyophilised meningococcal component can also be reconstituted with an oil-in-water emulsion.
摘要翻译：使用液体Hib组分重建冻干的脑膜炎球菌组分，从而产生组合的脑膜炎疫苗。冻干的脑膜炎球菌成分也可以用水包油乳剂重构。

10. 发明申请

WO2008017956A2 FROZEN STOCKPILING OF INFLUENZA VACCINES 审中-公开
标题翻译：流感疫苗的冷冻库存
公开(公告)号：WO2008017956A2
公开(公告)日：2008-02-14
申请号：PCT/IB2007/002980
申请日：2007-07-20
申请人： NOVARTIS AG , CONTORNI, Mario
发明人： CONTORNI, Mario
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , C12N2760/16134
摘要： A problem with stockpiling influenza vaccines is their short shelf life. Storage volume is another problem. The invention prepares and stockpiles bulk vaccine, and the bulk is stored under frozen conditions. Compared to final vaccine, the higher antigen concentration and absence of packaging materials (boxes, vials, etc.) in the bulk means that the storage space requirements are hugely reduced. A process for preparing an influenza vaccine bulk thus comprises the steps of: (a) preparing bulk vaccine antigen from a source of influenza virus; and (b) storing the bulk vaccine prepared in step (a) under frozen conditions.
摘要翻译：储存流感疫苗的问题是其保质期短。存储量是另一个问题。本发明制备并储存散装疫苗，并且散装物在冷冻条件下储存。与最终疫苗相比，批量中较高的抗原浓度和不含包装材料（包装盒，小瓶等）意味着储存空间要求大大降低。因此，制备流感疫苗批量的方法包括以下步骤：（a）从流感病毒来源制备批量疫苗抗原; 和（b）在冷冻条件下储存步骤（a）中制备的散装疫苗。

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