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1. 发明申请

WO2008005560A3 PREVENTION OF THROMBOTIC DISORDERS WITH ACTIVE VITAMIN D COMPOUNDS 审中-公开
公开(公告)号：WO2008005560A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/015632
申请日：2007-07-09
申请人： NOVACEA, INC. , CURD, John G. , HENNER, William David , BEER, Tomasz M. , GOODWIN, Bradford S. , LALANI, Alshad S.
发明人： CURD, John G. , HENNER, William David , BEER, Tomasz M. , GOODWIN, Bradford S. , LALANI, Alshad S.
IPC分类号： A61K31/00
摘要： The present invention relates to a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof. According to the invention, the active vitamin D compound or the mimic thereof may be administered by HDPA so that high doses of the active vitamin D compound or the mimic thereof can be administered to an animal without inducing severe symptomatic hypercalcemia. The invention also relates a method for preventing, treating, or ameliorating thrombotic disorders in an animal comprising administering to the animal an active vitamin D compound or a mimic thereof in combination with one or more other therapeutic agents.

2. 发明申请

WO2004110380A2 TREATMENT OF IMMUNE-MEDIATED DISORDERS WITH ACTIVE VITAMIN D COMPOUNDS ALONE OR IN COMBINATION WITH OTHER THERAPEUTIC AGENTS 审中-公开
标题翻译：用活性维生素D化合物治疗免疫介导的疾病，或与其他治疗药物组合
公开(公告)号：WO2004110380A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/018184
申请日：2004-06-10
申请人： NOVACEA, INC. , CURD, John G. , WHITEHOUSE, Martha J.
发明人： CURD, John G. , WHITEHOUSE, Martha J.
IPC分类号： A61K
CPC分类号： A61K31/59 , A61K9/4858 , A61K2300/00
摘要： The present invention relates to a method for treating, ameliorating, or preventing immune-mediated disorders in an animal by administering to the animal active vitamin D compounds. The invention further relates to a method for treating, ameliorating, or preventing immune-mediated disorders in an animal by administering to the animal active vitamin D compounds in combination with other therapeutic agents.
摘要翻译：本发明涉及通过向动物施用活性维生素D化合物来治疗，改善或预防动物中免疫介导的病症的方法。本发明进一步涉及一种通过向动物施用活性维生素D化合物与其它治疗剂组合来治疗，改善或预防动物免疫介导的病症的方法。

3. 发明申请

WO2004110151A1 TREATMENT OF CANCER WITH ACTIVE VITAMIN D COMPOUNDS IN COMBINATION WITH RADIOTHERAPEUTIC AGENTS AND TREATMENTS 审中-公开
标题翻译：用活性维生素D化合物与放射治疗剂和治疗组合治疗癌症
公开(公告)号：WO2004110151A1
公开(公告)日：2004-12-23
申请号：PCT/US2004/018186
申请日：2004-06-10
申请人： NOVACEA, INC. , CURD, John G.
发明人： CURD, John G.
IPC分类号： A01N45/00
CPC分类号： A61K9/4858 , A61K9/4866 , A61K31/355 , A61K31/59 , A61K31/593 , A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K45/06 , A61K51/00 , A61K2300/00
摘要： The present invention relates to a method for treating cancer in an animal by administering to the animal an active vitamin D compound in combination with a radiotherapeutic agent or treatment.
摘要翻译：本发明涉及一种通过向动物施用活性维生素D化合物与放射治疗剂或治疗组合来治疗动物的癌症的方法。

4. 发明申请

WO2010048330A1 TREATMENT OF CANCER USING HYPOXIA ACTIVATED PRODRUGS 审中-公开
标题翻译：使用HYPOXIA激活的PRODRUGS治疗癌症
公开(公告)号：WO2010048330A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/061541
申请日：2009-10-21
申请人： THRESHOLD PHARMACEUTICALS, INC. , CURD, John G. , KROLL, Stewart , MATTEUCCI, Mark , HART, Charles P. , DUAN, Jian-Xin
发明人： CURD, John G. , KROLL, Stewart , MATTEUCCI, Mark , HART, Charles P. , DUAN, Jian-Xin
IPC分类号： G01N33/574
CPC分类号： A61K31/675 , A61K9/0019 , A61K31/337 , A61K31/4985 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： Cancer can be treated by administration of a hypoxia-activated prodrug, such as TH-302, alone or in combination with other anticancer agents and/or radiation therapy. In combination therapy, the hypoxia-activated prodrug and another anticancer agent or radiation therapy may be administered within the same 24-hour period, and administration of the hypoxia-activated prodrug may be completed prior to beginning administration of the other anticancer agent or radiation therapy.
摘要翻译：可以通过单独或与其它抗癌剂和/或放射治疗组合施用缺氧活化的前药如TH-302来治疗癌症。在联合治疗中，缺氧活化的前药和另一种抗癌剂或放射治疗可以在相同的24小时内施用，并且在开始施用其它抗癌剂或放射治疗之前可以完成给予缺氧活化的前药。

5. 发明申请

WO2004043360A2 METHODS OF USING VITAMIN D COMPOUNDS IN THE TREATMENT OF MYELODYSPLASTIC SYNDROMES 审中-公开
标题翻译：维生素D化合物治疗骨髓增生异常综合征的方法
公开(公告)号：WO2004043360A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035244
申请日：2003-11-06
申请人： NOVACEA, INC.
发明人： WHITEHOUSE, Martha J. , CURD, John G.
IPC分类号： A61K
CPC分类号： A61K31/59
摘要： Methods of treating MDS, or ameliorating a symptom thereof, are disclosed. Specific methods encompass the administration of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Other methods include intermittent administration of a high dose of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Such intermittent administration allows high doses of the vitamin D compounds to be administered while minimizing or eliminating hypercalcemia.
摘要翻译：公开了治疗MDS或改善其症状的方法。具体方法包括单独或与一种或多种另外的活性剂组合施用一种或多种维生素D化合物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。其他方法包括单独或与一种或多种另外的活性剂组合的间歇给药高剂量的一种或多种维生素D化合物或其药学上可接受的盐，溶剂化物，水合物，立体异构体，包合物或前药。这种间歇给药可以使高剂量的维生素D化合物给药，同时最大限度地减少或消除高钙血症。

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