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1. 发明申请

WO0216927A3 SAMPLE INTRODUCTION INTERFACE FOR ANALYTICAL PROCESSING 审中-公开
标题翻译：样品介绍界面进行分析处理
公开(公告)号：WO0216927A3
公开(公告)日：2003-01-03
申请号：PCT/US0126341
申请日：2001-08-23
申请人： NEWTON SCIENT INC
发明人： HUGHEY BARBARA J , SKIPPER PAUL L , WISHNOK JOHN S , SHEFER RUTH E , FRIED NAOMI A , MEHL JOHN T , TANNENBAUM STEVEN R
IPC分类号： G01N30/72 , G01N30/84 , H01J49/04 , H01J49/00
CPC分类号： H01J49/0463 , G01N30/7233 , G01N2030/8405 , H01J49/0445
摘要： An interface for introducing a non-gaseous sample as a predetermined gaseous form into an accelerator mass spectrometer which comprises a nebulizer that receives the non-gaseous sample to provide a fine spray of the sample, converter that receives at least a portion of said fine spray and converts the desired elements to the predetermined gaseous form and a flow line that transports the predetermined gaseous form to the accelerator mass spectrometer.
摘要翻译：用于将非气态样品作为预定气体形式引入加速器质谱仪的界面，该加速器质谱仪包括接收非气态样品以提供样品的细微喷雾的雾化器，其接收至少一部分所述细小喷雾并将期望的元素转换成预定的气体形式和将预定气体形式输送到加速器质谱仪的流动管线。

2. 发明申请

WO0217348A2 SAMPLE INTRODUCTION INTERFACE FOR ANALYTICAL PROCESSING OF A SAMPLE PLACED ON A SUBSTRATE 审中-公开
标题翻译：样品介绍用于分层加工的样品置于基材上
公开(公告)号：WO0217348A2
公开(公告)日：2002-02-28
申请号：PCT/US0126324
申请日：2001-08-23
申请人： NEWTON SCIENT INC
发明人： HUGHEY BARBARA J , SKIPPER PAUL L , WISHNOK JOHN S , SHEFER RUTH E , FRIED NAOMI A , MEHL JOHN T , TANNENBAUM STEVEN R
IPC分类号： G01N30/72 , G01N30/84 , H01J49/04 , H01J49/00
CPC分类号： H01J49/0463 , G01N30/7233 , G01N2030/8405 , H01J49/0445
摘要： An interface system for introducing a non-gaseous sample as a predetermined gaseous form into an analytical instrument which comprises a substrate that receives the non-gaseous sample and a directed energy source that heats at least a portion of said substrate containing the non-gaseous sample to convert the sample to the predetermined gaseous form.
摘要翻译：一种用于将非气态样品作为预定气体形式引入到分析仪器中的界面系统，该分析仪器包括接收非气态样品的基底和加热含有非气态样品的所述基底的至少一部分的定向能量源以将样品转化为预定的气体形式。

3. 发明申请

WO2009006592A3 COMPACT HIGH VOLTAGE X-RAY SOURCE SYSTEM AND METHOD FOR X-RAY INSPECTION APPLICATIONS 审中-公开
标题翻译：紧凑的高电压X射线源系统和X射线检测应用的方法
公开(公告)号：WO2009006592A3
公开(公告)日：2009-03-26
申请号：PCT/US2008069195
申请日：2008-07-03
申请人： NEWTON SCIENT INC , KLINKOWSTEIN ROBERT E , SHEFER RUTH E
发明人： KLINKOWSTEIN ROBERT E , SHEFER RUTH E
IPC分类号： H01J35/00 , H05G1/06 , H05G1/10
CPC分类号： H05G1/10 , H01J2235/02 , H01J2235/087 , H01J2235/12 , H05G1/06
摘要： An x-ray system is disclosed that includes a bipolar x-ray tube (50). The bipolar x-ray tube includes two insulators (58,60) that are separated by an intermediate electrode (56) in an embodiment, wherein each insulator forms a portion of an outer wall of a vacuum envelope of the bipolar x-ray tube surrounding at least a portion of a path (76) of an electron beam within the vacuum envelope. In further embodiments, the bipolar x-ray tube includes a first electrode (54) at a positive high voltage potential with respect to a reference potential, a second electrode (56) at a negative high voltage potential with respect to the reference potential, and an x-ray transmissive window (88) that is at the positive high voltage potential.
摘要翻译：公开了一种包括双极X射线管（50）的X射线系统。双极X射线管包括在一个实施例中由中间电极（56）分开的两个绝缘体（58,60），其中每个绝缘体形成双极X射线管的真空外壳的一部分外围位于真空外壳内的电子束的路径（76）的至少一部分。在另外的实施例中，双极X射线管包括相对于参考电位处于正高电压电位的第一电极（54），相对于参考电位处于负高电压电位的第二电极（56），以及处于正高电压电位的x射线透射窗（88）。

4. 发明申请

WO2004026007A3 X-RAY FEEDBACK STABILIZATION OF AN X-RAY TUBE 审中-公开
标题翻译： X射线管的X射线反馈稳定
公开(公告)号：WO2004026007A3
公开(公告)日：2004-07-15
申请号：PCT/US0328401
申请日：2003-09-10
申请人： NEWTON SCIENT INC
发明人： SHEFER RUTH E , KLINKOWSTEIN ROBERT E , MARMAR EARL S
IPC分类号： H01J35/18 , H05G1/30 , H05G1/34
CPC分类号： H05G1/30 , H01J35/18 , H05G1/34
摘要： A feedback controlled X-ray tube. An X-ray detector detects the emitted X-rays and provides a detected X-ray signal indicative thereof to a control system, which provides the current control signal, providing feedback stabilization of the X-ray output from a source of X-rays, such as, for example an X-ray tube.
摘要翻译：反馈控制的X射线管。 X射线检测器检测发射的X射线，并向控制系统提供检测到的X射线信号，该控制系统提供电流控制信号，提供来自X射线源的X射线输出的反馈稳定性，例如，例如X射线管。

5. 发明申请

WO2004075610A3 INTEGRATED X-RAY SOURCE MODULE 审中-公开
标题翻译：集成X射线源模块
公开(公告)号：WO2004075610A3
公开(公告)日：2004-11-25
申请号：PCT/US2004005190
申请日：2004-02-20
申请人： INPHO INC , NEWTON SCIENT INC , FEDA FRANCIS M , OETTINGER PETER E , SHEFER RUTH E , KLINKOWSTEIN ROBERT E
发明人： FEDA FRANCIS M , OETTINGER PETER E , SHEFER RUTH E , KLINKOWSTEIN ROBERT E
IPC分类号： H05G1/06 , H05G1/10
CPC分类号： H05G1/06 , H05G1/10
摘要： Described is a self-contained, small, lightweight, power-efficient and radiation-shielded module (400) that includes a miniature vacuum X-ray tube (120) emitting X-rays of a controlled intensity and defined spectrum. Feedback control circuits are used to monitor and maintain the beam current and voltage (700). The X-ray tube (120), highvoltage power supply (118), and the resonant converter (108) are encapsulated in a solid highvoltage insulating material (600). The module (400) can be configured into complex geometries and can be powered by commercially available small, compact, low-voltage batteries.
摘要翻译：描述了一种独立的，小型的，轻便的，功率高效的和辐射屏蔽模块（400），其包括发射受控强度和限定光谱的X射线的微型真空X射线管（120）。反馈控制电路用于监测和维持射束电流和电压（700）。 X射线管（120），高压电源（118）和谐振转换器（108）被封装在固体高压绝缘材料（600）中。模块（400）可以配置成复杂的几何形状，并且可以由市售的小型紧凑型低压电池供电。

6. 发明申请

WO9707122A2 PRODUCTION OF <64>Cu AND OTHER RADIONUCLIDES USING A CHARGED-PARTICLE ACCELERATOR 审中-公开
标题翻译：使用充电颗粒加速器生产六价铜和其他放射性核素
公开(公告)号：WO9707122A2
公开(公告)日：1997-02-27
申请号：PCT/US9613027
申请日：1996-08-09
申请人： UNIV WASHINGTON , NEWTON SCIENT INC
发明人： WELCH MICHAEL J , MCCARTHY DEBORAH W , SHEFER RUTH E , KLINKOWSTEIN ROBERT E
IPC分类号： G21G1/10 , C07F
CPC分类号： G21G1/10 , G21G2001/0094
摘要： Radionuclides are produced according to the present invention at commercially significant yields and at specific activities which are suitable for use in radiodiagnostic agents such as PET imaging agents and radiotherapeutic agents and/or compositions. In the method and system of the present invention, a solid target having an isotopically enriched target layer electroplated on an inert substrate is positioned in a specially designed target holder and irradiated with a charged-particle beam. The beam is preferably generated using an accelerator such as a biomedical cyclotron at energies ranging from about 5 MeV to about 25 MeV. The target is preferably directly irradiated, without an intervening attenuating foil, and with the charged particle beam impinging an area which substantially matches the target area. The irradiated target is remotely and automatically transferred from the target holder, preferably without transferring any target holder subassemblies, to a conveyance system which is preferably a pneumatic or hydraulic conveyance system, and then further transferred to an automated separation system. The system is effective for processing a single target or a plurality of targets. After separation, the unreacted target material can be recycled for preparation of other targets. In a preferred application of the invention, a biomedical cyclotron has been used to produce over 500 mCi of Cu having a specific activity of over 300 mCi/ nu g Cu according to the reaction Ni(p,n) Cu. These results indicate that accelerator-produced Cu is suitable for radiopharmaceutical diagnostic and therapeutic applications.
摘要翻译：放射性核素根据本发明以商业上显着的产率和适用于放射诊断剂如PET成像剂和放射治疗剂和/或组合物的特定活性制备。在本发明的方法和系统中，将具有在惰性基板上电镀的同位素富集目标层的固体靶放置在专门设计的靶保持器中并用带电粒子束照射。光束优选使用诸如生物医学回旋加速器的加速器在约5MeV至约25MeV的能量下产生。目标优选直接照射，没有中间的衰减箔，并且带电粒子束撞击基本上与目标区域匹配的区域。照射的目标物远程地并且自动地从目标保持器传送，优选地不将任何目标保持器组件传送到优选为气动或液压输送系统的输送系统，然后进一步转移到自动分离系统。该系统对于处理单个目标或多个目标是有效的。分离后，未反应的目标材料可以再循环用于制备其他靶。在本发明的优选应用中，根据Ni（p，n）的反应，已经使用生物医学回旋加速器来生产具有超过300mCi / nu g Cu的比活性的超过500mCi的64 Cu， 64>铜。这些结果表明，促进剂生产的<64> Cu适用于放射性药物诊断和治疗应用。

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