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1. 发明申请

WO2005054190A1 3-AMINOPYRROLIDONE DERIVATIVES 审中-公开
标题翻译： 3-氨基吡咯烷酮衍生物
公开(公告)号：WO2005054190A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/012957
申请日：2004-11-16
申请人： NEWRON PHARMACEUTICALS S.p.A. , THALER, Florian , SABIDO DAVID, Cibele, Maria , MAESTRONI, Sara , RAVEGLIA, Luca, Francesco , SALVATI, Patricia
发明人： THALER, Florian , SABIDO DAVID, Cibele, Maria , MAESTRONI, Sara , RAVEGLIA, Luca, Francesco , SALVATI, Patricia
IPC分类号： C07D207/273
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4412 , A61K31/55 , C07D211/76
摘要： This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I), wherein m is an integer from 1 to 3; X is methylene, oxygen, sulphur or a NR 6 group; R 1 is a straight or branched C 1 -C 8 alkyl or C 3 -C 8 alkenylene or C 3 -C 8 alkynylene chain, optionally substituted with CF 3 , phenyl, phenoxy or naphthyl, or phenyl the aromatic rings optionally substituted by one or more C 1 -C 4 alkyl, halogens, trifluoromethyl, hydroxy or C 1 -C 4 alkoxy groups; R 2 , R 3 are independently hydrogen, a C 1 -C 3 alkyl chain, halogen, trifluoromethyl, hydroxy or C 1 -C 4 alkoxy groups; R 4 , R 5 , R 6 are independently hydrogen or C 1 -C 6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及以下通式（I）的3-氨基吡咯烷酮衍生物和类似物的化合物和用途，其中m为1至3的整数; X是亚甲基，氧，硫或NR 6基团; R 1是任选被CF 3，苯基，苯氧基或萘基取代的直链或支链C 1 -C 8烷基或C 3 -C 8亚烯基或C 3 -C 8亚炔基链，或苯基，任选被一个或多个C 1 -C 4 烷基，卤素，三氟甲基，羟基或C 1 -C 4烷氧基; R 2，R 3独立地是氢，C 1 -C 3烷基链，卤素，三氟甲基，羟基或C 1 -C 4烷氧基; R 4，R 5，R 6独立地是氢或C 1 -C 6烷基; 和其药学上可接受的盐，其作为钠和/或钙通道调节剂是有活性的，因此可用于预防，缓解和治愈广泛范围的病理学，包括但不限于心血管，炎症，眼科，泌尿，代谢和胃肠道疾病其中上述机制被描述为发挥病理作用。

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