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1. 发明申请

WO2012103487A1 COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
标题翻译：作为造血剂改性剂的欧司康化合物及其用途
公开(公告)号：WO2012103487A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/022985
申请日：2012-01-27
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J. , KOMATSU, Li, Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li, Ni
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A61K31/37 , A61K8/498 , A61K8/97 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K9/2063 , A61K9/4866 , A61K36/48 , A61K45/06 , A61K47/20 , A61Q19/02 , A61K2300/00
摘要： Provided are coumarin compounds of formula I, for example, robustic acid methyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation wherein R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are described herein. Also provided are plant extracts containing a compound of formula I, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.
摘要翻译：提供式I的香豆素化合物，例如鲁尼酸甲基醚，以及这些化合物及其组合物用于调节（例如，抑制）黑素生成和色素沉积的用途，其中本文描述了R3，R4，R5，R6，R7和R8 。还提供含有式I化合物的植物提取物和这种植物提取物用于调节（例如抑制）黑素生成和色素沉着的用途。化合物或植物提取物可以制备为药物和化妆品组合物，并且可以用于预防和治疗与异常黑素生成活性相关的病症。

2. 发明申请

WO2011046978A3 STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
公开(公告)号：WO2011046978A3
公开(公告)日：2011-04-21
申请号：PCT/US2010/052394
申请日：2010-10-12
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J. , KOMATSU, Li Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li Ni
IPC分类号： A61K8/63 , A61K31/58 , A61K31/56 , A61Q19/02 , A61P17/00
摘要： Provided are steroidal compounds of formula I, for example, conessine, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. Also provided are plant extracts containing a compound of formula I, for example, conessine, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.

3. 发明申请

WO2009064493A1 TRICYCLIC COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
标题翻译：三元化合物作为成色剂改性剂及其用途
公开(公告)号：WO2009064493A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/012838
申请日：2008-11-14
申请人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE , ORLOW, Seth, J. , KOMATSU, Li, Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li, Ni
IPC分类号： A61K31/137 , A61K31/335 , A61K31/55 , A61K45/06 , A61P17/00
CPC分类号： A61K31/137 , A61K31/335 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： A method of identification of tricyclic compounds (formula I) that control melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to modify (e.g., inhibit) melanin production are disclosed. Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, hyperpigmentation and others.
摘要翻译：公开了鉴定控制黑色素合成（黑素生成）的三环化合物（式I）的方法，以及这些化合物及其组合物用于改变（例如抑制）黑色素生成的用途。式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗与异常黑素生成活性有因果关系的病症，包括作为非限制性实例，色素沉着过度等。

4. 发明申请

WO2009064492A1 QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
标题翻译：喹啉化合物作为成色剂改性剂及其用途
公开(公告)号：WO2009064492A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/012837
申请日：2008-11-14
申请人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE , ORLOW, Seth, J. , KOMATSU, Li Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li Ni
IPC分类号： A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/49 , A61K45/06 , A61P17/00
CPC分类号： A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/49 , A61K45/06 , A61K2300/00
摘要： A method of identification of quinoline compounds (formula I) that modify melanin synthesis (melano genesis), and the use of such compounds and compositions thereof to control (e.g., inhibit) melanin production are disclosed. Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, pigmentation deficiencies (albinism) and hyperpigmentation and others.
摘要翻译：公开了一种鉴定修饰黑色素合成的喹啉化合物（式I）的方法，以及这些化合物及其组合物用于控制（例如抑制）黑色素产生的用途。式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗与异常黑素生成活性有因果关系的病症，包括作为非限制性实例，色素沉着缺失（白化病）和色素沉着过度等。

5. 发明申请

WO2012091730A2 INDOLE ALKALOID COMPOUNDS AS MELANOGENESIS PROMOTERS AND USES THEREOF 审中-公开
标题翻译：吲哚类生物碱化合物作为黑色素生成促进剂及其用途
公开(公告)号：WO2012091730A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/001915
申请日：2011-11-16
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J. , KOMATSU, Li, Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li, Ni
IPC分类号： A61K31/437 , A61K31/4375 , C07D471/14 , C07D491/22 , A61P17/00 , A61K8/49 , A61Q19/02
CPC分类号： A61K31/475 , A61K8/4906 , A61K8/4926 , A61K31/437 , A61K31/4375 , A61K36/72 , A61K45/06 , A61Q17/04 , A61Q19/04 , C07D471/14 , C07D491/22 , A61K2300/00
摘要： Provided are indole alkaloid compounds of formula I, for example, pubescine, and the use of such compounds and compositions thereof to promote (e.g., enhance) melanogenesis and pigmentation. Also provided are plant extracts containing a compound of formula I, for example, pubescine, and the use of such a plant extract to promote (e.g., enhance) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.
摘要翻译：所提供的是式I的吲哚生物碱化合物，例如，毛素，以及这些化合物及其组合物用于促进（例如增强）黑素生成和色素沉着的用途。还提供了含有式I化合物例如巴西芹的植物提取物，以及使用这种植物提取物促进（例如增强）黑素生成和色素沉着。化合物或植物提取物可以制备成药物和化妆品组合物，并且可以用于预防和治疗与异常黑素生成活性有关的病症。

6. 发明申请

WO2011094016A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING 审中-公开
标题翻译：化合物，组合物和防止皮肤瑕疵的方法
公开(公告)号：WO2011094016A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/000163
申请日：2011-01-28
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J. , KOMATSU, Li, Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li, Ni
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A61K31/37 , A61K31/35
摘要： A method for preventing hyperpigmented skin, undesired pigmentation disorder of skin, or undesired darkening of skin using coumarin compounds, the use of such compounds, and compositions and formulations thereof are disclosed. In a particular embodiment, the coumarin compounds are selected from robustic acid methyl ether, scandenin, and coumophos. The compounds may be prepared as additives to pharmaceutical and cosmetic compositions, and in personal care products such as antiperspirants. In a particular embodiment extends to an antiperspirant product containing a skin darkening inhibitory amount of a compound of the invention. Also, the present skin darkening compounds may be prepared in combination with each other. The compounds, compositions and formulations of the invention may be used for the prevention of the onset or progression of conditions characterized by unwanted skin darkening, including those that may be causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.
摘要翻译：公开了一种使用香豆素化合物防止皮肤色素沉着过多，皮肤不希望的色素沉着失调或皮肤不希望的变暗的方法，使用这些化合物及其组合物和制剂。在一个具体的实施方案中，香豆素化合物选自鲁西酸甲基醚，斯堪迪汀和香豆磷。化合物可以制备成药物和化妆品组合物的添加剂，以及个人护理产品如止汗剂。在一个具体实施方案中延伸至含有皮肤变暗抑制量的本发明化合物的止汗剂产品。此外，本发明的皮肤变色化合物可以彼此组合制备。本发明的化合物，组合物和制剂可用于预防特征在于不想要的皮肤变暗的病症的发作或进展，包括可能与异常黑素生成活性有因果关系的那些，包括作为非限制性实例的色素沉着过度和别的。

7. 发明申请

WO2009134404A3 STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
公开(公告)号：WO2009134404A3
公开(公告)日：2009-11-05
申请号：PCT/US2009/002658
申请日：2009-04-30
申请人： NEW YORK UNIVERSITY OF SCHOOL OF MEDICINE , ORLOW, Seth, J. , KOMATSU, Li, Ni
发明人： ORLOW, Seth, J. , KOMATSU, Li, Ni
IPC分类号： A61K31/56 , A61K31/58 , A61P17/00 , A61K8/49 , A61Q19/02
摘要： A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: Me I The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.

8. 发明申请

WO2002087565A1 INHIBITION OF PIGMENTATION BY INHIBITION OF FATTY ACID SYNTHASE 审中-公开
标题翻译：通过抑制脂肪酸合成来抑制染色
公开(公告)号：WO2002087565A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/013894
申请日：2002-05-02
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J. , HALL, Andrea
发明人： ORLOW, Seth, J. , HALL, Andrea
IPC分类号： A61K31/34
CPC分类号： A61K31/00 , A61K31/34 , A61K31/365 , A61K31/38
摘要： The invention provides novel methods and pharmaceutical compositions designed to decrease melanin production by inhibiting fatty acid synthase in a melanocyte, thereby lightening skin pigmentation.
摘要翻译：本发明提供了通过抑制黑素细胞中的脂肪酸合成来减少黑色素产生的新方法和药物组合物，从而减轻皮肤色素沉着。

9. 发明申请

WO2009126274A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS, SUCH AS MELANOMAS AND GLIOMAS 审中-公开
公开(公告)号：WO2009126274A3
公开(公告)日：2009-10-15
申请号：PCT/US2009/002200
申请日：2009-04-08
申请人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE , ORLOW, Seth, J. , CHEN, Ming
发明人： ORLOW, Seth, J. , CHEN, Ming
IPC分类号： A61K31/4188 , A61P35/00 , A61K31/505
摘要： A method of potentiating the efficacy of an antineoplastic agent such as temozolomide, comprises the administration of an antifolate agent as defined herein. Also disclosed are compositions, including pharmaceutical compositions, comprising the antineoplastic agent and an antifolate agent, and the use of such compounds and compositions thereof to treat a variety of cancers, such as melanoma. Unit dosage forms and kits are also contemplated and disclosed.

10. 发明申请

WO2012103493A1 BENZOPYRAN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF 审中-公开
标题翻译：苯并噻唑化合物作为造血机制改造剂及其用途
公开(公告)号：WO2012103493A1
公开(公告)日：2012-08-02
申请号：PCT/US2012/022994
申请日：2012-01-27
申请人： NEW YORK UNIVERSITY , ORLOW, Seth, J.
发明人： ORLOW, Seth, J.
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A61K31/352 , A61K8/498 , A61Q19/02 , C07D493/04
摘要： Provided are benzopyran compounds of formula I, for example, pomiferin-3', 4 '-dimethyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. wherein R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are described herein. Also provided are plant extracts containing a compound of formula I, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.
摘要翻译：提供式I的苯并吡喃化合物，例如促红细胞生成素-3'，4'-二甲基醚，以及这些化合物及其组合物用于调节（例如抑制）黑素生成和色素沉着的用途。其中R3，R4，R5，R6，R7和R8如本文所述。还提供含有式I化合物的植物提取物和这种植物提取物用于调节（例如抑制）黑素生成和色素沉着的用途。化合物或植物提取物可以制备为药物和化妆品组合物，并且可以用于预防和治疗与异常黑素生成活性相关的病症。

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