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2. 发明申请

WO1997020808A1 PROCESS FOR THE PREPARATION OF PESTICIDES 审中-公开
标题翻译：制备农药的方法
公开(公告)号：WO1997020808A1
公开(公告)日：1997-06-12
申请号：PCT/EP1996005215
申请日：1996-11-26
申请人： NOVARTIS AG
发明人： NOVARTIS AG , FAROOQ, Saleem , TRAH, Stephan , ZIEGLER, Hugo , ZURFLÜH, René
IPC分类号： C07C251/60
CPC分类号： C07C249/12 , C07C251/48 , C07C251/60
摘要： The invention relates to a process for the preparation of compounds of formula (I), or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in which A, X, Y, Z, R2, R3, R4, R5, R7, R9 and n are as defined in claim 1 and the C=N double bond marked with E has the E configuration, which comprises: a1) reacting either a compound of formula (II) mentioned in the description with a compound of formula (III) mentioned in the description, in which X1 is a leaving group; or a2) a compound of formula (IV) mentioned in the description, if appropriate in the presence of a base, with a compound of formula (V) mentioned in the description; or b1) reacting a compound of formula (IV) mentioned in the description with a compound of the formula R7-A-X2 (VII), in which X2 is a leaving group, and either further reacting the compound thus obtainable, of formula (IV), for example according to method a2); or b2) reacting it with hydroxylamine or a salt thereof, if appropriate in the presence of a basic or acid catalyst, and further reacting the compound thus obtainable, of formula (II), for example according to method a1); or c) reacting a compound of formula (VIII), mentioned in the description with a C1-C6alkyl nitrite and further reacting the compound thus obtainable, of formula (VI), for example according to method b), the E isomers of the compounds of the formulae (II), (IV) and (VI), a process for their preparation and their use for the preparation of compounds of formula (I).
摘要翻译：本发明涉及一种在游离形式或盐形式中制备式（I）化合物或其合适的互变异构体的方法，其中A，X，Y，Z，R 2， R3，R4，R5，R7，R9和n如权利要求1中所定义，并且用E标记的C = N双键具有E构型，其包括：a1）使描述中提到的式（II）化合物与描述中提及的式（III）的化合物，其中X1是离去基团; 或者a2）在描述中提及的式（IV）化合物，如果合适的话，在碱的存在下与本说明书中提及的式（Ⅴ）化合物反应; 或b1）使本说明书中提到的式（IV）化合物与式R7-A-X2（VII）的化合物反应，其中X 2为离去基团，并进一步使由此得到的式（Ⅴ） IV），例如根据方法a2）; 或b2）如果合适，在碱性或酸性催化剂的存在下，使其与羟胺或其盐反应，并且使由此得到的式（II）化合物，例如根据方法a1）进一步反应。或c）使描述中提及的式（VIII）化合物与亚硝酸C1-C6烷基酯反应，并使由此得到的式（VI）化合物，例如根据方法b）进一步反应，化合物的E异构体的式（II），（IV）和（VI）的化合物，其制备方法及其用于制备式（I）化合物的用途。

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