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1. 发明申请

WO2013034622A1 POLYMORPHIC FORM OF PRIDOPIDINE HYDROCHLORIDE 审中-公开
标题翻译：孕激素氯吡格雷的多形态
公开(公告)号：WO2013034622A1
公开(公告)日：2013-03-14
申请号：PCT/EP2012/067371
申请日：2012-09-06
申请人： NEUROSEARCH A/S , SONESSON, Clas , PITTELKOW, Thomas , FRØSTRUP, Brian , ZIMMERMANN, Anne
发明人： SONESSON, Clas , PITTELKOW, Thomas , FRØSTRUP, Brian , ZIMMERMANN, Anne
IPC分类号： C07D211/24 , A61K31/445 , A61P25/28
CPC分类号： C07D211/30 , C07D211/24
摘要： This invention relates to a new crystalline form of Pridopidine, a drug substance currently in development for the treatment of Huntington's disease. More specifically the invention provides polymorphic Form II of the Pridopidine hydrochloride salt, a process for the preparation this polymorphic form, pharmaceutical compositions comprising polymorphic Form II, and methods of uses of this polymorphic form.
摘要翻译：本发明涉及一种新的结晶形式的派多定，目前正在开发用于治疗亨廷顿氏病的药物。更具体地，本发明提供了盐酸普拉头德盐的多晶型II，制备该多晶形式的方法，包含多晶型II的药物组合物，以及该多晶型形式的使用方法。

2. 发明申请

WO2009043834A1 PHARMACEUTICAL COMPOSITIONS OF 5-HYDR0XYTRYPT0PHAN AND SEROTONIN-ENHANCING COMPOUND 审中-公开
标题翻译： 5-羟色胺和葡萄糖苷增强化合物的药物组合物
公开(公告)号：WO2009043834A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063012
申请日：2008-09-29
申请人： NeuroSearch A/S , JACOBSEN, Jacob Pade Ramsøe , FRØSTRUP, Brian
发明人： JACOBSEN, Jacob Pade Ramsøe , FRØSTRUP, Brian
IPC分类号： A61K31/135 , A61K31/138 , A61K31/15 , A61K31/343 , A61K31/405 , A61K31/4525 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , A61P3/04 , A61K45/06
CPC分类号： A61K31/405 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/343 , A61K31/4525 , A61K45/06 , A61K2300/00
摘要： This invention relates to novel pharmaceutical compositions comprising a therapeutically effective amount of a slow-release formulation of 5-hydroxytryptophan (5-HTP) and a serotonin-enhancing compound. The pharmaceutical compositions for use according to the invention are contemplated particularly useful for combating CNS disorders, including depressive disorders, bipolar disorders, anxiety disorders, obesity and pain.
摘要翻译：本发明涉及包含治疗有效量的5-羟色氨酸缓冲制剂（5-HTP）和5-羟色胺增强化合物的新型药物组合物。根据本发明使用的药物组合物特别适用于对抗CNS障碍，包括抑郁障碍，双相性精神障碍，焦虑症，肥胖症和疼痛。

3. 发明申请

WO2006064031A1 ENANTIOMERS OF 3-HETEROARYL-8H-8-AZABICYCLO(3.2.1)OCT-2-ENE AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 审中-公开
标题翻译： 3-异丁基-8,8-氮杂双环（3.2.1）OCT-2-环己酮的单体和它们作为单胺神经递质抑制剂的用途
公开(公告)号：WO2006064031A1
公开(公告)日：2006-06-22
申请号：PCT/EP2005/056801
申请日：2005-12-15
申请人： NEUROSEARCH A/S , PETERS, Dan , BROWN, David, Tristam , EGESTAD, Börje , DAM, Eva , JONES, David, Spencer , FRØSTRUP, Brian , NIELSEN, Elsebet, Østergaard , OLSEN, Gunnar, M. , REDROBE, John Paul
发明人： PETERS, Dan , BROWN, David, Tristam , EGESTAD, Börje , DAM, Eva , JONES, David, Spencer , FRØSTRUP, Brian , NIELSEN, Elsebet, Østergaard , OLSEN, Gunnar, M. , REDROBE, John Paul
IPC分类号： C07D409/04 , A61K31/46 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/36 , A61P29/00
CPC分类号： C07D451/02
摘要： This invention relates to novel enantiomers of 3-heteroaryl-8H-8azabicyclo- [3.2.1] oct-2-ene useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作单胺神经递质再摄取抑制剂的3-杂芳基-8,8-8氮杂双环[3.2.1]辛-2-烯的新型对映异构体。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

4. 发明申请

WO2005011694A1 2-METHOXYMETHYL-3-(3,4-DICHLOROPHENYL)-8-AZABICYCLO[3.2.1]OCTANE TARTRATE SALTS 审中-公开
标题翻译： 2-甲氧基甲基-3-（3,4-二氯苯基）-8-氮杂双环[3.2.1]十八烷酸钠盐
公开(公告)号：WO2005011694A1
公开(公告)日：2005-02-10
申请号：PCT/EP2004/051651
申请日：2004-07-29
申请人： NEUROSEARCH A/S , FRØSTRUP, Brian , WÄTJEN, Frank , JENSEN, Klaus, Snej
发明人： FRØSTRUP, Brian , WÄTJEN, Frank , JENSEN, Klaus, Snej
IPC分类号： A61K31/46
CPC分类号： C07D451/02
摘要： This invention relates to novel (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4dichlorophenyl)-8-azabicyclo[3.2. 1 ]octane tartrate salts, such as L-tartrate monohydrates and anhydrates. The salts are useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these salts in a method for therapy and to pharmaceutical compositions comprising the salts of the invention.
摘要翻译：本发明涉及新的（1R，2R，3S，5S）-2-甲氧基甲基-3-（3,4-二氯苯基）-8-氮杂双环[3.2。 1]辛烷酒石酸盐，如L-酒石酸盐一水合物和水合物。这些盐可用作单胺神经递质再摄取抑制剂。在其它方面，本发明涉及这些盐在治疗方法中的用途以及包含本发明的盐的药物组合物。

5. 发明申请

WO2013086425A1 THE HYDROBROMIDE SALT OF PRIDOPIDINE 审中-公开
标题翻译：孕激素盐酸氢盐
公开(公告)号：WO2013086425A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068582
申请日：2012-12-07
申请人： IVAX INTERNATIONAL GMBH , TEVA PHARMACEUTICALS USA, INC. , ZIMMERMANN, Anne , FRØSTRUP, Brian
发明人： ZIMMERMANN, Anne , FRØSTRUP, Brian
IPC分类号： A61K31/4453 , A61P25/28 , C07D211/00
CPC分类号： A61K31/451 , C07D211/24
摘要： A salt of Pridopidine, a drug substance treats of Huntington's disease, include pharmaceutically acceptable hydfobromide salt, pharmaceutical compositions comprising this salt, and uses of this salt as a drug substance. The salt compounds improve symptoms of psychosis, including schizo-phrenia and schizophreniform disorders as well as drug induced psychotic disorders, behavioral disorders usually first diagnosed in infancy, childhood, or adolescence as well as in impulse control disorders, and speech disorders such as stuttering may improve. Other psychotic disorders not characterized as schizophrenia, schizo affective syndromes as well as psychotic symptoms, delusions and hallucinations induced by other drugs may also improve. Disruptive behavior disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder and oppositional defiant disorder may also improve, and tic disorders such as Gilles de la Tourette' s syndrome. Salt compounds may be used for treating substance abuse disorders as well as disorders characterized by misuse of food.
摘要翻译：药物物质治疗亨廷顿舞蹈病的药物物质包括药学上可接受的氢溴酸盐，包含该盐的药物组合物以及该盐作为药物物质的用途。盐类化合物改善精神病的症状，包括分裂性精神分裂症和精神分裂症样疾病以及药物诱发的精神病，通常在婴儿期，儿童期或青春期以及冲动控制障碍中首先诊断的行为障碍，以及言语障碍（例如口吃）提高。其他未被鉴定为精神分裂症，分裂症状综合征以及其他药物引起的精神病症状，妄想和幻觉的其他精神障碍也可能改善。诸如注意缺陷多动障碍（ADHD），进行障碍和对抗性疾病的破坏性行为障碍也可能改善，以及诸如Gilles de la Tourette综合征的tic疾病。盐化合物可用于治疗药物滥用障碍以及滥用食物特征的疾病。

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