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1. 发明申请

WO2009012600A1 FUSION PROTEINS 审中-公开
标题翻译：融合蛋白
公开(公告)号：WO2009012600A1
公开(公告)日：2009-01-29
申请号：PCT/CA2008/001384
申请日：2008-07-25
申请人： NOVAGEN HOLDING CORPORATION , WANG, Haitao , DU, Yong , ZHANG, Rui , XU, Jing , LIU, Longbin
发明人： WANG, Haitao , DU, Yong , ZHANG, Rui , XU, Jing , LIU, Longbin
IPC分类号： C12N15/62 , A61K47/48 , A61P37/04 , C07K16/00 , C07K19/00 , C12N15/13 , C12N15/18 , C12N15/27 , C12N15/63 , C12N5/10 , C12P21/02 , A61K38/17
CPC分类号： C12N15/62 , A61K47/6811 , A61K47/6835 , C07K2317/53 , C07K2319/30
摘要： A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.
摘要翻译：提供了具有非免疫球蛋白多肽的融合蛋白，其具有接近其C末端的半胱氨酸残基和具有突变的铰链区的免疫球蛋白组分。该突变包括位于位于最接近非Ig组分的半胱氨酸残基的半胱氨酸残基的天然铰链区的位置的点突变位点。与非免疫球蛋白多肽的半胱氨酸残基和突变的铰链区的任何剩余半胱氨酸残基的距离足以防止其间形成二硫键。

2. 发明申请

WO2008154719A1 RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS 审中-公开
标题翻译：重组人类干扰素蛋白
公开(公告)号：WO2008154719A1
公开(公告)日：2008-12-24
申请号：PCT/CA2007/001123
申请日：2007-06-22
申请人： NOVAGEN HOLDING CORPORATION , WANG, Haitao , MAO, Chunsheng , LI, Jizhi , WANG, Ling , DU, Yong , LIU, Longbin , XU, Jing , ZHANG, Rui
发明人： WANG, Haitao , MAO, Chunsheng , LI, Jizhi , WANG, Ling , DU, Yong , LIU, Longbin , XU, Jing , ZHANG, Rui
IPC分类号： C12N15/20 , A61K38/21 , A61P31/12 , A61P35/00 , A61P37/02 , C07K14/555 , C07K19/00
CPC分类号： C07K14/56 , A61K38/00 , C07K14/555
摘要： This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.
摘要翻译：本申请涉及重组人类干扰素样蛋白。在一个实施方案中，与天然存在的人干扰素α2b（HuIFN-a2b）相比，描述了通过基因改组技术产生的重组蛋白质具有增强的抗病毒和抗增殖活性。本发明包括编码蛋白质的多核苷酸和包含多核苷酸的重组载体和宿主细胞。优选地，多核苷酸选自各自具有与SEQ ID：No.1至少93％相同的序列的多核苷酸，并且所述蛋白质选自蛋白质组，其各自具有与SEQ ID NO：至少85％相同的氨基酸序列否：2.包含蛋白质的蛋白质和组合物可用于治疗对干扰素治疗（例如病毒性疾病和癌症）有反应的病症。

3. 发明申请

WO2007085084A1 RECOMBINANT HUMAN EPO-FC FUSION PROTEINS WITH PROLONGED HALF-LIFE AND ENHANCED ERYTHROPOIETIC ACTIVITY IN VIVO 审中-公开
标题翻译：重组人EPO-FC融合蛋白，具有延长的半衰期和增强的生殖活性
公开(公告)号：WO2007085084A1
公开(公告)日：2007-08-02
申请号：PCT/CA2007/000107
申请日：2007-01-25
申请人： NOVAGEN HOLDING CORPORATION , WANG, Haitao , DU, Yong , ZHANG, Rui , XU, Jing , LIU, Longbin
发明人： WANG, Haitao , DU, Yong , ZHANG, Rui , XU, Jing , LIU, Longbin
IPC分类号： C12N15/62 , A61K38/18 , A61K47/42 , A61K47/48 , A61P7/00 , C07K14/505 , C07K16/18 , C07K19/00 , C12N15/13 , C12N15/18 , C12P21/02
CPC分类号： C07K14/505 , A61K9/0019 , A61K38/00 , A61K47/6811 , C07K2317/53 , C07K2319/30
摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.
摘要翻译：描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

4. 发明申请

WO2008073737A2 POWER CONTROL METHOD AND APPARATUS FOR WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：用于无线通信系统的功率控制方法和设备
公开(公告)号：WO2008073737A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/086245
申请日：2007-12-03
申请人： ADAPTIX, INC. , WANG, Haitao
发明人： WANG, Haitao
IPC分类号： H04Q7/20
CPC分类号： H04W52/10 , H04W52/08
摘要： Open loop transmit power calculations made by a wireless communication receiving device use only the portion of the received signal power that is due to the transmitting device serving the wireless device, rather than using the total received power from all transmitting devices. In one embodiment a discernable signal trait of, such as a preamble, is used to identify signal power from a serving transmitter. In some embodiments, open loop power control may also used to transmit power limits established from closed loop power control sessions, in order to minimize power fluctuations. Digitally scaling data values compensates for transmitter power level settings by adjusting data values prior to modulation such that the modulated waveform contains a different power level than the original data values would provide.
摘要翻译：由无线通信接收设备进行的开环发射功率计算仅使用由于服务于无线设备的发射设备而导致的接收信号功率的部分，而不是使用来自所有设备的总接收功率传输设备。在一个实施例中，诸如前导码的可辨别信号特征用于识别来自服务发射机的信号功率。在一些实施例中，开环功率控制还可以用于传输从闭环功率控制会话建立的功率限制，以最小化功率波动。数字调节数据值通过在调制之前调节数据值来补偿发射机功率电平设置，使得调制波形包含与原始数据值相比不同的功率电平。

5. 发明申请

WO2010003305A1 SOLAR COMPONENT AND DEVICES CONTAINING THE SAME 审中-公开
标题翻译：太阳能组件和包含该组件的设备
公开(公告)号：WO2010003305A1
公开(公告)日：2010-01-14
申请号：PCT/CN2009/000543
申请日：2009-05-19
申请人： BYD COMPANY LIMITED , ZHANG, Yazhao , WANG, Haitao
发明人： ZHANG, Yazhao , WANG, Haitao
IPC分类号： H01L31/04
CPC分类号： H02S40/425 , F21S8/085 , F21S9/037 , F21W2131/103 , F21Y2115/10 , H01L31/035281 , H01L31/048 , H05B37/00 , Y02B20/72 , Y02E10/50
摘要： Solar component (10) and devices containing the same are disclosed. The solar component (10) includes coupling an upper member (14),a lower member (16), and at least two side members to form a cavity (18) for housing a plurality of solar cells (20). Adjacent solar cells (20) may have unused spaces (26) thereby allowing apertures (24) to be formed through the upper member (14) and the lower member (16). The apertures (24) are capable of allowing air flow through the cavity (18) thereby leading to reduce wind resistance of the solar component (10).
摘要翻译：公开了太阳能组件（10）及其装置。太阳能组件（10）包括联接上部构件（14），下部构件（16）和至少两个侧部构件以形成用于容纳多个太阳能电池（20）的空腔（18）。相邻的太阳能电池（20）可以具有未使用的空间（26），从而允许通过上部构件（14）和下部构件（16）形成孔（24）。孔（24）能够允许空气流过空腔（18），从而降低太阳能组件（10）的风阻。

6. 发明申请

WO2010000173A1 SOLAR-POWERED DEVICE 审中-公开
标题翻译：太阳能设备
公开(公告)号：WO2010000173A1
公开(公告)日：2010-01-07
申请号：PCT/CN2009/072207
申请日：2009-06-10
申请人： BYD COMPANY LIMITED , ZHANG, Yazhao , YANG, Wu , ZHOU, Dahong , WANG, Haitao
发明人： ZHANG, Yazhao , YANG, Wu , ZHOU, Dahong , WANG, Haitao
IPC分类号： H02J7/34
CPC分类号： H02J7/355 , H01L31/048 , H02S40/38 , Y02E10/50
摘要： A solar-powered device (10) has a body (12) for accommodating at least one energy storage module (20) and at least one control module (22). The body includes an opening (14) formed at the upper surface (18) of the body. At least one solar panel (24) may be coupled to the upper surface of the body and cover the opening.
摘要翻译：太阳能装置（10）具有用于容纳至少一个储能模块（20）和至少一个控制模块（22）的主体（12）。主体包括形成在主体的上表面（18）处的开口（14）。至少一个太阳能电池板（24）可以联接到主体的上表面并覆盖开口。

7. 发明申请

WO2008073739A1 SYSTEMS AND METHODS FOR ACHIEVING REDUCED INTER-SECTOR PILOT INTERFERENCEN IN A MOBILE COMMUNICATION SYSTEM 审中-公开
标题翻译：用于在移动通信系统中实现减少的间隔导频干扰的系统和方法
公开(公告)号：WO2008073739A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/086250
申请日：2007-12-03
申请人： ADAPTIX, INC. , JIANG, Zhucheng , WANG, Haitao
发明人： JIANG, Zhucheng , WANG, Haitao
IPC分类号： H04Q7/20
CPC分类号： H04W16/12
摘要： The pilots of a wireless system are arranged to reduce inter-sector interference by establishing a systematic assignment of pilots across the system. In one embodiment, the pilots are differently coded and directionally positioned within a cell such that the same pilot from adjacent cells do not overlap. In one embodiment, Walsh codes are used to create the differently coded pilot signals.
摘要翻译：无线系统的飞行员被安排为通过在系统上建立导频的系统分配来减少扇区间干扰。在一个实施例中，导频被不同地编码并定向地定位在小区内，使得来自相邻小区的相同导频不重叠。在一个实施例中，沃尔什码用于创建不同编码的导频信号。

8. 发明申请

WO2008067344A2 AUTOMATIC GAIN CONTROL METHOD AND APPARATUS FOR WIRELESS COMMUNICATION SYSTEMS 审中-公开
标题翻译：自动增益控制方法和无线通信系统的设备
公开(公告)号：WO2008067344A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085695
申请日：2007-11-28
申请人： ADAPTIX, INC. , WANG, Haitao
发明人： WANG, Haitao
IPC分类号： H04L27/08
CPC分类号： H03G3/3042 , H04L27/2601 , H04L27/2626
摘要： A system and method are provided for automatic gain control (AGC) using an adaptive reference and a threshold. An adaptive reference allows for adjusting the target power based on variations in operating parameters and conditions, such as a change to a modulation schemes which requires a different signal to noise ratio (SNR) to maintain performance. A gain adjustment threshold allows for rapid AGC response while reducing the potential effects of hysterisis. AGC levels may be changed during symbol prefixes or suffixes, and avoided during a data portion of a signal. Embodiments allow for symbol-by symbol AGC changes in OFDM, OFDMA, and TDD systems.
摘要翻译：提供了一种使用自适应参考和阈值进行自动增益控制（AGC）的系统和方法。自适应参考允许基于操作参数和条件的变化来调整目标功率，例如需要不同信噪比（SNR）以维持性能的调制方案的改变。增益调整阈值允许快速AGC响应，同时减少滞后的潜在影响。 AGC电平可以在符号前缀或后缀期间改变，并且在信号的数据部分期间被避免。实施例允许OFDM，OFDMA和TDD系统中的逐符号AGC改变。

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